Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study
Samo za registrovane korisnike
2016
Autori
Čabarkapa, AndreaŽivković, Lada
Borozan, Sunčica
Zlatkovic-Svenda, Mirjana
Dekanski, Dragana
Jancić, Ivan
Radak-Perović, Marija
Bajić, Vladan
Spremo-Potparević, Biljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The effects of co-administration of dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters of cell damage and inflammation in patients with early and long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 and 6weeks. Patients were assigned to groups: the early phase RA group on MTX monotherapy (E MTX), and the two RA groups that received co-treatment with DOLE and MTX: early (E MTX+DOLE) and long-term phase patients (L-t MTX+ DOLE). Baseline values indicated increased parameters of cell damage and disruption of redox balance in all groups. After three weeks the E MTX+DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicatorsthiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. In E MTX group catalase activity remained unaltered while significant lipid peroxidation and DNA damage reductions were seen only after six weeks. L-t MTX...+DOLE group showed only modest alterations of cell damage parameters during six weeks. Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Copyright
Ključne reči:
dry olive leaf extract / methotrexate / inflammation / oxidative stress / cell damageIzvor:
Phytotherapy Research, 2016, 30, 10, 1615-1623Izdavač:
- Wiley-Blackwell, Hoboken
Finansiranje / projekti:
- Aberacije ćelijskog ciklusa i uticaj oksidativnog stresa na neurodegenerativne procese i malignu transformaciju ćelije (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.1002/ptr.5662
ISSN: 0951-418X
PubMed: 27271301
WoS: 000385700400007
Scopus: 2-s2.0-84973563650
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Čabarkapa, Andrea AU - Živković, Lada AU - Borozan, Sunčica AU - Zlatkovic-Svenda, Mirjana AU - Dekanski, Dragana AU - Jancić, Ivan AU - Radak-Perović, Marija AU - Bajić, Vladan AU - Spremo-Potparević, Biljana PY - 2016 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1418 AB - The effects of co-administration of dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters of cell damage and inflammation in patients with early and long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 and 6weeks. Patients were assigned to groups: the early phase RA group on MTX monotherapy (E MTX), and the two RA groups that received co-treatment with DOLE and MTX: early (E MTX+DOLE) and long-term phase patients (L-t MTX+ DOLE). Baseline values indicated increased parameters of cell damage and disruption of redox balance in all groups. After three weeks the E MTX+DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicatorsthiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. In E MTX group catalase activity remained unaltered while significant lipid peroxidation and DNA damage reductions were seen only after six weeks. L-t MTX+DOLE group showed only modest alterations of cell damage parameters during six weeks. Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Copyright PB - Wiley-Blackwell, Hoboken T2 - Phytotherapy Research T1 - Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study VL - 30 IS - 10 SP - 1615 EP - 1623 DO - 10.1002/ptr.5662 ER -
@article{ author = "Čabarkapa, Andrea and Živković, Lada and Borozan, Sunčica and Zlatkovic-Svenda, Mirjana and Dekanski, Dragana and Jancić, Ivan and Radak-Perović, Marija and Bajić, Vladan and Spremo-Potparević, Biljana", year = "2016", abstract = "The effects of co-administration of dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters of cell damage and inflammation in patients with early and long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 and 6weeks. Patients were assigned to groups: the early phase RA group on MTX monotherapy (E MTX), and the two RA groups that received co-treatment with DOLE and MTX: early (E MTX+DOLE) and long-term phase patients (L-t MTX+ DOLE). Baseline values indicated increased parameters of cell damage and disruption of redox balance in all groups. After three weeks the E MTX+DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicatorsthiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. In E MTX group catalase activity remained unaltered while significant lipid peroxidation and DNA damage reductions were seen only after six weeks. L-t MTX+DOLE group showed only modest alterations of cell damage parameters during six weeks. Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Copyright", publisher = "Wiley-Blackwell, Hoboken", journal = "Phytotherapy Research", title = "Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study", volume = "30", number = "10", pages = "1615-1623", doi = "10.1002/ptr.5662" }
Čabarkapa, A., Živković, L., Borozan, S., Zlatkovic-Svenda, M., Dekanski, D., Jancić, I., Radak-Perović, M., Bajić, V.,& Spremo-Potparević, B.. (2016). Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study. in Phytotherapy Research Wiley-Blackwell, Hoboken., 30(10), 1615-1623. https://doi.org/10.1002/ptr.5662
Čabarkapa A, Živković L, Borozan S, Zlatkovic-Svenda M, Dekanski D, Jancić I, Radak-Perović M, Bajić V, Spremo-Potparević B. Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study. in Phytotherapy Research. 2016;30(10):1615-1623. doi:10.1002/ptr.5662 .
Čabarkapa, Andrea, Živković, Lada, Borozan, Sunčica, Zlatkovic-Svenda, Mirjana, Dekanski, Dragana, Jancić, Ivan, Radak-Perović, Marija, Bajić, Vladan, Spremo-Potparević, Biljana, "Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study" in Phytotherapy Research, 30, no. 10 (2016):1615-1623, https://doi.org/10.1002/ptr.5662 . .