Genotoxicity of the anticoccidial agent salinomycin
Апстракт
This report presents an analysis of genotoxic effects of the ionophoric antibiotic salinomycin commonly used in the control of coccidiosis. Mutagenic properties were determined, after application of increasing doses to experimental chinchilla rabbits, by monitoring mitotic activity of bone marrow cells, numerical chromosomal alterations and structural chromosomal aberrations. Moderate to non-significant genotoxicity was observed, except for the frequency of structural chromosomal aberrations where 19% of the examined mitoses displayed aberrations. This could lead to sterility or termination of embryonic development and, therefore, calls for caution in its use in clinical practice and poultry farming.
Кључне речи:
genotoxicity / mutagenicity / chromosomal aberrations / anticoccidials / salinomycinИзвор:
Acta Veterinaria-Beograd, 1998, 48, 4, 245-253Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Dimitrijević, Sanda AU - Savovski, K AU - Dimitrijević, B PY - 1998 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/97 AB - This report presents an analysis of genotoxic effects of the ionophoric antibiotic salinomycin commonly used in the control of coccidiosis. Mutagenic properties were determined, after application of increasing doses to experimental chinchilla rabbits, by monitoring mitotic activity of bone marrow cells, numerical chromosomal alterations and structural chromosomal aberrations. Moderate to non-significant genotoxicity was observed, except for the frequency of structural chromosomal aberrations where 19% of the examined mitoses displayed aberrations. This could lead to sterility or termination of embryonic development and, therefore, calls for caution in its use in clinical practice and poultry farming. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Genotoxicity of the anticoccidial agent salinomycin VL - 48 IS - 4 SP - 245 EP - 253 UR - https://hdl.handle.net/21.15107/rcub_veterinar_97 ER -
@article{ author = "Dimitrijević, Sanda and Savovski, K and Dimitrijević, B", year = "1998", abstract = "This report presents an analysis of genotoxic effects of the ionophoric antibiotic salinomycin commonly used in the control of coccidiosis. Mutagenic properties were determined, after application of increasing doses to experimental chinchilla rabbits, by monitoring mitotic activity of bone marrow cells, numerical chromosomal alterations and structural chromosomal aberrations. Moderate to non-significant genotoxicity was observed, except for the frequency of structural chromosomal aberrations where 19% of the examined mitoses displayed aberrations. This could lead to sterility or termination of embryonic development and, therefore, calls for caution in its use in clinical practice and poultry farming.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Genotoxicity of the anticoccidial agent salinomycin", volume = "48", number = "4", pages = "245-253", url = "https://hdl.handle.net/21.15107/rcub_veterinar_97" }
Dimitrijević, S., Savovski, K.,& Dimitrijević, B.. (1998). Genotoxicity of the anticoccidial agent salinomycin. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 48(4), 245-253. https://hdl.handle.net/21.15107/rcub_veterinar_97
Dimitrijević S, Savovski K, Dimitrijević B. Genotoxicity of the anticoccidial agent salinomycin. in Acta Veterinaria-Beograd. 1998;48(4):245-253. https://hdl.handle.net/21.15107/rcub_veterinar_97 .
Dimitrijević, Sanda, Savovski, K, Dimitrijević, B, "Genotoxicity of the anticoccidial agent salinomycin" in Acta Veterinaria-Beograd, 48, no. 4 (1998):245-253, https://hdl.handle.net/21.15107/rcub_veterinar_97 .