The influence of thymic extract on hematological parameter values in irradiated Wistar rats

Abstract

In this study, results obtained by following up the changes in hematological parameter values in Wistar rats irradiated with 4 Gy and treated with calves thymic extract Thymex-L are presented. Following irradiation, white blood picture parameters were dramatically decreased and gradually increased from day 14. This elevation was higher in the Thymex-L treated group and the differences were statistically significant for total leukocyte, lymphocyte and neutrophyl granulocyte count starting from day 14. A significant increase of the monocyte count was observed only at day 28. Parameters of the red blood picture (erythrocyte count, hemoglobin concentration and packed red blood cell volume) were increased starting from day 21. We were able to conclude that treatment of irradiated Wistar rats with thymic extract results in a significant improvement of hematological parameter values.

U ovom radu su izneti rezultati ispitivanja efekta preparata Thymex-L dobijenog iz ekstrakta goveđeg timusa na dinamiku promena osnovnih hematoloških parametara pacova soja Wistar kod kojih je prethodno izvršeno jednokratno ozračivanje celog tela X zracima u ukupnoj dozi od 4 Gy. Nakon 28 dana ogleda i sukcesivnog praćenja vrednosti ispitivanih parametara registrovano je statistički značajno povećanje ukupnog broja leukocita broja limfocita i neutrofilnih granulocita, počevši od 14. dana ogleda u grupi ozračenih pacova tretiranih ekstraktom timusa. Do značajnog povećanja broja monocita došlo tek 28. dana. Statistički značajno povećanje broja eritrocita, koncentracije hemoglobina, hematokritske vrednosti i broja trombocita registrovano je počevši od 21 dana ogleda pa sve do kraja ispitivanja.