Clinical observations and safety profile of oral herbal products, souroubea and Platanus spp; a pilot-toxicology study in dogs
Klinička zapažanja i bezbednost dva biljna proizvoda souroubea i platanus spp nakon oralne primene; preliminarna toksikološka ispitivanja kod pasa
Аутори
Villalobos, PedroBaker, John
Vindas, Pablo Sanchez
Durst, Tony
Masic, Aleksandar
Arnason, John T.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This pilot-study evaluated the toxicity and safety profile of two herbal products Souroubea spp Botanical Blend (SSBB) and Platanus Tree Bark (PTB) after oral administration to dogs at elevated doses for 28 days. SSBB and PTB botanicals are the major active ingredients of Sin Susto™, a novel natural product for the treatment of anxiety in dogs. Three healthy female dogs were administered elevated doses of either SSBB, PTB or a placebo and then monitored for the occurrence of any systemic and local adverse events. Data from this pilot-study revealed that SSBB and PTB had no untoward effects on the health of dogs and were deemed safe which enabled the design and execution of a larger controlled target safety and toxicology study for Sin Susto.
Ova preliminarna studija procenjuje toksičnost i bezbednost dva biljna sastojka Souroubea spp Botanical Blend (SSBB) i Platanus Tree Bark (PTB) nakon oralne primene kod pasa u povišenim dozama u trajanju od 28 dana. Biljne mešavine SSBB i PTB su dva glavna aktivna sastojka u Sin Susto™, novog prirodnog proizvoda registrovanog za preventivu/smanjenje anksioznosti kod pasa. Tri zdrave ženke pasa su primale povišene doze SSBB, PTB ili placebo nakon čega je praćena pojava sistemskih ili lokalnih neželjenih efekata. Podaci iz ovog preliminarnog istraživanja su pokazali da SSBB i PTB nisu izazvali nikakve neželjene efekte kod pasa i mogu se smatrati bezbednim što je omogućilo dalje istraživanje i izvođenje kontrolisanih ispitivanja u cilju demonstriranja bezbednosti i toksičnosti preparata Sin Susto™ kod pasa.
Кључне речи:
anxiety / dogs / Souroubea spp / Platanus / Sin Susto™Извор:
Acta Veterinaria-Beograd, 2014, 64, 2, 269-275Финансирање / пројекти:
- Funding for the pilot toxicology study was provided by the I2I grant program of the Natural Sciences and Engineering Research Council of Canada (NSERC).
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Villalobos, Pedro AU - Baker, John AU - Vindas, Pablo Sanchez AU - Durst, Tony AU - Masic, Aleksandar AU - Arnason, John T. PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2180 AB - This pilot-study evaluated the toxicity and safety profile of two herbal products Souroubea spp Botanical Blend (SSBB) and Platanus Tree Bark (PTB) after oral administration to dogs at elevated doses for 28 days. SSBB and PTB botanicals are the major active ingredients of Sin Susto™, a novel natural product for the treatment of anxiety in dogs. Three healthy female dogs were administered elevated doses of either SSBB, PTB or a placebo and then monitored for the occurrence of any systemic and local adverse events. Data from this pilot-study revealed that SSBB and PTB had no untoward effects on the health of dogs and were deemed safe which enabled the design and execution of a larger controlled target safety and toxicology study for Sin Susto. AB - Ova preliminarna studija procenjuje toksičnost i bezbednost dva biljna sastojka Souroubea spp Botanical Blend (SSBB) i Platanus Tree Bark (PTB) nakon oralne primene kod pasa u povišenim dozama u trajanju od 28 dana. Biljne mešavine SSBB i PTB su dva glavna aktivna sastojka u Sin Susto™, novog prirodnog proizvoda registrovanog za preventivu/smanjenje anksioznosti kod pasa. Tri zdrave ženke pasa su primale povišene doze SSBB, PTB ili placebo nakon čega je praćena pojava sistemskih ili lokalnih neželjenih efekata. Podaci iz ovog preliminarnog istraživanja su pokazali da SSBB i PTB nisu izazvali nikakve neželjene efekte kod pasa i mogu se smatrati bezbednim što je omogućilo dalje istraživanje i izvođenje kontrolisanih ispitivanja u cilju demonstriranja bezbednosti i toksičnosti preparata Sin Susto™ kod pasa. T2 - Acta Veterinaria-Beograd T1 - Clinical observations and safety profile of oral herbal products, souroubea and Platanus spp; a pilot-toxicology study in dogs T1 - Klinička zapažanja i bezbednost dva biljna proizvoda souroubea i platanus spp nakon oralne primene; preliminarna toksikološka ispitivanja kod pasa VL - 64 IS - 2 SP - 269 EP - 275 DO - 10.2478/acve-2014-0025 ER -
@article{ author = "Villalobos, Pedro and Baker, John and Vindas, Pablo Sanchez and Durst, Tony and Masic, Aleksandar and Arnason, John T.", year = "2014", abstract = "This pilot-study evaluated the toxicity and safety profile of two herbal products Souroubea spp Botanical Blend (SSBB) and Platanus Tree Bark (PTB) after oral administration to dogs at elevated doses for 28 days. SSBB and PTB botanicals are the major active ingredients of Sin Susto™, a novel natural product for the treatment of anxiety in dogs. Three healthy female dogs were administered elevated doses of either SSBB, PTB or a placebo and then monitored for the occurrence of any systemic and local adverse events. Data from this pilot-study revealed that SSBB and PTB had no untoward effects on the health of dogs and were deemed safe which enabled the design and execution of a larger controlled target safety and toxicology study for Sin Susto., Ova preliminarna studija procenjuje toksičnost i bezbednost dva biljna sastojka Souroubea spp Botanical Blend (SSBB) i Platanus Tree Bark (PTB) nakon oralne primene kod pasa u povišenim dozama u trajanju od 28 dana. Biljne mešavine SSBB i PTB su dva glavna aktivna sastojka u Sin Susto™, novog prirodnog proizvoda registrovanog za preventivu/smanjenje anksioznosti kod pasa. Tri zdrave ženke pasa su primale povišene doze SSBB, PTB ili placebo nakon čega je praćena pojava sistemskih ili lokalnih neželjenih efekata. Podaci iz ovog preliminarnog istraživanja su pokazali da SSBB i PTB nisu izazvali nikakve neželjene efekte kod pasa i mogu se smatrati bezbednim što je omogućilo dalje istraživanje i izvođenje kontrolisanih ispitivanja u cilju demonstriranja bezbednosti i toksičnosti preparata Sin Susto™ kod pasa.", journal = "Acta Veterinaria-Beograd", title = "Clinical observations and safety profile of oral herbal products, souroubea and Platanus spp; a pilot-toxicology study in dogs, Klinička zapažanja i bezbednost dva biljna proizvoda souroubea i platanus spp nakon oralne primene; preliminarna toksikološka ispitivanja kod pasa", volume = "64", number = "2", pages = "269-275", doi = "10.2478/acve-2014-0025" }
Villalobos, P., Baker, J., Vindas, P. S., Durst, T., Masic, A.,& Arnason, J. T.. (2014). Clinical observations and safety profile of oral herbal products, souroubea and Platanus spp; a pilot-toxicology study in dogs. in Acta Veterinaria-Beograd, 64(2), 269-275. https://doi.org/10.2478/acve-2014-0025
Villalobos P, Baker J, Vindas PS, Durst T, Masic A, Arnason JT. Clinical observations and safety profile of oral herbal products, souroubea and Platanus spp; a pilot-toxicology study in dogs. in Acta Veterinaria-Beograd. 2014;64(2):269-275. doi:10.2478/acve-2014-0025 .
Villalobos, Pedro, Baker, John, Vindas, Pablo Sanchez, Durst, Tony, Masic, Aleksandar, Arnason, John T., "Clinical observations and safety profile of oral herbal products, souroubea and Platanus spp; a pilot-toxicology study in dogs" in Acta Veterinaria-Beograd, 64, no. 2 (2014):269-275, https://doi.org/10.2478/acve-2014-0025 . .