Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
2016
Authors
Dejanović, BratislavStevanović, Ivana
Ninković, Milica
Stojanović, Ivana
Lavrnja, Irena
Radičević, Tatjana
Pavlović, Miloš
Article (Published version)
Metadata
Show full item recordAbstract
This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may con...tribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning.
Keywords:
agmatine / antioxidant defense / astrocytes / chlorpromazine / oxidative stressSource:
Journal of Veterinary Science, 2016, 17, 1, 53-61Publisher:
- Korean Soc Veterinary Science, Seoul
Funding / projects:
- Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-41014)
- Military Medical Academy [MBMA/3/13-15, MBMA/6/15-17]
DOI: 10.4142/jvs.2016.17.1.53
ISSN: 1229-845X
PubMed: 27051340
WoS: 000373246900007
Scopus: 2-s2.0-84962704615
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Fakultet veterinarske medicineTY - JOUR AU - Dejanović, Bratislav AU - Stevanović, Ivana AU - Ninković, Milica AU - Stojanović, Ivana AU - Lavrnja, Irena AU - Radičević, Tatjana AU - Pavlović, Miloš PY - 2016 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1430 AB - This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may contribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning. PB - Korean Soc Veterinary Science, Seoul T2 - Journal of Veterinary Science T1 - Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats VL - 17 IS - 1 SP - 53 EP - 61 DO - 10.4142/jvs.2016.17.1.53 ER -
@article{ author = "Dejanović, Bratislav and Stevanović, Ivana and Ninković, Milica and Stojanović, Ivana and Lavrnja, Irena and Radičević, Tatjana and Pavlović, Miloš", year = "2016", abstract = "This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may contribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning.", publisher = "Korean Soc Veterinary Science, Seoul", journal = "Journal of Veterinary Science", title = "Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats", volume = "17", number = "1", pages = "53-61", doi = "10.4142/jvs.2016.17.1.53" }
Dejanović, B., Stevanović, I., Ninković, M., Stojanović, I., Lavrnja, I., Radičević, T.,& Pavlović, M.. (2016). Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats. in Journal of Veterinary Science Korean Soc Veterinary Science, Seoul., 17(1), 53-61. https://doi.org/10.4142/jvs.2016.17.1.53
Dejanović B, Stevanović I, Ninković M, Stojanović I, Lavrnja I, Radičević T, Pavlović M. Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats. in Journal of Veterinary Science. 2016;17(1):53-61. doi:10.4142/jvs.2016.17.1.53 .
Dejanović, Bratislav, Stevanović, Ivana, Ninković, Milica, Stojanović, Ivana, Lavrnja, Irena, Radičević, Tatjana, Pavlović, Miloš, "Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats" in Journal of Veterinary Science, 17, no. 1 (2016):53-61, https://doi.org/10.4142/jvs.2016.17.1.53 . .