TY  - CONF
AU  - Aničić, Milan
AU  - Vučićević, Miloš
AU  - Prošić, Isidora
AU  - Vučićević, Ivana
AU  - Jelisić, Stefan
AU  - Marinković, Darko
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3151
AB  - Чинчиле (Chinchilla lanigera) су мали сисари који припадају реду Rodentia и породици Chinchilidae. У природи живе на простору Анда у Јужној Америци. Данас се гаје у зоо вртовима, као кућни љубимци и узгајају на фармама због крзна. Салмонелоза је зоонотска болест која се јавља у целом свету. Изазивају је бактерије из рода Salmonella, које се сматрају стриктно патогеним код сисара и птица. Инфекција салмонелама код чинчила најчешће се јавља у септикемичној форми. У овом раду описане су патоморфолошке промене код чинчила угинулих од салмонелозе.
На Катедру за патологију достављени су лешеви две угинуле чинчиле код којих је пре угинућа клинички запажен крвави исцедак из стиднице. Спољашњим прегледом угинулих животиња уочено је да су биле у доброј кондицији, длака перианалне регије била је упрљана смеђе-црвеним садржајем, а из стиднице се изливао тамноцрвени садржај. Унутрашњим прегледом запажена је увећана, проширена материца напетог зида, плаво-црвене боје, наглашених крвних судова, испуњена трошним, безструктурним, сиво-ружичастим садржајем. Јетра је била благо тупих рубова, светлосмеђе боје. Плућа су била мозаичног изгледа, са ситним, тачкастим, тамноцрвеним подручјима. Узорци ткива са обдукције фиксирани су у пуферизованом формалину и након обраде у аутоматском ткивном процесору обојени хематоксилином и еозином.
Хистопатолошким прегледом је запажено псеудомембранозно запаљење материце са великом количином фибринонекротичног садржаја у којем су уочене колоније бактерија, док је мишићни слој био прожет интензивним крвављењима. Уочена су крвављења и у мозгу, плућима, срцу, бубрезима, јетри и цревима. Местимично се у крвним судовима мањег промера уочавао фибрински тромб. У плућима је запажен периваскуларни едем, док су у јетри уочена расута некротична подручја и мултифокални хепатитис, а код једне животиње су били присутни и знаци регенерације хепатоцита (увећане ћелије са базофилијом цитоплазме, двоједарне ћелије, крупна једра). Микробиолошким испитивањем узорака органа утврђено је присуство бактерије Salmonella enterica subspecies enterica серотип Typhimurium (Salmonella Typhimurium).
AB  - Chinchillas (Chinchilla lanigera) are small mammals of the order Rodentia and the family Chinchilidae with natural habitats in the Andes in South America. They are kept in zoos, as pets and farmed for fur. Salmonellosis is a zoonotic disease known worldwide. It is caused by bacteria from the genus Salmonella, which are considered strictly pathogenic in mammals and birds. In chinchillas, infection with Salmonella sp. is usually in the form of septicemia. This paper describes pathomorphological changes in chinchillas died from salmonellosis.
Carcasses of two chinchillas with bloody vulvar discharge noticed clinically were delivered to the Department of pathology. External examination revealed that animals were in good body condition, with the tan-red stained perianal area and dark red secret from the vulva. An internal examination showed an enlarged, bluish-red uterus with accentuated vasculature filled with friable, amorphous greyish-pink content. The liver was slightly enlarged and pale tan. Lungs had a mosaic appearance with punctuated dark red areas. Necropsy tissue samples were fixed in buffered formalin, processed in an automatic tissue processor and stained with hematoxylin and eosin.
Microscopic examination showed pseudomembranous inflammation of the uterus with a large amount of fibrinonecrotic content in which many bacterial colonies were present. At the same time in muscle layers, there was intense hemorrhage. Hemorrhages were also seen in the brain, lungs, heart, kidney, liver and intestine. Occasionally in small blood vessels, there was fibrin thrombus. In the lungs, perivascular edema was noticed. The liver had disseminated necrotic areas and multifocal hepatitis, and in one animal, there were signs of hepatocyte regeneration (enlarged cells with cytoplasmic basophilia, binucleated cells, and large nuclei). Microbiological examination of organ samples revealed the presence of Salmonella enterica subspecies enterica serotype Typhimurium (Salmonella Typhimurium).
PB  - Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze
C3  - XXV Simpozijum epizootiologa i epidemiologa (XXV Epizootiološki dani), Novi Sad, 24 - 26. april 2023
T1  - Fibrinonekrotični endometritis i septikemija kod uzgajanih činčila usled infekcije sa Salmonella typhimurium
T1  - Fibrinonecrotic endometritis and septicemia in farmed chinchilas due to Salmonella typhimurium infection
SP  - 136
EP  - 137
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3151
ER  - 

@conference{
author = "Aničić, Milan and Vučićević, Miloš and Prošić, Isidora and Vučićević, Ivana and Jelisić, Stefan and Marinković, Darko",
year = "2023",
abstract = "Чинчиле (Chinchilla lanigera) су мали сисари који припадају реду Rodentia и породици Chinchilidae. У природи живе на простору Анда у Јужној Америци. Данас се гаје у зоо вртовима, као кућни љубимци и узгајају на фармама због крзна. Салмонелоза је зоонотска болест која се јавља у целом свету. Изазивају је бактерије из рода Salmonella, које се сматрају стриктно патогеним код сисара и птица. Инфекција салмонелама код чинчила најчешће се јавља у септикемичној форми. У овом раду описане су патоморфолошке промене код чинчила угинулих од салмонелозе.
На Катедру за патологију достављени су лешеви две угинуле чинчиле код којих је пре угинућа клинички запажен крвави исцедак из стиднице. Спољашњим прегледом угинулих животиња уочено је да су биле у доброј кондицији, длака перианалне регије била је упрљана смеђе-црвеним садржајем, а из стиднице се изливао тамноцрвени садржај. Унутрашњим прегледом запажена је увећана, проширена материца напетог зида, плаво-црвене боје, наглашених крвних судова, испуњена трошним, безструктурним, сиво-ружичастим садржајем. Јетра је била благо тупих рубова, светлосмеђе боје. Плућа су била мозаичног изгледа, са ситним, тачкастим, тамноцрвеним подручјима. Узорци ткива са обдукције фиксирани су у пуферизованом формалину и након обраде у аутоматском ткивном процесору обојени хематоксилином и еозином.
Хистопатолошким прегледом је запажено псеудомембранозно запаљење материце са великом количином фибринонекротичног садржаја у којем су уочене колоније бактерија, док је мишићни слој био прожет интензивним крвављењима. Уочена су крвављења и у мозгу, плућима, срцу, бубрезима, јетри и цревима. Местимично се у крвним судовима мањег промера уочавао фибрински тромб. У плућима је запажен периваскуларни едем, док су у јетри уочена расута некротична подручја и мултифокални хепатитис, а код једне животиње су били присутни и знаци регенерације хепатоцита (увећане ћелије са базофилијом цитоплазме, двоједарне ћелије, крупна једра). Микробиолошким испитивањем узорака органа утврђено је присуство бактерије Salmonella enterica subspecies enterica серотип Typhimurium (Salmonella Typhimurium)., Chinchillas (Chinchilla lanigera) are small mammals of the order Rodentia and the family Chinchilidae with natural habitats in the Andes in South America. They are kept in zoos, as pets and farmed for fur. Salmonellosis is a zoonotic disease known worldwide. It is caused by bacteria from the genus Salmonella, which are considered strictly pathogenic in mammals and birds. In chinchillas, infection with Salmonella sp. is usually in the form of septicemia. This paper describes pathomorphological changes in chinchillas died from salmonellosis.
Carcasses of two chinchillas with bloody vulvar discharge noticed clinically were delivered to the Department of pathology. External examination revealed that animals were in good body condition, with the tan-red stained perianal area and dark red secret from the vulva. An internal examination showed an enlarged, bluish-red uterus with accentuated vasculature filled with friable, amorphous greyish-pink content. The liver was slightly enlarged and pale tan. Lungs had a mosaic appearance with punctuated dark red areas. Necropsy tissue samples were fixed in buffered formalin, processed in an automatic tissue processor and stained with hematoxylin and eosin.
Microscopic examination showed pseudomembranous inflammation of the uterus with a large amount of fibrinonecrotic content in which many bacterial colonies were present. At the same time in muscle layers, there was intense hemorrhage. Hemorrhages were also seen in the brain, lungs, heart, kidney, liver and intestine. Occasionally in small blood vessels, there was fibrin thrombus. In the lungs, perivascular edema was noticed. The liver had disseminated necrotic areas and multifocal hepatitis, and in one animal, there were signs of hepatocyte regeneration (enlarged cells with cytoplasmic basophilia, binucleated cells, and large nuclei). Microbiological examination of organ samples revealed the presence of Salmonella enterica subspecies enterica serotype Typhimurium (Salmonella Typhimurium).",
publisher = "Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze",
journal = "XXV Simpozijum epizootiologa i epidemiologa (XXV Epizootiološki dani), Novi Sad, 24 - 26. april 2023",
title = "Fibrinonekrotični endometritis i septikemija kod uzgajanih činčila usled infekcije sa Salmonella typhimurium, Fibrinonecrotic endometritis and septicemia in farmed chinchilas due to Salmonella typhimurium infection",
pages = "136-137",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3151"
}

Aničić, M., Vučićević, M., Prošić, I., Vučićević, I., Jelisić, S.,& Marinković, D.. (2023). Fibrinonekrotični endometritis i septikemija kod uzgajanih činčila usled infekcije sa Salmonella typhimurium. in XXV Simpozijum epizootiologa i epidemiologa (XXV Epizootiološki dani), Novi Sad, 24 - 26. april 2023
Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze., 136-137.
https://hdl.handle.net/21.15107/rcub_veterinar_3151

Aničić M, Vučićević M, Prošić I, Vučićević I, Jelisić S, Marinković D. Fibrinonekrotični endometritis i septikemija kod uzgajanih činčila usled infekcije sa Salmonella typhimurium. in XXV Simpozijum epizootiologa i epidemiologa (XXV Epizootiološki dani), Novi Sad, 24 - 26. april 2023. 2023;:136-137.
https://hdl.handle.net/21.15107/rcub_veterinar_3151 .

Aničić, Milan, Vučićević, Miloš, Prošić, Isidora, Vučićević, Ivana, Jelisić, Stefan, Marinković, Darko, "Fibrinonekrotični endometritis i septikemija kod uzgajanih činčila usled infekcije sa Salmonella typhimurium" in XXV Simpozijum epizootiologa i epidemiologa (XXV Epizootiološki dani), Novi Sad, 24 - 26. april 2023 (2023):136-137,
https://hdl.handle.net/21.15107/rcub_veterinar_3151 .

TY  - JOUR
AU  - Aničić, Milan
AU  - Pešić, Ana
AU  - Došenović, Milan
AU  - Nestorović, Ivan
AU  - Vučićević, Ivana
AU  - Marinković, Darko
AU  - Vučićević, Miloš
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3142
AB  - A 3-year-old intact male African pygmy hedgehog was presented at the Teaching Hospital
of the Faculty of Veterinary Medicine, University of Belgrade, with a growth on the left side of its
abdomen. After clinical examination, the mass was surgically removed, and histopathological findings
indicated a nerve sheath tumor. The hedgehog fully recovered after surgery and was euthanized eight
months later due to the appearance of multicentric changes in the internal organs. Further necropsy
and macroscopic, cytologic, histopathologic, and immunohistochemical findings revealed that the
tumor was a multicentric high-grade T-cell lymphoma. This is an unusual case of an African pygmy
hedgehog with two different neoplasms−a nerve sheath tumor followed by lymphoma.
PB  - Japanese Society of Veterinary Science
T2  - Journal of Veterinary Medical Science
T1  - A case of nerve sheath tumor followed by multicentric high-grade T-cell lymphoma in an African pygmy hedgehog (Atelerix albiventris)
VL  - 85
IS  - 8
SP  - 853
EP  - 857
DO  - 10.1292/jvms.23-0070
ER  - 

@article{
author = "Aničić, Milan and Pešić, Ana and Došenović, Milan and Nestorović, Ivan and Vučićević, Ivana and Marinković, Darko and Vučićević, Miloš",
year = "2023",
abstract = "A 3-year-old intact male African pygmy hedgehog was presented at the Teaching Hospital
of the Faculty of Veterinary Medicine, University of Belgrade, with a growth on the left side of its
abdomen. After clinical examination, the mass was surgically removed, and histopathological findings
indicated a nerve sheath tumor. The hedgehog fully recovered after surgery and was euthanized eight
months later due to the appearance of multicentric changes in the internal organs. Further necropsy
and macroscopic, cytologic, histopathologic, and immunohistochemical findings revealed that the
tumor was a multicentric high-grade T-cell lymphoma. This is an unusual case of an African pygmy
hedgehog with two different neoplasms−a nerve sheath tumor followed by lymphoma.",
publisher = "Japanese Society of Veterinary Science",
journal = "Journal of Veterinary Medical Science",
title = "A case of nerve sheath tumor followed by multicentric high-grade T-cell lymphoma in an African pygmy hedgehog (Atelerix albiventris)",
volume = "85",
number = "8",
pages = "853-857",
doi = "10.1292/jvms.23-0070"
}

Aničić, M., Pešić, A., Došenović, M., Nestorović, I., Vučićević, I., Marinković, D.,& Vučićević, M.. (2023). A case of nerve sheath tumor followed by multicentric high-grade T-cell lymphoma in an African pygmy hedgehog (Atelerix albiventris). in Journal of Veterinary Medical Science
Japanese Society of Veterinary Science., 85(8), 853-857.
https://doi.org/10.1292/jvms.23-0070

Aničić M, Pešić A, Došenović M, Nestorović I, Vučićević I, Marinković D, Vučićević M. A case of nerve sheath tumor followed by multicentric high-grade T-cell lymphoma in an African pygmy hedgehog (Atelerix albiventris). in Journal of Veterinary Medical Science. 2023;85(8):853-857.
doi:10.1292/jvms.23-0070 .

Aničić, Milan, Pešić, Ana, Došenović, Milan, Nestorović, Ivan, Vučićević, Ivana, Marinković, Darko, Vučićević, Miloš, "A case of nerve sheath tumor followed by multicentric high-grade T-cell lymphoma in an African pygmy hedgehog (Atelerix albiventris)" in Journal of Veterinary Medical Science, 85, no. 8 (2023):853-857,
https://doi.org/10.1292/jvms.23-0070 . .

TY  - CONF
AU  - Vučićević, Ivana
AU  - Labus, Tatjana
AU  - Nešić, Slađan
AU  - Vučićević, Miloš
AU  - Aleksić-Kovačević, Sanja
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3100
AB  - Zarazne bolesti su jedan od vodećih uzroka ekonomskih gubitaka
u živinarskoj proizvodnji. Živina je podložna različitim zaraznim bolestima
s obzirom na specifičan način uzgoja. Slobodno držanje živine,
kao vid uzgoja, karakteriše se slabim biosigurnosnim merama. Jedinke
u takvom načinu držanja mogu doći u kontakt i sa drugim vrstama
ptica, uključujući i migratorne vrste. Kod farmskog načina uzgoja
živine, biosigurnosne mere su na višem nivou, ali je visok proizvodni
pritisak uticao da jedinke postanu podložnije mnogim bolestima. Najznačajnije
zarazne bolesti živine koje su obavezne za prijavljivanje
nadležnim organima su atipična kuga živine, gamboro bolest, avijarna
influenca, infektivni laringotraheitis, tuberkuloza, Marekova bolest i
salmoneloza. U cilju sprečavanja pojave i kontrole bolesti kod živine,
kao i kod drugih životinjskih vrsta postupa se prema Zakonu o veterinarstvu
(“Službeni glasnik RS”, broj 91/05) i odgovarajućim podzakonskim
aktima. Radi otkrivanja uzroka uginuća, pored ostalih dijagnostičkih
procedura, vrši se i obdukcija leševa živine prema standardnim
protokolima za obdukciju ptica. Ukoliko je potrebno uraditi patohistološku
analizu, uzorci ne smeju biti deblji od 0,5 cm kako bi 10% puferizovani
formalin prodro kroz tkivo u procesu fiksacije tokom najmanje
48 časova. Nakon obdukcije, leševe živine treba neškodljivo ukloniti.
PB  - Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - XLIV seminar za inovacije znanja veterinara, Beograd, 24. februar 2023
T1  - Zarazne bolesti živine obavezne za prijavljivanje – klinička slika, patomorfološke promene i zakonski propisi / tehnika obdukcije živine i slanje materijala
SP  - 145
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3100
ER  - 

@conference{
author = "Vučićević, Ivana and Labus, Tatjana and Nešić, Slađan and Vučićević, Miloš and Aleksić-Kovačević, Sanja",
year = "2023",
abstract = "Zarazne bolesti su jedan od vodećih uzroka ekonomskih gubitaka
u živinarskoj proizvodnji. Živina je podložna različitim zaraznim bolestima
s obzirom na specifičan način uzgoja. Slobodno držanje živine,
kao vid uzgoja, karakteriše se slabim biosigurnosnim merama. Jedinke
u takvom načinu držanja mogu doći u kontakt i sa drugim vrstama
ptica, uključujući i migratorne vrste. Kod farmskog načina uzgoja
živine, biosigurnosne mere su na višem nivou, ali je visok proizvodni
pritisak uticao da jedinke postanu podložnije mnogim bolestima. Najznačajnije
zarazne bolesti živine koje su obavezne za prijavljivanje
nadležnim organima su atipična kuga živine, gamboro bolest, avijarna
influenca, infektivni laringotraheitis, tuberkuloza, Marekova bolest i
salmoneloza. U cilju sprečavanja pojave i kontrole bolesti kod živine,
kao i kod drugih životinjskih vrsta postupa se prema Zakonu o veterinarstvu
(“Službeni glasnik RS”, broj 91/05) i odgovarajućim podzakonskim
aktima. Radi otkrivanja uzroka uginuća, pored ostalih dijagnostičkih
procedura, vrši se i obdukcija leševa živine prema standardnim
protokolima za obdukciju ptica. Ukoliko je potrebno uraditi patohistološku
analizu, uzorci ne smeju biti deblji od 0,5 cm kako bi 10% puferizovani
formalin prodro kroz tkivo u procesu fiksacije tokom najmanje
48 časova. Nakon obdukcije, leševe živine treba neškodljivo ukloniti.",
publisher = "Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "XLIV seminar za inovacije znanja veterinara, Beograd, 24. februar 2023",
title = "Zarazne bolesti živine obavezne za prijavljivanje – klinička slika, patomorfološke promene i zakonski propisi / tehnika obdukcije živine i slanje materijala",
pages = "145-156",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3100"
}

Vučićević, I., Labus, T., Nešić, S., Vučićević, M.,& Aleksić-Kovačević, S.. (2023). Zarazne bolesti živine obavezne za prijavljivanje – klinička slika, patomorfološke promene i zakonski propisi / tehnika obdukcije živine i slanje materijala. in XLIV seminar za inovacije znanja veterinara, Beograd, 24. februar 2023
Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 145-156.
https://hdl.handle.net/21.15107/rcub_veterinar_3100

Vučićević I, Labus T, Nešić S, Vučićević M, Aleksić-Kovačević S. Zarazne bolesti živine obavezne za prijavljivanje – klinička slika, patomorfološke promene i zakonski propisi / tehnika obdukcije živine i slanje materijala. in XLIV seminar za inovacije znanja veterinara, Beograd, 24. februar 2023. 2023;:145-156.
https://hdl.handle.net/21.15107/rcub_veterinar_3100 .

Vučićević, Ivana, Labus, Tatjana, Nešić, Slađan, Vučićević, Miloš, Aleksić-Kovačević, Sanja, "Zarazne bolesti živine obavezne za prijavljivanje – klinička slika, patomorfološke promene i zakonski propisi / tehnika obdukcije živine i slanje materijala" in XLIV seminar za inovacije znanja veterinara, Beograd, 24. februar 2023 (2023):145-156,
https://hdl.handle.net/21.15107/rcub_veterinar_3100 .

TY  - CONF
AU  - Đurđević, Biljana
AU  - Vučićević, Ivana
AU  - Polaček, Vladimir
AU  - Pajić, Marko
AU  - Knežević, Slobodan
AU  - Petrović, Tamaš
AU  - Grubač, Siniša
AU  - Gajdov, Vladimir
AU  - Aleksić-Kovačević, Sanja
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3365
AB  - The highly pathogenic avian influenza (HPAI) epidemic in the 2021/2022 epidemiological year was the most
widespread in Europe, and HPAI H5N1 was by far the predominant virus type reported. In Serbia, since early
2021 and 2022, multiple outbreaks of HPAI have occurred. The H5N1 subtype was also dominant during this
epizootic, although a few cases of H5N8 subtype infection were reported in mute swans. This epizootic
affected backyard chickens (3 outbreaks), and the virus was also detected in wild birds, mostly in mute swans
(4 outbreaks). All cases were reported in the north of Serbia. Here we describe the pathological findings of
natural HPAI H5N1 infection in poultry species (chickens and turkeys) and wild birds (mute swans) that died
during this epizootic. Routine necropsies were carried out on the carcasses of 15 mute swans, 15 chickens,
and four turkeys. The external body and internal organs were examined grossly, and the gross pathology was
recorded and photographed. Body condition was estimated based on the amount of body fat and
musculature. Tissue samples of the brain, pancreas, spleen, and lungs were collected, and the supernatants
of the tissue homogenates were used for molecular diagnosis by RT-qPCR method. The affected birds showed
nervous manifestations (abnormal head position, tremors, leg paralysis) and all birds were in good condition.
The presence of influenza virus was detected in tissue samples of all tested animals. The external macroscopic
changes included cyanosis and necrosis in the crest and wattle, and these lesions were more pronounced in
chickens. In mute swans, there were no external lesions. The H5N1 HPAI virus produced several consistent
gross lesions among the species investigated. Foremost among these lesions was: multifocal pancreatic
necrosis and hemorrhages, petechial hemorrhages in coelomic and epicardial fat and epicardial petechiae.
The lungs showed moderate (turkeys) to severe (chickens and mute swans) diffuse congestion and oedema.
In most cases, mild splenomegaly and spleen necrosis were noted. Additionally, gizzard or proventricular
lesions were not observed in any bird. The natural HPAI H5N1 infection in poultry and mute swans showed
similar clinical disease, including neurological disorders, as well as similar pathologic presentation involving
necrotic lesions and vascular damage, primarily affecting the pancreas and myocardium. Evaluating the
pathological presentation of natural disease is particularly important in emerging infectious diseases such as
influenza A virus, in which different strains can have different pathogenicity and clinical presentations.
PB  - Scientific Veterinary Institute Novi Sad
C3  - 15th EPIZONE Annual Meeting, New perspectives for the new era, Novi sad, April 26 - 28, 2023
T1  - Pathology associated with highly pathogenic avian influenza H5N1 in naturally infected birds in Serbia in the 2021/2022 epidemiological year
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3365
ER  - 

@conference{
author = "Đurđević, Biljana and Vučićević, Ivana and Polaček, Vladimir and Pajić, Marko and Knežević, Slobodan and Petrović, Tamaš and Grubač, Siniša and Gajdov, Vladimir and Aleksić-Kovačević, Sanja",
year = "2023",
abstract = "The highly pathogenic avian influenza (HPAI) epidemic in the 2021/2022 epidemiological year was the most
widespread in Europe, and HPAI H5N1 was by far the predominant virus type reported. In Serbia, since early
2021 and 2022, multiple outbreaks of HPAI have occurred. The H5N1 subtype was also dominant during this
epizootic, although a few cases of H5N8 subtype infection were reported in mute swans. This epizootic
affected backyard chickens (3 outbreaks), and the virus was also detected in wild birds, mostly in mute swans
(4 outbreaks). All cases were reported in the north of Serbia. Here we describe the pathological findings of
natural HPAI H5N1 infection in poultry species (chickens and turkeys) and wild birds (mute swans) that died
during this epizootic. Routine necropsies were carried out on the carcasses of 15 mute swans, 15 chickens,
and four turkeys. The external body and internal organs were examined grossly, and the gross pathology was
recorded and photographed. Body condition was estimated based on the amount of body fat and
musculature. Tissue samples of the brain, pancreas, spleen, and lungs were collected, and the supernatants
of the tissue homogenates were used for molecular diagnosis by RT-qPCR method. The affected birds showed
nervous manifestations (abnormal head position, tremors, leg paralysis) and all birds were in good condition.
The presence of influenza virus was detected in tissue samples of all tested animals. The external macroscopic
changes included cyanosis and necrosis in the crest and wattle, and these lesions were more pronounced in
chickens. In mute swans, there were no external lesions. The H5N1 HPAI virus produced several consistent
gross lesions among the species investigated. Foremost among these lesions was: multifocal pancreatic
necrosis and hemorrhages, petechial hemorrhages in coelomic and epicardial fat and epicardial petechiae.
The lungs showed moderate (turkeys) to severe (chickens and mute swans) diffuse congestion and oedema.
In most cases, mild splenomegaly and spleen necrosis were noted. Additionally, gizzard or proventricular
lesions were not observed in any bird. The natural HPAI H5N1 infection in poultry and mute swans showed
similar clinical disease, including neurological disorders, as well as similar pathologic presentation involving
necrotic lesions and vascular damage, primarily affecting the pancreas and myocardium. Evaluating the
pathological presentation of natural disease is particularly important in emerging infectious diseases such as
influenza A virus, in which different strains can have different pathogenicity and clinical presentations.",
publisher = "Scientific Veterinary Institute Novi Sad",
journal = "15th EPIZONE Annual Meeting, New perspectives for the new era, Novi sad, April 26 - 28, 2023",
title = "Pathology associated with highly pathogenic avian influenza H5N1 in naturally infected birds in Serbia in the 2021/2022 epidemiological year",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3365"
}

Đurđević, B., Vučićević, I., Polaček, V., Pajić, M., Knežević, S., Petrović, T., Grubač, S., Gajdov, V.,& Aleksić-Kovačević, S.. (2023). Pathology associated with highly pathogenic avian influenza H5N1 in naturally infected birds in Serbia in the 2021/2022 epidemiological year. in 15th EPIZONE Annual Meeting, New perspectives for the new era, Novi sad, April 26 - 28, 2023
Scientific Veterinary Institute Novi Sad..
https://hdl.handle.net/21.15107/rcub_veterinar_3365

Đurđević B, Vučićević I, Polaček V, Pajić M, Knežević S, Petrović T, Grubač S, Gajdov V, Aleksić-Kovačević S. Pathology associated with highly pathogenic avian influenza H5N1 in naturally infected birds in Serbia in the 2021/2022 epidemiological year. in 15th EPIZONE Annual Meeting, New perspectives for the new era, Novi sad, April 26 - 28, 2023. 2023;.
https://hdl.handle.net/21.15107/rcub_veterinar_3365 .

Đurđević, Biljana, Vučićević, Ivana, Polaček, Vladimir, Pajić, Marko, Knežević, Slobodan, Petrović, Tamaš, Grubač, Siniša, Gajdov, Vladimir, Aleksić-Kovačević, Sanja, "Pathology associated with highly pathogenic avian influenza H5N1 in naturally infected birds in Serbia in the 2021/2022 epidemiological year" in 15th EPIZONE Annual Meeting, New perspectives for the new era, Novi sad, April 26 - 28, 2023 (2023),
https://hdl.handle.net/21.15107/rcub_veterinar_3365 .

TY  - JOUR
AU  - Đurđević, Biljana
AU  - Polaček, Vladimir
AU  - Pajić, Marko
AU  - Petrović, Tamaš
AU  - Vučićević, Ivana
AU  - Vidanović, Dejan
AU  - Aleksić-Kovačević, Sanja
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2706
AB  - In winter 2016/2017, the highly pathogenic avian influenza virus H5N8 was detected in
backyard poultry in Serbia for the first time. The second HPAI outbreak case in backyard poultry
was reported in 2022, caused by subtype H5N1. This is the first study that documents the laboratory
identification and pathology associated with highly pathogenic avian influenza in poultry in Serbia
during the first and second introduction waves. In both cases, the diagnosis was based on real-time
reverse transcriptase PCR. The most common observed lesions included subepicardial hemorrhages,
congestion and hemorrhages in the lungs, and petechial hemorrhages in coelomic and epicardial adipose tissue. Histologically, the observed lesions were mostly nonpurulent encephalitis accompanied
by encephalomalacia, multifocal necrosis in the spleen, pancreas, and kidneys, pulmonary congestion,
and myocardial and pulmonary hemorrhages. In H5N8-infected chickens, immunohistochemical
examination revealed strong positive IHC staining in the brain and lungs. Following these outbreaks,
strict control measures were implemented on farms and backyard holdings to prevent the occurrence
and spread of the disease. Extensive surveillance of birds for avian influenza virus did not detect
any additional cases in poultry. These outbreaks highlight the importance of a rapid detection and
response system in order to quickly suppress outbreaks.
PB  - MDPI
T2  - Animals
T1  - Highly Pathogenic Avian Influenza H5N8 Outbreak in Backyard Chickens in Serbia
VL  - 13
IS  - 4
SP  - 700
DO  - 10.3390/ani13040700
ER  - 

@article{
author = "Đurđević, Biljana and Polaček, Vladimir and Pajić, Marko and Petrović, Tamaš and Vučićević, Ivana and Vidanović, Dejan and Aleksić-Kovačević, Sanja",
year = "2023",
abstract = "In winter 2016/2017, the highly pathogenic avian influenza virus H5N8 was detected in
backyard poultry in Serbia for the first time. The second HPAI outbreak case in backyard poultry
was reported in 2022, caused by subtype H5N1. This is the first study that documents the laboratory
identification and pathology associated with highly pathogenic avian influenza in poultry in Serbia
during the first and second introduction waves. In both cases, the diagnosis was based on real-time
reverse transcriptase PCR. The most common observed lesions included subepicardial hemorrhages,
congestion and hemorrhages in the lungs, and petechial hemorrhages in coelomic and epicardial adipose tissue. Histologically, the observed lesions were mostly nonpurulent encephalitis accompanied
by encephalomalacia, multifocal necrosis in the spleen, pancreas, and kidneys, pulmonary congestion,
and myocardial and pulmonary hemorrhages. In H5N8-infected chickens, immunohistochemical
examination revealed strong positive IHC staining in the brain and lungs. Following these outbreaks,
strict control measures were implemented on farms and backyard holdings to prevent the occurrence
and spread of the disease. Extensive surveillance of birds for avian influenza virus did not detect
any additional cases in poultry. These outbreaks highlight the importance of a rapid detection and
response system in order to quickly suppress outbreaks.",
publisher = "MDPI",
journal = "Animals",
title = "Highly Pathogenic Avian Influenza H5N8 Outbreak in Backyard Chickens in Serbia",
volume = "13",
number = "4",
pages = "700",
doi = "10.3390/ani13040700"
}

Đurđević, B., Polaček, V., Pajić, M., Petrović, T., Vučićević, I., Vidanović, D.,& Aleksić-Kovačević, S.. (2023). Highly Pathogenic Avian Influenza H5N8 Outbreak in Backyard Chickens in Serbia. in Animals
MDPI., 13(4), 700.
https://doi.org/10.3390/ani13040700

Đurđević B, Polaček V, Pajić M, Petrović T, Vučićević I, Vidanović D, Aleksić-Kovačević S. Highly Pathogenic Avian Influenza H5N8 Outbreak in Backyard Chickens in Serbia. in Animals. 2023;13(4):700.
doi:10.3390/ani13040700 .

Đurđević, Biljana, Polaček, Vladimir, Pajić, Marko, Petrović, Tamaš, Vučićević, Ivana, Vidanović, Dejan, Aleksić-Kovačević, Sanja, "Highly Pathogenic Avian Influenza H5N8 Outbreak in Backyard Chickens in Serbia" in Animals, 13, no. 4 (2023):700,
https://doi.org/10.3390/ani13040700 . .

TY  - JOUR
AU  - Đurđević, Biljana
AU  - Vučićević, Ivana
AU  - Bogunović, Danica
AU  - Pajić, Marko
AU  - Vejnović, Branislav
AU  - Prodanov-Radulović, Jasna
AU  - Polaček, Vladimir
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2786
AB  - Background The Sarconema eurycerca heart infection may be one of the main causes of death in swans and geese due to
severe heart lesions. To date, there have been no reports of Sarconema eurycerca in mute swans (Cygnus olor) in Serbia and
this parasite has never been morphologically characterized in wild birds from this region.
Methods In spring 2021, eight dead mute swans (Cygnus olor) were collected during avian influenza surveillance on the territory
of the Province of Vojvodina and submitted to Scientific Veterinary Institute “Novi Sad” to determine the cause of death.
The presence of highly pathogenic avian influenza subtype H5N1 was determined in all swans using molecular methods.
Results Necropsy of the swans revealed changes characteristic for highly pathogenic avian influenza infection, such as severe
haemorrhages and necrosis in different organs. Three of the eight swans showed massive subepicardial haemorrhages and
myocarditis with intralesional 2–4 cm long whitish roundworms. Histopathologically, haemorrhages and many adult heart
worms were observed in the myocardium. Based on morphological features of parasites, infection by Sarconema eurycerca
was concluded.
Conclusion According to the available scientific literature, the presence of heart roundworms in swans has not yet been
confirmed in our country. This report is the first published case of cardiac filariasis associated with S. eurycerca infection
in mute swans in the Republic of Serbia.
PB  - Springer
T2  - Acta Parasitologica
T1  - First Report of Sarconema eurycerca Heart Infection in Mute Swans in Serbia
VL  - 67
IS  - 4
SP  - 1773
EP  - 1777
DO  - 10.1007/s11686-022-00616-3
ER  - 

@article{
author = "Đurđević, Biljana and Vučićević, Ivana and Bogunović, Danica and Pajić, Marko and Vejnović, Branislav and Prodanov-Radulović, Jasna and Polaček, Vladimir",
year = "2022",
abstract = "Background The Sarconema eurycerca heart infection may be one of the main causes of death in swans and geese due to
severe heart lesions. To date, there have been no reports of Sarconema eurycerca in mute swans (Cygnus olor) in Serbia and
this parasite has never been morphologically characterized in wild birds from this region.
Methods In spring 2021, eight dead mute swans (Cygnus olor) were collected during avian influenza surveillance on the territory
of the Province of Vojvodina and submitted to Scientific Veterinary Institute “Novi Sad” to determine the cause of death.
The presence of highly pathogenic avian influenza subtype H5N1 was determined in all swans using molecular methods.
Results Necropsy of the swans revealed changes characteristic for highly pathogenic avian influenza infection, such as severe
haemorrhages and necrosis in different organs. Three of the eight swans showed massive subepicardial haemorrhages and
myocarditis with intralesional 2–4 cm long whitish roundworms. Histopathologically, haemorrhages and many adult heart
worms were observed in the myocardium. Based on morphological features of parasites, infection by Sarconema eurycerca
was concluded.
Conclusion According to the available scientific literature, the presence of heart roundworms in swans has not yet been
confirmed in our country. This report is the first published case of cardiac filariasis associated with S. eurycerca infection
in mute swans in the Republic of Serbia.",
publisher = "Springer",
journal = "Acta Parasitologica",
title = "First Report of Sarconema eurycerca Heart Infection in Mute Swans in Serbia",
volume = "67",
number = "4",
pages = "1773-1777",
doi = "10.1007/s11686-022-00616-3"
}

Đurđević, B., Vučićević, I., Bogunović, D., Pajić, M., Vejnović, B., Prodanov-Radulović, J.,& Polaček, V.. (2022). First Report of Sarconema eurycerca Heart Infection in Mute Swans in Serbia. in Acta Parasitologica
Springer., 67(4), 1773-1777.
https://doi.org/10.1007/s11686-022-00616-3

Đurđević B, Vučićević I, Bogunović D, Pajić M, Vejnović B, Prodanov-Radulović J, Polaček V. First Report of Sarconema eurycerca Heart Infection in Mute Swans in Serbia. in Acta Parasitologica. 2022;67(4):1773-1777.
doi:10.1007/s11686-022-00616-3 .

Đurđević, Biljana, Vučićević, Ivana, Bogunović, Danica, Pajić, Marko, Vejnović, Branislav, Prodanov-Radulović, Jasna, Polaček, Vladimir, "First Report of Sarconema eurycerca Heart Infection in Mute Swans in Serbia" in Acta Parasitologica, 67, no. 4 (2022):1773-1777,
https://doi.org/10.1007/s11686-022-00616-3 . .

TY  - CONF
AU  - Maletić, Jelena
AU  - Kureljušić, Branislav
AU  - Spalević, Ljiljana
AU  - Vučićević, Ivana
AU  - Veljović, Ljubiša
AU  - Milovanović, Bojan
AU  - Milićević, Vesna
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2866
AB  - Marek’s disease virus and avian leucosis virus are causes of contagious, immunosuppressive, and oncogenic diseases. Many
reports have described single virus infection, but detailed description of co-infection with Marek’s disease virus and avian
leucosis virus has been provided in a few previous reports. The aim of this study was to determine the cause of health disorders
in a flock of the Banat Naked Neck hens at the age of 11 weeks. Clinical examination of the flock showed signs of cachexia,
apathy, dropped wings, nervous symptoms in the form of bilateral leg paresis, sporadic diarrhoea, and the mortality reaching
20%. Post-mortem examinations showed the following changes: chronic pseudomembranous typhlitis, intestinal ascaridiasis,
splenomegaly, granulomatous pneumonia, multiple yellowish caseous foci in the liver, and white tumour masses in the heart.
Histopathological examination of the spleen, proventriculus and heart tissue revealed polymorphic infiltrates, while
granulomatous inflammation was observed in the lung and liver. Gomori methenamine silver stain method revealed septate and
arborized hyphae resembling the Aspergillus spp. fungi in the liver and lung granulomas. Bacteriological examination of faeces
revealed the presence of Escherichia coli, and parasitological examination of the small intestine determined the presence of
oocyst of Eimeria acervulina and Eimeria tenella in the caecum. The genomes of Marek's disease virus and avian leucosis
virus were determined by polymerase chain reaction in tissue samples. In this case, specific pathological lesions, as well as
molecular finding confirmed co-infection with Marek’s disease virus and avian leucosis virus.
AB  - Virus Marekove bolesti i virus ptičje leukoze uzrokuju zarazne, imunosupresivne i onkogene bolesti. Mnoga izvješća
opisuju infekciju pojedinim virusom, ali tek mali broj izvješća podrobnije opisuje koinfekciju virusom Marekove bolesti i
virusom ptičje leukoze. Cilj ovog istraživanja bio je utvrditi uzrok zdravstvenih poremećaja u jatu kokoši pasmine Banatski
gološijan u dobi od 11 tjedana. Klinički pregled jata pokazao je znakove kaheksije, apatije, spuštena krila, živčane
simptome u obliku pareze nogu, sporadični proljev te 20%-tnu smrtnost. Postmortem pregledi pokazali su sljedeće
promjene: kronični pseudomembranski tiflitis, crijevnu askaridijazu, splenomegaliju, granulomatoznu pneumoniju,
višestruka žućkasta sirasta žarišta u jetri i bijele tumorske tvorbe u srcu. Patohistološki pregled tkivnih uzoraka slezene,
proventrikla i srca otkrio je polimorfne infiltrate, dok je u plućima i jetri zabilježena granulomatozna upala. Metenamin
srebrno bojenje po Gomoriju otkrilo je septirane i arborizirane hife nalik gljivama Aspergillus spp. u jetrenim i plućnim
granulomima. Bakteriološke pretrage fecesa pokazale su prisutnost Escherichia coli, dok je parazitološka pretraga tankog
crijeva utvrdila prisutnost oocita Eimeria acervulina te Eimeria tenella u cekumu. PCR-om su genomi virusa Marekove
bolesti i virusa ptičje leukoze utvrđeni u tkivnim uzorcima. U ovom istraživanju su specifične patološke promjene i
molekularni nalazi potvrdili koinfekciju virusom Marekove bolesti i virusom ptičje leukoze.
C3  - XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022
T1  - Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens
T1  - Koinfekcija virusom Marekove bolesti i virusom ptičje leukoze kod kokoši pasmine banatski gološijan
SP  - 210
EP  - 217
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2866
ER  - 

@conference{
author = "Maletić, Jelena and Kureljušić, Branislav and Spalević, Ljiljana and Vučićević, Ivana and Veljović, Ljubiša and Milovanović, Bojan and Milićević, Vesna",
year = "2022",
abstract = "Marek’s disease virus and avian leucosis virus are causes of contagious, immunosuppressive, and oncogenic diseases. Many
reports have described single virus infection, but detailed description of co-infection with Marek’s disease virus and avian
leucosis virus has been provided in a few previous reports. The aim of this study was to determine the cause of health disorders
in a flock of the Banat Naked Neck hens at the age of 11 weeks. Clinical examination of the flock showed signs of cachexia,
apathy, dropped wings, nervous symptoms in the form of bilateral leg paresis, sporadic diarrhoea, and the mortality reaching
20%. Post-mortem examinations showed the following changes: chronic pseudomembranous typhlitis, intestinal ascaridiasis,
splenomegaly, granulomatous pneumonia, multiple yellowish caseous foci in the liver, and white tumour masses in the heart.
Histopathological examination of the spleen, proventriculus and heart tissue revealed polymorphic infiltrates, while
granulomatous inflammation was observed in the lung and liver. Gomori methenamine silver stain method revealed septate and
arborized hyphae resembling the Aspergillus spp. fungi in the liver and lung granulomas. Bacteriological examination of faeces
revealed the presence of Escherichia coli, and parasitological examination of the small intestine determined the presence of
oocyst of Eimeria acervulina and Eimeria tenella in the caecum. The genomes of Marek's disease virus and avian leucosis
virus were determined by polymerase chain reaction in tissue samples. In this case, specific pathological lesions, as well as
molecular finding confirmed co-infection with Marek’s disease virus and avian leucosis virus., Virus Marekove bolesti i virus ptičje leukoze uzrokuju zarazne, imunosupresivne i onkogene bolesti. Mnoga izvješća
opisuju infekciju pojedinim virusom, ali tek mali broj izvješća podrobnije opisuje koinfekciju virusom Marekove bolesti i
virusom ptičje leukoze. Cilj ovog istraživanja bio je utvrditi uzrok zdravstvenih poremećaja u jatu kokoši pasmine Banatski
gološijan u dobi od 11 tjedana. Klinički pregled jata pokazao je znakove kaheksije, apatije, spuštena krila, živčane
simptome u obliku pareze nogu, sporadični proljev te 20%-tnu smrtnost. Postmortem pregledi pokazali su sljedeće
promjene: kronični pseudomembranski tiflitis, crijevnu askaridijazu, splenomegaliju, granulomatoznu pneumoniju,
višestruka žućkasta sirasta žarišta u jetri i bijele tumorske tvorbe u srcu. Patohistološki pregled tkivnih uzoraka slezene,
proventrikla i srca otkrio je polimorfne infiltrate, dok je u plućima i jetri zabilježena granulomatozna upala. Metenamin
srebrno bojenje po Gomoriju otkrilo je septirane i arborizirane hife nalik gljivama Aspergillus spp. u jetrenim i plućnim
granulomima. Bakteriološke pretrage fecesa pokazale su prisutnost Escherichia coli, dok je parazitološka pretraga tankog
crijeva utvrdila prisutnost oocita Eimeria acervulina te Eimeria tenella u cekumu. PCR-om su genomi virusa Marekove
bolesti i virusa ptičje leukoze utvrđeni u tkivnim uzorcima. U ovom istraživanju su specifične patološke promjene i
molekularni nalazi potvrdili koinfekciju virusom Marekove bolesti i virusom ptičje leukoze.",
journal = "XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022",
title = "Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens, Koinfekcija virusom Marekove bolesti i virusom ptičje leukoze kod kokoši pasmine banatski gološijan",
pages = "210-217",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2866"
}

Maletić, J., Kureljušić, B., Spalević, L., Vučićević, I., Veljović, L., Milovanović, B.,& Milićević, V.. (2022). Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens. in XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022, 210-217.
https://hdl.handle.net/21.15107/rcub_veterinar_2866

Maletić J, Kureljušić B, Spalević L, Vučićević I, Veljović L, Milovanović B, Milićević V. Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens. in XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022. 2022;:210-217.
https://hdl.handle.net/21.15107/rcub_veterinar_2866 .

Maletić, Jelena, Kureljušić, Branislav, Spalević, Ljiljana, Vučićević, Ivana, Veljović, Ljubiša, Milovanović, Bojan, Milićević, Vesna, "Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens" in XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022 (2022):210-217,
https://hdl.handle.net/21.15107/rcub_veterinar_2866 .

TY  - CONF
AU  - Nešić, Slađan
AU  - Vučićević, Ivana
AU  - Jelisić, Stefan
AU  - Aleksić-Kovačević, Sanja
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2426
AB  - Ovčija svrabež (Scrapie, engl.) je neurodegenerativno oboljenje ovaca iz grupe transmisivnih spongiformnih encefalopatija (TSE).
Oboljenja iz grupe TSE se nazivaju prionske bolesti, jer je patološki
prion protein etiološki faktor za razvoj ovih oboljenja. Ovčija svrabež
se javlja u dve forme, kao klasična i atipična. Osetljivost ovaca na ovčiju svrabež zavisi od polimorfizma gena prionskog proteina i prirode
uzročnika prionske bolesti. Kodoni 136, 154 i 171 gena prion proteina
određuju stepen otpornosti, tj. sklonosti za Scrapie. Pošto je svaki alel
obeležen troslovnim kodom, utvrđeno je da su jedinke sa ARR alelom
visoko rezistentne na klasičnu ovčiju svrabež, ali ne pruža nikakvu posebnu zaštitu protiv atipične forme Scrapie-a. Primenom qPCR metode može se sprovesti genotipizacija jedinki u cilju uspešne selekcije
rezistentnih jedinki na ovčiju svrabež. Za metodu je neophodno uzeti
odgovarajući materijal i pripremiti ga za određivanje alela. Određivanje alela qPCR tehnikom sa Taquman probom je moguće iz krvi sa ili
bez dodatka antikoagulansa. Za dijagnostiku prisustva patološkog prion proteina kod ovaca u Laboratoriji za patologiju primenjuje se ELISA
metoda. Neophodno tkivo za dijagnostiku patološkog prion proteina
je obeks produžene moždine. Produžena moždina ovaca se uzorkuje
kroz foramen magnum specijalizovanim kašikama za uzorkovanja tkiva malih preživara
AB  - Scrapie is a neurodegenerative disease belonging to the group of transmissible
spongiform encephalopathies (TSE). Diseases from the TSE group are also known as prion
diseases because they are caused by the pathological prion protein. Scrapie is a disease
that has two forms, classical and atypical. The susceptibility of sheep to Scrapie depends
on the polymorphism of the prion protein gene and the nature of the agent causing prion
disease. Codons 136, 154 and 171 of the prion protein gene determine a certain degree
of resistance, ie the tendency for Scrapie. Since each allele is marked with a three-letter
code, individuals with the ARR allele were found to be highly resistant to classical Scrapie,
but did not provide any special protection against the atypical form. Using the qPCR
method, genotyping of individuals can be performed for the successful selection of Scrapie
resistant animals. It is necessary to sample the appropriate material for qPCR method and
to prepare it for the determination of alleles. Determination of alleles by qPCR technique
with Taquman test is possible from blood with or without anticoagulants. In the Laboratory
of Pathology, the ELISA method is used to diagnose the presence of pathological prion
protein in sheep. The Material necessary for the diagnosis of pathological prion protein
is the region of obex of medulla oblongata. The medulla oblongata of sheep is sampled
through the foramen magnum with specialized spoons for sampling the tissues of small
ruminants.
PB  - Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - Zbornik radova - XLIII seminar inovacija znanja veterinara
T1  - Otpornost ovaca na ovčiju svrabež i postupak uzorkovanja materijala za dijagnostiku patološkog prion proteina kod ovaca
T1  - Sheep resistance to scrapie and sampling procedure for diagnosis of pathological prion protein in sheep
SP  - 161
EP  - 167
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2426
ER  - 

@conference{
author = "Nešić, Slađan and Vučićević, Ivana and Jelisić, Stefan and Aleksić-Kovačević, Sanja",
year = "2022",
abstract = "Ovčija svrabež (Scrapie, engl.) je neurodegenerativno oboljenje ovaca iz grupe transmisivnih spongiformnih encefalopatija (TSE).
Oboljenja iz grupe TSE se nazivaju prionske bolesti, jer je patološki
prion protein etiološki faktor za razvoj ovih oboljenja. Ovčija svrabež
se javlja u dve forme, kao klasična i atipična. Osetljivost ovaca na ovčiju svrabež zavisi od polimorfizma gena prionskog proteina i prirode
uzročnika prionske bolesti. Kodoni 136, 154 i 171 gena prion proteina
određuju stepen otpornosti, tj. sklonosti za Scrapie. Pošto je svaki alel
obeležen troslovnim kodom, utvrđeno je da su jedinke sa ARR alelom
visoko rezistentne na klasičnu ovčiju svrabež, ali ne pruža nikakvu posebnu zaštitu protiv atipične forme Scrapie-a. Primenom qPCR metode može se sprovesti genotipizacija jedinki u cilju uspešne selekcije
rezistentnih jedinki na ovčiju svrabež. Za metodu je neophodno uzeti
odgovarajući materijal i pripremiti ga za određivanje alela. Određivanje alela qPCR tehnikom sa Taquman probom je moguće iz krvi sa ili
bez dodatka antikoagulansa. Za dijagnostiku prisustva patološkog prion proteina kod ovaca u Laboratoriji za patologiju primenjuje se ELISA
metoda. Neophodno tkivo za dijagnostiku patološkog prion proteina
je obeks produžene moždine. Produžena moždina ovaca se uzorkuje
kroz foramen magnum specijalizovanim kašikama za uzorkovanja tkiva malih preživara, Scrapie is a neurodegenerative disease belonging to the group of transmissible
spongiform encephalopathies (TSE). Diseases from the TSE group are also known as prion
diseases because they are caused by the pathological prion protein. Scrapie is a disease
that has two forms, classical and atypical. The susceptibility of sheep to Scrapie depends
on the polymorphism of the prion protein gene and the nature of the agent causing prion
disease. Codons 136, 154 and 171 of the prion protein gene determine a certain degree
of resistance, ie the tendency for Scrapie. Since each allele is marked with a three-letter
code, individuals with the ARR allele were found to be highly resistant to classical Scrapie,
but did not provide any special protection against the atypical form. Using the qPCR
method, genotyping of individuals can be performed for the successful selection of Scrapie
resistant animals. It is necessary to sample the appropriate material for qPCR method and
to prepare it for the determination of alleles. Determination of alleles by qPCR technique
with Taquman test is possible from blood with or without anticoagulants. In the Laboratory
of Pathology, the ELISA method is used to diagnose the presence of pathological prion
protein in sheep. The Material necessary for the diagnosis of pathological prion protein
is the region of obex of medulla oblongata. The medulla oblongata of sheep is sampled
through the foramen magnum with specialized spoons for sampling the tissues of small
ruminants.",
publisher = "Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "Zbornik radova - XLIII seminar inovacija znanja veterinara",
title = "Otpornost ovaca na ovčiju svrabež i postupak uzorkovanja materijala za dijagnostiku patološkog prion proteina kod ovaca, Sheep resistance to scrapie and sampling procedure for diagnosis of pathological prion protein in sheep",
pages = "161-167",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2426"
}

Nešić, S., Vučićević, I., Jelisić, S.,& Aleksić-Kovačević, S.. (2022). Otpornost ovaca na ovčiju svrabež i postupak uzorkovanja materijala za dijagnostiku patološkog prion proteina kod ovaca. in Zbornik radova - XLIII seminar inovacija znanja veterinara
Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 161-167.
https://hdl.handle.net/21.15107/rcub_veterinar_2426

Nešić S, Vučićević I, Jelisić S, Aleksić-Kovačević S. Otpornost ovaca na ovčiju svrabež i postupak uzorkovanja materijala za dijagnostiku patološkog prion proteina kod ovaca. in Zbornik radova - XLIII seminar inovacija znanja veterinara. 2022;:161-167.
https://hdl.handle.net/21.15107/rcub_veterinar_2426 .

Nešić, Slađan, Vučićević, Ivana, Jelisić, Stefan, Aleksić-Kovačević, Sanja, "Otpornost ovaca na ovčiju svrabež i postupak uzorkovanja materijala za dijagnostiku patološkog prion proteina kod ovaca" in Zbornik radova - XLIII seminar inovacija znanja veterinara (2022):161-167,
https://hdl.handle.net/21.15107/rcub_veterinar_2426 .

TY  - CONF
AU  - Milčić Matić, Natalija
AU  - Vučićević, Ivana
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2894
PB  - Beograd : Fakultet veterinarske medicine
C3  - Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09 - 11. jun, 2022
T1  - Mastocitomi – da li je hirurgija jedino rešenje?
SP  - 12
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2894
ER  - 

@conference{
author = "Milčić Matić, Natalija and Vučićević, Ivana",
year = "2022",
publisher = "Beograd : Fakultet veterinarske medicine",
journal = "Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09 - 11. jun, 2022",
title = "Mastocitomi – da li je hirurgija jedino rešenje?",
pages = "12-14",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2894"
}

Milčić Matić, N.,& Vučićević, I.. (2022). Mastocitomi – da li je hirurgija jedino rešenje?. in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09 - 11. jun, 2022
Beograd : Fakultet veterinarske medicine., 12-14.
https://hdl.handle.net/21.15107/rcub_veterinar_2894

Milčić Matić N, Vučićević I. Mastocitomi – da li je hirurgija jedino rešenje?. in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09 - 11. jun, 2022. 2022;:12-14.
https://hdl.handle.net/21.15107/rcub_veterinar_2894 .

Milčić Matić, Natalija, Vučićević, Ivana, "Mastocitomi – da li je hirurgija jedino rešenje?" in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09 - 11. jun, 2022 (2022):12-14,
https://hdl.handle.net/21.15107/rcub_veterinar_2894 .

TY  - CONF
AU  - Salai, Romina
AU  - Kiškarolj, Ferenc
AU  - Aničić, Milan
AU  - Vučićević, Ivana
AU  - Aleksić-Kovačević, Sanja
AU  - Marinković, Darko
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2924
AB  - У раду су приказани налази патоморфолошког (макроскопског и
хистопатолошког) прегледа угинулих животиња пореклом из Зоо врта Палић са
припадајућим микробиолошким резултатима. Обдукције угинулих животиња и
микробиолошки прегледи су извршени у Ветеринарском специјалистичком
институту „Суботица“, док су хистопатолошка испитивања ткивних узорака
урађена на Катедри за патологију Факултета ветеринарске медицине у Београду.
Приказани су морфолошки и микробиолошки налази код укупно 23
појединачних случајева 20 различитих врста птица и сисара. Доминантани
патоморфолошки налази били су заступљени у форми инфламаторних,
дегенеративно-некротичних и неопластичних промена у гастроинтестиналном
систему, бубрезима и плућима, док је микробиолошким испитивањима
установљено присуство бактерија из рода Escherichia, Salmonella, Pasteurella,
Pseudomonas, Streptococcus i Staphylococcus и гљивица из рода Aspergillus.
Иако су дивље животиње у зоо врту прилично адаптиране на услове средине у
којима живе, узроци обољења и угинућа животиња су делимично последица
измењених услова живота у којима бораве у зоо врту а који се најчешће значајно
разликују од услова природног станишта у дивљини.
AB  - Pathomorphological findings (macroscopic and histopathologic) with corresponding
microbiological results originated from animals died in Zoo Palić were presented in
this paper.
Necropsies and microbiological examinations were performed in Veterinary
Specialist Institute Subotica, while histopathological examination of tissue samples
were performed on Department of Pathology, Faculty of Veterinary Medicine in
Belgrade.
Morphological and microbiological findings of twenty-three cases originated from 20
different avian and mammalian species were shown.
Dominant pathomorphological findings were in form of inflammatory, degenerativenecrotic and neoplastic changes of gastrointestinal system, kidneys and lungs, while
microbiological examination revealed presence of bacteria from genus Escherichia,
Salmonella, Pasteurella, Pseudomonas, Streptococcus and Staphylococcus and
fungus from genus Aspergillus.
Although wild animals in Zoo are pretty adapted on the living conditions, the causes
of their death still are partly due to altered conditions in Zoo which in most cases are
significantly different from the natural wild habita
PB  - Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze
C3  - XXIV Simpozijum epizootiologa i epidemiologa (XXIV Epizootiološki dani), Subotica, 27 - 29. april 2022
T1  - Prikaz patomorfoloških i laboratorijskih nalaza kod životinja iz Zoo vrta Palić uginulih u periodu od 2017. do 2021. godine
SP  - 50
EP  - 51
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2924
ER  - 

@conference{
author = "Salai, Romina and Kiškarolj, Ferenc and Aničić, Milan and Vučićević, Ivana and Aleksić-Kovačević, Sanja and Marinković, Darko",
year = "2022",
abstract = "У раду су приказани налази патоморфолошког (макроскопског и
хистопатолошког) прегледа угинулих животиња пореклом из Зоо врта Палић са
припадајућим микробиолошким резултатима. Обдукције угинулих животиња и
микробиолошки прегледи су извршени у Ветеринарском специјалистичком
институту „Суботица“, док су хистопатолошка испитивања ткивних узорака
урађена на Катедри за патологију Факултета ветеринарске медицине у Београду.
Приказани су морфолошки и микробиолошки налази код укупно 23
појединачних случајева 20 различитих врста птица и сисара. Доминантани
патоморфолошки налази били су заступљени у форми инфламаторних,
дегенеративно-некротичних и неопластичних промена у гастроинтестиналном
систему, бубрезима и плућима, док је микробиолошким испитивањима
установљено присуство бактерија из рода Escherichia, Salmonella, Pasteurella,
Pseudomonas, Streptococcus i Staphylococcus и гљивица из рода Aspergillus.
Иако су дивље животиње у зоо врту прилично адаптиране на услове средине у
којима живе, узроци обољења и угинућа животиња су делимично последица
измењених услова живота у којима бораве у зоо врту а који се најчешће значајно
разликују од услова природног станишта у дивљини., Pathomorphological findings (macroscopic and histopathologic) with corresponding
microbiological results originated from animals died in Zoo Palić were presented in
this paper.
Necropsies and microbiological examinations were performed in Veterinary
Specialist Institute Subotica, while histopathological examination of tissue samples
were performed on Department of Pathology, Faculty of Veterinary Medicine in
Belgrade.
Morphological and microbiological findings of twenty-three cases originated from 20
different avian and mammalian species were shown.
Dominant pathomorphological findings were in form of inflammatory, degenerativenecrotic and neoplastic changes of gastrointestinal system, kidneys and lungs, while
microbiological examination revealed presence of bacteria from genus Escherichia,
Salmonella, Pasteurella, Pseudomonas, Streptococcus and Staphylococcus and
fungus from genus Aspergillus.
Although wild animals in Zoo are pretty adapted on the living conditions, the causes
of their death still are partly due to altered conditions in Zoo which in most cases are
significantly different from the natural wild habita",
publisher = "Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze",
journal = "XXIV Simpozijum epizootiologa i epidemiologa (XXIV Epizootiološki dani), Subotica, 27 - 29. april 2022",
title = "Prikaz patomorfoloških i laboratorijskih nalaza kod životinja iz Zoo vrta Palić uginulih u periodu od 2017. do 2021. godine",
pages = "50-51",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2924"
}

Salai, R., Kiškarolj, F., Aničić, M., Vučićević, I., Aleksić-Kovačević, S.,& Marinković, D.. (2022). Prikaz patomorfoloških i laboratorijskih nalaza kod životinja iz Zoo vrta Palić uginulih u periodu od 2017. do 2021. godine. in XXIV Simpozijum epizootiologa i epidemiologa (XXIV Epizootiološki dani), Subotica, 27 - 29. april 2022
Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze., 50-51.
https://hdl.handle.net/21.15107/rcub_veterinar_2924

Salai R, Kiškarolj F, Aničić M, Vučićević I, Aleksić-Kovačević S, Marinković D. Prikaz patomorfoloških i laboratorijskih nalaza kod životinja iz Zoo vrta Palić uginulih u periodu od 2017. do 2021. godine. in XXIV Simpozijum epizootiologa i epidemiologa (XXIV Epizootiološki dani), Subotica, 27 - 29. april 2022. 2022;:50-51.
https://hdl.handle.net/21.15107/rcub_veterinar_2924 .

Salai, Romina, Kiškarolj, Ferenc, Aničić, Milan, Vučićević, Ivana, Aleksić-Kovačević, Sanja, Marinković, Darko, "Prikaz patomorfoloških i laboratorijskih nalaza kod životinja iz Zoo vrta Palić uginulih u periodu od 2017. do 2021. godine" in XXIV Simpozijum epizootiologa i epidemiologa (XXIV Epizootiološki dani), Subotica, 27 - 29. april 2022 (2022):50-51,
https://hdl.handle.net/21.15107/rcub_veterinar_2924 .

TY  - CONF
AU  - Đurđević, Biljana
AU  - Pajić, Marko
AU  - Polaček, Vladimir
AU  - Knežević, Slobodan
AU  - Ratajac, Ratko
AU  - Mihaljev, Žarko
AU  - Aleksić-Kovačević, Sanja
AU  - Vučićević, Ivana
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3361
AB  - The eastern imperial eagle (Aquila heliaca) is one of the critically endangered
species in Serbia, with a small global population that will likely continue to decline. Despite
many biological and ecological studies on this species, little is known regarding the prevalence and incidence of infectious diseases in these birds. Here we present the pathological,
microbiological and toxicological findings in one imperial eagle.
PB  - European Society of Veterinary Pathology
C3  - Annual ESVP/ECVP Congress 2022, Athens, Greece, September 7 - 10, 2022
T1  - Pathological, Microbiological and Toxicological Findings in an Eastern Imperial Eagle
SP  - 57
EP  - 57
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3361
ER  - 

@conference{
author = "Đurđević, Biljana and Pajić, Marko and Polaček, Vladimir and Knežević, Slobodan and Ratajac, Ratko and Mihaljev, Žarko and Aleksić-Kovačević, Sanja and Vučićević, Ivana",
year = "2022",
abstract = "The eastern imperial eagle (Aquila heliaca) is one of the critically endangered
species in Serbia, with a small global population that will likely continue to decline. Despite
many biological and ecological studies on this species, little is known regarding the prevalence and incidence of infectious diseases in these birds. Here we present the pathological,
microbiological and toxicological findings in one imperial eagle.",
publisher = "European Society of Veterinary Pathology",
journal = "Annual ESVP/ECVP Congress 2022, Athens, Greece, September 7 - 10, 2022",
title = "Pathological, Microbiological and Toxicological Findings in an Eastern Imperial Eagle",
pages = "57-57",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3361"
}

Đurđević, B., Pajić, M., Polaček, V., Knežević, S., Ratajac, R., Mihaljev, Ž., Aleksić-Kovačević, S.,& Vučićević, I.. (2022). Pathological, Microbiological and Toxicological Findings in an Eastern Imperial Eagle. in Annual ESVP/ECVP Congress 2022, Athens, Greece, September 7 - 10, 2022
European Society of Veterinary Pathology., 57-57.
https://hdl.handle.net/21.15107/rcub_veterinar_3361

Đurđević B, Pajić M, Polaček V, Knežević S, Ratajac R, Mihaljev Ž, Aleksić-Kovačević S, Vučićević I. Pathological, Microbiological and Toxicological Findings in an Eastern Imperial Eagle. in Annual ESVP/ECVP Congress 2022, Athens, Greece, September 7 - 10, 2022. 2022;:57-57.
https://hdl.handle.net/21.15107/rcub_veterinar_3361 .

Đurđević, Biljana, Pajić, Marko, Polaček, Vladimir, Knežević, Slobodan, Ratajac, Ratko, Mihaljev, Žarko, Aleksić-Kovačević, Sanja, Vučićević, Ivana, "Pathological, Microbiological and Toxicological Findings in an Eastern Imperial Eagle" in Annual ESVP/ECVP Congress 2022, Athens, Greece, September 7 - 10, 2022 (2022):57-57,
https://hdl.handle.net/21.15107/rcub_veterinar_3361 .

TY  - JOUR
AU  - Đurđević, B.
AU  - Polaček, V.
AU  - Pajić, M.
AU  - Knežević, S.
AU  - Petrović, T.
AU  - Vučićević, Ivana
AU  - Aleksić-Kovačević, Sanja
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2865
PB  - Elsevier
T2  - Journal Of Comparative Pathology
T1  - New field outbreaks of highly pathogenic avian influenza h5n8 in mute swans in Serbia - pathological findings
VL  - 191
SP  - 53
EP  - 53
DO  - 10.1016/j.jcpa.2021.11.120
ER  - 

@article{
author = "Đurđević, B. and Polaček, V. and Pajić, M. and Knežević, S. and Petrović, T. and Vučićević, Ivana and Aleksić-Kovačević, Sanja",
year = "2022",
publisher = "Elsevier",
journal = "Journal Of Comparative Pathology",
title = "New field outbreaks of highly pathogenic avian influenza h5n8 in mute swans in Serbia - pathological findings",
volume = "191",
pages = "53-53",
doi = "10.1016/j.jcpa.2021.11.120"
}

Đurđević, B., Polaček, V., Pajić, M., Knežević, S., Petrović, T., Vučićević, I.,& Aleksić-Kovačević, S.. (2022). New field outbreaks of highly pathogenic avian influenza h5n8 in mute swans in Serbia - pathological findings. in Journal Of Comparative Pathology
Elsevier., 191, 53-53.
https://doi.org/10.1016/j.jcpa.2021.11.120

Đurđević B, Polaček V, Pajić M, Knežević S, Petrović T, Vučićević I, Aleksić-Kovačević S. New field outbreaks of highly pathogenic avian influenza h5n8 in mute swans in Serbia - pathological findings. in Journal Of Comparative Pathology. 2022;191:53-53.
doi:10.1016/j.jcpa.2021.11.120 .

Đurđević, B., Polaček, V., Pajić, M., Knežević, S., Petrović, T., Vučićević, Ivana, Aleksić-Kovačević, Sanja, "New field outbreaks of highly pathogenic avian influenza h5n8 in mute swans in Serbia - pathological findings" in Journal Of Comparative Pathology, 191 (2022):53-53,
https://doi.org/10.1016/j.jcpa.2021.11.120 . .

TY  - CONF
AU  - Vučićević, Ivana
AU  - Nešić, Slađan
AU  - Jelisić, Stefan
AU  - Aleksić-Kovačević, Sanja
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2868
AB  - Monitoring of scrapie in sheep and goats has been carried out for many years in Serbia.
Despite many years of monitoring, only one case of this disease has been reported in sheep,
but given that, there are numerous cases of the disease in some neighboring countries, it is
very important to determine the presence of resistant genes in the sheep population in Serbia.
Genetic susceptibility to scrapie is influenced mainly by the prion protein polymorphisms
of codons136, 154, and 171. The ARR allele is considered to provide very strong resistance
against classical scrapie and the VRQ genotype is the most susceptible. In order to examine
the genetic makeup of sheep in Serbia related to scrapie, we optimized TaqMan probes of
real-time polymerase chain reaction (qPCR) techniques for three codons. We analyzed blood
samples from 100 sheep using qPCR and the results showed that AA homozygous for the 136
codon were the most common. For codon 154 the most frequent genotype was RR and for
codon 171 the most frequent genotype was QQ.
C3  - 10th Iberian Congress on Prions, Vila Real, Portugal, 2022
T1  - Identification of the presence of a scrapie resistance gene in sheep on the territory of the Republic of Serbia
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2868
ER  - 

@conference{
author = "Vučićević, Ivana and Nešić, Slađan and Jelisić, Stefan and Aleksić-Kovačević, Sanja",
year = "2022",
abstract = "Monitoring of scrapie in sheep and goats has been carried out for many years in Serbia.
Despite many years of monitoring, only one case of this disease has been reported in sheep,
but given that, there are numerous cases of the disease in some neighboring countries, it is
very important to determine the presence of resistant genes in the sheep population in Serbia.
Genetic susceptibility to scrapie is influenced mainly by the prion protein polymorphisms
of codons136, 154, and 171. The ARR allele is considered to provide very strong resistance
against classical scrapie and the VRQ genotype is the most susceptible. In order to examine
the genetic makeup of sheep in Serbia related to scrapie, we optimized TaqMan probes of
real-time polymerase chain reaction (qPCR) techniques for three codons. We analyzed blood
samples from 100 sheep using qPCR and the results showed that AA homozygous for the 136
codon were the most common. For codon 154 the most frequent genotype was RR and for
codon 171 the most frequent genotype was QQ.",
journal = "10th Iberian Congress on Prions, Vila Real, Portugal, 2022",
title = "Identification of the presence of a scrapie resistance gene in sheep on the territory of the Republic of Serbia",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2868"
}

Vučićević, I., Nešić, S., Jelisić, S.,& Aleksić-Kovačević, S.. (2022). Identification of the presence of a scrapie resistance gene in sheep on the territory of the Republic of Serbia. in 10th Iberian Congress on Prions, Vila Real, Portugal, 2022.
https://hdl.handle.net/21.15107/rcub_veterinar_2868

Vučićević I, Nešić S, Jelisić S, Aleksić-Kovačević S. Identification of the presence of a scrapie resistance gene in sheep on the territory of the Republic of Serbia. in 10th Iberian Congress on Prions, Vila Real, Portugal, 2022. 2022;.
https://hdl.handle.net/21.15107/rcub_veterinar_2868 .

Vučićević, Ivana, Nešić, Slađan, Jelisić, Stefan, Aleksić-Kovačević, Sanja, "Identification of the presence of a scrapie resistance gene in sheep on the territory of the Republic of Serbia" in 10th Iberian Congress on Prions, Vila Real, Portugal, 2022 (2022),
https://hdl.handle.net/21.15107/rcub_veterinar_2868 .

TY  - JOUR
PY  - 2022
UR  - https://repo.niv.ns.ac.rs/xmlui/handle/123456789/470
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2462
AB  - This experiment was performed to investigate the protective effect of a new combined adsorbent (bentonite + yeast cellwall extract) previously tested in vitro, on the occurrence of pathological lesions in broilers fed a diet contaminated with aflatoxinB1 until 21 days of age. A total of 96 one-day old Ross 308 hybrid broiler chickens were divided into four groups: group I (control),group II (5 g/kg adsorbent), group III (5 g/kg adsorbent + 2 mg/kg aflatoxin B1), and group IV (2 mg/kg aflatoxin B1). Grossly,AFB1 and AFB1+adsorbent fed birds showed enlargement, friable texture of liver and enlargement and pallorness of kidneys. Spleenrevealed size reduction. No gross-pathological changes were observed in control and group II. Histopathologically, lesions wereobserved in aflatoxicated groups. Liver revealed vacuolar cell degeneration, periportal and perivascular infiltration of mononuclearcells. Kidneys revealed mild to moderate degree of haemorrhages, tubular epithelial necrosis and infiltration of mononuclearcells along with heterophils. In group IV, catarrhal enteritis characterized by desquamation of epithelial cells were found in theduodenum. A milder form of gross and histopathological lesions was seen in group III. In conclusion, the present study revealedthat supplementation of a new combined toxin binder product in the concentration of 5 g/kg could not completely ameliorateaflatoxicity in broilers, although it met the stringent European regulation requirements for the minimum of 90% aflatoxin bindingefficiency in in vitro study.
PB  - Kafkas University, Faculty of Veterinary Medicine
T1  - Evaluation of the Effects of New Combined Adsorbent on Occurrence of Pathological Lesions in Aflatoxin B1‐Challenged Broiler Chickens
VL  - 28
IS  - 4
SP  - 185
EP  - 191
DO  - 10.9775/kvfd.2021.26654
ER  - 

@article{
year = "2022",
abstract = "This experiment was performed to investigate the protective effect of a new combined adsorbent (bentonite + yeast cellwall extract) previously tested in vitro, on the occurrence of pathological lesions in broilers fed a diet contaminated with aflatoxinB1 until 21 days of age. A total of 96 one-day old Ross 308 hybrid broiler chickens were divided into four groups: group I (control),group II (5 g/kg adsorbent), group III (5 g/kg adsorbent + 2 mg/kg aflatoxin B1), and group IV (2 mg/kg aflatoxin B1). Grossly,AFB1 and AFB1+adsorbent fed birds showed enlargement, friable texture of liver and enlargement and pallorness of kidneys. Spleenrevealed size reduction. No gross-pathological changes were observed in control and group II. Histopathologically, lesions wereobserved in aflatoxicated groups. Liver revealed vacuolar cell degeneration, periportal and perivascular infiltration of mononuclearcells. Kidneys revealed mild to moderate degree of haemorrhages, tubular epithelial necrosis and infiltration of mononuclearcells along with heterophils. In group IV, catarrhal enteritis characterized by desquamation of epithelial cells were found in theduodenum. A milder form of gross and histopathological lesions was seen in group III. In conclusion, the present study revealedthat supplementation of a new combined toxin binder product in the concentration of 5 g/kg could not completely ameliorateaflatoxicity in broilers, although it met the stringent European regulation requirements for the minimum of 90% aflatoxin bindingefficiency in in vitro study.",
publisher = "Kafkas University, Faculty of Veterinary Medicine",
title = "Evaluation of the Effects of New Combined Adsorbent on Occurrence of Pathological Lesions in Aflatoxin B1‐Challenged Broiler Chickens",
volume = "28",
number = "4",
pages = "185-191",
doi = "10.9775/kvfd.2021.26654"
}

(2022). Evaluation of the Effects of New Combined Adsorbent on Occurrence of Pathological Lesions in Aflatoxin B1‐Challenged Broiler Chickens. 
Kafkas University, Faculty of Veterinary Medicine., 28(4), 185-191.
https://doi.org/10.9775/kvfd.2021.26654

Evaluation of the Effects of New Combined Adsorbent on Occurrence of Pathological Lesions in Aflatoxin B1‐Challenged Broiler Chickens. 2022;28(4):185-191.
doi:10.9775/kvfd.2021.26654 .

"Evaluation of the Effects of New Combined Adsorbent on Occurrence of Pathological Lesions in Aflatoxin B1‐Challenged Broiler Chickens", 28, no. 4 (2022):185-191,
https://doi.org/10.9775/kvfd.2021.26654 . .

TY  - CONF
AU  - Rajčić, Antonija
AU  - Baltić, Milan Ž.
AU  - Branković-Lazić, Ivana
AU  - Starčević, Marija
AU  - Baltić, Branislav
AU  - Vučićević, Ivana
AU  - Nešić, Slađan
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2250
AB  - The genetic selection toward bigger broilers provoked the development of muscular myopathies and abnormalities. Since the affected meat is downgraded and often inadequate for further processing, economic losses to the broiler industry are inevitable. In addition, not only the nutritional value of the meat has been decreased, but also sensory properties and technological traits seem to concern consumers more. This can have a very negative attitude toward poultry meat as consumers connect these traits with poor animal welfare. To avoid these problems in the future, new studies must be focused on identifying markers in live birds for newly developed myopathies. Also, better strategies for determining genetic factors, nutritional and slaughter conditions, and hence meat quality, are a complex concept, and all factors together have an impact on parameters of meat quality.
PB  - Iop Publishing Ltd, Bristol
C3  - 61st International Meat Industry Conference (MEATCON2021)
T1  - Intensive genetic selection and meat quality concerns in the modern broiler industry
VL  - 854
SP  - 012077
DO  - 10.1088/1755-1315/854/1/012077
ER  - 

@conference{
author = "Rajčić, Antonija and Baltić, Milan Ž. and Branković-Lazić, Ivana and Starčević, Marija and Baltić, Branislav and Vučićević, Ivana and Nešić, Slađan",
year = "2021",
abstract = "The genetic selection toward bigger broilers provoked the development of muscular myopathies and abnormalities. Since the affected meat is downgraded and often inadequate for further processing, economic losses to the broiler industry are inevitable. In addition, not only the nutritional value of the meat has been decreased, but also sensory properties and technological traits seem to concern consumers more. This can have a very negative attitude toward poultry meat as consumers connect these traits with poor animal welfare. To avoid these problems in the future, new studies must be focused on identifying markers in live birds for newly developed myopathies. Also, better strategies for determining genetic factors, nutritional and slaughter conditions, and hence meat quality, are a complex concept, and all factors together have an impact on parameters of meat quality.",
publisher = "Iop Publishing Ltd, Bristol",
journal = "61st International Meat Industry Conference (MEATCON2021)",
title = "Intensive genetic selection and meat quality concerns in the modern broiler industry",
volume = "854",
pages = "012077",
doi = "10.1088/1755-1315/854/1/012077"
}

Rajčić, A., Baltić, M. Ž., Branković-Lazić, I., Starčević, M., Baltić, B., Vučićević, I.,& Nešić, S.. (2021). Intensive genetic selection and meat quality concerns in the modern broiler industry. in 61st International Meat Industry Conference (MEATCON2021)
Iop Publishing Ltd, Bristol., 854, 012077.
https://doi.org/10.1088/1755-1315/854/1/012077

Rajčić A, Baltić MŽ, Branković-Lazić I, Starčević M, Baltić B, Vučićević I, Nešić S. Intensive genetic selection and meat quality concerns in the modern broiler industry. in 61st International Meat Industry Conference (MEATCON2021). 2021;854:012077.
doi:10.1088/1755-1315/854/1/012077 .

Rajčić, Antonija, Baltić, Milan Ž., Branković-Lazić, Ivana, Starčević, Marija, Baltić, Branislav, Vučićević, Ivana, Nešić, Slađan, "Intensive genetic selection and meat quality concerns in the modern broiler industry" in 61st International Meat Industry Conference (MEATCON2021), 854 (2021):012077,
https://doi.org/10.1088/1755-1315/854/1/012077 . .

TY  - JOUR
AU  - Nešić, Slađan
AU  - Vučićević, Ivana
AU  - Marinković, Darko
AU  - Kukolj, Vladimir
AU  - Aničić, Milan
AU  - Ristoski, Trpe
AU  - Nikolić, Sonja
AU  - Aleksić-Kovačević, Sanja
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2075
AB  - The ageing process is accompanied by numerous changes in the brain of dogs, such as accumulation of amyloid, fibrosis of blood vessel walls and meninges, accumulation of lipofuscin, and the presence of polyglucosan bodies (PGBs), satellitosis and neuronophagia. In this study, the presence of lipofuscin and PGBs in various parts of the brain in dogs of different sexes and ages was examined. For this purpose, brain samples were stained using haematoxylin eosin, modified Ziehl Neelsen and Periodic acid Schiff (PAS) methods. Lipofuscin was visualised by Ziehl Neelsen and PAS methods of specific staining on the same brain tissue segments. Lipofuscin had accumulated in 93% of old (more than 10 years old) dog brains, mostly in neurons of the medulla oblongata. The percentage of age-related lipofuscin pigment in other examined brain tissue segments was lower than in the medulla oblongata. There was a small difference in the percentage of lipofuscin-positive individuals between the two staining methods. The presence of PGBs was established by the PAS method for the vast majority (about 93%) of the old dogs (more than 10 years old), while PGBs were not detected in the group of young dogs (up to 5 years old). However, PGBs occurred in all examined segments of the dog’s brain tissues (for each of the tissue types, from 90% to 93% of dogs were positive for PGBs). The results obtained the oldest dogs (15 years old) harboured PGBs both extracellularly and intracellularly, while in other dogs, only extracellular PGBs were seen. Lipofuscin was accumulated mostly in large neurons of olivary nuclei of the medulla oblongata. PGBs were confirmed in all examined segments of the brain tissue of dogs more than 10 years old. This is one of the numerous indications that old dogs could be a very good animal model for studying the normal ageing process or neurodegenerative diseases.
AB  - Proces starenja prate brojne promene u mozgu pasa kao što su nagomilavanje amiloida, fibroza zida krvnih sudova i moždanih ovojnica, nakupljanje lipofuscina i prisustvo poliglukoznih tela (PGB), satelitoza i neuronofagija. U ovom radu ispitivano je prisustvo lipofuscina i PGB u različitim delovima centralnog nervnog sistema kod pasa različitog pola i starosti. Uzorci mozga obojeni su hematoksilin eozinom, modifikovanom Ziehl Neelsen metodom i perjodna kiselina-Schiff (PAS) metodom. Lipofuscin je modifikovanom Ziehl Neelsen i PAS metodom specifično dokazan u istim segmentima moždanog tkiva. Dobijeni rezultati pokazuju da je lipofuscin akumuliran uglavnom u neuronima produžene moždine kod 93% pasa. Zastupljenost pigmenta u ostalim segmentima mozga bio je niži u poređenju sa produženom moždinom. Korišćenjem obe metode bojenja, ustanovljena je mala razlika u procentu pozitivnih jedinki. Prisustvo PGB dokazano je PAS metodom kod velikog broja (oko 93%) pasa eksperimentalne grupe, dok u kontrolnoj grupi njihovo prisustvo nije ustanovljeno. U svim ispitivanim segmentima moždanog tkiva kod pasa iz eksperimentalne grupe, dokazana su PGB i to od 90% do 93%. Dobijeni rezultati ukazuju da su kod najstarijih pasa iz eksperimentalne grupe PGB bila lokalizovana i van ćelije i unutar nje, a kod drugih samo ekstracelularno. Lipofuscin je akumuliran uglavnom u velikim neuronima olivarnih jedara produžene moždine. PGB su dokazana u svim ispitivanim segmentima moždanog tkiva pasa starijih od 10 godina. Ovo je jedan od brojnih dokaza da stari psi predstavljaju dobar animalni model za proučavanje normalnog procesa starenja ili neurodegenerativnih bolesti.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old
T1  - Histohemijske karakteristike i distribucija lipofuscina i poliglukozanskih tela u mozgu pasa starijih od 10 godina
VL  - 75
IS  - 1
SP  - 57
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2075
ER  - 

@article{
author = "Nešić, Slađan and Vučićević, Ivana and Marinković, Darko and Kukolj, Vladimir and Aničić, Milan and Ristoski, Trpe and Nikolić, Sonja and Aleksić-Kovačević, Sanja",
year = "2021",
abstract = "The ageing process is accompanied by numerous changes in the brain of dogs, such as accumulation of amyloid, fibrosis of blood vessel walls and meninges, accumulation of lipofuscin, and the presence of polyglucosan bodies (PGBs), satellitosis and neuronophagia. In this study, the presence of lipofuscin and PGBs in various parts of the brain in dogs of different sexes and ages was examined. For this purpose, brain samples were stained using haematoxylin eosin, modified Ziehl Neelsen and Periodic acid Schiff (PAS) methods. Lipofuscin was visualised by Ziehl Neelsen and PAS methods of specific staining on the same brain tissue segments. Lipofuscin had accumulated in 93% of old (more than 10 years old) dog brains, mostly in neurons of the medulla oblongata. The percentage of age-related lipofuscin pigment in other examined brain tissue segments was lower than in the medulla oblongata. There was a small difference in the percentage of lipofuscin-positive individuals between the two staining methods. The presence of PGBs was established by the PAS method for the vast majority (about 93%) of the old dogs (more than 10 years old), while PGBs were not detected in the group of young dogs (up to 5 years old). However, PGBs occurred in all examined segments of the dog’s brain tissues (for each of the tissue types, from 90% to 93% of dogs were positive for PGBs). The results obtained the oldest dogs (15 years old) harboured PGBs both extracellularly and intracellularly, while in other dogs, only extracellular PGBs were seen. Lipofuscin was accumulated mostly in large neurons of olivary nuclei of the medulla oblongata. PGBs were confirmed in all examined segments of the brain tissue of dogs more than 10 years old. This is one of the numerous indications that old dogs could be a very good animal model for studying the normal ageing process or neurodegenerative diseases., Proces starenja prate brojne promene u mozgu pasa kao što su nagomilavanje amiloida, fibroza zida krvnih sudova i moždanih ovojnica, nakupljanje lipofuscina i prisustvo poliglukoznih tela (PGB), satelitoza i neuronofagija. U ovom radu ispitivano je prisustvo lipofuscina i PGB u različitim delovima centralnog nervnog sistema kod pasa različitog pola i starosti. Uzorci mozga obojeni su hematoksilin eozinom, modifikovanom Ziehl Neelsen metodom i perjodna kiselina-Schiff (PAS) metodom. Lipofuscin je modifikovanom Ziehl Neelsen i PAS metodom specifično dokazan u istim segmentima moždanog tkiva. Dobijeni rezultati pokazuju da je lipofuscin akumuliran uglavnom u neuronima produžene moždine kod 93% pasa. Zastupljenost pigmenta u ostalim segmentima mozga bio je niži u poređenju sa produženom moždinom. Korišćenjem obe metode bojenja, ustanovljena je mala razlika u procentu pozitivnih jedinki. Prisustvo PGB dokazano je PAS metodom kod velikog broja (oko 93%) pasa eksperimentalne grupe, dok u kontrolnoj grupi njihovo prisustvo nije ustanovljeno. U svim ispitivanim segmentima moždanog tkiva kod pasa iz eksperimentalne grupe, dokazana su PGB i to od 90% do 93%. Dobijeni rezultati ukazuju da su kod najstarijih pasa iz eksperimentalne grupe PGB bila lokalizovana i van ćelije i unutar nje, a kod drugih samo ekstracelularno. Lipofuscin je akumuliran uglavnom u velikim neuronima olivarnih jedara produžene moždine. PGB su dokazana u svim ispitivanim segmentima moždanog tkiva pasa starijih od 10 godina. Ovo je jedan od brojnih dokaza da stari psi predstavljaju dobar animalni model za proučavanje normalnog procesa starenja ili neurodegenerativnih bolesti.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old, Histohemijske karakteristike i distribucija lipofuscina i poliglukozanskih tela u mozgu pasa starijih od 10 godina",
volume = "75",
number = "1",
pages = "57-68",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2075"
}

Nešić, S., Vučićević, I., Marinković, D., Kukolj, V., Aničić, M., Ristoski, T., Nikolić, S.,& Aleksić-Kovačević, S.. (2021). Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 75(1), 57-68.
https://hdl.handle.net/21.15107/rcub_veterinar_2075

Nešić S, Vučićević I, Marinković D, Kukolj V, Aničić M, Ristoski T, Nikolić S, Aleksić-Kovačević S. Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old. in Veterinarski Glasnik. 2021;75(1):57-68.
https://hdl.handle.net/21.15107/rcub_veterinar_2075 .

Nešić, Slađan, Vučićević, Ivana, Marinković, Darko, Kukolj, Vladimir, Aničić, Milan, Ristoski, Trpe, Nikolić, Sonja, Aleksić-Kovačević, Sanja, "Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old" in Veterinarski Glasnik, 75, no. 1 (2021):57-68,
https://hdl.handle.net/21.15107/rcub_veterinar_2075 .

TY  - CONF
AU  - Đurđević, Biljana
AU  - Samojlović, Milena
AU  - Lazić, Gospava
AU  - Nešić, Ksenija
AU  - Vučićević, Ivana
AU  - Polaček, Vladimir
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3747
AB  - Бовина спонгиформна енцефалопатија (БСЕ) или болест “лудих крава” је прогресивно,
фатално, неуродегенеративно обољење говеда. Спада у групу трансмисивих
спонгиформних енцефалопатија (ТСЕ), познатих и као прионске болести. Узрочник
обољења је абнормални, патолошки прион протеин који се акумулира у можданом
ткиву, доводећи до карактеристичних хистопатолошких промена. Болест је откривена
осамдесетих година прошлог века, и као потпуно нова и непозната болест крава са
израженим неуролошким знацима, представљала је не само изазов, него и обавезу
научне и стручне јавности да утврди етиолошки агенс и покуша зауставити даље
ширење болести. Епизоотиолошким истраживањима утврђено је да се болест преноси
путем контаминиране хране, пре свега месно-коштаног брашна (МКБ) преживара које
садржи инфективни прион протеин. Европска Комисија прописује неколико регулатива
којима се забрањује употреба ових хранива у исхрани преживара, и тиме спречава
“рециклирање” БСЕ агенса у популацији преживара. Као једна од мера контроле и
превенције обољења врши се преглед хране за животиње, а класична (оптичка)
микроскопија је уз методу полимеразне ланчане реакције (PCR), званични метод у
Европској Унији и код нас за утврђивање прерађених протеина животињског порекла у
храни за животиње. Принцип методе своди се на детектовање састојака животињског
порекла у узорку хране који је припремљен на одговарајући начин а сама
идентификација делова анималног порекла обавља се у две фракције узорка. На основу
типичних, микроскопски уочљивих карактеристика посматрају се фрагменти костију,
мишићна влакна, длаке, перје, рожина, шкрге и други делови животињских ткива и тела.
Микроскопијом се лако уочава разлика између МКБ добијеног од копнених животиња
и рибљег брашна, а главни недостатак методе огледа се у немогућности утврђивања
врсте копнене животиње од које потичу састојци хране. Овом методом могу се
детектовати анимални протеини у врло малим количинама (< 0,1%), чинећи је веома
осетљивом, а предност методе огледа се свакако и због саме брзине извођења, и не
захтева скупу опрему и реагенсе. У нашој земљи, овај метод се успешно спроводи у две
акредитоване лабораторије (Научни институт за ветеринарство „Србије“ и Научни
институт за ветеринарство „Нови Сад“), а успешност се огледа и у сарадњи са
референтним ЕУ лабораторијама и упоредним међулабораторијским испитивањима.
AB  - Bovine spongiform encephalopathy (BSE) or "mad cow disease” is a progressive, fatal,
neurodegenerative disease of cattle. It belongs to the transmissible spongiform
encephalopathies (TSE), also known as prion diseases. The causative agent is an
abnormal, pathological prion protein that accumulates in brain tissue, leading to
characteristic histopathological changes. The disease was discovered in the 1980s, and as
a completely new and unknown disease of cows with pronounced neurological signs, was
not only a challenge, but also an obligation of the scientific and professional public to
determine the etiological agent and try to stop the further spread of the disease.
Epizootiological studies have established that the disease is transmitted through
contaminated feed, primarily meat and bone meal (MBM) of ruminants containing
infectious prion protein. The European Commission has issued several regulations
prohibiting the use of these nutrients in the ruminant diet, thereby preventing the
"recycling" of BSE agents in the ruminant population. The officially accepted methods by
the European Union for detection of presence of animal proteins in feed are classical light
microscopy and PCR, as one of the control measures in prevention and control of disease.
The principle of the method is to detect the components of animal origin in a feed sample
that has been properly prepared. The identification of the components of animal origin is
carried out in two fractions of the sample. Bone, muscle fibers, hair, feathers, horns, gills
and other parts of animal tissues can be observed on the basis of typical, microscopically
characteristics. Microscopy can easily discern the difference between MBM obtained
from terrestrial animals and fishmeal, and the main disadvantage of the method is the
inability to determine the species of terrestrial animal from which the food components
originate. Animal proteins could be detected in very small amounts (<0.1%) by this
method making it very sensitive, and the advantage of the method is certainly due to its
speed of execution, and does not require expensive equipment and reagents. In our
country, this method is successfully implemented in two accredited laboratories
(“Scientific Veterinary Institute of Serbia” and Scientific Veterinary Institute “Novi
Sad”), and the success is reflected in cooperation with EU reference laboratories and
comparative inter-laboratory testing.
PB  - Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze
C3  - XXII/XXIII Simpozijum epizootiologa i epidemiologa (XXII/XXIII Epizootiološki dani), on-line, Beograd, 26 - 28. april 2021
T1  - Kontrola hrane za životinje klasičnom mikroskopijom - primena metode u prevenciji bovine spongiformne encefalopatije
T1  - Control of feed by classical microscopy - appliction of the method in the prevention of bovine spongiform encephalopathy
SP  - 156
EP  - 157
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3747
ER  - 

@conference{
author = "Đurđević, Biljana and Samojlović, Milena and Lazić, Gospava and Nešić, Ksenija and Vučićević, Ivana and Polaček, Vladimir",
year = "2021",
abstract = "Бовина спонгиформна енцефалопатија (БСЕ) или болест “лудих крава” је прогресивно,
фатално, неуродегенеративно обољење говеда. Спада у групу трансмисивих
спонгиформних енцефалопатија (ТСЕ), познатих и као прионске болести. Узрочник
обољења је абнормални, патолошки прион протеин који се акумулира у можданом
ткиву, доводећи до карактеристичних хистопатолошких промена. Болест је откривена
осамдесетих година прошлог века, и као потпуно нова и непозната болест крава са
израженим неуролошким знацима, представљала је не само изазов, него и обавезу
научне и стручне јавности да утврди етиолошки агенс и покуша зауставити даље
ширење болести. Епизоотиолошким истраживањима утврђено је да се болест преноси
путем контаминиране хране, пре свега месно-коштаног брашна (МКБ) преживара које
садржи инфективни прион протеин. Европска Комисија прописује неколико регулатива
којима се забрањује употреба ових хранива у исхрани преживара, и тиме спречава
“рециклирање” БСЕ агенса у популацији преживара. Као једна од мера контроле и
превенције обољења врши се преглед хране за животиње, а класична (оптичка)
микроскопија је уз методу полимеразне ланчане реакције (PCR), званични метод у
Европској Унији и код нас за утврђивање прерађених протеина животињског порекла у
храни за животиње. Принцип методе своди се на детектовање састојака животињског
порекла у узорку хране који је припремљен на одговарајући начин а сама
идентификација делова анималног порекла обавља се у две фракције узорка. На основу
типичних, микроскопски уочљивих карактеристика посматрају се фрагменти костију,
мишићна влакна, длаке, перје, рожина, шкрге и други делови животињских ткива и тела.
Микроскопијом се лако уочава разлика између МКБ добијеног од копнених животиња
и рибљег брашна, а главни недостатак методе огледа се у немогућности утврђивања
врсте копнене животиње од које потичу састојци хране. Овом методом могу се
детектовати анимални протеини у врло малим количинама (< 0,1%), чинећи је веома
осетљивом, а предност методе огледа се свакако и због саме брзине извођења, и не
захтева скупу опрему и реагенсе. У нашој земљи, овај метод се успешно спроводи у две
акредитоване лабораторије (Научни институт за ветеринарство „Србије“ и Научни
институт за ветеринарство „Нови Сад“), а успешност се огледа и у сарадњи са
референтним ЕУ лабораторијама и упоредним међулабораторијским испитивањима., Bovine spongiform encephalopathy (BSE) or "mad cow disease” is a progressive, fatal,
neurodegenerative disease of cattle. It belongs to the transmissible spongiform
encephalopathies (TSE), also known as prion diseases. The causative agent is an
abnormal, pathological prion protein that accumulates in brain tissue, leading to
characteristic histopathological changes. The disease was discovered in the 1980s, and as
a completely new and unknown disease of cows with pronounced neurological signs, was
not only a challenge, but also an obligation of the scientific and professional public to
determine the etiological agent and try to stop the further spread of the disease.
Epizootiological studies have established that the disease is transmitted through
contaminated feed, primarily meat and bone meal (MBM) of ruminants containing
infectious prion protein. The European Commission has issued several regulations
prohibiting the use of these nutrients in the ruminant diet, thereby preventing the
"recycling" of BSE agents in the ruminant population. The officially accepted methods by
the European Union for detection of presence of animal proteins in feed are classical light
microscopy and PCR, as one of the control measures in prevention and control of disease.
The principle of the method is to detect the components of animal origin in a feed sample
that has been properly prepared. The identification of the components of animal origin is
carried out in two fractions of the sample. Bone, muscle fibers, hair, feathers, horns, gills
and other parts of animal tissues can be observed on the basis of typical, microscopically
characteristics. Microscopy can easily discern the difference between MBM obtained
from terrestrial animals and fishmeal, and the main disadvantage of the method is the
inability to determine the species of terrestrial animal from which the food components
originate. Animal proteins could be detected in very small amounts (<0.1%) by this
method making it very sensitive, and the advantage of the method is certainly due to its
speed of execution, and does not require expensive equipment and reagents. In our
country, this method is successfully implemented in two accredited laboratories
(“Scientific Veterinary Institute of Serbia” and Scientific Veterinary Institute “Novi
Sad”), and the success is reflected in cooperation with EU reference laboratories and
comparative inter-laboratory testing.",
publisher = "Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze",
journal = "XXII/XXIII Simpozijum epizootiologa i epidemiologa (XXII/XXIII Epizootiološki dani), on-line, Beograd, 26 - 28. april 2021",
title = "Kontrola hrane za životinje klasičnom mikroskopijom - primena metode u prevenciji bovine spongiformne encefalopatije, Control of feed by classical microscopy - appliction of the method in the prevention of bovine spongiform encephalopathy",
pages = "156-157",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3747"
}

Đurđević, B., Samojlović, M., Lazić, G., Nešić, K., Vučićević, I.,& Polaček, V.. (2021). Kontrola hrane za životinje klasičnom mikroskopijom - primena metode u prevenciji bovine spongiformne encefalopatije. in XXII/XXIII Simpozijum epizootiologa i epidemiologa (XXII/XXIII Epizootiološki dani), on-line, Beograd, 26 - 28. april 2021
Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze., 156-157.
https://hdl.handle.net/21.15107/rcub_veterinar_3747

Đurđević B, Samojlović M, Lazić G, Nešić K, Vučićević I, Polaček V. Kontrola hrane za životinje klasičnom mikroskopijom - primena metode u prevenciji bovine spongiformne encefalopatije. in XXII/XXIII Simpozijum epizootiologa i epidemiologa (XXII/XXIII Epizootiološki dani), on-line, Beograd, 26 - 28. april 2021. 2021;:156-157.
https://hdl.handle.net/21.15107/rcub_veterinar_3747 .

Đurđević, Biljana, Samojlović, Milena, Lazić, Gospava, Nešić, Ksenija, Vučićević, Ivana, Polaček, Vladimir, "Kontrola hrane za životinje klasičnom mikroskopijom - primena metode u prevenciji bovine spongiformne encefalopatije" in XXII/XXIII Simpozijum epizootiologa i epidemiologa (XXII/XXIII Epizootiološki dani), on-line, Beograd, 26 - 28. april 2021 (2021):156-157,
https://hdl.handle.net/21.15107/rcub_veterinar_3747 .

TY  - CONF
AU  - Vučićević, Ivana
AU  - Đurđević, Biljana
AU  - Nešić, Slađan
AU  - Aleksić-Kovačević, Sanja
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3580
AB  - Трансмисивне спонгиформне енцефалопатије (ТСЕ) су фаталне
неуродегенеративне болести људи и различитих животињских врста узроковане
патолошким прион протеинима. Постоји неколико врста ТСЕ које се јављају код
животиња. Разликујемо овчију сврабеж, која је позната више од 300 година и
јавља се код оваца и коза; затим спонгиформну енцефалопатију говеда, као
једину прионску болест животиња која има зоонотски потенцијал; потом
спонгиформну енцефалопатију мачака, трансмисивну енцефалопатију нерчева
и хроничну слабост јелена која изазива забринутост због ширења међу
јеленском дивљачи. На основу епидемиологије и патогенезе, све врсте ТСЕ се
могу сврстати у две групе. Прву групу чине ТСЕ које се могу преносити
хоризонтално директно између животиња, које имају способност да се одрже у
популацији, при чему је у раној фази болести инфективни агенс присутан у
лимфним чворовима. Овој групи припадају овчија сврабеж и хронична слабост
јелена. Другу групу чине ТСЕ других животињских врста, за које је
карактеристичан орални пут инфекције, немогућност одржавања у популацији
домаћина и ограничено присуство приона у лимфатичном ткиву. Овчија
сврабеж и хронична слабост јелена се такође могу преносити и индиректно у
спољашњој средини. Забележено је вертикално преношење ТСЕ код оваца и
неких врста јеленске дивљачи. Постељица, млеко и колострум малих преживара
и јеленске дивљачи могу садржати патолошке прион протеине. Измет и телесне
течности оваца и јеленске дивљачи, као што су пљувачка, крв и урин такође
могу бити инфективни. Приони су пронађени у басту роговља јеленске
дивњачи, које се некад користи као састојак суплемената за људску исхрану.
Приони су доказани и у кожи хрчака којима је per os апликован прион протеин
узрочник овчије сврабежи. Имајући у виду да се овчија сврабеж и хронична
слабост јелена јављају код различитих животињских врста, врло је занимљиво
да ове две болести имају много заједничких карактеристика.
AB  - Transmissible spongiform encephalopathies (TSEs) are fatal protein-misfolding
neurodegenerative diseases of humans and different animal species. TSEs affecting
animals include scrapie, recognized for over 300 years in sheep and goats; bovine
spongiform encephalopathy (BSE), the only animal prion disease known to affect
humans; feline spongiform encephalopathy (FSE), transmissible mink
encephalopathy (TME) and chronic wasting disease (CWD) that is of considerable
concern within cervids. Based on epidemiology and pathogenesis, all these TSEs can
be classified into two groups. The first group comprises TSEs that can be transmitted
horizontally between animals, have the ability to sustain into the host population and
the presence of the agent in the lymph nodes in the early stage of the disease. To this
group belong Scrapie and CWD. The second group consists of TSEs of other animal
species, which are characterized by the oral route of infection, inability to sustain into
host populations and limited involvement of lymph nodes. Scrapie and CWD can be
also transmitted indirectly via the environment. Vertical transmission has been
reported in sheep and some cervid species. The placenta milk and colostrum of small
ruminants and cervids can contain pathologic prion proteins. Bodily secretions of
sheep and cervids, such as saliva, blood, urine and feces can be infectious too. Prions
were found in the antler velvet of cervids, which humans consume as a nutritional
supplement. In the skin of hamsters orally infected with scrapie, prions were also
observed. Bearing in mind that Scrapie and CWD occur in different species, it is very
interesting that these two diseases have many features in common.
PB  - Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze
C3  - XXII / XXIII Simpozijum epizootiologa i epidemiologa / XXII / XXIII Epizootiološki dani, Beograd, 26 - 28. april, 2021
T1  - Zajedničke osobine ovčije svrabeži i hronične slabosti jelena
T1  - Common features of scrapie and chronic wasting desease
SP  - 136
EP  - 137
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3580
ER  - 

@conference{
author = "Vučićević, Ivana and Đurđević, Biljana and Nešić, Slađan and Aleksić-Kovačević, Sanja",
year = "2021",
abstract = "Трансмисивне спонгиформне енцефалопатије (ТСЕ) су фаталне
неуродегенеративне болести људи и различитих животињских врста узроковане
патолошким прион протеинима. Постоји неколико врста ТСЕ које се јављају код
животиња. Разликујемо овчију сврабеж, која је позната више од 300 година и
јавља се код оваца и коза; затим спонгиформну енцефалопатију говеда, као
једину прионску болест животиња која има зоонотски потенцијал; потом
спонгиформну енцефалопатију мачака, трансмисивну енцефалопатију нерчева
и хроничну слабост јелена која изазива забринутост због ширења међу
јеленском дивљачи. На основу епидемиологије и патогенезе, све врсте ТСЕ се
могу сврстати у две групе. Прву групу чине ТСЕ које се могу преносити
хоризонтално директно између животиња, које имају способност да се одрже у
популацији, при чему је у раној фази болести инфективни агенс присутан у
лимфним чворовима. Овој групи припадају овчија сврабеж и хронична слабост
јелена. Другу групу чине ТСЕ других животињских врста, за које је
карактеристичан орални пут инфекције, немогућност одржавања у популацији
домаћина и ограничено присуство приона у лимфатичном ткиву. Овчија
сврабеж и хронична слабост јелена се такође могу преносити и индиректно у
спољашњој средини. Забележено је вертикално преношење ТСЕ код оваца и
неких врста јеленске дивљачи. Постељица, млеко и колострум малих преживара
и јеленске дивљачи могу садржати патолошке прион протеине. Измет и телесне
течности оваца и јеленске дивљачи, као што су пљувачка, крв и урин такође
могу бити инфективни. Приони су пронађени у басту роговља јеленске
дивњачи, које се некад користи као састојак суплемената за људску исхрану.
Приони су доказани и у кожи хрчака којима је per os апликован прион протеин
узрочник овчије сврабежи. Имајући у виду да се овчија сврабеж и хронична
слабост јелена јављају код различитих животињских врста, врло је занимљиво
да ове две болести имају много заједничких карактеристика., Transmissible spongiform encephalopathies (TSEs) are fatal protein-misfolding
neurodegenerative diseases of humans and different animal species. TSEs affecting
animals include scrapie, recognized for over 300 years in sheep and goats; bovine
spongiform encephalopathy (BSE), the only animal prion disease known to affect
humans; feline spongiform encephalopathy (FSE), transmissible mink
encephalopathy (TME) and chronic wasting disease (CWD) that is of considerable
concern within cervids. Based on epidemiology and pathogenesis, all these TSEs can
be classified into two groups. The first group comprises TSEs that can be transmitted
horizontally between animals, have the ability to sustain into the host population and
the presence of the agent in the lymph nodes in the early stage of the disease. To this
group belong Scrapie and CWD. The second group consists of TSEs of other animal
species, which are characterized by the oral route of infection, inability to sustain into
host populations and limited involvement of lymph nodes. Scrapie and CWD can be
also transmitted indirectly via the environment. Vertical transmission has been
reported in sheep and some cervid species. The placenta milk and colostrum of small
ruminants and cervids can contain pathologic prion proteins. Bodily secretions of
sheep and cervids, such as saliva, blood, urine and feces can be infectious too. Prions
were found in the antler velvet of cervids, which humans consume as a nutritional
supplement. In the skin of hamsters orally infected with scrapie, prions were also
observed. Bearing in mind that Scrapie and CWD occur in different species, it is very
interesting that these two diseases have many features in common.",
publisher = "Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze",
journal = "XXII / XXIII Simpozijum epizootiologa i epidemiologa / XXII / XXIII Epizootiološki dani, Beograd, 26 - 28. april, 2021",
title = "Zajedničke osobine ovčije svrabeži i hronične slabosti jelena, Common features of scrapie and chronic wasting desease",
pages = "136-137",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3580"
}

Vučićević, I., Đurđević, B., Nešić, S.,& Aleksić-Kovačević, S.. (2021). Zajedničke osobine ovčije svrabeži i hronične slabosti jelena. in XXII / XXIII Simpozijum epizootiologa i epidemiologa / XXII / XXIII Epizootiološki dani, Beograd, 26 - 28. april, 2021
Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze., 136-137.
https://hdl.handle.net/21.15107/rcub_veterinar_3580

Vučićević I, Đurđević B, Nešić S, Aleksić-Kovačević S. Zajedničke osobine ovčije svrabeži i hronične slabosti jelena. in XXII / XXIII Simpozijum epizootiologa i epidemiologa / XXII / XXIII Epizootiološki dani, Beograd, 26 - 28. april, 2021. 2021;:136-137.
https://hdl.handle.net/21.15107/rcub_veterinar_3580 .

Vučićević, Ivana, Đurđević, Biljana, Nešić, Slađan, Aleksić-Kovačević, Sanja, "Zajedničke osobine ovčije svrabeži i hronične slabosti jelena" in XXII / XXIII Simpozijum epizootiologa i epidemiologa / XXII / XXIII Epizootiološki dani, Beograd, 26 - 28. april, 2021 (2021):136-137,
https://hdl.handle.net/21.15107/rcub_veterinar_3580 .

TY  - CONF
AU  - Vučićević, Ivana
AU  - Đurđević, Biljana
AU  - Nešić, Slađan
AU  - Aleksić-Kovačević, Sanja
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2005
AB  - Usled jesenje migracije ptica ka teritoriji Evrope, postoji kontinui- rani rizik od pojave novih slučajeva visoko patogene avijarne influence (HPAI), kako kod divljih, tako i kod domaćih ptica. Tokom jeseni 2020. godine dijagnostikovano je preko 300 slučajeva HPAI-A(H5) kod divljih ptica i živine u zemljama EU. Broj žarišta HPAI se drastično povećava i dok je proteklih godina glavni uzročnik epidemije bio A(H5N8) podtip virusa, sada je zastupljeno nekoliko podtipova: A(H5N8), A(H5N5) i A(H5N1). Kod infekcije HPAI virusima, tip promena koje se sreću na obdukciji, kao i njihova lokalizacija mogu se donekle razlikovati u zavi- snosti od podtipa virusa i vrste ptica. Promene se javljaju u vidu nekro- za, edema i hemoragija, a najčešće su locirane na plućima, srcu, jetri, slezini, bubrezima, mozgu i koži. Obdukcija ptica sumnjivih na HPAI se obavlja u prostorijama sa biosigurnosnim nivoom 2, noseći, pored standardne zaštitne opreme još i maske N95. Obdukcija se vrši prema standardnim protokolima za obdukciju ptica koji uključuju spoljašnji i unutrašnji pregled leša. Prilikom obdukcije, potrebno je uzeti uzorke tkiva promenjenih organa i ona, koja su namenjena za patohistološ- ku analizu, fiksirati u 10% puferizovanom formalinu najmanje 48 ča- sova. Uzorci ne smeju biti deblji od 0,5 cm, kako bi fiksativ magao da prodre kroz tkivo. Obdukovane leševe ptica treba neškodljivo ukloniti, kao materijal kategorije 1.
PB  - Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - XLII seminar za inovacije znanja veterinara, Beograd, 18 - 19. februar, 2021
T1  - Patomorfološke promene kod avijarne influence domaćih i divljih ptica – tehnike obdukcije ptica; pravilno uzorkovanje i slanje materijala za dijagnostiku
SP  - 149
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2005
ER  - 

@conference{
author = "Vučićević, Ivana and Đurđević, Biljana and Nešić, Slađan and Aleksić-Kovačević, Sanja",
year = "2021",
abstract = "Usled jesenje migracije ptica ka teritoriji Evrope, postoji kontinui- rani rizik od pojave novih slučajeva visoko patogene avijarne influence (HPAI), kako kod divljih, tako i kod domaćih ptica. Tokom jeseni 2020. godine dijagnostikovano je preko 300 slučajeva HPAI-A(H5) kod divljih ptica i živine u zemljama EU. Broj žarišta HPAI se drastično povećava i dok je proteklih godina glavni uzročnik epidemije bio A(H5N8) podtip virusa, sada je zastupljeno nekoliko podtipova: A(H5N8), A(H5N5) i A(H5N1). Kod infekcije HPAI virusima, tip promena koje se sreću na obdukciji, kao i njihova lokalizacija mogu se donekle razlikovati u zavi- snosti od podtipa virusa i vrste ptica. Promene se javljaju u vidu nekro- za, edema i hemoragija, a najčešće su locirane na plućima, srcu, jetri, slezini, bubrezima, mozgu i koži. Obdukcija ptica sumnjivih na HPAI se obavlja u prostorijama sa biosigurnosnim nivoom 2, noseći, pored standardne zaštitne opreme još i maske N95. Obdukcija se vrši prema standardnim protokolima za obdukciju ptica koji uključuju spoljašnji i unutrašnji pregled leša. Prilikom obdukcije, potrebno je uzeti uzorke tkiva promenjenih organa i ona, koja su namenjena za patohistološ- ku analizu, fiksirati u 10% puferizovanom formalinu najmanje 48 ča- sova. Uzorci ne smeju biti deblji od 0,5 cm, kako bi fiksativ magao da prodre kroz tkivo. Obdukovane leševe ptica treba neškodljivo ukloniti, kao materijal kategorije 1.",
publisher = "Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "XLII seminar za inovacije znanja veterinara, Beograd, 18 - 19. februar, 2021",
title = "Patomorfološke promene kod avijarne influence domaćih i divljih ptica – tehnike obdukcije ptica; pravilno uzorkovanje i slanje materijala za dijagnostiku",
pages = "149-158",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2005"
}

Vučićević, I., Đurđević, B., Nešić, S.,& Aleksić-Kovačević, S.. (2021). Patomorfološke promene kod avijarne influence domaćih i divljih ptica – tehnike obdukcije ptica; pravilno uzorkovanje i slanje materijala za dijagnostiku. in XLII seminar za inovacije znanja veterinara, Beograd, 18 - 19. februar, 2021
Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 149-158.
https://hdl.handle.net/21.15107/rcub_veterinar_2005

Vučićević I, Đurđević B, Nešić S, Aleksić-Kovačević S. Patomorfološke promene kod avijarne influence domaćih i divljih ptica – tehnike obdukcije ptica; pravilno uzorkovanje i slanje materijala za dijagnostiku. in XLII seminar za inovacije znanja veterinara, Beograd, 18 - 19. februar, 2021. 2021;:149-158.
https://hdl.handle.net/21.15107/rcub_veterinar_2005 .

Vučićević, Ivana, Đurđević, Biljana, Nešić, Slađan, Aleksić-Kovačević, Sanja, "Patomorfološke promene kod avijarne influence domaćih i divljih ptica – tehnike obdukcije ptica; pravilno uzorkovanje i slanje materijala za dijagnostiku" in XLII seminar za inovacije znanja veterinara, Beograd, 18 - 19. februar, 2021 (2021):149-158,
https://hdl.handle.net/21.15107/rcub_veterinar_2005 .

TY  - JOUR
AU  - Nešić, Slađan
AU  - Jelisić, Stefan
AU  - Aleksić-Kovačević, Sanja
AU  - Aničić, Milan
AU  - Vučićević, Ivana
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2191
AB  - Scrapie is an infectious neurodegenerative disease affecting the central nervous system of sheep and goats that belongs to transmissible spongiform encephalopathies. The disease is caused by the accumulation of proteinase-resistant isoform of the prion protein. The sheep predisposition to scrapie is associated with polymorphisms of the PrP gene. Genetic susceptibility to scrapie is mainly related to codons 136, 154, and 171. ARR sheep are strongly scrapie resistant and VRQ genotype is the most susceptible. Many countries have scrapie eradication programs based on using rams with resistant genotype. The eradication program has not yet been implemented in the Republic of Serbia. To examine the genetic makeup of sheep in Serbia related to scrapie, we optimized TaqMan probes of real-time polymerase chain reaction (qPCR) technique for three codons. Blood samples from 100 sheep were analyzed by qPCR and the majority of the examined sheep were AA homozygous for the 136 codon. For codon 154 the most frequent genotype was RR and for codon 171 the most frequent genotype was QQ.
AB  - Ovčija svrabež je infektivno neurodegenerativno oboljenje iz grupe transmisivnih encefalopatija koje uzrokuje promene u moždanom tkivu ovaca i koza. Oboljenje je uzrokovano akumulacijom proteinaza-rezistentne izoforme prion proteina. Osetljivost ovaca na ovo oboljenje uslovljena je polimorfi zmom PrP gena. Genetska otpornost na ovčiju svrabež prevashodno je uslovljena kodonima 136, 154 i 171. Najotpornije su ovce sa ARR genotipom, dok se ovce sa VRQ genotipom smatraju najosetljivijim. Mnoge zemlje su sprovele programe eradikacije ovčije svrabeži bazirane na korišćenju priplodnih ovnova koji imaju rezistentan genotip. Ovakav program još nije sproveden u Republici Srbiji. U cilju ispitivanja genetskog statusa ovaca u Srbiji u pogledu otpornosti na ovčiju svrabež, optimizovali smo TaqMan probu, kvantitativne lančane reakcije polimeraze (qPCR) tehnike za sva tri kodona. Ispitivanjem uzoroka krvi od 100 ovaca primenom RT-PCR ustanovljeno je da je većina ovaca AA homozigot za kodon 136. Za kodon 154 najčešći genotip je RR, a za kodon 171 genotip QQ.
T2  - Acta Veterinaria-Beograd
T1  - Scrapie resistance gene identification using optimized TaqMan test qPCR method in sheep on the territory of the Republic of Serbia
T1  - Identifikacija optimizovanom taqman probom qpcr metodom gena rezistencije na scrapie kod ovaca na teritoriji Republike Srbije
VL  - 71
IS  - 2
SP  - 189
EP  - 197
DO  - 10.2478/acve-2021-0016
ER  - 

@article{
author = "Nešić, Slađan and Jelisić, Stefan and Aleksić-Kovačević, Sanja and Aničić, Milan and Vučićević, Ivana",
year = "2021",
abstract = "Scrapie is an infectious neurodegenerative disease affecting the central nervous system of sheep and goats that belongs to transmissible spongiform encephalopathies. The disease is caused by the accumulation of proteinase-resistant isoform of the prion protein. The sheep predisposition to scrapie is associated with polymorphisms of the PrP gene. Genetic susceptibility to scrapie is mainly related to codons 136, 154, and 171. ARR sheep are strongly scrapie resistant and VRQ genotype is the most susceptible. Many countries have scrapie eradication programs based on using rams with resistant genotype. The eradication program has not yet been implemented in the Republic of Serbia. To examine the genetic makeup of sheep in Serbia related to scrapie, we optimized TaqMan probes of real-time polymerase chain reaction (qPCR) technique for three codons. Blood samples from 100 sheep were analyzed by qPCR and the majority of the examined sheep were AA homozygous for the 136 codon. For codon 154 the most frequent genotype was RR and for codon 171 the most frequent genotype was QQ., Ovčija svrabež je infektivno neurodegenerativno oboljenje iz grupe transmisivnih encefalopatija koje uzrokuje promene u moždanom tkivu ovaca i koza. Oboljenje je uzrokovano akumulacijom proteinaza-rezistentne izoforme prion proteina. Osetljivost ovaca na ovo oboljenje uslovljena je polimorfi zmom PrP gena. Genetska otpornost na ovčiju svrabež prevashodno je uslovljena kodonima 136, 154 i 171. Najotpornije su ovce sa ARR genotipom, dok se ovce sa VRQ genotipom smatraju najosetljivijim. Mnoge zemlje su sprovele programe eradikacije ovčije svrabeži bazirane na korišćenju priplodnih ovnova koji imaju rezistentan genotip. Ovakav program još nije sproveden u Republici Srbiji. U cilju ispitivanja genetskog statusa ovaca u Srbiji u pogledu otpornosti na ovčiju svrabež, optimizovali smo TaqMan probu, kvantitativne lančane reakcije polimeraze (qPCR) tehnike za sva tri kodona. Ispitivanjem uzoroka krvi od 100 ovaca primenom RT-PCR ustanovljeno je da je većina ovaca AA homozigot za kodon 136. Za kodon 154 najčešći genotip je RR, a za kodon 171 genotip QQ.",
journal = "Acta Veterinaria-Beograd",
title = "Scrapie resistance gene identification using optimized TaqMan test qPCR method in sheep on the territory of the Republic of Serbia, Identifikacija optimizovanom taqman probom qpcr metodom gena rezistencije na scrapie kod ovaca na teritoriji Republike Srbije",
volume = "71",
number = "2",
pages = "189-197",
doi = "10.2478/acve-2021-0016"
}

Nešić, S., Jelisić, S., Aleksić-Kovačević, S., Aničić, M.,& Vučićević, I.. (2021). Scrapie resistance gene identification using optimized TaqMan test qPCR method in sheep on the territory of the Republic of Serbia. in Acta Veterinaria-Beograd, 71(2), 189-197.
https://doi.org/10.2478/acve-2021-0016

Nešić S, Jelisić S, Aleksić-Kovačević S, Aničić M, Vučićević I. Scrapie resistance gene identification using optimized TaqMan test qPCR method in sheep on the territory of the Republic of Serbia. in Acta Veterinaria-Beograd. 2021;71(2):189-197.
doi:10.2478/acve-2021-0016 .

Nešić, Slađan, Jelisić, Stefan, Aleksić-Kovačević, Sanja, Aničić, Milan, Vučićević, Ivana, "Scrapie resistance gene identification using optimized TaqMan test qPCR method in sheep on the territory of the Republic of Serbia" in Acta Veterinaria-Beograd, 71, no. 2 (2021):189-197,
https://doi.org/10.2478/acve-2021-0016 . .

TY  - JOUR
AU  - Vučićević, Miloš
AU  - Vučićević, Ivana
AU  - Došenović, Milan
AU  - Ristanić, Marko
AU  - Aleksić, Nevenka
AU  - Resanović, Radmila
AU  - Stanimirović, Zoran
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2038
AB  - Eight lovebirds of both sexes and different age were admitted showing alterations in
behaviour and apathy. During the initial examination delamination of the beak was
noted in all birds and discrete areas of alopecia in three of eight birds. Based on clinical
experience, molecular diagnostic on PBFD, sequencing of obtained amplicons, and
histopathological examination were performed. All birds tested positive on the presence
of PBFD virus, despite the fact they did not exhibit expected clinical signs for PBFD.
Sequencing results showed 100% match with sequences previously isolated from parrots
with PBFD exhibiting classical PBFD manifestation. Histopathological examination
showed similar findings as in previously described cases of PBFD in parrots. Other
studies on psittacine birds correlate clinical manifestations and nucleotide variations
with geographic localization. Our results indicate that the clinical manifestation of the
disease is more dependent on bird species than on the genetic variation of the virus or
the geographical distribution.
AB  - Osam rozenkolisa oba pola različite starosti su primljeni na pregled zbog uočenih promena u ponašanju i apatije. Tokom inicijalnog pregleda kod svih ptica je uočena delaminacija kljuna, a kod tri jedinke bila su prisutna i diskretna polja alopecije. Na osnovu
kliničkog iskustva postavljena je sumnja na oboljenje bolest kljuna i perja te je urađena
molekularna dijagnostika na pristutvo virusa bolesti kljuna i perja, sekvencioniranje
dobijenih amplifikata i patohistološko ispitivanje. Rezultati ispitivanja su potvrdili prisustvo virusa u uzorcima od svih ispitivanih jedinki, poklapanje nukleotidnih sekvecni
od 100% sa uzorcima od drugih ptica sa drugačijom kliničkom slikom, a patohistološke promene su identične onima opisanim kod bolesti kljuna i perja. Studije brojnih
autora povezivale su kliničku manifestaciju bolesti sa nukleotidnim varijacijama ili geografskom lokalizacijom. Međutim, opisani rezultati bi mogli da ukazuju da je kliničko
ispoljavanje bolesti više zavisno od vrste domaćina nego od genotipa virusa koji bolest
izaziva i od teritorije na kojoj se bolest ispoljava.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Is PBFD simptomatology species specific rather then strain specific? – a case of 8 lovebirds
T1  - Da li je simptomatologija PBFD više zavisna od vrste domaćina nego od soja virusa? – Slučaj 8 rozenkolisa
VL  - 70
IS  - 3
SP  - 386
EP  - 394
DO  - 10.2478/acve-2020-0029
ER  - 

@article{
author = "Vučićević, Miloš and Vučićević, Ivana and Došenović, Milan and Ristanić, Marko and Aleksić, Nevenka and Resanović, Radmila and Stanimirović, Zoran",
year = "2020",
abstract = "Eight lovebirds of both sexes and different age were admitted showing alterations in
behaviour and apathy. During the initial examination delamination of the beak was
noted in all birds and discrete areas of alopecia in three of eight birds. Based on clinical
experience, molecular diagnostic on PBFD, sequencing of obtained amplicons, and
histopathological examination were performed. All birds tested positive on the presence
of PBFD virus, despite the fact they did not exhibit expected clinical signs for PBFD.
Sequencing results showed 100% match with sequences previously isolated from parrots
with PBFD exhibiting classical PBFD manifestation. Histopathological examination
showed similar findings as in previously described cases of PBFD in parrots. Other
studies on psittacine birds correlate clinical manifestations and nucleotide variations
with geographic localization. Our results indicate that the clinical manifestation of the
disease is more dependent on bird species than on the genetic variation of the virus or
the geographical distribution., Osam rozenkolisa oba pola različite starosti su primljeni na pregled zbog uočenih promena u ponašanju i apatije. Tokom inicijalnog pregleda kod svih ptica je uočena delaminacija kljuna, a kod tri jedinke bila su prisutna i diskretna polja alopecije. Na osnovu
kliničkog iskustva postavljena je sumnja na oboljenje bolest kljuna i perja te je urađena
molekularna dijagnostika na pristutvo virusa bolesti kljuna i perja, sekvencioniranje
dobijenih amplifikata i patohistološko ispitivanje. Rezultati ispitivanja su potvrdili prisustvo virusa u uzorcima od svih ispitivanih jedinki, poklapanje nukleotidnih sekvecni
od 100% sa uzorcima od drugih ptica sa drugačijom kliničkom slikom, a patohistološke promene su identične onima opisanim kod bolesti kljuna i perja. Studije brojnih
autora povezivale su kliničku manifestaciju bolesti sa nukleotidnim varijacijama ili geografskom lokalizacijom. Međutim, opisani rezultati bi mogli da ukazuju da je kliničko
ispoljavanje bolesti više zavisno od vrste domaćina nego od genotipa virusa koji bolest
izaziva i od teritorije na kojoj se bolest ispoljava.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Is PBFD simptomatology species specific rather then strain specific? – a case of 8 lovebirds, Da li je simptomatologija PBFD više zavisna od vrste domaćina nego od soja virusa? – Slučaj 8 rozenkolisa",
volume = "70",
number = "3",
pages = "386-394",
doi = "10.2478/acve-2020-0029"
}

Vučićević, M., Vučićević, I., Došenović, M., Ristanić, M., Aleksić, N., Resanović, R.,& Stanimirović, Z.. (2020). Is PBFD simptomatology species specific rather then strain specific? – a case of 8 lovebirds. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(3), 386-394.
https://doi.org/10.2478/acve-2020-0029

Vučićević M, Vučićević I, Došenović M, Ristanić M, Aleksić N, Resanović R, Stanimirović Z. Is PBFD simptomatology species specific rather then strain specific? – a case of 8 lovebirds. in Acta Veterinaria-Beograd. 2020;70(3):386-394.
doi:10.2478/acve-2020-0029 .

Vučićević, Miloš, Vučićević, Ivana, Došenović, Milan, Ristanić, Marko, Aleksić, Nevenka, Resanović, Radmila, Stanimirović, Zoran, "Is PBFD simptomatology species specific rather then strain specific? – a case of 8 lovebirds" in Acta Veterinaria-Beograd, 70, no. 3 (2020):386-394,
https://doi.org/10.2478/acve-2020-0029 . .

TY  - JOUR
AU  - Nešić, Slađan
AU  - Andrić, Nenad
AU  - Vučićević, Ivana
AU  - Marinković, Darko
AU  - Kukolj, Vladimir
AU  - Aničić, Milan
AU  - Aleksić-Kovačević, Sanja
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1876
PB  - Elsevier Sci Ltd, Oxford
T2  - Journal of Comparative Pathology
T1  - Characteristic Histopathological Features of Necrotizing Encephalitis and Syringomyelia in the Central Nervous System of a Yorkshire Terrier
VL  - 174
SP  - 168
DO  - 10.1016/j.jcpa.2019.10.091
ER  - 

@article{
author = "Nešić, Slađan and Andrić, Nenad and Vučićević, Ivana and Marinković, Darko and Kukolj, Vladimir and Aničić, Milan and Aleksić-Kovačević, Sanja",
year = "2020",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Journal of Comparative Pathology",
title = "Characteristic Histopathological Features of Necrotizing Encephalitis and Syringomyelia in the Central Nervous System of a Yorkshire Terrier",
volume = "174",
pages = "168",
doi = "10.1016/j.jcpa.2019.10.091"
}

Nešić, S., Andrić, N., Vučićević, I., Marinković, D., Kukolj, V., Aničić, M.,& Aleksić-Kovačević, S.. (2020). Characteristic Histopathological Features of Necrotizing Encephalitis and Syringomyelia in the Central Nervous System of a Yorkshire Terrier. in Journal of Comparative Pathology
Elsevier Sci Ltd, Oxford., 174, 168.
https://doi.org/10.1016/j.jcpa.2019.10.091

Nešić S, Andrić N, Vučićević I, Marinković D, Kukolj V, Aničić M, Aleksić-Kovačević S. Characteristic Histopathological Features of Necrotizing Encephalitis and Syringomyelia in the Central Nervous System of a Yorkshire Terrier. in Journal of Comparative Pathology. 2020;174:168.
doi:10.1016/j.jcpa.2019.10.091 .

Nešić, Slađan, Andrić, Nenad, Vučićević, Ivana, Marinković, Darko, Kukolj, Vladimir, Aničić, Milan, Aleksić-Kovačević, Sanja, "Characteristic Histopathological Features of Necrotizing Encephalitis and Syringomyelia in the Central Nervous System of a Yorkshire Terrier" in Journal of Comparative Pathology, 174 (2020):168,
https://doi.org/10.1016/j.jcpa.2019.10.091 . .

TY  - CONF
AU  - Vučićević, Ivana
AU  - Marinković, Darko
AU  - Kukolj, Vladimir
AU  - Nešić, Slađan
AU  - Aničić, Milan
AU  - Aleksić-Kovačević, Sanja
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2908
AB  - Transmisivne spongiformne encefalopatije (TSE) su neurodegenerativna oboljenja životinja i ljudi koja se karakterišu nakupljanjem izmenjenog oblika prionskog proteina (PrPres) u mozgu. Asimptomatski
period može trajati i nekoliko godina, ali je bolest uvek sa smrtnim ishodom. Monitoring TSE obuhvata ispitivanje prisustva PrPres kod goveda, a zatim i kod ovaca i koza, kod kojih uzrokuje oboljenje pod nazivom “ovčija svrabež”. U novije vreme se, u većini zemalja EU, naročita pažnja poklanja prisustvu PrPres kod jelenske divljači i pojavi hronične slabosti jelena. Spongiformna encefalopatija goveda i “ovčija
svrabež” se javljaju u klasičnoj i atipičnoj formi, pri čemu se smatra da
atipična forma nastaje spontano i da nije kontagiozna. Na osnovu OIE
podele, razlikuju se dve kategorije statusa u pogledu prisustva bovine
spongiformne encefalopatije (BSE). Od 2019. godine, Republika Srbija je stekla status zemlje sa zanemarljivim rizikom. Radi održavanja
ovog statusa zemlje, potrebno je od svih propisanih vrsta i kategorija životinja vršiti pravilno uzorkovanje i ispitivanje tkiva. Za analizu se
uzorkuje deo produžene moždine u nivou obex-a, odnosno ceo mozak kod klinički sumnjivih slučajeva. Uzorkovanje produžene moždine, bez otvaranja lobanje, obavlja se upotrebom instrumenta u obliku kašike sa oštrim ivicama. Greške prilikom uzorkovanja, pakovanja,
slanja i obeležavanja uzorkovanog materijala mogu ugroziti verodostojnost rezultata laboratorijske analize.
PB  - Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - XLI Seminar za inovacije znanja veterinara, Beograd, 2020
T1  - Uzorkovanje tkiva za dijagnostiku TSE u zemlji sa statusom zanemarljivog rizika
SP  - 77
EP  - 86
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2908
ER  - 

@conference{
author = "Vučićević, Ivana and Marinković, Darko and Kukolj, Vladimir and Nešić, Slađan and Aničić, Milan and Aleksić-Kovačević, Sanja",
year = "2020",
abstract = "Transmisivne spongiformne encefalopatije (TSE) su neurodegenerativna oboljenja životinja i ljudi koja se karakterišu nakupljanjem izmenjenog oblika prionskog proteina (PrPres) u mozgu. Asimptomatski
period može trajati i nekoliko godina, ali je bolest uvek sa smrtnim ishodom. Monitoring TSE obuhvata ispitivanje prisustva PrPres kod goveda, a zatim i kod ovaca i koza, kod kojih uzrokuje oboljenje pod nazivom “ovčija svrabež”. U novije vreme se, u većini zemalja EU, naročita pažnja poklanja prisustvu PrPres kod jelenske divljači i pojavi hronične slabosti jelena. Spongiformna encefalopatija goveda i “ovčija
svrabež” se javljaju u klasičnoj i atipičnoj formi, pri čemu se smatra da
atipična forma nastaje spontano i da nije kontagiozna. Na osnovu OIE
podele, razlikuju se dve kategorije statusa u pogledu prisustva bovine
spongiformne encefalopatije (BSE). Od 2019. godine, Republika Srbija je stekla status zemlje sa zanemarljivim rizikom. Radi održavanja
ovog statusa zemlje, potrebno je od svih propisanih vrsta i kategorija životinja vršiti pravilno uzorkovanje i ispitivanje tkiva. Za analizu se
uzorkuje deo produžene moždine u nivou obex-a, odnosno ceo mozak kod klinički sumnjivih slučajeva. Uzorkovanje produžene moždine, bez otvaranja lobanje, obavlja se upotrebom instrumenta u obliku kašike sa oštrim ivicama. Greške prilikom uzorkovanja, pakovanja,
slanja i obeležavanja uzorkovanog materijala mogu ugroziti verodostojnost rezultata laboratorijske analize.",
publisher = "Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "XLI Seminar za inovacije znanja veterinara, Beograd, 2020",
title = "Uzorkovanje tkiva za dijagnostiku TSE u zemlji sa statusom zanemarljivog rizika",
pages = "77-86",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2908"
}

Vučićević, I., Marinković, D., Kukolj, V., Nešić, S., Aničić, M.,& Aleksić-Kovačević, S.. (2020). Uzorkovanje tkiva za dijagnostiku TSE u zemlji sa statusom zanemarljivog rizika. in XLI Seminar za inovacije znanja veterinara, Beograd, 2020
Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 77-86.
https://hdl.handle.net/21.15107/rcub_veterinar_2908

Vučićević I, Marinković D, Kukolj V, Nešić S, Aničić M, Aleksić-Kovačević S. Uzorkovanje tkiva za dijagnostiku TSE u zemlji sa statusom zanemarljivog rizika. in XLI Seminar za inovacije znanja veterinara, Beograd, 2020. 2020;:77-86.
https://hdl.handle.net/21.15107/rcub_veterinar_2908 .

Vučićević, Ivana, Marinković, Darko, Kukolj, Vladimir, Nešić, Slađan, Aničić, Milan, Aleksić-Kovačević, Sanja, "Uzorkovanje tkiva za dijagnostiku TSE u zemlji sa statusom zanemarljivog rizika" in XLI Seminar za inovacije znanja veterinara, Beograd, 2020 (2020):77-86,
https://hdl.handle.net/21.15107/rcub_veterinar_2908 .

TY  - CONF
AU  - Vučićević, Ivana
AU  - Prodanov-Radulović, Jasna
AU  - Polaček, Vladimir
AU  - Aleksić-Kovačević, Sanja
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3581
AB  - Swine respiratory diseases have been significantly put under control in the
Republic of Serbia during the past decade, due to the implementation of
appropriate prophylactic measures and diagnosis. Despite the reduced incidence
of pneumonia on swine farms, respiratory diseases are still one of the most
important health problem in modern pig breeding. The most common causes of
bacterial pneumonia among the examined material from pig farms in Vojvodina
(Serbia) are Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella
bronchiseptica and Haemophilus parasuis. These pathogens are most commonly
diagnosed in feral pigs. Bacterial pneumonias are usually secondary infection
manifest as exudative pneumonias that can be purulent (Pasteurella multocida,
Mycoplasma hyopneumoniae), or apostematous (Bordatella bronchiseptica,
Actinomyces pyogenesu) or fibrino-purulent (Haemophilus parasuis) and fibrinohemorrhagic bronchopneumonia (Actynobacillus pleuropneumoniae), mainly
accompanied by fibrinous pleurisy. Purulent bronchopneumonias are
characterized by the accumulation of purulent exudate in the airways and have a
lobular distribution. Fibrinous bronchopneumonias are characterized by the
accumulation of fibrin in the bronchoalveolar spaces, with changes affecting
entire lobes. Bacteria that cause fibrinous bronchopneumonias damage blood
vessels and cause changes that can be classified into stages of splenization, red
hepatization, gray hepatization and resolution. Viral pneumonias are more often
diagnosed in domestic swine, primarily caused by swine reproductive and
respiratory virus, influenza virus, circovirus type 2, as well as Aujeszky's disease
virus. Viral pneumonias in swine are acute interstitial pneumonias in which the
exudative and proliferative phases can be distinguished. During the acute phase,
"fetalization of the lungs" can occur, which is characterized by a reduced alveolar
spaces and thickened alveolar walls.
The lungs affected by interstitial pneumonia are rubbery and a rib imprint can be
seen on the surface. In addition to bacterial and viral, verminous pneumonias are common in swine. Although the morphological characteristics of bacterial and
viral pneumonias can be clearly distinguished, it is important to emphasize that
the pathogenesis of swine respiratory diseases often involves several different
agents and that the changes depend on the dominant etiological agent.
PB  - Banja Luka : Veterinarska komora Republike Srpske
C3  - 25. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), naučni skup sa međunarodnim učešćem, Teslić,  2020
T1  - Karakter patomorfoloških promena najčešćih pneumonija kod svinja na teritoriji Republike Srbije
T1  - Character of pathomorphological changes of the most common pneumonia in pigs in the Republic of Serbia
SP  - 202
EP  - 205
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3581
ER  - 

@conference{
author = "Vučićević, Ivana and Prodanov-Radulović, Jasna and Polaček, Vladimir and Aleksić-Kovačević, Sanja",
year = "2020",
abstract = "Swine respiratory diseases have been significantly put under control in the
Republic of Serbia during the past decade, due to the implementation of
appropriate prophylactic measures and diagnosis. Despite the reduced incidence
of pneumonia on swine farms, respiratory diseases are still one of the most
important health problem in modern pig breeding. The most common causes of
bacterial pneumonia among the examined material from pig farms in Vojvodina
(Serbia) are Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella
bronchiseptica and Haemophilus parasuis. These pathogens are most commonly
diagnosed in feral pigs. Bacterial pneumonias are usually secondary infection
manifest as exudative pneumonias that can be purulent (Pasteurella multocida,
Mycoplasma hyopneumoniae), or apostematous (Bordatella bronchiseptica,
Actinomyces pyogenesu) or fibrino-purulent (Haemophilus parasuis) and fibrinohemorrhagic bronchopneumonia (Actynobacillus pleuropneumoniae), mainly
accompanied by fibrinous pleurisy. Purulent bronchopneumonias are
characterized by the accumulation of purulent exudate in the airways and have a
lobular distribution. Fibrinous bronchopneumonias are characterized by the
accumulation of fibrin in the bronchoalveolar spaces, with changes affecting
entire lobes. Bacteria that cause fibrinous bronchopneumonias damage blood
vessels and cause changes that can be classified into stages of splenization, red
hepatization, gray hepatization and resolution. Viral pneumonias are more often
diagnosed in domestic swine, primarily caused by swine reproductive and
respiratory virus, influenza virus, circovirus type 2, as well as Aujeszky's disease
virus. Viral pneumonias in swine are acute interstitial pneumonias in which the
exudative and proliferative phases can be distinguished. During the acute phase,
"fetalization of the lungs" can occur, which is characterized by a reduced alveolar
spaces and thickened alveolar walls.
The lungs affected by interstitial pneumonia are rubbery and a rib imprint can be
seen on the surface. In addition to bacterial and viral, verminous pneumonias are common in swine. Although the morphological characteristics of bacterial and
viral pneumonias can be clearly distinguished, it is important to emphasize that
the pathogenesis of swine respiratory diseases often involves several different
agents and that the changes depend on the dominant etiological agent.",
publisher = "Banja Luka : Veterinarska komora Republike Srpske",
journal = "25. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), naučni skup sa međunarodnim učešćem, Teslić,  2020",
title = "Karakter patomorfoloških promena najčešćih pneumonija kod svinja na teritoriji Republike Srbije, Character of pathomorphological changes of the most common pneumonia in pigs in the Republic of Serbia",
pages = "202-205",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3581"
}

Vučićević, I., Prodanov-Radulović, J., Polaček, V.,& Aleksić-Kovačević, S.. (2020). Karakter patomorfoloških promena najčešćih pneumonija kod svinja na teritoriji Republike Srbije. in 25. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), naučni skup sa međunarodnim učešćem, Teslić,  2020
Banja Luka : Veterinarska komora Republike Srpske., 202-205.
https://hdl.handle.net/21.15107/rcub_veterinar_3581

Vučićević I, Prodanov-Radulović J, Polaček V, Aleksić-Kovačević S. Karakter patomorfoloških promena najčešćih pneumonija kod svinja na teritoriji Republike Srbije. in 25. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), naučni skup sa međunarodnim učešćem, Teslić,  2020. 2020;:202-205.
https://hdl.handle.net/21.15107/rcub_veterinar_3581 .

Vučićević, Ivana, Prodanov-Radulović, Jasna, Polaček, Vladimir, Aleksić-Kovačević, Sanja, "Karakter patomorfoloških promena najčešćih pneumonija kod svinja na teritoriji Republike Srbije" in 25. Godišnje savjetovanje doktora veterinarske medicine Republike Srpske (Bosna i Hercegovina), naučni skup sa međunarodnim učešćem, Teslić,  2020 (2020):202-205,
https://hdl.handle.net/21.15107/rcub_veterinar_3581 .

TY  - JOUR
AU  - Prodanov-Radulović, Jasna
AU  - Vučićević, Ivana
AU  - Polgek, Vladimir
AU  - Aleksić-Kovačević, Sanja
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1819
AB  - Swine respiratory diseases represent one of the most frequent health issues in pig production worldwide. Despite the great progress that has been made in the field of diagnostics, control and prophylaxis, respiratory diseases still remain the most challenging health problem in modern commercial pig production. The list of infectious agents that cause respiratory diseases in swine is extensive and includes both, bacterial and viral pathogens. In Serbia, more than fifteen years after the introduction of modern vaccines, the list of bacterial pathogens related to swine respiratory infections still include Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Haemophilus parasuis and Pasteurella multocida. On the other hand, most commonly involved viral pathogens are Porcine Reproductive and Respiratory Syndrome Virus, Swine influenza virus, Porcine circovirus type 2 and Pseudorabies virus. The morphological features of pneumonia where several agents are involved, depend on the predominant etiological agent. Expanding knowledge of the main pathogens associated with swine respiratory diseases and the effects of their interactions on the disease outcome is important for further investigations of lung diseases and implementation of control strategies in commercial pig populations in Serbia. This review discusses the latest findings on swine respiratory disease and current trends in Serbian pig production.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Current swine respiratory diseases morphology in intensive swine production in Serbia
VL  - 70
IS  - 1
SP  - 1
EP  - 36
DO  - 10.2478/acve-2020-0001
ER  - 

@article{
author = "Prodanov-Radulović, Jasna and Vučićević, Ivana and Polgek, Vladimir and Aleksić-Kovačević, Sanja",
year = "2020",
abstract = "Swine respiratory diseases represent one of the most frequent health issues in pig production worldwide. Despite the great progress that has been made in the field of diagnostics, control and prophylaxis, respiratory diseases still remain the most challenging health problem in modern commercial pig production. The list of infectious agents that cause respiratory diseases in swine is extensive and includes both, bacterial and viral pathogens. In Serbia, more than fifteen years after the introduction of modern vaccines, the list of bacterial pathogens related to swine respiratory infections still include Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Haemophilus parasuis and Pasteurella multocida. On the other hand, most commonly involved viral pathogens are Porcine Reproductive and Respiratory Syndrome Virus, Swine influenza virus, Porcine circovirus type 2 and Pseudorabies virus. The morphological features of pneumonia where several agents are involved, depend on the predominant etiological agent. Expanding knowledge of the main pathogens associated with swine respiratory diseases and the effects of their interactions on the disease outcome is important for further investigations of lung diseases and implementation of control strategies in commercial pig populations in Serbia. This review discusses the latest findings on swine respiratory disease and current trends in Serbian pig production.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Current swine respiratory diseases morphology in intensive swine production in Serbia",
volume = "70",
number = "1",
pages = "1-36",
doi = "10.2478/acve-2020-0001"
}

Prodanov-Radulović, J., Vučićević, I., Polgek, V.,& Aleksić-Kovačević, S.. (2020). Current swine respiratory diseases morphology in intensive swine production in Serbia. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(1), 1-36.
https://doi.org/10.2478/acve-2020-0001

Prodanov-Radulović J, Vučićević I, Polgek V, Aleksić-Kovačević S. Current swine respiratory diseases morphology in intensive swine production in Serbia. in Acta Veterinaria-Beograd. 2020;70(1):1-36.
doi:10.2478/acve-2020-0001 .

Prodanov-Radulović, Jasna, Vučićević, Ivana, Polgek, Vladimir, Aleksić-Kovačević, Sanja, "Current swine respiratory diseases morphology in intensive swine production in Serbia" in Acta Veterinaria-Beograd, 70, no. 1 (2020):1-36,
https://doi.org/10.2478/acve-2020-0001 . .