Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination
Апстракт
A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of s...imultaneous determination.
Кључне речи:
voltammetric method / chlorpromazine / thioridazine / boron-doped diamond electrode / human urineИзвор:
International Journal of Electrochemical Science, 2017, 12, 5, 3709-3720Издавач:
- Electrochemical Science Group, Beograd
Финансирање / пројекти:
- Вишескално структурирање полимерних нанокомпозита и функционалних материјала применом различитих прекурсора (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45022)
- Magbiovin project [621375]
DOI: 10.20964/2017.05.34
ISSN: 1452-3981
WoS: 000402485100013
Scopus: 2-s2.0-85019613952
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Petković, B. B. AU - Kuzmanović, D. AU - Dimitrijević, T. AU - Krstić, Milena AU - Stanković, D.M. PY - 2017 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1475 AB - A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination. PB - Electrochemical Science Group, Beograd T2 - International Journal of Electrochemical Science T1 - Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination VL - 12 IS - 5 SP - 3709 EP - 3720 DO - 10.20964/2017.05.34 ER -
@article{ author = "Petković, B. B. and Kuzmanović, D. and Dimitrijević, T. and Krstić, Milena and Stanković, D.M.", year = "2017", abstract = "A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.", publisher = "Electrochemical Science Group, Beograd", journal = "International Journal of Electrochemical Science", title = "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination", volume = "12", number = "5", pages = "3709-3720", doi = "10.20964/2017.05.34" }
Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstić, M.,& Stanković, D.M.. (2017). Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science Electrochemical Science Group, Beograd., 12(5), 3709-3720. https://doi.org/10.20964/2017.05.34
Petković BB, Kuzmanović D, Dimitrijević T, Krstić M, Stanković D. Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science. 2017;12(5):3709-3720. doi:10.20964/2017.05.34 .
Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstić, Milena, Stanković, D.M., "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination" in International Journal of Electrochemical Science, 12, no. 5 (2017):3709-3720, https://doi.org/10.20964/2017.05.34 . .