Veljović, Ljubiša

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  • Veljović, Ljubiša (4)
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Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination

Maletić, Jelena; Spalević, Ljiljana; Kureljušić, Branislav; Veljović, Ljubiša; Maksimović-Zorić, Jelena; Maletić, Milan; Milićević, Vesna

(Sciendo, 2023)

TY  - JOUR
AU  - Maletić, Jelena
AU  - Spalević, Ljiljana
AU  - Kureljušić, Branislav
AU  - Veljović, Ljubiša
AU  - Maksimović-Zorić, Jelena
AU  - Maletić, Milan
AU  - Milićević, Vesna
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2815
AB  - Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: Adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity. In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood sera. Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (≥ 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera. The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control
PB  - Sciendo
T2  - Acta Veterinaria
T1  - Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination
VL  - 73
IS  - 1
SP  - 133
EP  - 142
DO  - 10.2478/acve-2023-0010
ER  - 
@article{
author = "Maletić, Jelena and Spalević, Ljiljana and Kureljušić, Branislav and Veljović, Ljubiša and Maksimović-Zorić, Jelena and Maletić, Milan and Milićević, Vesna",
year = "2023",
abstract = "Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: Adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity. In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood sera. Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (≥ 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera. The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control",
publisher = "Sciendo",
journal = "Acta Veterinaria",
title = "Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination",
volume = "73",
number = "1",
pages = "133-142",
doi = "10.2478/acve-2023-0010"
}
Maletić, J., Spalević, L., Kureljušić, B., Veljović, L., Maksimović-Zorić, J., Maletić, M.,& Milićević, V.. (2023). Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination. in Acta Veterinaria
Sciendo., 73(1), 133-142.
https://doi.org/10.2478/acve-2023-0010
Maletić J, Spalević L, Kureljušić B, Veljović L, Maksimović-Zorić J, Maletić M, Milićević V. Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination. in Acta Veterinaria. 2023;73(1):133-142.
doi:10.2478/acve-2023-0010 .
Maletić, Jelena, Spalević, Ljiljana, Kureljušić, Branislav, Veljović, Ljubiša, Maksimović-Zorić, Jelena, Maletić, Milan, Milićević, Vesna, "Fowl Adenovirus Infection-Potential Cause of a Suppressed Humoral Immune Response of Broilers to Newcastle Disease Vaccination" in Acta Veterinaria, 73, no. 1 (2023):133-142,
https://doi.org/10.2478/acve-2023-0010 . .

Prevalencija virusnih uzročnika proliva kod teladi na farmama muznih krava u Srbiji

Milićević, Vesna; Maletić, Jelena; Kureljušić, Branislav; Maksimović Zorić, Jelena; Veljović, Ljubiša; Glišić, Dimitrije; Jezdimirović, Nemanja; Maletić, Milan

(Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze, 2022)

TY  - CONF
AU  - Milićević, Vesna
AU  - Maletić, Jelena
AU  - Kureljušić, Branislav
AU  - Maksimović Zorić, Jelena
AU  - Veljović, Ljubiša
AU  - Glišić, Dimitrije
AU  - Jezdimirović, Nemanja
AU  - Maletić, Milan
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3178
AB  - Неонатална дијареја телади је један од најважнијих здравствених проблема са којима се суочава савремена говедарска производња и која узрокује значајне економске губитке због високог морбидитета и морталитета. Иако болест могу изазвати инфективни и неинфективни фактори, различити патогени, укључујући вирусе, бактерије и протозое, сматрају се примарним узрочницима овог обољења. Ипак, коинфекција инфективних агенаса је најчешћи узрок дијареје код телади. Овом студијом су истраживани главни вирусни патогени који изазивају неонаталну дијареју телади у Србији. Шездесет четири узорка фецеса сакупљена су од телади са дијарејом, до 3 месеца старости, са 13 фарми музних крава и тестирана на главне вирусне инфективне агенсе, укључујући говеђи ротавирус (БоРоВ), говеђи коронавирус (БоКоВ) и вирус вирусне дијареје говеда (БВДВ) коришћењем ланчане реакције полимеразе - ПЦР. Резултати ПЦР-а су показали да је 15.4% фарми било позитивно на БВДВ и БоКоВ, док је на 76.9% фарми откривен БоРоВ. Истовремена циркулација БВДВ, БоРоВ и БоКоВ детектована је на 1 фарми, а циркулација БВДВ и БоРоВ на другој. Поред тога, коинфекција БВДВ и БоРоВ је потврђена код 2 телади, док је коинфекција БоКоВ и БоРоВ откривена код 1 телета са исте фарме. Код једног телета са друге фарме откривена је коинфекција БВДВ и БоРоВ. Ови резултати су показали да је инфекција БоРоВ код телади најзаступљенија без обзира на примену вакцинације у контроли пролива, а углавном због велике разноликости сојева ротавируса типа А. Резултати ове студије могу помоћи да се скрене пажња на важност и потребу тачне дијагнозе неонаталне дијареје телади и преиспитивања спроведених мера за њену контролу.
AB  - Neonatal calf diarrhoea (NCD) is one of the most important health issues facing the modern dairy industry and causes substantial economic losses due to high morbidity and mortality. Although the disease can be caused by infectious and non-infectious factors, various pathogens, including viruses, bacteria and protozoa, are considered as the primary causes of NDT. However, co-infection of these infectious agents is most common in calves with diarrhoea. The present study investigated the main viral pathogens causing NCD among calves in Serbia. Sixty-four faecal samples were collected from diarrheic calves from 13 dairy farms and tested for major viral infectious agents, including bovine rotavirus (BoRoV), bovine coronavirus (BoCoV), and bovine viral diarrhoea virus (BVDV) using polymerase chain reaction (PCR). The PCR results showed that 15.4% of farms were positive for BVDV and BoCoV, while at 76.9% of farms BoRoV was detected. Simultaneous circulation of BVDV, BoRoV and BoCoV was detected on 1 farm, and circulation of BVDV and BoRoV on another one. Furthermore, coinfection of BVDV and BoRoV was confirmed in 2 calves, whereas coinfection of BoCoV and BoRoV was detected in 1 calf from the same farm. BVDV and BoRoV coinfection was detected in one calf from another farm. These results showed that BoRoV infection in neonatal calves is the most prevalent despite applied vaccination, mainly due to the high diversity of Rotavirus A strains. The results of this study may help to draw attention to the importance and the need for accurate diagnosis of NCD and reconsideration of implemented measures to control NCD.
PB  - Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze
C3  - XXIV Simpozijum epizootiologa i epidemiologa /XXIV Epizootiološki dani, Subotica, 27 - 29. april, 2022
T1  - Prevalencija virusnih uzročnika proliva kod teladi na farmama muznih krava u Srbiji
T1  - Prevalence of viral diarrhea in calves on dairy farms in Serbia
SP  - 82
EP  - 83
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3178
ER  - 
@conference{
author = "Milićević, Vesna and Maletić, Jelena and Kureljušić, Branislav and Maksimović Zorić, Jelena and Veljović, Ljubiša and Glišić, Dimitrije and Jezdimirović, Nemanja and Maletić, Milan",
year = "2022",
abstract = "Неонатална дијареја телади је један од најважнијих здравствених проблема са којима се суочава савремена говедарска производња и која узрокује значајне економске губитке због високог морбидитета и морталитета. Иако болест могу изазвати инфективни и неинфективни фактори, различити патогени, укључујући вирусе, бактерије и протозое, сматрају се примарним узрочницима овог обољења. Ипак, коинфекција инфективних агенаса је најчешћи узрок дијареје код телади. Овом студијом су истраживани главни вирусни патогени који изазивају неонаталну дијареју телади у Србији. Шездесет четири узорка фецеса сакупљена су од телади са дијарејом, до 3 месеца старости, са 13 фарми музних крава и тестирана на главне вирусне инфективне агенсе, укључујући говеђи ротавирус (БоРоВ), говеђи коронавирус (БоКоВ) и вирус вирусне дијареје говеда (БВДВ) коришћењем ланчане реакције полимеразе - ПЦР. Резултати ПЦР-а су показали да је 15.4% фарми било позитивно на БВДВ и БоКоВ, док је на 76.9% фарми откривен БоРоВ. Истовремена циркулација БВДВ, БоРоВ и БоКоВ детектована је на 1 фарми, а циркулација БВДВ и БоРоВ на другој. Поред тога, коинфекција БВДВ и БоРоВ је потврђена код 2 телади, док је коинфекција БоКоВ и БоРоВ откривена код 1 телета са исте фарме. Код једног телета са друге фарме откривена је коинфекција БВДВ и БоРоВ. Ови резултати су показали да је инфекција БоРоВ код телади најзаступљенија без обзира на примену вакцинације у контроли пролива, а углавном због велике разноликости сојева ротавируса типа А. Резултати ове студије могу помоћи да се скрене пажња на важност и потребу тачне дијагнозе неонаталне дијареје телади и преиспитивања спроведених мера за њену контролу., Neonatal calf diarrhoea (NCD) is one of the most important health issues facing the modern dairy industry and causes substantial economic losses due to high morbidity and mortality. Although the disease can be caused by infectious and non-infectious factors, various pathogens, including viruses, bacteria and protozoa, are considered as the primary causes of NDT. However, co-infection of these infectious agents is most common in calves with diarrhoea. The present study investigated the main viral pathogens causing NCD among calves in Serbia. Sixty-four faecal samples were collected from diarrheic calves from 13 dairy farms and tested for major viral infectious agents, including bovine rotavirus (BoRoV), bovine coronavirus (BoCoV), and bovine viral diarrhoea virus (BVDV) using polymerase chain reaction (PCR). The PCR results showed that 15.4% of farms were positive for BVDV and BoCoV, while at 76.9% of farms BoRoV was detected. Simultaneous circulation of BVDV, BoRoV and BoCoV was detected on 1 farm, and circulation of BVDV and BoRoV on another one. Furthermore, coinfection of BVDV and BoRoV was confirmed in 2 calves, whereas coinfection of BoCoV and BoRoV was detected in 1 calf from the same farm. BVDV and BoRoV coinfection was detected in one calf from another farm. These results showed that BoRoV infection in neonatal calves is the most prevalent despite applied vaccination, mainly due to the high diversity of Rotavirus A strains. The results of this study may help to draw attention to the importance and the need for accurate diagnosis of NCD and reconsideration of implemented measures to control NCD.",
publisher = "Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze",
journal = "XXIV Simpozijum epizootiologa i epidemiologa /XXIV Epizootiološki dani, Subotica, 27 - 29. april, 2022",
title = "Prevalencija virusnih uzročnika proliva kod teladi na farmama muznih krava u Srbiji, Prevalence of viral diarrhea in calves on dairy farms in Serbia",
pages = "82-83",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3178"
}
Milićević, V., Maletić, J., Kureljušić, B., Maksimović Zorić, J., Veljović, L., Glišić, D., Jezdimirović, N.,& Maletić, M.. (2022). Prevalencija virusnih uzročnika proliva kod teladi na farmama muznih krava u Srbiji. in XXIV Simpozijum epizootiologa i epidemiologa /XXIV Epizootiološki dani, Subotica, 27 - 29. april, 2022
Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze., 82-83.
https://hdl.handle.net/21.15107/rcub_veterinar_3178
Milićević V, Maletić J, Kureljušić B, Maksimović Zorić J, Veljović L, Glišić D, Jezdimirović N, Maletić M. Prevalencija virusnih uzročnika proliva kod teladi na farmama muznih krava u Srbiji. in XXIV Simpozijum epizootiologa i epidemiologa /XXIV Epizootiološki dani, Subotica, 27 - 29. april, 2022. 2022;:82-83.
https://hdl.handle.net/21.15107/rcub_veterinar_3178 .
Milićević, Vesna, Maletić, Jelena, Kureljušić, Branislav, Maksimović Zorić, Jelena, Veljović, Ljubiša, Glišić, Dimitrije, Jezdimirović, Nemanja, Maletić, Milan, "Prevalencija virusnih uzročnika proliva kod teladi na farmama muznih krava u Srbiji" in XXIV Simpozijum epizootiologa i epidemiologa /XXIV Epizootiološki dani, Subotica, 27 - 29. april, 2022 (2022):82-83,
https://hdl.handle.net/21.15107/rcub_veterinar_3178 .

Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens

Maletić, Jelena; Kureljušić, Branislav; Spalević, Ljiljana; Vučićević, Ivana; Veljović, Ljubiša; Milovanović, Bojan; Milićević, Vesna

(2022)

TY  - CONF
AU  - Maletić, Jelena
AU  - Kureljušić, Branislav
AU  - Spalević, Ljiljana
AU  - Vučićević, Ivana
AU  - Veljović, Ljubiša
AU  - Milovanović, Bojan
AU  - Milićević, Vesna
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2866
AB  - Marek’s disease virus and avian leucosis virus are causes of contagious, immunosuppressive, and oncogenic diseases. Many
reports have described single virus infection, but detailed description of co-infection with Marek’s disease virus and avian
leucosis virus has been provided in a few previous reports. The aim of this study was to determine the cause of health disorders
in a flock of the Banat Naked Neck hens at the age of 11 weeks. Clinical examination of the flock showed signs of cachexia,
apathy, dropped wings, nervous symptoms in the form of bilateral leg paresis, sporadic diarrhoea, and the mortality reaching
20%. Post-mortem examinations showed the following changes: chronic pseudomembranous typhlitis, intestinal ascaridiasis,
splenomegaly, granulomatous pneumonia, multiple yellowish caseous foci in the liver, and white tumour masses in the heart.
Histopathological examination of the spleen, proventriculus and heart tissue revealed polymorphic infiltrates, while
granulomatous inflammation was observed in the lung and liver. Gomori methenamine silver stain method revealed septate and
arborized hyphae resembling the Aspergillus spp. fungi in the liver and lung granulomas. Bacteriological examination of faeces
revealed the presence of Escherichia coli, and parasitological examination of the small intestine determined the presence of
oocyst of Eimeria acervulina and Eimeria tenella in the caecum. The genomes of Marek's disease virus and avian leucosis
virus were determined by polymerase chain reaction in tissue samples. In this case, specific pathological lesions, as well as
molecular finding confirmed co-infection with Marek’s disease virus and avian leucosis virus.
AB  - Virus Marekove bolesti i virus ptičje leukoze uzrokuju zarazne, imunosupresivne i onkogene bolesti. Mnoga izvješća
opisuju infekciju pojedinim virusom, ali tek mali broj izvješća podrobnije opisuje koinfekciju virusom Marekove bolesti i
virusom ptičje leukoze. Cilj ovog istraživanja bio je utvrditi uzrok zdravstvenih poremećaja u jatu kokoši pasmine Banatski
gološijan u dobi od 11 tjedana. Klinički pregled jata pokazao je znakove kaheksije, apatije, spuštena krila, živčane
simptome u obliku pareze nogu, sporadični proljev te 20%-tnu smrtnost. Postmortem pregledi pokazali su sljedeće
promjene: kronični pseudomembranski tiflitis, crijevnu askaridijazu, splenomegaliju, granulomatoznu pneumoniju,
višestruka žućkasta sirasta žarišta u jetri i bijele tumorske tvorbe u srcu. Patohistološki pregled tkivnih uzoraka slezene,
proventrikla i srca otkrio je polimorfne infiltrate, dok je u plućima i jetri zabilježena granulomatozna upala. Metenamin
srebrno bojenje po Gomoriju otkrilo je septirane i arborizirane hife nalik gljivama Aspergillus spp. u jetrenim i plućnim
granulomima. Bakteriološke pretrage fecesa pokazale su prisutnost Escherichia coli, dok je parazitološka pretraga tankog
crijeva utvrdila prisutnost oocita Eimeria acervulina te Eimeria tenella u cekumu. PCR-om su genomi virusa Marekove
bolesti i virusa ptičje leukoze utvrđeni u tkivnim uzorcima. U ovom istraživanju su specifične patološke promjene i
molekularni nalazi potvrdili koinfekciju virusom Marekove bolesti i virusom ptičje leukoze.
C3  - XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022
T1  - Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens
T1  - Koinfekcija virusom Marekove bolesti i virusom ptičje leukoze kod kokoši pasmine banatski gološijan
SP  - 210
EP  - 217
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2866
ER  - 
@conference{
author = "Maletić, Jelena and Kureljušić, Branislav and Spalević, Ljiljana and Vučićević, Ivana and Veljović, Ljubiša and Milovanović, Bojan and Milićević, Vesna",
year = "2022",
abstract = "Marek’s disease virus and avian leucosis virus are causes of contagious, immunosuppressive, and oncogenic diseases. Many
reports have described single virus infection, but detailed description of co-infection with Marek’s disease virus and avian
leucosis virus has been provided in a few previous reports. The aim of this study was to determine the cause of health disorders
in a flock of the Banat Naked Neck hens at the age of 11 weeks. Clinical examination of the flock showed signs of cachexia,
apathy, dropped wings, nervous symptoms in the form of bilateral leg paresis, sporadic diarrhoea, and the mortality reaching
20%. Post-mortem examinations showed the following changes: chronic pseudomembranous typhlitis, intestinal ascaridiasis,
splenomegaly, granulomatous pneumonia, multiple yellowish caseous foci in the liver, and white tumour masses in the heart.
Histopathological examination of the spleen, proventriculus and heart tissue revealed polymorphic infiltrates, while
granulomatous inflammation was observed in the lung and liver. Gomori methenamine silver stain method revealed septate and
arborized hyphae resembling the Aspergillus spp. fungi in the liver and lung granulomas. Bacteriological examination of faeces
revealed the presence of Escherichia coli, and parasitological examination of the small intestine determined the presence of
oocyst of Eimeria acervulina and Eimeria tenella in the caecum. The genomes of Marek's disease virus and avian leucosis
virus were determined by polymerase chain reaction in tissue samples. In this case, specific pathological lesions, as well as
molecular finding confirmed co-infection with Marek’s disease virus and avian leucosis virus., Virus Marekove bolesti i virus ptičje leukoze uzrokuju zarazne, imunosupresivne i onkogene bolesti. Mnoga izvješća
opisuju infekciju pojedinim virusom, ali tek mali broj izvješća podrobnije opisuje koinfekciju virusom Marekove bolesti i
virusom ptičje leukoze. Cilj ovog istraživanja bio je utvrditi uzrok zdravstvenih poremećaja u jatu kokoši pasmine Banatski
gološijan u dobi od 11 tjedana. Klinički pregled jata pokazao je znakove kaheksije, apatije, spuštena krila, živčane
simptome u obliku pareze nogu, sporadični proljev te 20%-tnu smrtnost. Postmortem pregledi pokazali su sljedeće
promjene: kronični pseudomembranski tiflitis, crijevnu askaridijazu, splenomegaliju, granulomatoznu pneumoniju,
višestruka žućkasta sirasta žarišta u jetri i bijele tumorske tvorbe u srcu. Patohistološki pregled tkivnih uzoraka slezene,
proventrikla i srca otkrio je polimorfne infiltrate, dok je u plućima i jetri zabilježena granulomatozna upala. Metenamin
srebrno bojenje po Gomoriju otkrilo je septirane i arborizirane hife nalik gljivama Aspergillus spp. u jetrenim i plućnim
granulomima. Bakteriološke pretrage fecesa pokazale su prisutnost Escherichia coli, dok je parazitološka pretraga tankog
crijeva utvrdila prisutnost oocita Eimeria acervulina te Eimeria tenella u cekumu. PCR-om su genomi virusa Marekove
bolesti i virusa ptičje leukoze utvrđeni u tkivnim uzorcima. U ovom istraživanju su specifične patološke promjene i
molekularni nalazi potvrdili koinfekciju virusom Marekove bolesti i virusom ptičje leukoze.",
journal = "XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022",
title = "Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens, Koinfekcija virusom Marekove bolesti i virusom ptičje leukoze kod kokoši pasmine banatski gološijan",
pages = "210-217",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2866"
}
Maletić, J., Kureljušić, B., Spalević, L., Vučićević, I., Veljović, L., Milovanović, B.,& Milićević, V.. (2022). Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens. in XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022, 210-217.
https://hdl.handle.net/21.15107/rcub_veterinar_2866
Maletić J, Kureljušić B, Spalević L, Vučićević I, Veljović L, Milovanović B, Milićević V. Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens. in XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022. 2022;:210-217.
https://hdl.handle.net/21.15107/rcub_veterinar_2866 .
Maletić, Jelena, Kureljušić, Branislav, Spalević, Ljiljana, Vučićević, Ivana, Veljović, Ljubiša, Milovanović, Bojan, Milićević, Vesna, "Co-infection with Marek’s disease virus and avian leukosis virus in the banat naked neck hens" in XIV Symposium poultry days 2022 With International Participation, Croatia, Poreč, May 11‐14, 2022 (2022):210-217,
https://hdl.handle.net/21.15107/rcub_veterinar_2866 .

Cutaneous lymphoma in a cow - a case report

Kureljušić, Branislav; Maksimović, Slobodan; Vujinović, Slobodan; Savić, Božidar; Milićević, Vesna; Veljović, Ljubiša; Jezdimirović, Nemanja; Žutić, Jadranka

(FVM, 2019)

TY  - JOUR
AU  - Kureljušić, Branislav
AU  - Maksimović, Slobodan
AU  - Vujinović, Slobodan
AU  - Savić, Božidar
AU  - Milićević, Vesna
AU  - Veljović, Ljubiša
AU  - Jezdimirović, Nemanja
AU  - Žutić, Jadranka
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1901
AB  - U ovom radu prikazan je slučaj krave simentalske rase, starosti dve godine i šest meseci kod koje je postojala sumnja na nodularni dermatitis, sredinom 2017 godine. Kliničkim pregledom ustanovljeni su brojni noduli veličine od nekoliko milimetara do približno 10 centimetara diseminovani dominantno po koži vimena i perineuma, od kojih su neki konfluirali i egzulcerisali. Opšte stanje krave je bilo nepromenjeno. Krava je prema rezultatima laboratorijskih analiza bila negativna na prisustvo antitela protiv virusa leukoze goveda, pokazala je negativnu reakciju pri tuberkulinizaciji i bila je vakcinisana protiv nodularnog dermatitisa. Nakon hirurške ekscizije kožnog čvora, uzorak je bio negativan na prisustvo genoma virusa nodularnog dermatitisa. Kako bismo ustanovili morfologiju kožne lezije, urađena je histopatološka analiza. Histopatološka analiza je pokazala infiltraciju dermisa i subkutisa brojnim mononukleranim ćelijama koje pokazuju ćelijsku atipiju. Tada je postavljena sumnja da se radi o kutanom limfomu. Nadalje, imunohistohemijsko ispitivanje je potvrdilo da se u infiltratu nalaze isključivo CD3 imunopozitivne ćelije što sugeriše da se radi o T-ćelijskom neepiteliotropnom limfomu
AB  - In this paper the case of a 2.5-year-old Simmental cow, with suspicion of lumpy skin disease in mid-2017 in Serbia will be presented. Clinical examination revealed numerous nodules of varied size from a few millimeters to approximately 10 centimeters disseminated predominantly on the skin of the udder and the perineum, some of which were coalescing and exulcerated. The general condition of the affected animal was unchanged. According to the results of laboratory analysis, the cow was negative for the presence of antibodies against the bovine leukemia virus, showed a negative reaction in tuberculinization and was vaccinated against lumpy skin disease virus. After the surgical excision of one skin node, the sample tested negative for the genome of lumpy skin disease virus. In order to establish the morphology of the skin lesion, a histopathological analysis was performed. Histopathological analysis showed the infiltration of the corium and subcutaneous tissue by numerous mononuclear cells showing cellular atypia. Suspicion of cutaneous lymphoma was established. Furthermore, the immunohistochemical examination confirmed that the infiltrate contained exclusively CD3-immunopositive cells, suggesting a T-cell origin nonepitheliotropic lymphoma.
PB  - FVM
T2  - Veterinarski Glasnik
T1  - Cutaneous lymphoma in a cow - a case report
T1  - Kutani limfom kod krave – prikaz slučaja
VL  - 73
IS  - 1
SP  - 50
EP  - 56
DO  - 10.2298/VETGL180904004K
ER  - 
@article{
author = "Kureljušić, Branislav and Maksimović, Slobodan and Vujinović, Slobodan and Savić, Božidar and Milićević, Vesna and Veljović, Ljubiša and Jezdimirović, Nemanja and Žutić, Jadranka",
year = "2019",
abstract = "U ovom radu prikazan je slučaj krave simentalske rase, starosti dve godine i šest meseci kod koje je postojala sumnja na nodularni dermatitis, sredinom 2017 godine. Kliničkim pregledom ustanovljeni su brojni noduli veličine od nekoliko milimetara do približno 10 centimetara diseminovani dominantno po koži vimena i perineuma, od kojih su neki konfluirali i egzulcerisali. Opšte stanje krave je bilo nepromenjeno. Krava je prema rezultatima laboratorijskih analiza bila negativna na prisustvo antitela protiv virusa leukoze goveda, pokazala je negativnu reakciju pri tuberkulinizaciji i bila je vakcinisana protiv nodularnog dermatitisa. Nakon hirurške ekscizije kožnog čvora, uzorak je bio negativan na prisustvo genoma virusa nodularnog dermatitisa. Kako bismo ustanovili morfologiju kožne lezije, urađena je histopatološka analiza. Histopatološka analiza je pokazala infiltraciju dermisa i subkutisa brojnim mononukleranim ćelijama koje pokazuju ćelijsku atipiju. Tada je postavljena sumnja da se radi o kutanom limfomu. Nadalje, imunohistohemijsko ispitivanje je potvrdilo da se u infiltratu nalaze isključivo CD3 imunopozitivne ćelije što sugeriše da se radi o T-ćelijskom neepiteliotropnom limfomu, In this paper the case of a 2.5-year-old Simmental cow, with suspicion of lumpy skin disease in mid-2017 in Serbia will be presented. Clinical examination revealed numerous nodules of varied size from a few millimeters to approximately 10 centimeters disseminated predominantly on the skin of the udder and the perineum, some of which were coalescing and exulcerated. The general condition of the affected animal was unchanged. According to the results of laboratory analysis, the cow was negative for the presence of antibodies against the bovine leukemia virus, showed a negative reaction in tuberculinization and was vaccinated against lumpy skin disease virus. After the surgical excision of one skin node, the sample tested negative for the genome of lumpy skin disease virus. In order to establish the morphology of the skin lesion, a histopathological analysis was performed. Histopathological analysis showed the infiltration of the corium and subcutaneous tissue by numerous mononuclear cells showing cellular atypia. Suspicion of cutaneous lymphoma was established. Furthermore, the immunohistochemical examination confirmed that the infiltrate contained exclusively CD3-immunopositive cells, suggesting a T-cell origin nonepitheliotropic lymphoma.",
publisher = "FVM",
journal = "Veterinarski Glasnik",
title = "Cutaneous lymphoma in a cow - a case report, Kutani limfom kod krave – prikaz slučaja",
volume = "73",
number = "1",
pages = "50-56",
doi = "10.2298/VETGL180904004K"
}
Kureljušić, B., Maksimović, S., Vujinović, S., Savić, B., Milićević, V., Veljović, L., Jezdimirović, N.,& Žutić, J.. (2019). Cutaneous lymphoma in a cow - a case report. in Veterinarski Glasnik
FVM., 73(1), 50-56.
https://doi.org/10.2298/VETGL180904004K
Kureljušić B, Maksimović S, Vujinović S, Savić B, Milićević V, Veljović L, Jezdimirović N, Žutić J. Cutaneous lymphoma in a cow - a case report. in Veterinarski Glasnik. 2019;73(1):50-56.
doi:10.2298/VETGL180904004K .
Kureljušić, Branislav, Maksimović, Slobodan, Vujinović, Slobodan, Savić, Božidar, Milićević, Vesna, Veljović, Ljubiša, Jezdimirović, Nemanja, Žutić, Jadranka, "Cutaneous lymphoma in a cow - a case report" in Veterinarski Glasnik, 73, no. 1 (2019):50-56,
https://doi.org/10.2298/VETGL180904004K . .