Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro
Само за регистроване кориснике
2009
Аутори
Atrrog, Abubaker A. B.Natić, Maja
Tosti, Tomislav
Milojković-Opsenica, Dušanka
Đorđević, Iris
Tešević, Vele
Jadranin, Milka
Milosavljević, Slobodan M.
Lazić, Milan
Radulović, Siniša
Tešić, Živoslav
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R-M(0) and C-0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright
Кључне речи:
guaianolides / reversed-phase thin-layer chromatography / lipophilicity / structure-activity relationship / PCAИзвор:
Biomedical Chromatography, 2009, 23, 3, 250-256Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Синтеза, анализа и активност нових органских полидентатних лиганада и њихових комплекса са d-металима (RS-MESTD-MPN2006-2010-142062)
DOI: 10.1002/bmc.1091
ISSN: 0269-3879
PubMed: 18816478
WoS: 000263776700003
Scopus: 2-s2.0-65249100236
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Atrrog, Abubaker A. B. AU - Natić, Maja AU - Tosti, Tomislav AU - Milojković-Opsenica, Dušanka AU - Đorđević, Iris AU - Tešević, Vele AU - Jadranin, Milka AU - Milosavljević, Slobodan M. AU - Lazić, Milan AU - Radulović, Siniša AU - Tešić, Živoslav PY - 2009 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/619 AB - In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R-M(0) and C-0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright PB - Wiley, Hoboken T2 - Biomedical Chromatography T1 - Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro VL - 23 IS - 3 SP - 250 EP - 256 DO - 10.1002/bmc.1091 ER -
@article{ author = "Atrrog, Abubaker A. B. and Natić, Maja and Tosti, Tomislav and Milojković-Opsenica, Dušanka and Đorđević, Iris and Tešević, Vele and Jadranin, Milka and Milosavljević, Slobodan M. and Lazić, Milan and Radulović, Siniša and Tešić, Živoslav", year = "2009", abstract = "In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R-M(0) and C-0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright", publisher = "Wiley, Hoboken", journal = "Biomedical Chromatography", title = "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro", volume = "23", number = "3", pages = "250-256", doi = "10.1002/bmc.1091" }
Atrrog, A. A. B., Natić, M., Tosti, T., Milojković-Opsenica, D., Đorđević, I., Tešević, V., Jadranin, M., Milosavljević, S. M., Lazić, M., Radulović, S.,& Tešić, Ž.. (2009). Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography Wiley, Hoboken., 23(3), 250-256. https://doi.org/10.1002/bmc.1091
Atrrog AAB, Natić M, Tosti T, Milojković-Opsenica D, Đorđević I, Tešević V, Jadranin M, Milosavljević SM, Lazić M, Radulović S, Tešić Ž. Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography. 2009;23(3):250-256. doi:10.1002/bmc.1091 .
Atrrog, Abubaker A. B., Natić, Maja, Tosti, Tomislav, Milojković-Opsenica, Dušanka, Đorđević, Iris, Tešević, Vele, Jadranin, Milka, Milosavljević, Slobodan M., Lazić, Milan, Radulović, Siniša, Tešić, Živoslav, "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro" in Biomedical Chromatography, 23, no. 3 (2009):250-256, https://doi.org/10.1002/bmc.1091 . .