Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study
Само за регистроване кориснике
2023
Аутори
Radaković, MilenaFrancuski Andrić, Jelena
Spariosu, Kristina
Vejnović, Branislav
Kovačević Filipović, Milica
Andrić, Nenad
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most
common neurological condition, oxidant–antioxidant status in epileptic dogs is still unknown. The aim of this
study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs
with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers:
advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances
(TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1
(PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP
is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the
healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the
dogs with... IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity
across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with
IE are characterized by an impaired serum oxidant–antioxidant balance and lower BChE activity, which may
contribute to a better understanding of IE pathogenesis.
Кључне речи:
Butyrylcholinesterase / Dogs / Idiopathic epilepsy / Oxidative stressИзвор:
Research in Veterinary Science, 2023, 165, 105076-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200143 (Универзитет у Београду, Факултет ветеринарске медицине) (RS-MESTD-inst-2020-200143)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Radaković, Milena AU - Francuski Andrić, Jelena AU - Spariosu, Kristina AU - Vejnović, Branislav AU - Kovačević Filipović, Milica AU - Andrić, Nenad PY - 2023 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3391 AB - Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most common neurological condition, oxidant–antioxidant status in epileptic dogs is still unknown. The aim of this study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers: advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances (TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1 (PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the dogs with IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with IE are characterized by an impaired serum oxidant–antioxidant balance and lower BChE activity, which may contribute to a better understanding of IE pathogenesis. PB - Elsevier T2 - Research in Veterinary Science T1 - Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study VL - 165 SP - 105076 DO - 10.1016/j.rvsc.2023.105076 ER -
@article{ author = "Radaković, Milena and Francuski Andrić, Jelena and Spariosu, Kristina and Vejnović, Branislav and Kovačević Filipović, Milica and Andrić, Nenad", year = "2023", abstract = "Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most common neurological condition, oxidant–antioxidant status in epileptic dogs is still unknown. The aim of this study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers: advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances (TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1 (PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the dogs with IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with IE are characterized by an impaired serum oxidant–antioxidant balance and lower BChE activity, which may contribute to a better understanding of IE pathogenesis.", publisher = "Elsevier", journal = "Research in Veterinary Science", title = "Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study", volume = "165", pages = "105076", doi = "10.1016/j.rvsc.2023.105076" }
Radaković, M., Francuski Andrić, J., Spariosu, K., Vejnović, B., Kovačević Filipović, M.,& Andrić, N.. (2023). Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study. in Research in Veterinary Science Elsevier., 165, 105076. https://doi.org/10.1016/j.rvsc.2023.105076
Radaković M, Francuski Andrić J, Spariosu K, Vejnović B, Kovačević Filipović M, Andrić N. Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study. in Research in Veterinary Science. 2023;165:105076. doi:10.1016/j.rvsc.2023.105076 .
Radaković, Milena, Francuski Andrić, Jelena, Spariosu, Kristina, Vejnović, Branislav, Kovačević Filipović, Milica, Andrić, Nenad, "Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study" in Research in Veterinary Science, 165 (2023):105076, https://doi.org/10.1016/j.rvsc.2023.105076 . .