Genotoxicity of the anticoccidial agent salinomycin
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This report presents an analysis of genotoxic effects of the ionophoric antibiotic salinomycin commonly used in the control of coccidiosis. Mutagenic properties were determined, after application of increasing doses to experimental chinchilla rabbits, by monitoring mitotic activity of bone marrow cells, numerical chromosomal alterations and structural chromosomal aberrations. Moderate to non-significant genotoxicity was observed, except for the frequency of structural chromosomal aberrations where 19% of the examined mitoses displayed aberrations. This could lead to sterility or termination of embryonic development and, therefore, calls for caution in its use in clinical practice and poultry farming.
Keywords:genotoxicity / mutagenicity / chromosomal aberrations / anticoccidials / salinomycin
Source:Acta veterinaria - Beograd, 1998, 48, 4, 245-253
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd