Efficiency of sepiolite in broilers diet as uranium adsorbent
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2015
Authors
Mitrović, BranislavaJovanović, Milijan
Lazarević Macanović, Mirjana
Janacković, Đorđe
Krstić, Nikola
Stojanović, Mirjana
Mirilović, Milorad
Article (Published version)
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The use of phosphate mineral products in animal nutrition, as a major source of phosphor and calcium, can lead to uranium entering the food chain. The aim of the present study was to determine the protective effect of natural sepiolite and sepiolite treated with acid for broilers after oral intake of uranium. The broilers were contaminated for 7 days with 25 mg/uranyl nitrate per day. Two different adsorbents (natural sepiolite and sepiolite treated with acid) were given via gastric tube immediately after the oral administration of uranium. Natural sepiolite reduced uranium distribution by 57 % in kidney, 80 % in liver, 42 % in brain, and 56 % in muscle. A lower protective effect was observed after the administration of sepiolite treated with acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and necrosis, and histopathological lesions on kidney in the form of edema and abruption of epithelial cells in tubules. When broilers received onl...y sepiolite treated with acid (no uranyl nitrate), shortening of intestinal villi occurred. Kidney injuries were evident when uranium concentrations in kidney were 0.88 and 1.25 A mu g/g dry weight. It is concluded that adding of natural sepiolite to the diets of broilers can reduce uranium distribution in organs by significant amount without adverse side effects.
Keywords:
Adsorbents / Broilers / Histopathology / Sepiolite / Toxicity / UraniumSource:
Radiation and Environmental Biophysics, 2015, 54, 2, 217-224Publisher:
- Springer, New York
Funding / projects:
- Development of technologies and products based on mineral raw materials and waste biomass for protection of natural resources for safe food production (RS-MESTD-Technological Development (TD or TR)-31003)
- Development of technological processes for obtaining of ecological materials based on nonmetallic minerals (RS-MESTD-Technological Development (TD or TR)-34013)
DOI: 10.1007/s00411-015-0589-2
ISSN: 0301-634X
PubMed: 25652083
WoS: 000353356700008
Scopus: 2-s2.0-84939960269
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Fakultet veterinarske medicineTY - JOUR AU - Mitrović, Branislava AU - Jovanović, Milijan AU - Lazarević Macanović, Mirjana AU - Janacković, Đorđe AU - Krstić, Nikola AU - Stojanović, Mirjana AU - Mirilović, Milorad PY - 2015 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1195 AB - The use of phosphate mineral products in animal nutrition, as a major source of phosphor and calcium, can lead to uranium entering the food chain. The aim of the present study was to determine the protective effect of natural sepiolite and sepiolite treated with acid for broilers after oral intake of uranium. The broilers were contaminated for 7 days with 25 mg/uranyl nitrate per day. Two different adsorbents (natural sepiolite and sepiolite treated with acid) were given via gastric tube immediately after the oral administration of uranium. Natural sepiolite reduced uranium distribution by 57 % in kidney, 80 % in liver, 42 % in brain, and 56 % in muscle. A lower protective effect was observed after the administration of sepiolite treated with acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and necrosis, and histopathological lesions on kidney in the form of edema and abruption of epithelial cells in tubules. When broilers received only sepiolite treated with acid (no uranyl nitrate), shortening of intestinal villi occurred. Kidney injuries were evident when uranium concentrations in kidney were 0.88 and 1.25 A mu g/g dry weight. It is concluded that adding of natural sepiolite to the diets of broilers can reduce uranium distribution in organs by significant amount without adverse side effects. PB - Springer, New York T2 - Radiation and Environmental Biophysics T1 - Efficiency of sepiolite in broilers diet as uranium adsorbent VL - 54 IS - 2 SP - 217 EP - 224 DO - 10.1007/s00411-015-0589-2 ER -
@article{ author = "Mitrović, Branislava and Jovanović, Milijan and Lazarević Macanović, Mirjana and Janacković, Đorđe and Krstić, Nikola and Stojanović, Mirjana and Mirilović, Milorad", year = "2015", abstract = "The use of phosphate mineral products in animal nutrition, as a major source of phosphor and calcium, can lead to uranium entering the food chain. The aim of the present study was to determine the protective effect of natural sepiolite and sepiolite treated with acid for broilers after oral intake of uranium. The broilers were contaminated for 7 days with 25 mg/uranyl nitrate per day. Two different adsorbents (natural sepiolite and sepiolite treated with acid) were given via gastric tube immediately after the oral administration of uranium. Natural sepiolite reduced uranium distribution by 57 % in kidney, 80 % in liver, 42 % in brain, and 56 % in muscle. A lower protective effect was observed after the administration of sepiolite treated with acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and necrosis, and histopathological lesions on kidney in the form of edema and abruption of epithelial cells in tubules. When broilers received only sepiolite treated with acid (no uranyl nitrate), shortening of intestinal villi occurred. Kidney injuries were evident when uranium concentrations in kidney were 0.88 and 1.25 A mu g/g dry weight. It is concluded that adding of natural sepiolite to the diets of broilers can reduce uranium distribution in organs by significant amount without adverse side effects.", publisher = "Springer, New York", journal = "Radiation and Environmental Biophysics", title = "Efficiency of sepiolite in broilers diet as uranium adsorbent", volume = "54", number = "2", pages = "217-224", doi = "10.1007/s00411-015-0589-2" }
Mitrović, B., Jovanović, M., Lazarević Macanović, M., Janacković, Đ., Krstić, N., Stojanović, M.,& Mirilović, M.. (2015). Efficiency of sepiolite in broilers diet as uranium adsorbent. in Radiation and Environmental Biophysics Springer, New York., 54(2), 217-224. https://doi.org/10.1007/s00411-015-0589-2
Mitrović B, Jovanović M, Lazarević Macanović M, Janacković Đ, Krstić N, Stojanović M, Mirilović M. Efficiency of sepiolite in broilers diet as uranium adsorbent. in Radiation and Environmental Biophysics. 2015;54(2):217-224. doi:10.1007/s00411-015-0589-2 .
Mitrović, Branislava, Jovanović, Milijan, Lazarević Macanović, Mirjana, Janacković, Đorđe, Krstić, Nikola, Stojanović, Mirjana, Mirilović, Milorad, "Efficiency of sepiolite in broilers diet as uranium adsorbent" in Radiation and Environmental Biophysics, 54, no. 2 (2015):217-224, https://doi.org/10.1007/s00411-015-0589-2 . .