TY  - JOUR
AU  - Stevanović, Ivana
AU  - Mancić, Bojana
AU  - Ilić, Tihomir
AU  - Milosavljević, Petar
AU  - Lavrnja, Irena
AU  - Stojanović, Ivana
AU  - Ninković, Milica
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1750
AB  - Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in the activity of excitatory and inhibitory systems, restores these functions and suppresses the progression of disability in experimental autoimmune encephalitis (EAE). The structural type of TMS, the arrangement as theta burst stimulation (TBS) has been applied as intermittent TBS (iTBS) and continuous TBS (cTBS) protocols to female adult DA rats. The animals were randomly divided into experimental groups: control group (C), group treated with complete Freunds adjuvant (CFA), experimental autoimmune encephalomyelitis (EAE) group, group treated with iTBS post EAE immunization (EAE + iTBS), group treated with cTBS post EAE immunization (EAE + cTBS), group of healthy animals treated with iTBS or cTBS. Therapeutic protocols of iTBS or cTBS in all EAE groups of animals were performed starting from 14 days post immunization (dpi), for 10 days with time point decapitation at 24 dpi. After decapitation, spinal cords were analysed for BDNF and Ki67 expression. The results revealed reduced BDNF expression in the rats spinal cord of EAE animals in the stage of remission, which was associated with increased Ki67 and GFAP expressions. Decreased Iba 1 and BDNF expression, contrary to increased Iba 1 and Ki67 expression, suggests clustered microglia in the resolution phase of EAE. Enhanced GABA expression in spinal cord sections indicates higher GABA metabolic turnover, and also GAD activity in astrocytes, or prominent activity of GABAergic neurons. Both TBS protocols induced advance BDNF expression; amongst iTBS application provoked elevating of BDNF and stabilizing of GFAP and Ki67 expressions.
PB  - Termedia Publishing House Ltd, Poznan
T2  - Folia Neuropathologica
T1  - Theta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitis
VL  - 57
IS  - 2
SP  - 129
EP  - 145
DO  - 10.5114/fn.2019.86294
ER  - 

@article{
author = "Stevanović, Ivana and Mancić, Bojana and Ilić, Tihomir and Milosavljević, Petar and Lavrnja, Irena and Stojanović, Ivana and Ninković, Milica",
year = "2019",
abstract = "Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in the activity of excitatory and inhibitory systems, restores these functions and suppresses the progression of disability in experimental autoimmune encephalitis (EAE). The structural type of TMS, the arrangement as theta burst stimulation (TBS) has been applied as intermittent TBS (iTBS) and continuous TBS (cTBS) protocols to female adult DA rats. The animals were randomly divided into experimental groups: control group (C), group treated with complete Freunds adjuvant (CFA), experimental autoimmune encephalomyelitis (EAE) group, group treated with iTBS post EAE immunization (EAE + iTBS), group treated with cTBS post EAE immunization (EAE + cTBS), group of healthy animals treated with iTBS or cTBS. Therapeutic protocols of iTBS or cTBS in all EAE groups of animals were performed starting from 14 days post immunization (dpi), for 10 days with time point decapitation at 24 dpi. After decapitation, spinal cords were analysed for BDNF and Ki67 expression. The results revealed reduced BDNF expression in the rats spinal cord of EAE animals in the stage of remission, which was associated with increased Ki67 and GFAP expressions. Decreased Iba 1 and BDNF expression, contrary to increased Iba 1 and Ki67 expression, suggests clustered microglia in the resolution phase of EAE. Enhanced GABA expression in spinal cord sections indicates higher GABA metabolic turnover, and also GAD activity in astrocytes, or prominent activity of GABAergic neurons. Both TBS protocols induced advance BDNF expression; amongst iTBS application provoked elevating of BDNF and stabilizing of GFAP and Ki67 expressions.",
publisher = "Termedia Publishing House Ltd, Poznan",
journal = "Folia Neuropathologica",
title = "Theta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitis",
volume = "57",
number = "2",
pages = "129-145",
doi = "10.5114/fn.2019.86294"
}

Stevanović, I., Mancić, B., Ilić, T., Milosavljević, P., Lavrnja, I., Stojanović, I.,& Ninković, M.. (2019). Theta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitis. in Folia Neuropathologica
Termedia Publishing House Ltd, Poznan., 57(2), 129-145.
https://doi.org/10.5114/fn.2019.86294

Stevanović I, Mancić B, Ilić T, Milosavljević P, Lavrnja I, Stojanović I, Ninković M. Theta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitis. in Folia Neuropathologica. 2019;57(2):129-145.
doi:10.5114/fn.2019.86294 .

Stevanović, Ivana, Mancić, Bojana, Ilić, Tihomir, Milosavljević, Petar, Lavrnja, Irena, Stojanović, Ivana, Ninković, Milica, "Theta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitis" in Folia Neuropathologica, 57, no. 2 (2019):129-145,
https://doi.org/10.5114/fn.2019.86294 . .

TY  - JOUR
AU  - Dejanović, Bratislav
AU  - Vukovic-Dejanović, Vesna
AU  - Ninković, Milica
AU  - Lavrnja, Irena
AU  - Stojanović, Ivana
AU  - Pavlović, Miloš
AU  - Begović, Vesna
AU  - Mirković, Dšsko
AU  - Stevanović, Ivana
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1653
AB  - This study was aimed to study the potentially beneficial effects of agmatine on oxidative/nitrosative stress development in the brain of Wistar rats during subacute chlorpromazine treatment. The animals were divided into control (0.9% saline), chlorpromazine (38.7 mg/kg b.w.), chlorpromazine+agmatine (agmatine 75 mg/kg b.w. immediately after chlorpromazine, 38.7 mg/ kg b.w. i.p.) and agmatine (75 mg/kg b.w.) groups. All the tested substances were administered intraperitoneally for 15 consecutive days and the rats were sacrificed by decapitation on day 15. Subacute administration of chlorpromazine resulted in increased lipid peroxidation, nitric oxide concentration and superoxide anion production, while completely damaging the antioxidant defence system in the cerebral cortex, striatum, and hippocampus. However, the combined treatment with chlorpromazine and agmatine significantly attenuated the oxidative/nitrosative stress indices and restored the antioxidant capacity to the control values in all of the examined brain regions. Western blot analysis supported biochemical findings in all groups, but the most notable changes were found in the hippocampus. Our results suggest potentially beneficial effects of agmatine, which may be useful in the modified antioxidant approach in chlorpromazine-therapy.
PB  - Veterinarni A Farmaceuticka Univerzita Brno, Brno
T2  - Acta Veterinaria - Brno
T1  - Effects of agmatine on chlorpromazine-induced neuronal injury in rat
VL  - 87
IS  - 2
SP  - 145
EP  - 153
DO  - 10.2754/avb201887020145
ER  - 

@article{
author = "Dejanović, Bratislav and Vukovic-Dejanović, Vesna and Ninković, Milica and Lavrnja, Irena and Stojanović, Ivana and Pavlović, Miloš and Begović, Vesna and Mirković, Dšsko and Stevanović, Ivana",
year = "2018",
abstract = "This study was aimed to study the potentially beneficial effects of agmatine on oxidative/nitrosative stress development in the brain of Wistar rats during subacute chlorpromazine treatment. The animals were divided into control (0.9% saline), chlorpromazine (38.7 mg/kg b.w.), chlorpromazine+agmatine (agmatine 75 mg/kg b.w. immediately after chlorpromazine, 38.7 mg/ kg b.w. i.p.) and agmatine (75 mg/kg b.w.) groups. All the tested substances were administered intraperitoneally for 15 consecutive days and the rats were sacrificed by decapitation on day 15. Subacute administration of chlorpromazine resulted in increased lipid peroxidation, nitric oxide concentration and superoxide anion production, while completely damaging the antioxidant defence system in the cerebral cortex, striatum, and hippocampus. However, the combined treatment with chlorpromazine and agmatine significantly attenuated the oxidative/nitrosative stress indices and restored the antioxidant capacity to the control values in all of the examined brain regions. Western blot analysis supported biochemical findings in all groups, but the most notable changes were found in the hippocampus. Our results suggest potentially beneficial effects of agmatine, which may be useful in the modified antioxidant approach in chlorpromazine-therapy.",
publisher = "Veterinarni A Farmaceuticka Univerzita Brno, Brno",
journal = "Acta Veterinaria - Brno",
title = "Effects of agmatine on chlorpromazine-induced neuronal injury in rat",
volume = "87",
number = "2",
pages = "145-153",
doi = "10.2754/avb201887020145"
}

Dejanović, B., Vukovic-Dejanović, V., Ninković, M., Lavrnja, I., Stojanović, I., Pavlović, M., Begović, V., Mirković, D.,& Stevanović, I.. (2018). Effects of agmatine on chlorpromazine-induced neuronal injury in rat. in Acta Veterinaria - Brno
Veterinarni A Farmaceuticka Univerzita Brno, Brno., 87(2), 145-153.
https://doi.org/10.2754/avb201887020145

Dejanović B, Vukovic-Dejanović V, Ninković M, Lavrnja I, Stojanović I, Pavlović M, Begović V, Mirković D, Stevanović I. Effects of agmatine on chlorpromazine-induced neuronal injury in rat. in Acta Veterinaria - Brno. 2018;87(2):145-153.
doi:10.2754/avb201887020145 .

Dejanović, Bratislav, Vukovic-Dejanović, Vesna, Ninković, Milica, Lavrnja, Irena, Stojanović, Ivana, Pavlović, Miloš, Begović, Vesna, Mirković, Dšsko, Stevanović, Ivana, "Effects of agmatine on chlorpromazine-induced neuronal injury in rat" in Acta Veterinaria - Brno, 87, no. 2 (2018):145-153,
https://doi.org/10.2754/avb201887020145 . .

TY  - JOUR
AU  - Dejanović, Bratislav
AU  - Stevanović, Ivana
AU  - Ninković, Milica
AU  - Stojanović, Ivana
AU  - Lavrnja, Irena
AU  - Radičević, Tatjana
AU  - Pavlović, Miloš
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1430
AB  - This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may contribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning.
PB  - Korean Soc Veterinary Science, Seoul
T2  - Journal of Veterinary Science
T1  - Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
VL  - 17
IS  - 1
SP  - 53
EP  - 61
DO  - 10.4142/jvs.2016.17.1.53
ER  - 

@article{
author = "Dejanović, Bratislav and Stevanović, Ivana and Ninković, Milica and Stojanović, Ivana and Lavrnja, Irena and Radičević, Tatjana and Pavlović, Miloš",
year = "2016",
abstract = "This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may contribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning.",
publisher = "Korean Soc Veterinary Science, Seoul",
journal = "Journal of Veterinary Science",
title = "Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats",
volume = "17",
number = "1",
pages = "53-61",
doi = "10.4142/jvs.2016.17.1.53"
}

Dejanović, B., Stevanović, I., Ninković, M., Stojanović, I., Lavrnja, I., Radičević, T.,& Pavlović, M.. (2016). Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats. in Journal of Veterinary Science
Korean Soc Veterinary Science, Seoul., 17(1), 53-61.
https://doi.org/10.4142/jvs.2016.17.1.53

Dejanović B, Stevanović I, Ninković M, Stojanović I, Lavrnja I, Radičević T, Pavlović M. Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats. in Journal of Veterinary Science. 2016;17(1):53-61.
doi:10.4142/jvs.2016.17.1.53 .

Dejanović, Bratislav, Stevanović, Ivana, Ninković, Milica, Stojanović, Ivana, Lavrnja, Irena, Radičević, Tatjana, Pavlović, Miloš, "Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats" in Journal of Veterinary Science, 17, no. 1 (2016):53-61,
https://doi.org/10.4142/jvs.2016.17.1.53 . .

TY  - JOUR
AU  - Bulatović, Jelena
AU  - Marković, Nemanja
AU  - Stevanović, Oliver
AU  - Marinković, Darko
AU  - Stojanović, Ivana
AU  - Krstić, Nikola
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1382
AB  - Pathological modifications are rarely observed in the remains of wild animals from archaeological sites. We present one such specific, pathological change a case of spavin in a red deer specimen from the Early Neolithic site of Blagotin, in central Serbia. The left tarsal joint presented proliferative new bone formation, which was analyzed macroscopically, then subjected to X-ray and computed tomography (CT) imaging. We assume that the initial degenerative changes in this red deer tarsal joint were probably caused by ageing, although the environment may have likely contributed to the progression of the disorder. Spavin usually results in stiffness of the joints and in lameness, perhaps contributing in the animals capture by Neolithic hunters. This case is important in that it demonstrates that spavin is not necessarily a consequence of riding or traction work.
PB  - Elsevier Science Inc, New York
T2  - International Journal of Paleopathology
T1  - Spavin in red deer: A case study from the Early Neolithic Blagotin, Serbia
VL  - 14
SP  - 31
EP  - 35
DO  - 10.1016/j.ijpp.2016.04.006
ER  - 

@article{
author = "Bulatović, Jelena and Marković, Nemanja and Stevanović, Oliver and Marinković, Darko and Stojanović, Ivana and Krstić, Nikola",
year = "2016",
abstract = "Pathological modifications are rarely observed in the remains of wild animals from archaeological sites. We present one such specific, pathological change a case of spavin in a red deer specimen from the Early Neolithic site of Blagotin, in central Serbia. The left tarsal joint presented proliferative new bone formation, which was analyzed macroscopically, then subjected to X-ray and computed tomography (CT) imaging. We assume that the initial degenerative changes in this red deer tarsal joint were probably caused by ageing, although the environment may have likely contributed to the progression of the disorder. Spavin usually results in stiffness of the joints and in lameness, perhaps contributing in the animals capture by Neolithic hunters. This case is important in that it demonstrates that spavin is not necessarily a consequence of riding or traction work.",
publisher = "Elsevier Science Inc, New York",
journal = "International Journal of Paleopathology",
title = "Spavin in red deer: A case study from the Early Neolithic Blagotin, Serbia",
volume = "14",
pages = "31-35",
doi = "10.1016/j.ijpp.2016.04.006"
}

Bulatović, J., Marković, N., Stevanović, O., Marinković, D., Stojanović, I.,& Krstić, N.. (2016). Spavin in red deer: A case study from the Early Neolithic Blagotin, Serbia. in International Journal of Paleopathology
Elsevier Science Inc, New York., 14, 31-35.
https://doi.org/10.1016/j.ijpp.2016.04.006

Bulatović J, Marković N, Stevanović O, Marinković D, Stojanović I, Krstić N. Spavin in red deer: A case study from the Early Neolithic Blagotin, Serbia. in International Journal of Paleopathology. 2016;14:31-35.
doi:10.1016/j.ijpp.2016.04.006 .

Bulatović, Jelena, Marković, Nemanja, Stevanović, Oliver, Marinković, Darko, Stojanović, Ivana, Krstić, Nikola, "Spavin in red deer: A case study from the Early Neolithic Blagotin, Serbia" in International Journal of Paleopathology, 14 (2016):31-35,
https://doi.org/10.1016/j.ijpp.2016.04.006 . .

TY  - JOUR
AU  - Đurić, Ana
AU  - Begić, Aida
AU  - Gobeljić, Borko
AU  - Stanojević, Ivan
AU  - Ninković, Milica
AU  - Vojvodić, Danilo
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Prokić, Vera
AU  - Dejanović, Bratislav
AU  - Stojanović, Ivana
AU  - Pavlica, Marina
AU  - Đukić, Dusan
AU  - Saso, Luciano
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Topić, Aleksandra
AU  - Vujanović, Dragana
AU  - Stevanović, Ivana
AU  - Đukić, Mirjana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1302
AB  - The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
VL  - 86
SP  - 25
EP  - 33
DO  - 10.1016/j.fct.2015.09.004
ER  - 

@article{
author = "Đurić, Ana and Begić, Aida and Gobeljić, Borko and Stanojević, Ivan and Ninković, Milica and Vojvodić, Danilo and Pantelić, Ana and Zebić, Goran and Prokić, Vera and Dejanović, Bratislav and Stojanović, Ivana and Pavlica, Marina and Đukić, Dusan and Saso, Luciano and Đurđević, Dragan and Pavlović, Miloš and Topić, Aleksandra and Vujanović, Dragana and Stevanović, Ivana and Đukić, Mirjana",
year = "2015",
abstract = "The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium",
volume = "86",
pages = "25-33",
doi = "10.1016/j.fct.2015.09.004"
}

Đurić, A., Begić, A., Gobeljić, B., Stanojević, I., Ninković, M., Vojvodić, D., Pantelić, A., Zebić, G., Prokić, V., Dejanović, B., Stojanović, I., Pavlica, M., Đukić, D., Saso, L., Đurđević, D., Pavlović, M., Topić, A., Vujanović, D., Stevanović, I.,& Đukić, M.. (2015). Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 86, 25-33.
https://doi.org/10.1016/j.fct.2015.09.004

Đurić A, Begić A, Gobeljić B, Stanojević I, Ninković M, Vojvodić D, Pantelić A, Zebić G, Prokić V, Dejanović B, Stojanović I, Pavlica M, Đukić D, Saso L, Đurđević D, Pavlović M, Topić A, Vujanović D, Stevanović I, Đukić M. Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology. 2015;86:25-33.
doi:10.1016/j.fct.2015.09.004 .

Đurić, Ana, Begić, Aida, Gobeljić, Borko, Stanojević, Ivan, Ninković, Milica, Vojvodić, Danilo, Pantelić, Ana, Zebić, Goran, Prokić, Vera, Dejanović, Bratislav, Stojanović, Ivana, Pavlica, Marina, Đukić, Dusan, Saso, Luciano, Đurđević, Dragan, Pavlović, Miloš, Topić, Aleksandra, Vujanović, Dragana, Stevanović, Ivana, Đukić, Mirjana, "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium" in Food and Chemical Toxicology, 86 (2015):25-33,
https://doi.org/10.1016/j.fct.2015.09.004 . .