dc.creator | Krstić, Milena | |
dc.creator | Sovilj, Sofija P. | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Radosavljevic-Evans, Ivana | |
dc.creator | Borozan, Sunčica | |
dc.creator | Santibanez, Juan Francisco | |
dc.creator | Kocić, Jelena | |
dc.date.accessioned | 2020-06-03T13:21:36Z | |
dc.date.available | 2020-06-03T13:21:36Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/710 | |
dc.description.abstract | Three new complexes of the general formula L[RuCl3(DMSO)(3)] (1-3), where L = chlorpromazine hydrochloride, trifluoroperazine dihydrochloride or thioridazine hydrochloride, were prepared and characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, H-1 NMR and C-13 NMR). In addition, the crystal structure of the complex 2 containing trifluoroperazine dihydrochloride was solved by single crystal X-ray diffraction. The complex crystallizes in the monoclinic system, space group P2(1)/n, with a = 10.4935(7) angstrom, b = 18.6836(12) angstrom, c = 19.9250(13) angstrom, beta = 98.448(2)degrees, V = 3864.0(4) angstrom(3). The structure was refined to the agreement factors of R = 4.79%, R-w = 11.23%. The effect of three different doses (0.4, 4.5 and 90.4 mu M/kg bw) of complex 2 on superoxide dismutase (SOD) and catalase (CAT) activity was investigated under physiological conditions. Influence on nitrite production (NO2-) and the level of erythrocytes malondialdehyde (MDA) in rats blood was also evaluated. Complex 2 did not affect the CAT enzyme activity in vivo and did not cause the hydroxyl radicals production. In the 0.4 and 4.5 mu M/kg bw doses it showed almost the same or lower SOD activity and nitrite levels, while the dose of 90.4 mu M/kg bw significantly increased these parameters. Finally, the cytotoxicity of complexes were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon adenocarcinoma) and IM9 (myeloma multiple cells). Antiproliferative activity in vitro with low IC50 during 48 h of treatment was observed. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142028/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143018/RS// | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Medicinal Chemistry | |
dc.subject | Ruthenium complexes | en |
dc.subject | N-alkylphenothiazines | en |
dc.subject | Single crystal X-ray diffraction | en |
dc.subject | Antioxidant enzymes | en |
dc.subject | Cytotoxicity | en |
dc.title | New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Крстић, Милена; Сантибанез, Јуан Францисцо; Совиљ, Софија П.; Коцић, Јелена; Гргурић-Шипка, Сања; Борозан, Сунчица; Радосављевиц-Еванс, Ивана; | |
dc.citation.volume | 45 | |
dc.citation.issue | 9 | |
dc.citation.spage | 3669 | |
dc.citation.epage | 3676 | |
dc.citation.other | 45(9): 3669-3676 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000281568600019 | |
dc.identifier.doi | 10.1016/j.ejmech.2010.05.013 | |
dc.identifier.pmid | 20684856 | |
dc.identifier.scopus | 2-s2.0-77955560077 | |
dc.type.version | publishedVersion | |