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Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction
dc.creator | Vasiljević, Maja | |
dc.creator | Krstić, Vanja | |
dc.creator | Stanković, Sanja | |
dc.creator | Zrimsek, Petra | |
dc.creator | Svete, Alenka Nemec | |
dc.creator | Seliskar, Alenka | |
dc.date.accessioned | 2020-07-10T08:01:33Z | |
dc.date.available | 2019-07-03 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1467-2987 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/1851 | |
dc.description.abstract | Objective To investigate changes in serum cardiac troponin I (cTnI) concentrations in dogs in which medetomidine was used for sedation or for premedication prior to anaesthesia with propofol and sevoflurane. Study design Prospective clinical study. Animals A total of 66 client-owned dogs. Methods The dogs were sedated with medetomidine (0.04 mg kg(-1)) intravenously (IV) (group M; n = 20) and left to breath room air or anaesthetized with propofol (6.5 +/- 0.76 mg kg(-1) IV) and sevoflurane (4.5% vaporizer setting) in oxygen (group P + S; n = 20) or with medetomidine (0.04 mg kg(-1) IV), propofol (1.92 +/- 0.63 mg kg(-1)) and sevoflurane (3% vaporizer setting) in oxygen (group M + P + S; n = 26), respectively. After 35 minutes, medetomidine was antagonized with atipamezole (0.1 mg kg(-1) intramuscularly). Blood samples for serum cTnI determination were taken before sedation or anaesthesia, 6 and 12 hours and 4 days thereafter. Serum cTnI concentrations were measured with the Architect STAT Troponin-I assay. Results Before sedation or anaesthesia, cTnI concentrations were above the detection limit in 22 out of 66 (33%) of dogs. Compared to basal values, cTnI concentrations significantly increased at 6 and 12 hours in all groups and at day 4 in group M. There were no differences in cTnI concentration between groups at baseline, at 6 hours and at 4 days. At 12 hours, cTnI concentrations were significantly higher in groups M and P + S, respectively, compared to group M + P + S. Conclusions and clinical relevance Oxygenation during anaesthesia and reduction of propofol and sevoflurane dose due to the sparing effects of medetomidine might have played a role in alleviation of myocardial hypoxic injury as indicated by the less severe and short-lived increase of cTnI in the M + P + S group. | en |
dc.publisher | Elsevier Science Bv, Amsterdam | |
dc.relation | Slovenian Research AgencySlovenian Research Agency - Slovenia [P4-0053] | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Veterinary Anaesthesia and Analgesia | |
dc.subject | cardiac troponin I | en |
dc.subject | dogs | en |
dc.subject | medetomidine | en |
dc.subject | propofol | en |
dc.subject | sevoflurane | en |
dc.title | Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Селискар, Aленка; Зримсек, Петра; Свете, Aленка Немец; Васиљевић, Маја; Крстић, Вања; Станковић, Сања; | |
dc.citation.volume | 45 | |
dc.citation.issue | 6 | |
dc.citation.spage | 745 | |
dc.citation.epage | 753 | |
dc.citation.other | 45(6): 745-753 | |
dc.citation.rank | aM21 | |
dc.description.other | This is the peer-reviewed version of the article: Vasiljević, M.; Krstić, V.; Stanković, S.; Zrimsek, P.; Svete, A. N.; Seliskar, A. Cardiac Troponin I in Dogs Anaesthetized with Propofol and Sevoflurane: The Influence of Medetomidine Premedication and Inspired Oxygen Fraction. Veterinary Anaesthesia and Analgesia 2018, 45 (6), 745–753. [https://doi.org/10.1016/j.vaa.2018.07.003] | |
dc.identifier.wos | 000448668700004 | |
dc.identifier.doi | 10.1016/j.vaa.2018.07.003 | |
dc.identifier.pmid | 30309716 | |
dc.identifier.scopus | 2-s2.0-85054464408 | |
dc.identifier.fulltext | https://vet-erinar.vet.bg.ac.rs/bitstream/id/4888/Cardiac_troponin_I_acc_2018.pdf | |
dc.type.version | acceptedVersion |