Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
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2014
Authors
Aljančić, IvanaVucković, Ivan
Jadranin, Milka
Pesić, Milica
Đorđević, Iris
Podolski-Renić, Ana
Stojković, Sonja
Menković, Nebojša
Vajs, Vlatka
Milosavljević, Slobodan M.
Article (Published version)
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Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.
Keywords:
Helichrysum zivojinii / Asteraceae / Chalcone glucoside dimers / Flavonoid glucoside / Topoisomerase II alpha / HIF-1 alpha / MAP kinase pathway / Drug combinationSource:
Phytochemistry, 2014, 98, 190-196Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
DOI: 10.1016/j.phytochem.2013.11.025
ISSN: 0031-9422
PubMed: 24361288
WoS: 000331020000022
Scopus: 2-s2.0-84892946345
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Fakultet veterinarske medicineTY - JOUR AU - Aljančić, Ivana AU - Vucković, Ivan AU - Jadranin, Milka AU - Pesić, Milica AU - Đorđević, Iris AU - Podolski-Renić, Ana AU - Stojković, Sonja AU - Menković, Nebojša AU - Vajs, Vlatka AU - Milosavljević, Slobodan M. PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1102 AB - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Phytochemistry T1 - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines VL - 98 SP - 190 EP - 196 DO - 10.1016/j.phytochem.2013.11.025 ER -
@article{ author = "Aljančić, Ivana and Vucković, Ivan and Jadranin, Milka and Pesić, Milica and Đorđević, Iris and Podolski-Renić, Ana and Stojković, Sonja and Menković, Nebojša and Vajs, Vlatka and Milosavljević, Slobodan M.", year = "2014", abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Phytochemistry", title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines", volume = "98", pages = "190-196", doi = "10.1016/j.phytochem.2013.11.025" }
Aljančić, I., Vucković, I., Jadranin, M., Pesić, M., Đorđević, I., Podolski-Renić, A., Stojković, S., Menković, N., Vajs, V.,& Milosavljević, S. M.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry Pergamon-Elsevier Science Ltd, Oxford., 98, 190-196. https://doi.org/10.1016/j.phytochem.2013.11.025
Aljančić I, Vucković I, Jadranin M, Pesić M, Đorđević I, Podolski-Renić A, Stojković S, Menković N, Vajs V, Milosavljević SM. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196. doi:10.1016/j.phytochem.2013.11.025 .
Aljančić, Ivana, Vucković, Ivan, Jadranin, Milka, Pesić, Milica, Đorđević, Iris, Podolski-Renić, Ana, Stojković, Sonja, Menković, Nebojša, Vajs, Vlatka, Milosavljević, Slobodan M., "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196, https://doi.org/10.1016/j.phytochem.2013.11.025 . .