Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity
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Sovilj, Sofija P.
Sabo, Tibor J.
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Two new platinum(IV) complexes (1, trifluoperazinehydrochloride-aquapentachloridoplatinate(IV) and 2, chlorpromazine-chlorpromazinehydrochloridepentachloridoplatinate(IV)) were synthesized in the reaction of K-2[PtCl6] with trifluoperazine dihydrochloride (TF center dot 2HCl) or chlorpromazine hydrochloride (CP center dot HCl). The complexes were characterized by elemental analysis, molar conductivity measurement, and spectral (IR, H-1, C-13, 2D H-1-C-13 heteronuclear correlation spectra, Pt-195 NMR, and MS) methods. Outer-coordination sphere was proposed for 1; while in 2, the ligand was coordinated to the metal. The complexes exhibit antibacterial effect on strains of Bacillus subtilis, Bacillus cereus, Bacillus pumilus, and methicillin-resistant Staphylococci as Gram-positive bacteria and an Escherichia coli as Gram-negative bacteria, as well as the reference strains.
Keywords:Platinum(IV) / N-alkylphenothiazines / Antibacterial activity
Source:Journal of Coordination Chemistry, 2013, 66, 21, 3760-3769
- Taylor & Francis Ltd, Abingdon