Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine
Апстракт
A simple and efficient procedure is described for electrochemical determination of trifluoperazine (TFP), a prominent compound in a large group of phenothiazine derivatives with potent physiological activity. This method is based on the electrochemical oxidation of TFP in Britton-Robinson buffer solution in pH 6 at a boron-doped diamond electrode. Cyclic voltammetry provided a four well defined oxidation peaks at + 0.65, + 0.83, + 1.06 and + 1.35 V (vs. Ag/AgCl/3 M KCl electrode). Differential pulse voltammetry was applied as a very sensitive analytical technique for the determination of micromolar amounts of TFP. Two oxidation peaks on higher potentials were chosen for quantification of TFP. Under optimized conditions, the analytical curves obtained were linear in the TFP concentration range of 1.0 to 37.0 mmol L-1, with a detection limit of 0.7 and 0.6 mmol L-1, respectively. The effect of interfering agents (common urinary compounds) appeared to be negligible confirming the favourab...le selectivity of the method. The proposed method was analytically applied by determination of trifluoperazine content in model human urine samples with good accuracy (recoveries varied from 97% to 104%). The developed approach could be beneficial in analysis of TFP in biological samples using a boron-doped diamond electrode as an up-to-date electrochemical sensor and could represent an inexpensive analytical alternative to separation methods.
Извор:
RSC Advances, 2015, 5, 129, 107058-107063Издавач:
- Royal Soc Chemistry, Cambridge
Финансирање / пројекти:
DOI: 10.1039/c5ra18783d
ISSN: 2046-2069
WoS: 000367274300084
Scopus: 2-s2.0-84952033905
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Stanković, D. AU - Dimitrijević, T. AU - Kuzmanović, D. AU - Krstić, Milena AU - Petković, B. B. PY - 2015 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1311 AB - A simple and efficient procedure is described for electrochemical determination of trifluoperazine (TFP), a prominent compound in a large group of phenothiazine derivatives with potent physiological activity. This method is based on the electrochemical oxidation of TFP in Britton-Robinson buffer solution in pH 6 at a boron-doped diamond electrode. Cyclic voltammetry provided a four well defined oxidation peaks at + 0.65, + 0.83, + 1.06 and + 1.35 V (vs. Ag/AgCl/3 M KCl electrode). Differential pulse voltammetry was applied as a very sensitive analytical technique for the determination of micromolar amounts of TFP. Two oxidation peaks on higher potentials were chosen for quantification of TFP. Under optimized conditions, the analytical curves obtained were linear in the TFP concentration range of 1.0 to 37.0 mmol L-1, with a detection limit of 0.7 and 0.6 mmol L-1, respectively. The effect of interfering agents (common urinary compounds) appeared to be negligible confirming the favourable selectivity of the method. The proposed method was analytically applied by determination of trifluoperazine content in model human urine samples with good accuracy (recoveries varied from 97% to 104%). The developed approach could be beneficial in analysis of TFP in biological samples using a boron-doped diamond electrode as an up-to-date electrochemical sensor and could represent an inexpensive analytical alternative to separation methods. PB - Royal Soc Chemistry, Cambridge T2 - RSC Advances T1 - Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine VL - 5 IS - 129 SP - 107058 EP - 107063 DO - 10.1039/c5ra18783d ER -
@article{ author = "Stanković, D. and Dimitrijević, T. and Kuzmanović, D. and Krstić, Milena and Petković, B. B.", year = "2015", abstract = "A simple and efficient procedure is described for electrochemical determination of trifluoperazine (TFP), a prominent compound in a large group of phenothiazine derivatives with potent physiological activity. This method is based on the electrochemical oxidation of TFP in Britton-Robinson buffer solution in pH 6 at a boron-doped diamond electrode. Cyclic voltammetry provided a four well defined oxidation peaks at + 0.65, + 0.83, + 1.06 and + 1.35 V (vs. Ag/AgCl/3 M KCl electrode). Differential pulse voltammetry was applied as a very sensitive analytical technique for the determination of micromolar amounts of TFP. Two oxidation peaks on higher potentials were chosen for quantification of TFP. Under optimized conditions, the analytical curves obtained were linear in the TFP concentration range of 1.0 to 37.0 mmol L-1, with a detection limit of 0.7 and 0.6 mmol L-1, respectively. The effect of interfering agents (common urinary compounds) appeared to be negligible confirming the favourable selectivity of the method. The proposed method was analytically applied by determination of trifluoperazine content in model human urine samples with good accuracy (recoveries varied from 97% to 104%). The developed approach could be beneficial in analysis of TFP in biological samples using a boron-doped diamond electrode as an up-to-date electrochemical sensor and could represent an inexpensive analytical alternative to separation methods.", publisher = "Royal Soc Chemistry, Cambridge", journal = "RSC Advances", title = "Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine", volume = "5", number = "129", pages = "107058-107063", doi = "10.1039/c5ra18783d" }
Stanković, D., Dimitrijević, T., Kuzmanović, D., Krstić, M.,& Petković, B. B.. (2015). Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine. in RSC Advances Royal Soc Chemistry, Cambridge., 5(129), 107058-107063. https://doi.org/10.1039/c5ra18783d
Stanković D, Dimitrijević T, Kuzmanović D, Krstić M, Petković BB. Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine. in RSC Advances. 2015;5(129):107058-107063. doi:10.1039/c5ra18783d .
Stanković, D., Dimitrijević, T., Kuzmanović, D., Krstić, Milena, Petković, B. B., "Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine" in RSC Advances, 5, no. 129 (2015):107058-107063, https://doi.org/10.1039/c5ra18783d . .