Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine
Abstract
It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.
Keywords:
antidepressants / catecholamine enzymes / gene expression / atria / ventricles / ratsSource:
Archives of Biological Sciences, 2011, 63, 3, 597-601Publisher:
- Srpsko biološko društvo, Beograd, i dr.
Funding / projects:
- Effects of metabolic and nonmetabolic stressors on the expression and action of neuroendocrine regulators of energy homeostasis (RS-173023)
- Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-173044)
DOI: 10.2298/ABS1103597S
ISSN: 0354-4664
WoS: 000294400500010
Scopus: 2-s2.0-79961180596
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Fakultet veterinarske medicineTY - JOUR AU - Spasojević, Nataša AU - Jovanović, P. AU - Spasojević-Tišma, Vera AU - Đelić, Ninoslav AU - Dronjak, Slađana PY - 2011 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/763 AB - It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine VL - 63 IS - 3 SP - 597 EP - 601 DO - 10.2298/ABS1103597S ER -
@article{ author = "Spasojević, Nataša and Jovanović, P. and Spasojević-Tišma, Vera and Đelić, Ninoslav and Dronjak, Slađana", year = "2011", abstract = "It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine", volume = "63", number = "3", pages = "597-601", doi = "10.2298/ABS1103597S" }
Spasojević, N., Jovanović, P., Spasojević-Tišma, V., Đelić, N.,& Dronjak, S.. (2011). Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 63(3), 597-601. https://doi.org/10.2298/ABS1103597S
Spasojević N, Jovanović P, Spasojević-Tišma V, Đelić N, Dronjak S. Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine. in Archives of Biological Sciences. 2011;63(3):597-601. doi:10.2298/ABS1103597S .
Spasojević, Nataša, Jovanović, P., Spasojević-Tišma, Vera, Đelić, Ninoslav, Dronjak, Slađana, "Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine" in Archives of Biological Sciences, 63, no. 3 (2011):597-601, https://doi.org/10.2298/ABS1103597S . .