Investigations of efficacy of intramammary applied antimicrobials and glucocorticosteroides in the treatment of subclinical and clinical mastitis in cows

Abstract

Inflammation of the mammary gland, mastitis in cows, presents one of the most acute problems in intensive dairy production, inflicting huge economic losses. In the course of one year, 80 samples were taken at investigated farms from udder quarters of cows with clinical mastitis and 160 samples from udder quarters of cows with subclinical mastitis. The efficacy of three preparations, A, B, and C, was examined in the treatment of clinical and subclinical mastitis in cows. The investigations indicate that antibiotic preparation A (neomycin, polimixine B, oleandomycin and prednisolone) exhibited a greater efficacy in the treatment of clinical mastitis caused by Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis and Micrococcus sp., but a smaller efficacy in the treatment of subclinical mastitis caused by Staphylococcus aureus. Preparation B (amoxicillin, clavulanic acid and prednisolone) exhibited a higher efficacy in the treatment of clinical mastitis caused by Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis and Micrococcus, but a weaker effect in the treatment of subclinical mastitis caused by Staphylococcus aureus. Preparation C (procaine penicillin G, streptomycin, neomycin sulfate and prednisolone acetate) exihibited efficacy in the treatment of clinical and subclinical mastitis caused by Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, Micrococcus, Staphylococcus aureus and Esherichie coli.

Zapaljenje mlečne žlezde (mastitis) kod krava predstavlja jedan od najaktuelnijih problema u intenzivnoj proizvodnji mleka, nanoseći velike ekonomske gubitke. Sa ispitivanih farmi u toku jedne godine, uzeto je 80 uzoraka mleka iz četvrti vimena krava sa kliničkim mastitisom i 160 uzoraka mleka iz četvrti vimena krava sa supkliničkim mastitisom. Ispitana je efikasnost tri preparata - A, B i C, u lečenju krava od kliničkih i supkliničkih mastitisa. Preparat A (neomicin, polimiksin B, oleandomicin i prednizolon) pokazao je veću efikasnost u lečenju kliničkih mastitisa izazvanih bakterijama Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis i Micrococcus sp., ali slabiju efikasnost u lečenju supkliničkih mastitisa izazvanih Staphylococcus aureus. Preparat B (amoksicilin, klavulanska kiselina i prednizolon) pokazao je veću efikasnost u lečenju kliničkih mastitisa izazvanih bakterijama Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis i Micrococcus, ali slabije dejstvo u lečenju supkliničkih mastitisa izazvanih bakterijom Staphylococcus aureus. Preparat C (prokain penicilin G, streptomicin, neomicin sulfat i prednizolon acetat) pokazao je efikasnost u lečenju kliničkih i supkliničkih mastitisa izazvanih bakterijama Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, Micrococcus, Staphylococcus aureus i Esherichie coli.