TY  - JOUR
AU  - Janjić, Filip
AU  - Beletić, Anđelo
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Diklić, Miloš
AU  - Francuski Andrić, Jelena
AU  - Radonjić, Vladimir
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2338
AB  - The highest number of acute Babesia canis cases in dogs is recorded over the February-May (Feb-May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb-May period compared with the response in other time periods of the year was tested. A total of 63 client-owned dogs with acute B. canis infection were enrolled and the routine hematology and biochemistry parameters-serum amyloid A (SAA), IgG against B. canis, level of parasitemia, ceruloplasmin (CER), paraoxonase-1 (PON-1), and fibrinogen-were measured. Acute phase indexes (API) were calculated as (SAA×CER)/(Iron×PON-1) and (SAA×CER)/(Albumin×Iron). Statistics included Kruskal-Wallis test and logistic regression analysis. The results showed that in the Feb-May period, the following parameters were lower: creatinine, albumin, iron, and level of parasitemia. Furthermore, increased API values were more probable in the Feb-May than in the other periods. Together, higher acute phase response intensity and presumptive hemodilution in the Feb-May period indicate a more acute course of B. canis infection than in other time periods of the year.
PB  - Springer
T2  - International Journal of Biometeorology
T1  - Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis
DO  - 10.1007/s00484-021-02228-4
ER  - 

@article{
author = "Janjić, Filip and Beletić, Anđelo and Radaković, Milena and Spariosu, Kristina and Diklić, Miloš and Francuski Andrić, Jelena and Radonjić, Vladimir and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2022",
abstract = "The highest number of acute Babesia canis cases in dogs is recorded over the February-May (Feb-May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb-May period compared with the response in other time periods of the year was tested. A total of 63 client-owned dogs with acute B. canis infection were enrolled and the routine hematology and biochemistry parameters-serum amyloid A (SAA), IgG against B. canis, level of parasitemia, ceruloplasmin (CER), paraoxonase-1 (PON-1), and fibrinogen-were measured. Acute phase indexes (API) were calculated as (SAA×CER)/(Iron×PON-1) and (SAA×CER)/(Albumin×Iron). Statistics included Kruskal-Wallis test and logistic regression analysis. The results showed that in the Feb-May period, the following parameters were lower: creatinine, albumin, iron, and level of parasitemia. Furthermore, increased API values were more probable in the Feb-May than in the other periods. Together, higher acute phase response intensity and presumptive hemodilution in the Feb-May period indicate a more acute course of B. canis infection than in other time periods of the year.",
publisher = "Springer",
journal = "International Journal of Biometeorology",
title = "Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis",
doi = "10.1007/s00484-021-02228-4"
}

Janjić, F., Beletić, A., Radaković, M., Spariosu, K., Diklić, M., Francuski Andrić, J., Radonjić, V., Ajtić, J.,& Kovačević-Filipović, M.. (2022). Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis. in International Journal of Biometeorology
Springer..
https://doi.org/10.1007/s00484-021-02228-4

Janjić F, Beletić A, Radaković M, Spariosu K, Diklić M, Francuski Andrić J, Radonjić V, Ajtić J, Kovačević-Filipović M. Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis. in International Journal of Biometeorology. 2022;.
doi:10.1007/s00484-021-02228-4 .

Janjić, Filip, Beletić, Anđelo, Radaković, Milena, Spariosu, Kristina, Diklić, Miloš, Francuski Andrić, Jelena, Radonjić, Vladimir, Ajtić, Jelena, Kovačević-Filipović, Milica, "Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis" in International Journal of Biometeorology (2022),
https://doi.org/10.1007/s00484-021-02228-4 . .

TY  - CONF
AU  - Janjić, Filip
AU  - Sarvan, Darko
AU  - Tomanović, Snežana
AU  - Krstić, Vanja
AU  - Radonjić, Vladimir
AU  - Kovačević-Filipović, Milica
AU  - Ajtić, Jelena
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2487
AB  - Background: Canine babesiosis, a tick-borne disease caused by Babesia canis,
shows a seasonality whose relationship with local weather conditions has not been
fully investigated. Objectives: Meteorological conditions can favour the tick-vector
activity, and thus lead to an increased number of cases of canine babesiosis. Hence,
our study looks into the link between the number of recorded cases, on the one
hand, and temperature and relative humidity on the other with an aim to quantify
their correlations. Material and Methods: Over 2013–2016, the data were
collected in Belgrade, the capital of the Republic of Serbia. The meteorological
parameters were obtained from the Republic Hydrometeorological Service of
Serbia. The analysis includes correlations with a time lag, given in number of weeks,
which shifts corresponding correlation pairs and shows a delayed effect of weather
conditions. The time lag ranges between 0 and 52. Results: Canine babesiosis
occurrence shows a pronounced maximum in the spring and a less marked one in
the autumn. For the spring period, statistically significant correlation coefficients
imply that over one year prior to the disease spring peak, temperature is more
strongly linked with the number of cases than relative humidity. Conclusion:
Temperature and relative humidity, through their influence on population of
infected ticks, seem to be important meteorological drivers of the spring maximum
of canine babesios in Belgrade. Further understanding of this interplay can help
better contain the disease, and project its possible spread to other regions
prompted by climate change.
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology,  Belgrade, Serbia, October 5-8
T1  - Signature of weather conditions in the canine babesiosis spring peak in Belgrade, Serbia
SP  - 69
EP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2487
ER  - 

@conference{
author = "Janjić, Filip and Sarvan, Darko and Tomanović, Snežana and Krstić, Vanja and Radonjić, Vladimir and Kovačević-Filipović, Milica and Ajtić, Jelena",
year = "2022",
abstract = "Background: Canine babesiosis, a tick-borne disease caused by Babesia canis,
shows a seasonality whose relationship with local weather conditions has not been
fully investigated. Objectives: Meteorological conditions can favour the tick-vector
activity, and thus lead to an increased number of cases of canine babesiosis. Hence,
our study looks into the link between the number of recorded cases, on the one
hand, and temperature and relative humidity on the other with an aim to quantify
their correlations. Material and Methods: Over 2013–2016, the data were
collected in Belgrade, the capital of the Republic of Serbia. The meteorological
parameters were obtained from the Republic Hydrometeorological Service of
Serbia. The analysis includes correlations with a time lag, given in number of weeks,
which shifts corresponding correlation pairs and shows a delayed effect of weather
conditions. The time lag ranges between 0 and 52. Results: Canine babesiosis
occurrence shows a pronounced maximum in the spring and a less marked one in
the autumn. For the spring period, statistically significant correlation coefficients
imply that over one year prior to the disease spring peak, temperature is more
strongly linked with the number of cases than relative humidity. Conclusion:
Temperature and relative humidity, through their influence on population of
infected ticks, seem to be important meteorological drivers of the spring maximum
of canine babesios in Belgrade. Further understanding of this interplay can help
better contain the disease, and project its possible spread to other regions
prompted by climate change.",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology,  Belgrade, Serbia, October 5-8",
title = "Signature of weather conditions in the canine babesiosis spring peak in Belgrade, Serbia",
pages = "69-69",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2487"
}

Janjić, F., Sarvan, D., Tomanović, S., Krstić, V., Radonjić, V., Kovačević-Filipović, M.,& Ajtić, J.. (2022). Signature of weather conditions in the canine babesiosis spring peak in Belgrade, Serbia. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology,  Belgrade, Serbia, October 5-8, 69-69.
https://hdl.handle.net/21.15107/rcub_veterinar_2487

Janjić F, Sarvan D, Tomanović S, Krstić V, Radonjić V, Kovačević-Filipović M, Ajtić J. Signature of weather conditions in the canine babesiosis spring peak in Belgrade, Serbia. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology,  Belgrade, Serbia, October 5-8. 2022;:69-69.
https://hdl.handle.net/21.15107/rcub_veterinar_2487 .

Janjić, Filip, Sarvan, Darko, Tomanović, Snežana, Krstić, Vanja, Radonjić, Vladimir, Kovačević-Filipović, Milica, Ajtić, Jelena, "Signature of weather conditions in the canine babesiosis spring peak in Belgrade, Serbia" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology,  Belgrade, Serbia, October 5-8 (2022):69-69,
https://hdl.handle.net/21.15107/rcub_veterinar_2487 .

TY  - JOUR
AU  - Beletić, Anđelo
AU  - Janjić, Filip
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Francuski Andrić, Jelena
AU  - Chandrashekar, Ramaswamy
AU  - Tyrrell, Phyllis
AU  - Radonjić, Vladimir
AU  - Balint, Bela
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2015
AB  - The common signs of canine babesiosis caused by an infection with Babesia canis are fever, anorexia, lethargy, pulse alterations, anemia, and occasionally mild icterus. Dogs with these clinical signs can be divided into two groups: those with acute-phase reaction and those with systemic inflammatory response syndrome (SIRS). Factors associated with the occurrence of SIRS in canine babesiosis have not been thoroughly researched. This article outlines a cross-sectional study of 54 client-owned dogs with an acute B. canis infection, and evaluates the differences in age, gender, laboratory findings, parasite load, and seroreactivity against B. canis between the SIRS and the SIRS-free dogs. We have analyzed a complete blood count, serum biochemistry, serum amyloid A, ceruloplasmin, paraoxonase-1, serology, and PCR testing using standard methodologies. The frequency of SIRS among the investigated dogs reached 0.59. Male dogs and those seronegative against B. canis, were more frequent in the SIRS group, whilst age and parasite load could not be associated with the presence of SIRS. Dogs with SIRS had a lower count of total leukocytes, neutrophils, lymphocytes, and monocytes, and a lower concentration of iron and bilirubin compared with SIRS-free dogs. No significant differences in the concentration of acute-phase proteins have been noticed to exist between the groups of dogs. Further, the seronegative dogs had a lower count of lymphocytes and monocytes and a higher parasite load than the seroreactive dogs. Multivariate logistic regression analysis has identified leukopenia (<6 × 109/L) and monocytopenia (<0.2 × 109/L) as independent associates of SIRS in the investigated dogs, thus implying that these routine tests could be used as reliable markers for SIRS.
PB  - Elsevier
T2  - Veterinary Parasitology
T1  - Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors
VL  - 291
DO  - 10.1016/j.vetpar.2021.109366
ER  - 

@article{
author = "Beletić, Anđelo and Janjić, Filip and Radaković, Milena and Spariosu, Kristina and Francuski Andrić, Jelena and Chandrashekar, Ramaswamy and Tyrrell, Phyllis and Radonjić, Vladimir and Balint, Bela and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2021",
abstract = "The common signs of canine babesiosis caused by an infection with Babesia canis are fever, anorexia, lethargy, pulse alterations, anemia, and occasionally mild icterus. Dogs with these clinical signs can be divided into two groups: those with acute-phase reaction and those with systemic inflammatory response syndrome (SIRS). Factors associated with the occurrence of SIRS in canine babesiosis have not been thoroughly researched. This article outlines a cross-sectional study of 54 client-owned dogs with an acute B. canis infection, and evaluates the differences in age, gender, laboratory findings, parasite load, and seroreactivity against B. canis between the SIRS and the SIRS-free dogs. We have analyzed a complete blood count, serum biochemistry, serum amyloid A, ceruloplasmin, paraoxonase-1, serology, and PCR testing using standard methodologies. The frequency of SIRS among the investigated dogs reached 0.59. Male dogs and those seronegative against B. canis, were more frequent in the SIRS group, whilst age and parasite load could not be associated with the presence of SIRS. Dogs with SIRS had a lower count of total leukocytes, neutrophils, lymphocytes, and monocytes, and a lower concentration of iron and bilirubin compared with SIRS-free dogs. No significant differences in the concentration of acute-phase proteins have been noticed to exist between the groups of dogs. Further, the seronegative dogs had a lower count of lymphocytes and monocytes and a higher parasite load than the seroreactive dogs. Multivariate logistic regression analysis has identified leukopenia (<6 × 109/L) and monocytopenia (<0.2 × 109/L) as independent associates of SIRS in the investigated dogs, thus implying that these routine tests could be used as reliable markers for SIRS.",
publisher = "Elsevier",
journal = "Veterinary Parasitology",
title = "Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors",
volume = "291",
doi = "10.1016/j.vetpar.2021.109366"
}

Beletić, A., Janjić, F., Radaković, M., Spariosu, K., Francuski Andrić, J., Chandrashekar, R., Tyrrell, P., Radonjić, V., Balint, B., Ajtić, J.,& Kovačević-Filipović, M.. (2021). Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors. in Veterinary Parasitology
Elsevier., 291.
https://doi.org/10.1016/j.vetpar.2021.109366

Beletić A, Janjić F, Radaković M, Spariosu K, Francuski Andrić J, Chandrashekar R, Tyrrell P, Radonjić V, Balint B, Ajtić J, Kovačević-Filipović M. Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors. in Veterinary Parasitology. 2021;291.
doi:10.1016/j.vetpar.2021.109366 .

Beletić, Anđelo, Janjić, Filip, Radaković, Milena, Spariosu, Kristina, Francuski Andrić, Jelena, Chandrashekar, Ramaswamy, Tyrrell, Phyllis, Radonjić, Vladimir, Balint, Bela, Ajtić, Jelena, Kovačević-Filipović, Milica, "Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors" in Veterinary Parasitology, 291 (2021),
https://doi.org/10.1016/j.vetpar.2021.109366 . .

TY  - JOUR
AU  - Milanović, Zorana
AU  - Vekić, Jelena
AU  - Radonjić, Vladimir
AU  - Božović-Ilić, Anja
AU  - Zeljković, Aleksandra
AU  - Janac, Jelena
AU  - Spasojevic-Kalimanovska, Vesna
AU  - Buch, Jesse
AU  - Chandrashekar, Ramaswamy
AU  - Bojic-Trbojević, Zanka
AU  - Hajduković, Ljiljana
AU  - Christopher, Mary M.
AU  - Kovačević-Filipović, Milica
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1778
AB  - Background Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Hypothesis Dogs with B. canis-induced APR develop dyslipidemia with altered lipoprotein concentration and morphology. Animals Twenty-nine client-owned dogs with acute B. canis infection and 10 clinically healthy control dogs. Methods Observational cross-sectional study. Serum amyloid A (SAA) was measured using ELISA. Cholesterol, phospholipids, and triglycerides were determined biochemically. Lipoproteins were separated using agarose gel electrophoresis. Lipoprotein diameter was assessed by polyacrylamide gradient gel electrophoresis; correlation with ApoA-1 (radioimmunoassay) and SAA was determined. Results Dogs with B. canis infection had a marked APR (median SAA, 168.3 mu g/mL; range, 98.1-716.2 mu g/mL) compared with controls (3.2 mu g/mL, 2.0-4.2 mu g/mL) (P < .001). Dogs with B. canis infection had significantly lower median cholesterol (4.79 mmol/L, 1.89-7.64 mmol/L versus 6.15 mmol/L, 4.2-7.4 mmol/L) (P = .02), phospholipid (4.64 mmol/L, 2.6-6.6 mmol/L versus 5.72 mmol/L, 4.68-7.0 mmol/L) (P = .02), and alpha-lipoproteins (77.5%, 27.7%-93.5% versus 89.2%, 75.1%-93.5%) (P = .04), and higher ApoA-1 (1.36 U, 0.8-2.56 U versus 0.95 U, 0.73-1.54 U) concentrations (P = .02). Serum amyloid A correlated with high-density lipoproteins (HDLs) diameter (rho = .43; P = .03) and ApoA-1 (rho = .63, P < .001). Conclusions and Clinical Importance Major changes associated with B. canis-induced APR in dogs are related to concentration, composition, and morphology of HDL particles pointing to an altered reverse cholesterol transport. Parallel ApoA-1 and SAA concentration increase is a unique still unexplained pathophysiological finding.
PB  - Wiley, Hoboken
T2  - Journal of Veterinary Internal Medicine
T1  - Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs
VL  - 33
IS  - 4
SP  - 1686
EP  - 1694
DO  - 10.1111/jvim.15537
ER  - 

@article{
author = "Milanović, Zorana and Vekić, Jelena and Radonjić, Vladimir and Božović-Ilić, Anja and Zeljković, Aleksandra and Janac, Jelena and Spasojevic-Kalimanovska, Vesna and Buch, Jesse and Chandrashekar, Ramaswamy and Bojic-Trbojević, Zanka and Hajduković, Ljiljana and Christopher, Mary M. and Kovačević-Filipović, Milica",
year = "2019",
abstract = "Background Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Hypothesis Dogs with B. canis-induced APR develop dyslipidemia with altered lipoprotein concentration and morphology. Animals Twenty-nine client-owned dogs with acute B. canis infection and 10 clinically healthy control dogs. Methods Observational cross-sectional study. Serum amyloid A (SAA) was measured using ELISA. Cholesterol, phospholipids, and triglycerides were determined biochemically. Lipoproteins were separated using agarose gel electrophoresis. Lipoprotein diameter was assessed by polyacrylamide gradient gel electrophoresis; correlation with ApoA-1 (radioimmunoassay) and SAA was determined. Results Dogs with B. canis infection had a marked APR (median SAA, 168.3 mu g/mL; range, 98.1-716.2 mu g/mL) compared with controls (3.2 mu g/mL, 2.0-4.2 mu g/mL) (P < .001). Dogs with B. canis infection had significantly lower median cholesterol (4.79 mmol/L, 1.89-7.64 mmol/L versus 6.15 mmol/L, 4.2-7.4 mmol/L) (P = .02), phospholipid (4.64 mmol/L, 2.6-6.6 mmol/L versus 5.72 mmol/L, 4.68-7.0 mmol/L) (P = .02), and alpha-lipoproteins (77.5%, 27.7%-93.5% versus 89.2%, 75.1%-93.5%) (P = .04), and higher ApoA-1 (1.36 U, 0.8-2.56 U versus 0.95 U, 0.73-1.54 U) concentrations (P = .02). Serum amyloid A correlated with high-density lipoproteins (HDLs) diameter (rho = .43; P = .03) and ApoA-1 (rho = .63, P < .001). Conclusions and Clinical Importance Major changes associated with B. canis-induced APR in dogs are related to concentration, composition, and morphology of HDL particles pointing to an altered reverse cholesterol transport. Parallel ApoA-1 and SAA concentration increase is a unique still unexplained pathophysiological finding.",
publisher = "Wiley, Hoboken",
journal = "Journal of Veterinary Internal Medicine",
title = "Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs",
volume = "33",
number = "4",
pages = "1686-1694",
doi = "10.1111/jvim.15537"
}

Milanović, Z., Vekić, J., Radonjić, V., Božović-Ilić, A., Zeljković, A., Janac, J., Spasojevic-Kalimanovska, V., Buch, J., Chandrashekar, R., Bojic-Trbojević, Z., Hajduković, L., Christopher, M. M.,& Kovačević-Filipović, M.. (2019). Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs. in Journal of Veterinary Internal Medicine
Wiley, Hoboken., 33(4), 1686-1694.
https://doi.org/10.1111/jvim.15537

Milanović Z, Vekić J, Radonjić V, Božović-Ilić A, Zeljković A, Janac J, Spasojevic-Kalimanovska V, Buch J, Chandrashekar R, Bojic-Trbojević Z, Hajduković L, Christopher MM, Kovačević-Filipović M. Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs. in Journal of Veterinary Internal Medicine. 2019;33(4):1686-1694.
doi:10.1111/jvim.15537 .

Milanović, Zorana, Vekić, Jelena, Radonjić, Vladimir, Božović-Ilić, Anja, Zeljković, Aleksandra, Janac, Jelena, Spasojevic-Kalimanovska, Vesna, Buch, Jesse, Chandrashekar, Ramaswamy, Bojic-Trbojević, Zanka, Hajduković, Ljiljana, Christopher, Mary M., Kovačević-Filipović, Milica, "Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs" in Journal of Veterinary Internal Medicine, 33, no. 4 (2019):1686-1694,
https://doi.org/10.1111/jvim.15537 . .

TY  - JOUR
AU  - Janjić, Filip
AU  - Sarvan, Darko
AU  - Tomanović, Snežana
AU  - Cuk, Jelena
AU  - Krstić, Vanja
AU  - Radonjić, Vladimir
AU  - Kovačević-Filipović, Milica
AU  - Ajtić, Jelena
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1783
AB  - Belgrade, the capital of the Republic of Serbia, is an endemic location for canine babesiosis caused by Babesia canis. This tick-borne disease occurs seasonally in regions with moderate continental climate. However, recent clinical data show that 1) some cases of canine babesiosis have been recorded during the winter, and 2) canine babesiosis is spreading to the northern parts of Europe with a colder climate, which is a region previously free of this disease. Our study investigates the occurrence of canine babesiosis in different seasons over 2013-2016, and explores a short-term link between meteorological parameters and number of diagnosed cases of canine babesiosis in Belgrade. It also looks into possible long-term correlations that span one year before the onset of the disease. Based on 872 recorded cases over four years, our results show a bimodal seasonal distribution of canine babesiosis, with a pronounced peak in the spring, and a less conspicuous one in the autumn. Throughout the year, even over the coldest and warmest periods, there is a broad range of temperatures and relative humidifies when the disease is recorded. Over one year prior to the spring and autumn onset of the disease, we found a noticeable impact of temperature and relative humidity, and to a lesser extent, of atmospheric pressure and cloud cover, on the number of diagnosed cases. These findings imply short-term and long-term relationships between occurrence of acute canine babesiosis and certain meteorological parameters, and they open further questions that need to be investigated in order to understand the epidemiology of this disease.
PB  - Elsevier Gmbh, Munich
T2  - Ticks and Tick-Borne Diseases
T1  - A short-term and long-term relationship between occurrence of acute canine babesiosis and meteorological parameters in Belgrade, Serbia
VL  - 10
IS  - 6
SP  - UNSP 101273
DO  - 10.1016/j.ttbdis.2019.101273
ER  - 

@article{
author = "Janjić, Filip and Sarvan, Darko and Tomanović, Snežana and Cuk, Jelena and Krstić, Vanja and Radonjić, Vladimir and Kovačević-Filipović, Milica and Ajtić, Jelena",
year = "2019",
abstract = "Belgrade, the capital of the Republic of Serbia, is an endemic location for canine babesiosis caused by Babesia canis. This tick-borne disease occurs seasonally in regions with moderate continental climate. However, recent clinical data show that 1) some cases of canine babesiosis have been recorded during the winter, and 2) canine babesiosis is spreading to the northern parts of Europe with a colder climate, which is a region previously free of this disease. Our study investigates the occurrence of canine babesiosis in different seasons over 2013-2016, and explores a short-term link between meteorological parameters and number of diagnosed cases of canine babesiosis in Belgrade. It also looks into possible long-term correlations that span one year before the onset of the disease. Based on 872 recorded cases over four years, our results show a bimodal seasonal distribution of canine babesiosis, with a pronounced peak in the spring, and a less conspicuous one in the autumn. Throughout the year, even over the coldest and warmest periods, there is a broad range of temperatures and relative humidifies when the disease is recorded. Over one year prior to the spring and autumn onset of the disease, we found a noticeable impact of temperature and relative humidity, and to a lesser extent, of atmospheric pressure and cloud cover, on the number of diagnosed cases. These findings imply short-term and long-term relationships between occurrence of acute canine babesiosis and certain meteorological parameters, and they open further questions that need to be investigated in order to understand the epidemiology of this disease.",
publisher = "Elsevier Gmbh, Munich",
journal = "Ticks and Tick-Borne Diseases",
title = "A short-term and long-term relationship between occurrence of acute canine babesiosis and meteorological parameters in Belgrade, Serbia",
volume = "10",
number = "6",
pages = "UNSP 101273",
doi = "10.1016/j.ttbdis.2019.101273"
}

Janjić, F., Sarvan, D., Tomanović, S., Cuk, J., Krstić, V., Radonjić, V., Kovačević-Filipović, M.,& Ajtić, J.. (2019). A short-term and long-term relationship between occurrence of acute canine babesiosis and meteorological parameters in Belgrade, Serbia. in Ticks and Tick-Borne Diseases
Elsevier Gmbh, Munich., 10(6), UNSP 101273.
https://doi.org/10.1016/j.ttbdis.2019.101273

Janjić F, Sarvan D, Tomanović S, Cuk J, Krstić V, Radonjić V, Kovačević-Filipović M, Ajtić J. A short-term and long-term relationship between occurrence of acute canine babesiosis and meteorological parameters in Belgrade, Serbia. in Ticks and Tick-Borne Diseases. 2019;10(6):UNSP 101273.
doi:10.1016/j.ttbdis.2019.101273 .

Janjić, Filip, Sarvan, Darko, Tomanović, Snežana, Cuk, Jelena, Krstić, Vanja, Radonjić, Vladimir, Kovačević-Filipović, Milica, Ajtić, Jelena, "A short-term and long-term relationship between occurrence of acute canine babesiosis and meteorological parameters in Belgrade, Serbia" in Ticks and Tick-Borne Diseases, 10, no. 6 (2019):UNSP 101273,
https://doi.org/10.1016/j.ttbdis.2019.101273 . .

TY  - JOUR
AU  - Milanović, Zorana
AU  - Božović-Ilić, Anja
AU  - Francuski Andrić, Jelena
AU  - Radonjić, Vladimir
AU  - Beletić, Andelo
AU  - Kovačević-Filipović, Milica
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1520
AB  - Babesia canis and Dirofilaria immitis are emerging and geographically overlapping vector-borne pathogens in dogs. Infection with B. canis leads to acute-phase response (APR) that can be mild to severe and results in either non-complicated or complicated forms of the disease. The aim of this study was to determine whether acute B. canis infection is more severe in dogs with underlying asymptomatic D. immitis infection. Dogs of both sexes, different ages and breeds, with naturally occurring mono-infections with B. canis (n = 13) and D. immitis (n = 18) and co-infected dogs (n = 7) were enrolled as well as healthy controls (n = 15). Routine haematology and biochemistry, agarose gel electrophoresis (agEF) protein fraction separation and enzyme-linked immtmosorbent assay (ELISA) for serum amyloid A (SAA) were performed. Based on clinical and laboratory findings, sepsis was diagnosed in the majority of dogs with acute B. cants infection with or without underlying asymptomatic D. immitis infection. Overall, haematology, biochemistry and agEF pattern changes were induced and dictated by acute B. cards infection whether or not the dogs had an asymptomatic D. immitis infection. D. immitis infection slightly influenced the level of anaemia, slightly aggravated the level of dehydration and increased the concentration of gamma-globulins in acute-phase B. canis infection. D. immitis infection prevented B. canis-induced leukopenia. SAA equally increased in dogs with acute B. cans infection with or without underlying D. immitis infection. The level of SAA was not changed in dogs with asymptomatic D. immitis when compared to the controls. In conclusion, asymptomatic D. immitis infection does not influence overall APR after acute B. canis infection.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Ticks and Tick-Borne Diseases
T1  - Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs
VL  - 8
IS  - 6
SP  - 907
EP  - 914
DO  - 10.1016/j.ttbdis.2017.07.009
ER  - 

@article{
author = "Milanović, Zorana and Božović-Ilić, Anja and Francuski Andrić, Jelena and Radonjić, Vladimir and Beletić, Andelo and Kovačević-Filipović, Milica",
year = "2017",
abstract = "Babesia canis and Dirofilaria immitis are emerging and geographically overlapping vector-borne pathogens in dogs. Infection with B. canis leads to acute-phase response (APR) that can be mild to severe and results in either non-complicated or complicated forms of the disease. The aim of this study was to determine whether acute B. canis infection is more severe in dogs with underlying asymptomatic D. immitis infection. Dogs of both sexes, different ages and breeds, with naturally occurring mono-infections with B. canis (n = 13) and D. immitis (n = 18) and co-infected dogs (n = 7) were enrolled as well as healthy controls (n = 15). Routine haematology and biochemistry, agarose gel electrophoresis (agEF) protein fraction separation and enzyme-linked immtmosorbent assay (ELISA) for serum amyloid A (SAA) were performed. Based on clinical and laboratory findings, sepsis was diagnosed in the majority of dogs with acute B. cants infection with or without underlying asymptomatic D. immitis infection. Overall, haematology, biochemistry and agEF pattern changes were induced and dictated by acute B. cards infection whether or not the dogs had an asymptomatic D. immitis infection. D. immitis infection slightly influenced the level of anaemia, slightly aggravated the level of dehydration and increased the concentration of gamma-globulins in acute-phase B. canis infection. D. immitis infection prevented B. canis-induced leukopenia. SAA equally increased in dogs with acute B. cans infection with or without underlying D. immitis infection. The level of SAA was not changed in dogs with asymptomatic D. immitis when compared to the controls. In conclusion, asymptomatic D. immitis infection does not influence overall APR after acute B. canis infection.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Ticks and Tick-Borne Diseases",
title = "Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs",
volume = "8",
number = "6",
pages = "907-914",
doi = "10.1016/j.ttbdis.2017.07.009"
}

Milanović, Z., Božović-Ilić, A., Francuski Andrić, J., Radonjić, V., Beletić, A.,& Kovačević-Filipović, M.. (2017). Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs. in Ticks and Tick-Borne Diseases
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 8(6), 907-914.
https://doi.org/10.1016/j.ttbdis.2017.07.009

Milanović Z, Božović-Ilić A, Francuski Andrić J, Radonjić V, Beletić A, Kovačević-Filipović M. Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs. in Ticks and Tick-Borne Diseases. 2017;8(6):907-914.
doi:10.1016/j.ttbdis.2017.07.009 .

Milanović, Zorana, Božović-Ilić, Anja, Francuski Andrić, Jelena, Radonjić, Vladimir, Beletić, Andelo, Kovačević-Filipović, Milica, "Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs" in Ticks and Tick-Borne Diseases, 8, no. 6 (2017):907-914,
https://doi.org/10.1016/j.ttbdis.2017.07.009 . .