New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
Аутори
Jadranin, MilkaCvetković, Mirjana
Đorđević, Iris
Krstić, Gordana
Tešević, Vele
Milosavljević, Slobodan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Our previous phytochemical studies revealed that the
plant species of the genus Amphoricarpos from
Montenegro are characterized with an appreciable content
(>0.3–2.3% per dry weight of aerial plant material) of γsesquiterpene lactones with guaianolide skeleton, socalled amphoricarpolides that are mostly deposited on the
leaf surface (>1.0–3.4% per dry weight of leaves)
(Djordjević et al., 2021; Jadranin et al., 2013). These
compounds showed in vitro protective effect on
chromosome aberrations in peripheral human
lymphocytes (Cvetković et al., 2021) and in vitro
cytotoxic (Djordjević et al., 2021), antifungal (Jadranin et
al., 2013) and antibacterial (Gavrilović et al., 2016)
activities. The amphoricarpolides are significant as
chemotaxonomic markers as they gave insights about the
taxonomic status of the genus (Djordjević et al., 2021).
This study revealed results from reinvestigation of
sesquiterpene lactones composition in the crude and leaf
surface extracts of Amphor...icarpos plants by rapid
resolution liquid chromatography (RRLC) coupled with
quadrupole time-of-flight mass spectrometry (QToF MS)
and the tentative identification of undescribed
sesquiterpene lactones is presented.
Извор:
Macedonian Pharmaceutical Bulletin, 2022, 68, 71-72Издавач:
- Skopje : Macedonian Pharmaceutical Association
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200143 (Универзитет у Београду, Факултет ветеринарске медицине) (RS-MESTD-inst-2020-200143)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Jadranin, Milka AU - Cvetković, Mirjana AU - Đorđević, Iris AU - Krstić, Gordana AU - Tešević, Vele AU - Milosavljević, Slobodan PY - 2022 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2995 AB - Our previous phytochemical studies revealed that the plant species of the genus Amphoricarpos from Montenegro are characterized with an appreciable content (>0.3–2.3% per dry weight of aerial plant material) of γsesquiterpene lactones with guaianolide skeleton, socalled amphoricarpolides that are mostly deposited on the leaf surface (>1.0–3.4% per dry weight of leaves) (Djordjević et al., 2021; Jadranin et al., 2013). These compounds showed in vitro protective effect on chromosome aberrations in peripheral human lymphocytes (Cvetković et al., 2021) and in vitro cytotoxic (Djordjević et al., 2021), antifungal (Jadranin et al., 2013) and antibacterial (Gavrilović et al., 2016) activities. The amphoricarpolides are significant as chemotaxonomic markers as they gave insights about the taxonomic status of the genus (Djordjević et al., 2021). This study revealed results from reinvestigation of sesquiterpene lactones composition in the crude and leaf surface extracts of Amphoricarpos plants by rapid resolution liquid chromatography (RRLC) coupled with quadrupole time-of-flight mass spectrometry (QToF MS) and the tentative identification of undescribed sesquiterpene lactones is presented. PB - Skopje : Macedonian Pharmaceutical Association T2 - Macedonian Pharmaceutical Bulletin T1 - New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry VL - 68 SP - 71 EP - 72 DO - 10.33320/maced.pharm.bull.2022.68.04.030 ER -
@article{ author = "Jadranin, Milka and Cvetković, Mirjana and Đorđević, Iris and Krstić, Gordana and Tešević, Vele and Milosavljević, Slobodan", year = "2022", abstract = "Our previous phytochemical studies revealed that the plant species of the genus Amphoricarpos from Montenegro are characterized with an appreciable content (>0.3–2.3% per dry weight of aerial plant material) of γsesquiterpene lactones with guaianolide skeleton, socalled amphoricarpolides that are mostly deposited on the leaf surface (>1.0–3.4% per dry weight of leaves) (Djordjević et al., 2021; Jadranin et al., 2013). These compounds showed in vitro protective effect on chromosome aberrations in peripheral human lymphocytes (Cvetković et al., 2021) and in vitro cytotoxic (Djordjević et al., 2021), antifungal (Jadranin et al., 2013) and antibacterial (Gavrilović et al., 2016) activities. The amphoricarpolides are significant as chemotaxonomic markers as they gave insights about the taxonomic status of the genus (Djordjević et al., 2021). This study revealed results from reinvestigation of sesquiterpene lactones composition in the crude and leaf surface extracts of Amphoricarpos plants by rapid resolution liquid chromatography (RRLC) coupled with quadrupole time-of-flight mass spectrometry (QToF MS) and the tentative identification of undescribed sesquiterpene lactones is presented.", publisher = "Skopje : Macedonian Pharmaceutical Association", journal = "Macedonian Pharmaceutical Bulletin", title = "New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry", volume = "68", pages = "71-72", doi = "10.33320/maced.pharm.bull.2022.68.04.030" }
Jadranin, M., Cvetković, M., Đorđević, I., Krstić, G., Tešević, V.,& Milosavljević, S.. (2022). New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin Skopje : Macedonian Pharmaceutical Association., 68, 71-72. https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030
Jadranin M, Cvetković M, Đorđević I, Krstić G, Tešević V, Milosavljević S. New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin. 2022;68:71-72. doi:10.33320/maced.pharm.bull.2022.68.04.030 .
Jadranin, Milka, Cvetković, Mirjana, Đorđević, Iris, Krstić, Gordana, Tešević, Vele, Milosavljević, Slobodan, "New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry" in Macedonian Pharmaceutical Bulletin, 68 (2022):71-72, https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030 . .