Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction
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Vasiljević, MajaKrstić, Vanja
Stanković, Sanja
Zrimsek, Petra
Svete, Alenka Nemec
Seliskar, Alenka
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Objective To investigate changes in serum cardiac troponin I (cTnI) concentrations in dogs in which medetomidine was used for sedation or for premedication prior to anaesthesia with propofol and sevoflurane. Study design Prospective clinical study. Animals A total of 66 client-owned dogs. Methods The dogs were sedated with medetomidine (0.04 mg kg(-1)) intravenously (IV) (group M; n = 20) and left to breath room air or anaesthetized with propofol (6.5 +/- 0.76 mg kg(-1) IV) and sevoflurane (4.5% vaporizer setting) in oxygen (group P + S; n = 20) or with medetomidine (0.04 mg kg(-1) IV), propofol (1.92 +/- 0.63 mg kg(-1)) and sevoflurane (3% vaporizer setting) in oxygen (group M + P + S; n = 26), respectively. After 35 minutes, medetomidine was antagonized with atipamezole (0.1 mg kg(-1) intramuscularly). Blood samples for serum cTnI determination were taken before sedation or anaesthesia, 6 and 12 hours and 4 days thereafter. Serum cTnI concentrations were measured with the Architect S...TAT Troponin-I assay. Results Before sedation or anaesthesia, cTnI concentrations were above the detection limit in 22 out of 66 (33%) of dogs. Compared to basal values, cTnI concentrations significantly increased at 6 and 12 hours in all groups and at day 4 in group M. There were no differences in cTnI concentration between groups at baseline, at 6 hours and at 4 days. At 12 hours, cTnI concentrations were significantly higher in groups M and P + S, respectively, compared to group M + P + S. Conclusions and clinical relevance Oxygenation during anaesthesia and reduction of propofol and sevoflurane dose due to the sparing effects of medetomidine might have played a role in alleviation of myocardial hypoxic injury as indicated by the less severe and short-lived increase of cTnI in the M + P + S group.
Keywords:
cardiac troponin I / dogs / medetomidine / propofol / sevofluraneSource:
Veterinary Anaesthesia and Analgesia, 2018, 45, 6, 745-753Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Slovenian Research AgencySlovenian Research Agency - Slovenia [P4-0053]
Note:
- Peer-reviewed manuscript:http://vet-erinar.vet.bg.ac.rs/handle/123456789/1851
DOI: 10.1016/j.vaa.2018.07.003
ISSN: 1467-2987
PubMed: 30309716
WoS: 000448668700004
Scopus: 2-s2.0-85054464408
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Fakultet veterinarske medicineTY - JOUR AU - Vasiljević, Maja AU - Krstić, Vanja AU - Stanković, Sanja AU - Zrimsek, Petra AU - Svete, Alenka Nemec AU - Seliskar, Alenka PY - 2018 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1582 AB - Objective To investigate changes in serum cardiac troponin I (cTnI) concentrations in dogs in which medetomidine was used for sedation or for premedication prior to anaesthesia with propofol and sevoflurane. Study design Prospective clinical study. Animals A total of 66 client-owned dogs. Methods The dogs were sedated with medetomidine (0.04 mg kg(-1)) intravenously (IV) (group M; n = 20) and left to breath room air or anaesthetized with propofol (6.5 +/- 0.76 mg kg(-1) IV) and sevoflurane (4.5% vaporizer setting) in oxygen (group P + S; n = 20) or with medetomidine (0.04 mg kg(-1) IV), propofol (1.92 +/- 0.63 mg kg(-1)) and sevoflurane (3% vaporizer setting) in oxygen (group M + P + S; n = 26), respectively. After 35 minutes, medetomidine was antagonized with atipamezole (0.1 mg kg(-1) intramuscularly). Blood samples for serum cTnI determination were taken before sedation or anaesthesia, 6 and 12 hours and 4 days thereafter. Serum cTnI concentrations were measured with the Architect STAT Troponin-I assay. Results Before sedation or anaesthesia, cTnI concentrations were above the detection limit in 22 out of 66 (33%) of dogs. Compared to basal values, cTnI concentrations significantly increased at 6 and 12 hours in all groups and at day 4 in group M. There were no differences in cTnI concentration between groups at baseline, at 6 hours and at 4 days. At 12 hours, cTnI concentrations were significantly higher in groups M and P + S, respectively, compared to group M + P + S. Conclusions and clinical relevance Oxygenation during anaesthesia and reduction of propofol and sevoflurane dose due to the sparing effects of medetomidine might have played a role in alleviation of myocardial hypoxic injury as indicated by the less severe and short-lived increase of cTnI in the M + P + S group. PB - Elsevier Science Bv, Amsterdam T2 - Veterinary Anaesthesia and Analgesia T1 - Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction VL - 45 IS - 6 SP - 745 EP - 753 DO - 10.1016/j.vaa.2018.07.003 ER -
@article{ author = "Vasiljević, Maja and Krstić, Vanja and Stanković, Sanja and Zrimsek, Petra and Svete, Alenka Nemec and Seliskar, Alenka", year = "2018", abstract = "Objective To investigate changes in serum cardiac troponin I (cTnI) concentrations in dogs in which medetomidine was used for sedation or for premedication prior to anaesthesia with propofol and sevoflurane. Study design Prospective clinical study. Animals A total of 66 client-owned dogs. Methods The dogs were sedated with medetomidine (0.04 mg kg(-1)) intravenously (IV) (group M; n = 20) and left to breath room air or anaesthetized with propofol (6.5 +/- 0.76 mg kg(-1) IV) and sevoflurane (4.5% vaporizer setting) in oxygen (group P + S; n = 20) or with medetomidine (0.04 mg kg(-1) IV), propofol (1.92 +/- 0.63 mg kg(-1)) and sevoflurane (3% vaporizer setting) in oxygen (group M + P + S; n = 26), respectively. After 35 minutes, medetomidine was antagonized with atipamezole (0.1 mg kg(-1) intramuscularly). Blood samples for serum cTnI determination were taken before sedation or anaesthesia, 6 and 12 hours and 4 days thereafter. Serum cTnI concentrations were measured with the Architect STAT Troponin-I assay. Results Before sedation or anaesthesia, cTnI concentrations were above the detection limit in 22 out of 66 (33%) of dogs. Compared to basal values, cTnI concentrations significantly increased at 6 and 12 hours in all groups and at day 4 in group M. There were no differences in cTnI concentration between groups at baseline, at 6 hours and at 4 days. At 12 hours, cTnI concentrations were significantly higher in groups M and P + S, respectively, compared to group M + P + S. Conclusions and clinical relevance Oxygenation during anaesthesia and reduction of propofol and sevoflurane dose due to the sparing effects of medetomidine might have played a role in alleviation of myocardial hypoxic injury as indicated by the less severe and short-lived increase of cTnI in the M + P + S group.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Veterinary Anaesthesia and Analgesia", title = "Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction", volume = "45", number = "6", pages = "745-753", doi = "10.1016/j.vaa.2018.07.003" }
Vasiljević, M., Krstić, V., Stanković, S., Zrimsek, P., Svete, A. N.,& Seliskar, A.. (2018). Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction. in Veterinary Anaesthesia and Analgesia Elsevier Science Bv, Amsterdam., 45(6), 745-753. https://doi.org/10.1016/j.vaa.2018.07.003
Vasiljević M, Krstić V, Stanković S, Zrimsek P, Svete AN, Seliskar A. Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction. in Veterinary Anaesthesia and Analgesia. 2018;45(6):745-753. doi:10.1016/j.vaa.2018.07.003 .
Vasiljević, Maja, Krstić, Vanja, Stanković, Sanja, Zrimsek, Petra, Svete, Alenka Nemec, Seliskar, Alenka, "Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction" in Veterinary Anaesthesia and Analgesia, 45, no. 6 (2018):745-753, https://doi.org/10.1016/j.vaa.2018.07.003 . .