Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test
Samo za registrovane korisnike
2017
Autori
Đoković, RadojicaDosković, Vladimir
Cincović, Marko
Belić, Branislava
Fratrić, Natalija
Jasović, Boban
Lalović, Miroslav
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The objective of this study was to determine insulin resistance in healthy (n=8) and ketotic (n=7) dairy cows based on the difference between basal and dynamic changes in glucose, insulin, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BHB) concentrations, and on the determination of their mutual relationship and relationship with insulin resistance indices (RQUICKI and RQUICKI-BHB), after intravenous glucose tolerance test (IVGTT). The RQUICKI index showed a significant linear correlation (P lt 0.05) with basal insulin, glucose, NEFA and BHB levels. However, RQUICKI-BHB index values exhibited a negative correlation (P lt 0.01) with basal NEFA and BHB values and their clearance rates, as well as with glucose clearance rate, and a positive correlation (P lt 0.05) with basal insulin values as well as with insulin and glucose responses during IVGTT. The correlation between basal values of these parameters and the values measured or calculated during IVGTT is the result of RQU...ICKI-BHB values, as the exclusion of RQUICKI-BHB leads to loss of the statistical significance of the correlations between basal and dynamic values. Insulin resistance in ketotic cows is characterized by decreased insulin response to glucose and increased insulin resistance of the tissue, their correlation being the result of the RQUICKI-BHB index value.
Ključne reči:
Cows / Glucose tolerance test / Insulin resistance / KetosisIzvor:
Pakistan Veterinary Journal, 2017, 37, 4, 387-392Izdavač:
- Univ Agriculture, Fac Veterinary Science, Faisalabad
Finansiranje / projekti:
- Ekološki pristup i uvođenje savremenih biotehnologija kao osnova unapređenja tehnologije proizvodnje gajenih preživara (RS-MESTD-Technological Development (TD or TR)-31001)
- Unapređenje zdravlja i dobrobiti visokoproduktivnih krava identifikacijom i otklanjanjem stresogenih faktora (RS-MESTD-Technological Development (TD or TR)-31062)
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Đoković, Radojica AU - Dosković, Vladimir AU - Cincović, Marko AU - Belić, Branislava AU - Fratrić, Natalija AU - Jasović, Boban AU - Lalović, Miroslav PY - 2017 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1547 AB - The objective of this study was to determine insulin resistance in healthy (n=8) and ketotic (n=7) dairy cows based on the difference between basal and dynamic changes in glucose, insulin, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BHB) concentrations, and on the determination of their mutual relationship and relationship with insulin resistance indices (RQUICKI and RQUICKI-BHB), after intravenous glucose tolerance test (IVGTT). The RQUICKI index showed a significant linear correlation (P lt 0.05) with basal insulin, glucose, NEFA and BHB levels. However, RQUICKI-BHB index values exhibited a negative correlation (P lt 0.01) with basal NEFA and BHB values and their clearance rates, as well as with glucose clearance rate, and a positive correlation (P lt 0.05) with basal insulin values as well as with insulin and glucose responses during IVGTT. The correlation between basal values of these parameters and the values measured or calculated during IVGTT is the result of RQUICKI-BHB values, as the exclusion of RQUICKI-BHB leads to loss of the statistical significance of the correlations between basal and dynamic values. Insulin resistance in ketotic cows is characterized by decreased insulin response to glucose and increased insulin resistance of the tissue, their correlation being the result of the RQUICKI-BHB index value. PB - Univ Agriculture, Fac Veterinary Science, Faisalabad T2 - Pakistan Veterinary Journal T1 - Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test VL - 37 IS - 4 SP - 387 EP - 392 UR - https://hdl.handle.net/21.15107/rcub_veterinar_1547 ER -
@article{ author = "Đoković, Radojica and Dosković, Vladimir and Cincović, Marko and Belić, Branislava and Fratrić, Natalija and Jasović, Boban and Lalović, Miroslav", year = "2017", abstract = "The objective of this study was to determine insulin resistance in healthy (n=8) and ketotic (n=7) dairy cows based on the difference between basal and dynamic changes in glucose, insulin, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BHB) concentrations, and on the determination of their mutual relationship and relationship with insulin resistance indices (RQUICKI and RQUICKI-BHB), after intravenous glucose tolerance test (IVGTT). The RQUICKI index showed a significant linear correlation (P lt 0.05) with basal insulin, glucose, NEFA and BHB levels. However, RQUICKI-BHB index values exhibited a negative correlation (P lt 0.01) with basal NEFA and BHB values and their clearance rates, as well as with glucose clearance rate, and a positive correlation (P lt 0.05) with basal insulin values as well as with insulin and glucose responses during IVGTT. The correlation between basal values of these parameters and the values measured or calculated during IVGTT is the result of RQUICKI-BHB values, as the exclusion of RQUICKI-BHB leads to loss of the statistical significance of the correlations between basal and dynamic values. Insulin resistance in ketotic cows is characterized by decreased insulin response to glucose and increased insulin resistance of the tissue, their correlation being the result of the RQUICKI-BHB index value.", publisher = "Univ Agriculture, Fac Veterinary Science, Faisalabad", journal = "Pakistan Veterinary Journal", title = "Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test", volume = "37", number = "4", pages = "387-392", url = "https://hdl.handle.net/21.15107/rcub_veterinar_1547" }
Đoković, R., Dosković, V., Cincović, M., Belić, B., Fratrić, N., Jasović, B.,& Lalović, M.. (2017). Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test. in Pakistan Veterinary Journal Univ Agriculture, Fac Veterinary Science, Faisalabad., 37(4), 387-392. https://hdl.handle.net/21.15107/rcub_veterinar_1547
Đoković R, Dosković V, Cincović M, Belić B, Fratrić N, Jasović B, Lalović M. Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test. in Pakistan Veterinary Journal. 2017;37(4):387-392. https://hdl.handle.net/21.15107/rcub_veterinar_1547 .
Đoković, Radojica, Dosković, Vladimir, Cincović, Marko, Belić, Branislava, Fratrić, Natalija, Jasović, Boban, Lalović, Miroslav, "Estimation of insulin resistance in healthy and ketotic cows during an intravenous glucose tolerance test" in Pakistan Veterinary Journal, 37, no. 4 (2017):387-392, https://hdl.handle.net/21.15107/rcub_veterinar_1547 .