Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test
Само за регистроване кориснике
2017
Аутори
Đoković, RadojicaDosković, Vladimir
Cincović, Marko
Belić, Branislava
Fratrić, Natalija
Jasović, Boban
Lalović, Miroslav
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The objective of this study was to determine insulin resistance in healthy (n=8) and ketotic (n=7) dairy cows based on the difference between basal and dynamic changes in glucose, insulin, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BHB) concentrations, and on the determination of their mutual relationship and relationship with insulin resistance indices (RQUICKI and RQUICKI-BHB), after intravenous glucose tolerance test (IVGTT). The RQUICKI index showed a significant linear correlation (P lt 0.05) with basal insulin, glucose, NEFA and BHB levels. However, RQUICKI-BHB index values exhibited a negative correlation (P lt 0.01) with basal NEFA and BHB values and their clearance rates, as well as with glucose clearance rate, and a positive correlation (P lt 0.05) with basal insulin values as well as with insulin and glucose responses during IVGTT. The correlation between basal values of these parameters and the values measured or calculated during IVGTT is the result of RQU...ICKI-BHB values, as the exclusion of RQUICKI-BHB leads to loss of the statistical significance of the correlations between basal and dynamic values. Insulin resistance in ketotic cows is characterized by decreased insulin response to glucose and increased insulin resistance of the tissue, their correlation being the result of the RQUICKI-BHB index value.
Кључне речи:
Cows / Glucose tolerance test / Insulin resistance / KetosisИзвор:
Pakistan Veterinary Journal, 2017, 37, 4, 387-392Издавач:
- Univ Agriculture, Fac Veterinary Science, Faisalabad
Финансирање / пројекти:
- Еколошки приступ и увођење савремених биотехнологија као основа унапређења технологије производње гајених преживара (RS-31001)
- Унапређење здравља и добробити високопродуктивних крава идентификацијом и отклањањем стресогених фактора (RS-31062)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Đoković, Radojica AU - Dosković, Vladimir AU - Cincović, Marko AU - Belić, Branislava AU - Fratrić, Natalija AU - Jasović, Boban AU - Lalović, Miroslav PY - 2017 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1547 AB - The objective of this study was to determine insulin resistance in healthy (n=8) and ketotic (n=7) dairy cows based on the difference between basal and dynamic changes in glucose, insulin, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BHB) concentrations, and on the determination of their mutual relationship and relationship with insulin resistance indices (RQUICKI and RQUICKI-BHB), after intravenous glucose tolerance test (IVGTT). The RQUICKI index showed a significant linear correlation (P lt 0.05) with basal insulin, glucose, NEFA and BHB levels. However, RQUICKI-BHB index values exhibited a negative correlation (P lt 0.01) with basal NEFA and BHB values and their clearance rates, as well as with glucose clearance rate, and a positive correlation (P lt 0.05) with basal insulin values as well as with insulin and glucose responses during IVGTT. The correlation between basal values of these parameters and the values measured or calculated during IVGTT is the result of RQUICKI-BHB values, as the exclusion of RQUICKI-BHB leads to loss of the statistical significance of the correlations between basal and dynamic values. Insulin resistance in ketotic cows is characterized by decreased insulin response to glucose and increased insulin resistance of the tissue, their correlation being the result of the RQUICKI-BHB index value. PB - Univ Agriculture, Fac Veterinary Science, Faisalabad T2 - Pakistan Veterinary Journal T1 - Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test VL - 37 IS - 4 SP - 387 EP - 392 UR - https://hdl.handle.net/21.15107/rcub_veterinar_1547 ER -
@article{ author = "Đoković, Radojica and Dosković, Vladimir and Cincović, Marko and Belić, Branislava and Fratrić, Natalija and Jasović, Boban and Lalović, Miroslav", year = "2017", abstract = "The objective of this study was to determine insulin resistance in healthy (n=8) and ketotic (n=7) dairy cows based on the difference between basal and dynamic changes in glucose, insulin, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BHB) concentrations, and on the determination of their mutual relationship and relationship with insulin resistance indices (RQUICKI and RQUICKI-BHB), after intravenous glucose tolerance test (IVGTT). The RQUICKI index showed a significant linear correlation (P lt 0.05) with basal insulin, glucose, NEFA and BHB levels. However, RQUICKI-BHB index values exhibited a negative correlation (P lt 0.01) with basal NEFA and BHB values and their clearance rates, as well as with glucose clearance rate, and a positive correlation (P lt 0.05) with basal insulin values as well as with insulin and glucose responses during IVGTT. The correlation between basal values of these parameters and the values measured or calculated during IVGTT is the result of RQUICKI-BHB values, as the exclusion of RQUICKI-BHB leads to loss of the statistical significance of the correlations between basal and dynamic values. Insulin resistance in ketotic cows is characterized by decreased insulin response to glucose and increased insulin resistance of the tissue, their correlation being the result of the RQUICKI-BHB index value.", publisher = "Univ Agriculture, Fac Veterinary Science, Faisalabad", journal = "Pakistan Veterinary Journal", title = "Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test", volume = "37", number = "4", pages = "387-392", url = "https://hdl.handle.net/21.15107/rcub_veterinar_1547" }
Đoković, R., Dosković, V., Cincović, M., Belić, B., Fratrić, N., Jasović, B.,& Lalović, M.. (2017). Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test. in Pakistan Veterinary Journal Univ Agriculture, Fac Veterinary Science, Faisalabad., 37(4), 387-392. https://hdl.handle.net/21.15107/rcub_veterinar_1547
Đoković R, Dosković V, Cincović M, Belić B, Fratrić N, Jasović B, Lalović M. Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test. in Pakistan Veterinary Journal. 2017;37(4):387-392. https://hdl.handle.net/21.15107/rcub_veterinar_1547 .
Đoković, Radojica, Dosković, Vladimir, Cincović, Marko, Belić, Branislava, Fratrić, Natalija, Jasović, Boban, Lalović, Miroslav, "Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test" in Pakistan Veterinary Journal, 37, no. 4 (2017):387-392, https://hdl.handle.net/21.15107/rcub_veterinar_1547 .