Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 4. Dandelion extract - Ciprofloxacin/pyralene
Апстракт
The article describes a study of the protective effect of dandelion (Taraxacum officinale L. Asteraceae) in combination with two xenobiotics: ciprofloxacin and pyralene. For that purpose, methanolic extracts of the plant flower, leaf, stem, and root upon removal of the solvent were successively extracted with ether, chloroform, ethyl acetate, and n-butanol. The extracts were evaporated to dryness and then dissolved in 50% ethanol to obtain 6% (w/v) solutions. These solutions, either alone or in combination with different doses of ciprofloxacin or pyralene, were used to study their effect on liposomal lipid peroxidation (LPx) induced by Fe 2+ and ascorbic acid. It appeared that almost all the individual extracts exhibited an antioxidant effect and in combination with pyralene decreased its pro-oxidative action on liposomal LPx. At lower concentrations, ciprofloxacin alone did not exhibit an antioxidant effect, but at higher concentrations it acted as a pro-oxidant, the effect being lowe...red by the presence of dandelion extracts. It is interesting to note that the extract of dandelion stem exhibited a very strong protective effect.
Кључне речи:
dandelion / polychlorinated biphenyls / liposomes / lipid peroxidation / ciprofloxacinИзвор:
Oxidation Communications, 2001, 24, 3, 344-351Издавач:
- Scibulcom Ltd, Sofia
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Popović, M. AU - Kaurinović, B AU - Mimica-Dukić, Neda AU - Vojinović-Miloradov, Mirjana AU - Ćupić, Vitomir PY - 2001 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/183 AB - The article describes a study of the protective effect of dandelion (Taraxacum officinale L. Asteraceae) in combination with two xenobiotics: ciprofloxacin and pyralene. For that purpose, methanolic extracts of the plant flower, leaf, stem, and root upon removal of the solvent were successively extracted with ether, chloroform, ethyl acetate, and n-butanol. The extracts were evaporated to dryness and then dissolved in 50% ethanol to obtain 6% (w/v) solutions. These solutions, either alone or in combination with different doses of ciprofloxacin or pyralene, were used to study their effect on liposomal lipid peroxidation (LPx) induced by Fe 2+ and ascorbic acid. It appeared that almost all the individual extracts exhibited an antioxidant effect and in combination with pyralene decreased its pro-oxidative action on liposomal LPx. At lower concentrations, ciprofloxacin alone did not exhibit an antioxidant effect, but at higher concentrations it acted as a pro-oxidant, the effect being lowered by the presence of dandelion extracts. It is interesting to note that the extract of dandelion stem exhibited a very strong protective effect. PB - Scibulcom Ltd, Sofia T2 - Oxidation Communications T1 - Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 4. Dandelion extract - Ciprofloxacin/pyralene VL - 24 IS - 3 SP - 344 EP - 351 UR - https://hdl.handle.net/21.15107/rcub_veterinar_183 ER -
@article{ author = "Popović, M. and Kaurinović, B and Mimica-Dukić, Neda and Vojinović-Miloradov, Mirjana and Ćupić, Vitomir", year = "2001", abstract = "The article describes a study of the protective effect of dandelion (Taraxacum officinale L. Asteraceae) in combination with two xenobiotics: ciprofloxacin and pyralene. For that purpose, methanolic extracts of the plant flower, leaf, stem, and root upon removal of the solvent were successively extracted with ether, chloroform, ethyl acetate, and n-butanol. The extracts were evaporated to dryness and then dissolved in 50% ethanol to obtain 6% (w/v) solutions. These solutions, either alone or in combination with different doses of ciprofloxacin or pyralene, were used to study their effect on liposomal lipid peroxidation (LPx) induced by Fe 2+ and ascorbic acid. It appeared that almost all the individual extracts exhibited an antioxidant effect and in combination with pyralene decreased its pro-oxidative action on liposomal LPx. At lower concentrations, ciprofloxacin alone did not exhibit an antioxidant effect, but at higher concentrations it acted as a pro-oxidant, the effect being lowered by the presence of dandelion extracts. It is interesting to note that the extract of dandelion stem exhibited a very strong protective effect.", publisher = "Scibulcom Ltd, Sofia", journal = "Oxidation Communications", title = "Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 4. Dandelion extract - Ciprofloxacin/pyralene", volume = "24", number = "3", pages = "344-351", url = "https://hdl.handle.net/21.15107/rcub_veterinar_183" }
Popović, M., Kaurinović, B., Mimica-Dukić, N., Vojinović-Miloradov, M.,& Ćupić, V.. (2001). Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 4. Dandelion extract - Ciprofloxacin/pyralene. in Oxidation Communications Scibulcom Ltd, Sofia., 24(3), 344-351. https://hdl.handle.net/21.15107/rcub_veterinar_183
Popović M, Kaurinović B, Mimica-Dukić N, Vojinović-Miloradov M, Ćupić V. Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 4. Dandelion extract - Ciprofloxacin/pyralene. in Oxidation Communications. 2001;24(3):344-351. https://hdl.handle.net/21.15107/rcub_veterinar_183 .
Popović, M., Kaurinović, B, Mimica-Dukić, Neda, Vojinović-Miloradov, Mirjana, Ćupić, Vitomir, "Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 4. Dandelion extract - Ciprofloxacin/pyralene" in Oxidation Communications, 24, no. 3 (2001):344-351, https://hdl.handle.net/21.15107/rcub_veterinar_183 .