Ivermectin effects on motor coordination and contractions of isolated rat diaphragm
Samo za registrovane korisnike
2011
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Ivermectin, the antiparasitic drug from the macrocyclic lactones class raises attention due to its high efficiency against nematodes and arthropods and very specific toxic and side effects that it may produce in host. Dominant clinical symptoms of adverse effects and toxicity of ivermectin in animals are tremor, ataxia, CNS depression and coma which often results in mortality. In our study increasing intravenous doses of ivermectin, (6 or more times higher than therapeutic dose: 1.25, 2.5, 3.75, 5.0, 6.25 and 7.5 mg/kg), caused dose-dependent disturbance of motor coordination in treated rats. The median effective dose (ED50) that was able to impair the rota-rod performance in rats treated 3 min before testing was 2.52 mg/kg. This effect weakens over time, while in the rats treated 60 min before the rota-rod test. ED50 of ivermectin was 4.21 mg/kg. Whereas, all tested doses of ivermectin did not cause any other clinical symptoms of toxicity. Ivermectin has no effect on the contractions ...of isolated diaphragm caused by the EFS, which effectively blocked mecamylamine (100 mu M) and pancuronium (1 and 2 mu M). Effect on motor coordination is the first detectable clinical symptom of ivermectin toxicity and apparently is a result of its central effects.
Ključne reči:
Ivermectin / Rota-rod test / Diaphragm contraction / EFSIzvor:
Research in Veterinary Science, 2011, 91, 3, 426-433Izdavač:
- Elsevier Sci Ltd, Oxford
Finansiranje / projekti:
- Ispitivanje mehanizama rezistencije i toksičnosti antihelmintika-GABA i nikotinskih agonista (RS-145026)
DOI: 10.1016/j.rvsc.2010.09.016
ISSN: 0034-5288
PubMed: 20971486
WoS: 000298939200018
Scopus: 2-s2.0-80555131947
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Trailović, Saša AU - Ivanović, Saša AU - Varagić, Vladislav M. PY - 2011 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/761 AB - Ivermectin, the antiparasitic drug from the macrocyclic lactones class raises attention due to its high efficiency against nematodes and arthropods and very specific toxic and side effects that it may produce in host. Dominant clinical symptoms of adverse effects and toxicity of ivermectin in animals are tremor, ataxia, CNS depression and coma which often results in mortality. In our study increasing intravenous doses of ivermectin, (6 or more times higher than therapeutic dose: 1.25, 2.5, 3.75, 5.0, 6.25 and 7.5 mg/kg), caused dose-dependent disturbance of motor coordination in treated rats. The median effective dose (ED50) that was able to impair the rota-rod performance in rats treated 3 min before testing was 2.52 mg/kg. This effect weakens over time, while in the rats treated 60 min before the rota-rod test. ED50 of ivermectin was 4.21 mg/kg. Whereas, all tested doses of ivermectin did not cause any other clinical symptoms of toxicity. Ivermectin has no effect on the contractions of isolated diaphragm caused by the EFS, which effectively blocked mecamylamine (100 mu M) and pancuronium (1 and 2 mu M). Effect on motor coordination is the first detectable clinical symptom of ivermectin toxicity and apparently is a result of its central effects. PB - Elsevier Sci Ltd, Oxford T2 - Research in Veterinary Science T1 - Ivermectin effects on motor coordination and contractions of isolated rat diaphragm VL - 91 IS - 3 SP - 426 EP - 433 DO - 10.1016/j.rvsc.2010.09.016 ER -
@article{ author = "Trailović, Saša and Ivanović, Saša and Varagić, Vladislav M.", year = "2011", abstract = "Ivermectin, the antiparasitic drug from the macrocyclic lactones class raises attention due to its high efficiency against nematodes and arthropods and very specific toxic and side effects that it may produce in host. Dominant clinical symptoms of adverse effects and toxicity of ivermectin in animals are tremor, ataxia, CNS depression and coma which often results in mortality. In our study increasing intravenous doses of ivermectin, (6 or more times higher than therapeutic dose: 1.25, 2.5, 3.75, 5.0, 6.25 and 7.5 mg/kg), caused dose-dependent disturbance of motor coordination in treated rats. The median effective dose (ED50) that was able to impair the rota-rod performance in rats treated 3 min before testing was 2.52 mg/kg. This effect weakens over time, while in the rats treated 60 min before the rota-rod test. ED50 of ivermectin was 4.21 mg/kg. Whereas, all tested doses of ivermectin did not cause any other clinical symptoms of toxicity. Ivermectin has no effect on the contractions of isolated diaphragm caused by the EFS, which effectively blocked mecamylamine (100 mu M) and pancuronium (1 and 2 mu M). Effect on motor coordination is the first detectable clinical symptom of ivermectin toxicity and apparently is a result of its central effects.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Research in Veterinary Science", title = "Ivermectin effects on motor coordination and contractions of isolated rat diaphragm", volume = "91", number = "3", pages = "426-433", doi = "10.1016/j.rvsc.2010.09.016" }
Trailović, S., Ivanović, S.,& Varagić, V. M.. (2011). Ivermectin effects on motor coordination and contractions of isolated rat diaphragm. in Research in Veterinary Science Elsevier Sci Ltd, Oxford., 91(3), 426-433. https://doi.org/10.1016/j.rvsc.2010.09.016
Trailović S, Ivanović S, Varagić VM. Ivermectin effects on motor coordination and contractions of isolated rat diaphragm. in Research in Veterinary Science. 2011;91(3):426-433. doi:10.1016/j.rvsc.2010.09.016 .
Trailović, Saša, Ivanović, Saša, Varagić, Vladislav M., "Ivermectin effects on motor coordination and contractions of isolated rat diaphragm" in Research in Veterinary Science, 91, no. 3 (2011):426-433, https://doi.org/10.1016/j.rvsc.2010.09.016 . .