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Histological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogs
dc.creator | Nešić, Slađan | |
dc.creator | Kukolj, Vladimir | |
dc.creator | Marinković, Darko | |
dc.creator | Vučićević, Ivana | |
dc.creator | Jovanović, Milijan | |
dc.date.accessioned | 2020-06-03T14:17:05Z | |
dc.date.available | 2020-06-03T14:17:05Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0165-2176 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/1508 | |
dc.description.abstract | Background: Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the wall of cerebral blood vessels. The deposits of amyloid occur frequently in the blood vessels of the frontal, parietal and occipital cortex. Objective: To examine the characteristics of CAA classified according to the Vonsattel scale in elderly dogs histologically and immunohistochemically as well as the semi-quantitative evaluation of the amyloid deposits in the different segments of the brain. Animals and methods: The brains of 36 dogs of different breeds and sexes, which had been routinely necropsied, were used and divided into two groups: dogs from 1 to 5 and 10 to 18 years old. The tissue sections were stained by hematoxylin-eosin, Congo red and immunohistochemically. Results: Amyloid was accumulated in the wall of cerebral blood vessels in 70% of dogs over the age of 10 years predominantly in the frontal cortex. CAA was demonstrated in elderly dogs as follows: in the frontal cortex (n=19 or 63%), the parietal cortex (n=12 or 40%), the hippocampus (40%) and the cerebellum (n=5 or 17%). The deposits of amyloid in the wall of blood vessels detected by Congo red staining were also A beta 1-14 and A beta 1-42 immunohistochemically positive. Most commonly, the amyloid deposits affected a moderate number of blood vessels. The accumulation of amyloid was immunohistochemically revealed in the blood vessel walls as well as in the senile plaques and neurons. Conclusion: The amount of amyloid in the arterial walls increased with age in dogs, whereas the amyloid accumulated in plaques was Congo red negative. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Veterinary Quarterly | |
dc.subject | Dog | en |
dc.subject | canine | en |
dc.subject | brain | en |
dc.subject | amyloid | en |
dc.subject | angiopathy | en |
dc.title | Histological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogs | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Кукољ, Владимир; Маринковић, Дарко; Нешић, Слађан; Вучићевић, Ивана; Јовановић, Милијан; | |
dc.citation.volume | 37 | |
dc.citation.issue | 1 | |
dc.citation.spage | 1 | |
dc.citation.epage | 7 | |
dc.citation.other | 37(1): 1-7 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000399584500001 | |
dc.identifier.doi | 10.1080/01652176.2016.1235301 | |
dc.identifier.pmid | 27669976 | |
dc.identifier.scopus | 2-s2.0-85028851512 | |
dc.identifier.fulltext | https://vet-erinar.vet.bg.ac.rs/bitstream/id/469/1507.pdf | |
dc.type.version | publishedVersion |