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dc.creatorDimitrijević, Sanda
dc.creatorSavovski, K
dc.creatorDimitrijević, B
dc.date.accessioned2020-06-03T12:38:09Z
dc.date.available2020-06-03T12:38:09Z
dc.date.issued1998
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/97
dc.description.abstractThis report presents an analysis of genotoxic effects of the ionophoric antibiotic salinomycin commonly used in the control of coccidiosis. Mutagenic properties were determined, after application of increasing doses to experimental chinchilla rabbits, by monitoring mitotic activity of bone marrow cells, numerical chromosomal alterations and structural chromosomal aberrations. Moderate to non-significant genotoxicity was observed, except for the frequency of structural chromosomal aberrations where 19% of the examined mitoses displayed aberrations. This could lead to sterility or termination of embryonic development and, therefore, calls for caution in its use in clinical practice and poultry farming.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsrestrictedAccess
dc.sourceActa veterinaria - Beograd
dc.subjectgenotoxicityen
dc.subjectmutagenicityen
dc.subjectchromosomal aberrationsen
dc.subjectanticoccidialsen
dc.subjectsalinomycinen
dc.titleGenotoxicity of the anticoccidial agent salinomycinen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДимитријевић, Б; Савовски, К; Димитријевић, Санда;
dc.citation.volume48
dc.citation.issue4
dc.citation.spage245
dc.citation.epage253
dc.citation.other48(4): 245-253
dc.citation.rankM23
dc.identifier.wos000076227300006
dc.identifier.scopus2-s2.0-3042896575
dc.identifier.rcubconv_1286
dc.type.versionpublishedVersion


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