Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes of Alzheimer disease patients
Само за регистроване кориснике
2006
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Premature centromere division (PCD) of the chromosome 18 was analyzed by using fluorescent in situ hybridization (FISH) on interphase peripheral blood lymphocytes isolated from six sporadic Alzheimer disease (AD) patients and six healthy elderly controls. Results of FISH analysis revealed that chromosome 18 expressed PCD in 5.18% interphase nuclei of AD patients, and in 2.59% interphase nuclei of age-matched controls (p < 0.05). Our study also showed that hypoploidy and hyperploidy frequency for chromosome 18 exhibited a statistically significant increase in the AD group compared to the control one. The increase in spontaneous aneuploidy of chromosome 18 in AD patients which is correlated with PCD shows that deregulation of the time of centromere separation can be considered as a manifestation of chromosome instability leading to aneuploidy.
Кључне речи:
Alzheimer disease / Premature centromere division / Chromosome 18 / Fluorescent in situ hybridizationИзвор:
Mechanisms of Ageing and Development, 2006, 127, 12, 892-896Издавач:
- Elsevier
Финансирање / пројекти:
- Евалуација дејства хормона и цитостатика прменом цитогенетичких анализа и Комет теста (RS-MESTD-MPN2006-2010-143018)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Živković, Lada AU - Spremo-Potparević, Biljana AU - Đelić, Ninoslav AU - Bajić, Vladan PY - 2006 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2812 AB - Premature centromere division (PCD) of the chromosome 18 was analyzed by using fluorescent in situ hybridization (FISH) on interphase peripheral blood lymphocytes isolated from six sporadic Alzheimer disease (AD) patients and six healthy elderly controls. Results of FISH analysis revealed that chromosome 18 expressed PCD in 5.18% interphase nuclei of AD patients, and in 2.59% interphase nuclei of age-matched controls (p < 0.05). Our study also showed that hypoploidy and hyperploidy frequency for chromosome 18 exhibited a statistically significant increase in the AD group compared to the control one. The increase in spontaneous aneuploidy of chromosome 18 in AD patients which is correlated with PCD shows that deregulation of the time of centromere separation can be considered as a manifestation of chromosome instability leading to aneuploidy. PB - Elsevier T2 - Mechanisms of Ageing and Development T1 - Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes of Alzheimer disease patients VL - 127 IS - 12 SP - 892 EP - 896 DO - 10.1016/j.mad.2006.09.004 ER -
@article{ author = "Živković, Lada and Spremo-Potparević, Biljana and Đelić, Ninoslav and Bajić, Vladan", year = "2006", abstract = "Premature centromere division (PCD) of the chromosome 18 was analyzed by using fluorescent in situ hybridization (FISH) on interphase peripheral blood lymphocytes isolated from six sporadic Alzheimer disease (AD) patients and six healthy elderly controls. Results of FISH analysis revealed that chromosome 18 expressed PCD in 5.18% interphase nuclei of AD patients, and in 2.59% interphase nuclei of age-matched controls (p < 0.05). Our study also showed that hypoploidy and hyperploidy frequency for chromosome 18 exhibited a statistically significant increase in the AD group compared to the control one. The increase in spontaneous aneuploidy of chromosome 18 in AD patients which is correlated with PCD shows that deregulation of the time of centromere separation can be considered as a manifestation of chromosome instability leading to aneuploidy.", publisher = "Elsevier", journal = "Mechanisms of Ageing and Development", title = "Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes of Alzheimer disease patients", volume = "127", number = "12", pages = "892-896", doi = "10.1016/j.mad.2006.09.004" }
Živković, L., Spremo-Potparević, B., Đelić, N.,& Bajić, V.. (2006). Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes of Alzheimer disease patients. in Mechanisms of Ageing and Development Elsevier., 127(12), 892-896. https://doi.org/10.1016/j.mad.2006.09.004
Živković L, Spremo-Potparević B, Đelić N, Bajić V. Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes of Alzheimer disease patients. in Mechanisms of Ageing and Development. 2006;127(12):892-896. doi:10.1016/j.mad.2006.09.004 .
Živković, Lada, Spremo-Potparević, Biljana, Đelić, Ninoslav, Bajić, Vladan, "Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes of Alzheimer disease patients" in Mechanisms of Ageing and Development, 127, no. 12 (2006):892-896, https://doi.org/10.1016/j.mad.2006.09.004 . .