Приказ основних података о документу
Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves
dc.creator | Kirovski, Danijela | |
dc.creator | Lazarević, Miodrag | |
dc.creator | Baricevic-Jones, Ivona | |
dc.creator | Nedić, Olgica | |
dc.creator | Masnikosa, Rornana | |
dc.creator | Nikolić-Judith, Anna | |
dc.date.accessioned | 2020-06-03T13:08:48Z | |
dc.date.available | 2020-06-03T13:08:48Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0830-9000 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/534 | |
dc.description.abstract | There is disagreement in the literature about the ability of neonatal calves to absorb perorally administered insulin. This study evaluated the absorption of a bolus of insulin administered alone or with an energy souce and its effects on the circulating insulin-like growth factor system and thyroid hormones in newborn Holstein-Friesian calves. Within 1 h of dosing, mean serum insulin and triiodothyronine (T3) concentrations had increased considerably, whether the insulin was applied alone (n = 4) or together with glucose (n = 4), accompanied by marked hypoglycemia. No significant changes were observed in control calves (n = 4) given the vehicle solution. Increased serum glucose and T3 concentrations with no change in insulinemia occurred in a 4th group of calves given glucose alone. At 32 h of age and after 3 meals of colostrum there were no differences in glycemia, insulinemia, or proteinemia among the 4 groups of calves examined. Mean serum insulin-like growth factor-I (IGF-I) tended to decrease over this period in the control group. The decrease was more pronounced in the insulin-treated group but absent in both groups that received glucose. These differences were associated with equivalent differences in abundance of the 40-45K IGF-binding protein-3 (IGFBP-3); however, lower molecular mass IGFBPs were not affected. The results show that a pharmacological peroral dose of insulin can lead to rapid systemic alterations in the IGF/IGFBP system in neonatal calves that can be modified by simultaneous administration of a small energy supply in the form of glucose. | en |
dc.publisher | Canadian Vet Med Assoc, Ottawa | |
dc.rights | restrictedAccess | |
dc.source | Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire | |
dc.title | Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Масникоса, Рорнана; Николић-Јудитх, Aнна; Барицевиц-Јонес, Ивона; Недић, Олгица; Кировски, Данијела; Лазаревић, Миодраг; | |
dc.citation.volume | 72 | |
dc.citation.issue | 3 | |
dc.citation.spage | 253 | |
dc.citation.epage | 258 | |
dc.citation.other | 72(3): 253-258 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000255703400006 | |
dc.identifier.pmid | 18505189 | |
dc.identifier.scopus | 2-s2.0-44649197208 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_veterinar_534 | |
dc.type.version | publishedVersion |