Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity
Authorized Users Only
2013
Authors
Poljarević, JelenaKrstić, Milena
Grgurić-Šipka, Sanja
Sovilj, Sofija P.
Mišić, Dušan
Sabo, Tibor J.
Article (Published version)
Metadata
Show full item recordAbstract
Two new platinum(IV) complexes (1, trifluoperazinehydrochloride-aquapentachloridoplatinate(IV) and 2, chlorpromazine-chlorpromazinehydrochloridepentachloridoplatinate(IV)) were synthesized in the reaction of K-2[PtCl6] with trifluoperazine dihydrochloride (TF center dot 2HCl) or chlorpromazine hydrochloride (CP center dot HCl). The complexes were characterized by elemental analysis, molar conductivity measurement, and spectral (IR, H-1, C-13, 2D H-1-C-13 heteronuclear correlation spectra, Pt-195 NMR, and MS) methods. Outer-coordination sphere was proposed for 1; while in 2, the ligand was coordinated to the metal. The complexes exhibit antibacterial effect on strains of Bacillus subtilis, Bacillus cereus, Bacillus pumilus, and methicillin-resistant Staphylococci as Gram-positive bacteria and an Escherichia coli as Gram-negative bacteria, as well as the reference strains.
Keywords:
Platinum(IV) / N-alkylphenothiazines / Antibacterial activitySource:
Journal of Coordination Chemistry, 2013, 66, 21, 3760-3769Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds (RS-MESTD-Basic Research (BR or ON)-172014)
DOI: 10.1080/00958972.2013.851788
ISSN: 0095-8972
WoS: 000327946400006
Scopus: 2-s2.0-84888176092
Collections
Institution/Community
Fakultet veterinarske medicineTY - JOUR AU - Poljarević, Jelena AU - Krstić, Milena AU - Grgurić-Šipka, Sanja AU - Sovilj, Sofija P. AU - Mišić, Dušan AU - Sabo, Tibor J. PY - 2013 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/989 AB - Two new platinum(IV) complexes (1, trifluoperazinehydrochloride-aquapentachloridoplatinate(IV) and 2, chlorpromazine-chlorpromazinehydrochloridepentachloridoplatinate(IV)) were synthesized in the reaction of K-2[PtCl6] with trifluoperazine dihydrochloride (TF center dot 2HCl) or chlorpromazine hydrochloride (CP center dot HCl). The complexes were characterized by elemental analysis, molar conductivity measurement, and spectral (IR, H-1, C-13, 2D H-1-C-13 heteronuclear correlation spectra, Pt-195 NMR, and MS) methods. Outer-coordination sphere was proposed for 1; while in 2, the ligand was coordinated to the metal. The complexes exhibit antibacterial effect on strains of Bacillus subtilis, Bacillus cereus, Bacillus pumilus, and methicillin-resistant Staphylococci as Gram-positive bacteria and an Escherichia coli as Gram-negative bacteria, as well as the reference strains. PB - Taylor & Francis Ltd, Abingdon T2 - Journal of Coordination Chemistry T1 - Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity VL - 66 IS - 21 SP - 3760 EP - 3769 DO - 10.1080/00958972.2013.851788 ER -
@article{ author = "Poljarević, Jelena and Krstić, Milena and Grgurić-Šipka, Sanja and Sovilj, Sofija P. and Mišić, Dušan and Sabo, Tibor J.", year = "2013", abstract = "Two new platinum(IV) complexes (1, trifluoperazinehydrochloride-aquapentachloridoplatinate(IV) and 2, chlorpromazine-chlorpromazinehydrochloridepentachloridoplatinate(IV)) were synthesized in the reaction of K-2[PtCl6] with trifluoperazine dihydrochloride (TF center dot 2HCl) or chlorpromazine hydrochloride (CP center dot HCl). The complexes were characterized by elemental analysis, molar conductivity measurement, and spectral (IR, H-1, C-13, 2D H-1-C-13 heteronuclear correlation spectra, Pt-195 NMR, and MS) methods. Outer-coordination sphere was proposed for 1; while in 2, the ligand was coordinated to the metal. The complexes exhibit antibacterial effect on strains of Bacillus subtilis, Bacillus cereus, Bacillus pumilus, and methicillin-resistant Staphylococci as Gram-positive bacteria and an Escherichia coli as Gram-negative bacteria, as well as the reference strains.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Journal of Coordination Chemistry", title = "Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity", volume = "66", number = "21", pages = "3760-3769", doi = "10.1080/00958972.2013.851788" }
Poljarević, J., Krstić, M., Grgurić-Šipka, S., Sovilj, S. P., Mišić, D.,& Sabo, T. J.. (2013). Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity. in Journal of Coordination Chemistry Taylor & Francis Ltd, Abingdon., 66(21), 3760-3769. https://doi.org/10.1080/00958972.2013.851788
Poljarević J, Krstić M, Grgurić-Šipka S, Sovilj SP, Mišić D, Sabo TJ. Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity. in Journal of Coordination Chemistry. 2013;66(21):3760-3769. doi:10.1080/00958972.2013.851788 .
Poljarević, Jelena, Krstić, Milena, Grgurić-Šipka, Sanja, Sovilj, Sofija P., Mišić, Dušan, Sabo, Tibor J., "Platinum(IV) complexes with N-alkylphenothiazines: synthesis, characterization, and antibacterial activity" in Journal of Coordination Chemistry, 66, no. 21 (2013):3760-3769, https://doi.org/10.1080/00958972.2013.851788 . .