Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles
2018
Authors
Mitrović, Marko JumakeTatalović, Nikola R.
Nikolic-Kokić, Aleksandra L.
Ciraj-Bjelac, Olivera F.
Krstić, Nikola
Orescanin-Dusić, Zorana S.
Krstić, Dragana Z.
Jovanović, Zoran M.
Blagojević, Duško P.
Lazarević Macanović, Mirjana
Article (Published version)
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In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influe...nce was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current.
Keywords:
computed tomography / oxidative stress / antioxidant enzymes / testicles / rabbitSource:
Archives of Biological Sciences, 2018, 70, 4, 675-680Publisher:
- Srpsko biološko društvo, Beograd
Funding / projects:
- Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-MESTD-Basic Research (BR or ON)-173014)
- Antioxidative defense, differentiation and regeneration potential of tissue specific mesenchymal stem cells during ageing (RS-MESTD-Basic Research (BR or ON)-175061)
DOI: 10.2298/ABS180413029M
ISSN: 0354-4664
WoS: 000452187000009
Scopus: 2-s2.0-85058821517
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Fakultet veterinarske medicineTY - JOUR AU - Mitrović, Marko Jumake AU - Tatalović, Nikola R. AU - Nikolic-Kokić, Aleksandra L. AU - Ciraj-Bjelac, Olivera F. AU - Krstić, Nikola AU - Orescanin-Dusić, Zorana S. AU - Krstić, Dragana Z. AU - Jovanović, Zoran M. AU - Blagojević, Duško P. AU - Lazarević Macanović, Mirjana PY - 2018 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1574 AB - In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. PB - Srpsko biološko društvo, Beograd T2 - Archives of Biological Sciences T1 - Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles VL - 70 IS - 4 SP - 675 EP - 680 DO - 10.2298/ABS180413029M ER -
@article{ author = "Mitrović, Marko Jumake and Tatalović, Nikola R. and Nikolic-Kokić, Aleksandra L. and Ciraj-Bjelac, Olivera F. and Krstić, Nikola and Orescanin-Dusić, Zorana S. and Krstić, Dragana Z. and Jovanović, Zoran M. and Blagojević, Duško P. and Lazarević Macanović, Mirjana", year = "2018", abstract = "In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current.", publisher = "Srpsko biološko društvo, Beograd", journal = "Archives of Biological Sciences", title = "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles", volume = "70", number = "4", pages = "675-680", doi = "10.2298/ABS180413029M" }
Mitrović, M. J., Tatalović, N. R., Nikolic-Kokić, A. L., Ciraj-Bjelac, O. F., Krstić, N., Orescanin-Dusić, Z. S., Krstić, D. Z., Jovanović, Z. M., Blagojević, D. P.,& Lazarević Macanović, M.. (2018). Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences Srpsko biološko društvo, Beograd., 70(4), 675-680. https://doi.org/10.2298/ABS180413029M
Mitrović MJ, Tatalović NR, Nikolic-Kokić AL, Ciraj-Bjelac OF, Krstić N, Orescanin-Dusić ZS, Krstić DZ, Jovanović ZM, Blagojević DP, Lazarević Macanović M. Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences. 2018;70(4):675-680. doi:10.2298/ABS180413029M .
Mitrović, Marko Jumake, Tatalović, Nikola R., Nikolic-Kokić, Aleksandra L., Ciraj-Bjelac, Olivera F., Krstić, Nikola, Orescanin-Dusić, Zorana S., Krstić, Dragana Z., Jovanović, Zoran M., Blagojević, Duško P., Lazarević Macanović, Mirjana, "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles" in Archives of Biological Sciences, 70, no. 4 (2018):675-680, https://doi.org/10.2298/ABS180413029M . .