TY  - JOUR
AU  - Pavlović, Miloš
AU  - Durić, Ana
AU  - Stevanović, Ivana
AU  - Begić, Aida
AU  - Vujanović, Dragana
AU  - Ninković, Milica
AU  - Dukić, Mirjana
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1694
AB  - We investigated the effect of disulfiram (DSF) on reproductive toxicity induced by subchronic exposure to cadmium (Cd). We examined the redox status and systemic testosterone changes in the testes and plasma of Cd-treated male Wistar rats. Rats were treated with 1 mg CdCl2/kg body weight (bw)/day (intraperitoneal administration) for 42 days; in the second experimental group, rats were given 178.5 mg DSF/kg bw/day by oral gavage for 21 days; in the third group, after administration of Cd for 21 days, DSF treatment was introduced on day 22 and lasted until day 42, with continuous Cd intake. Each experimental group had a matching control: untreated rats, rats that received for 21 days olive oil, the solvent for DSF; rats that started with olive oil intake from days 22-42. Exposure of rats to DSF modulated the oxidative status in the testes; thus, coexposure increased the Cd-induced reduction in total superoxide dismutase (tSOD), catalase ( CAT), glutathione reductase (GR) and total glutathione-S-transferase (tGST) activities, and lowered the Cd-increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) concentrations. DSF did not affect testosterone production diminished by Cd, as Leydig cells, once impaired by Cd, could not be reactivated by DSF.
PB  - Srpsko biološko društvo, Beograd
T2  - Archives of Biological Sciences
T1  - Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium
VL  - 71
IS  - 4
SP  - 747
EP  - 753
DO  - 10.2298/ABS190814057P
ER  - 

@article{
author = "Pavlović, Miloš and Durić, Ana and Stevanović, Ivana and Begić, Aida and Vujanović, Dragana and Ninković, Milica and Dukić, Mirjana",
year = "2019",
abstract = "We investigated the effect of disulfiram (DSF) on reproductive toxicity induced by subchronic exposure to cadmium (Cd). We examined the redox status and systemic testosterone changes in the testes and plasma of Cd-treated male Wistar rats. Rats were treated with 1 mg CdCl2/kg body weight (bw)/day (intraperitoneal administration) for 42 days; in the second experimental group, rats were given 178.5 mg DSF/kg bw/day by oral gavage for 21 days; in the third group, after administration of Cd for 21 days, DSF treatment was introduced on day 22 and lasted until day 42, with continuous Cd intake. Each experimental group had a matching control: untreated rats, rats that received for 21 days olive oil, the solvent for DSF; rats that started with olive oil intake from days 22-42. Exposure of rats to DSF modulated the oxidative status in the testes; thus, coexposure increased the Cd-induced reduction in total superoxide dismutase (tSOD), catalase ( CAT), glutathione reductase (GR) and total glutathione-S-transferase (tGST) activities, and lowered the Cd-increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) concentrations. DSF did not affect testosterone production diminished by Cd, as Leydig cells, once impaired by Cd, could not be reactivated by DSF.",
publisher = "Srpsko biološko društvo, Beograd",
journal = "Archives of Biological Sciences",
title = "Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium",
volume = "71",
number = "4",
pages = "747-753",
doi = "10.2298/ABS190814057P"
}

Pavlović, M., Durić, A., Stevanović, I., Begić, A., Vujanović, D., Ninković, M.,& Dukić, M.. (2019). Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd., 71(4), 747-753.
https://doi.org/10.2298/ABS190814057P

Pavlović M, Durić A, Stevanović I, Begić A, Vujanović D, Ninković M, Dukić M. Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium. in Archives of Biological Sciences. 2019;71(4):747-753.
doi:10.2298/ABS190814057P .

Pavlović, Miloš, Durić, Ana, Stevanović, Ivana, Begić, Aida, Vujanović, Dragana, Ninković, Milica, Dukić, Mirjana, "Disulfiram partially improves oxidative but not androgen status in rats exposed to cadmium" in Archives of Biological Sciences, 71, no. 4 (2019):747-753,
https://doi.org/10.2298/ABS190814057P . .

TY  - JOUR
AU  - Đurić, Ana
AU  - Begić, Aida
AU  - Gobeljić, Borko
AU  - Stanojević, Ivan
AU  - Ninković, Milica
AU  - Vojvodić, Danilo
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Prokić, Vera
AU  - Dejanović, Bratislav
AU  - Stojanović, Ivana
AU  - Pavlica, Marina
AU  - Đukić, Dusan
AU  - Saso, Luciano
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Topić, Aleksandra
AU  - Vujanović, Dragana
AU  - Stevanović, Ivana
AU  - Đukić, Mirjana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1302
AB  - The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
VL  - 86
SP  - 25
EP  - 33
DO  - 10.1016/j.fct.2015.09.004
ER  - 

@article{
author = "Đurić, Ana and Begić, Aida and Gobeljić, Borko and Stanojević, Ivan and Ninković, Milica and Vojvodić, Danilo and Pantelić, Ana and Zebić, Goran and Prokić, Vera and Dejanović, Bratislav and Stojanović, Ivana and Pavlica, Marina and Đukić, Dusan and Saso, Luciano and Đurđević, Dragan and Pavlović, Miloš and Topić, Aleksandra and Vujanović, Dragana and Stevanović, Ivana and Đukić, Mirjana",
year = "2015",
abstract = "The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium",
volume = "86",
pages = "25-33",
doi = "10.1016/j.fct.2015.09.004"
}

Đurić, A., Begić, A., Gobeljić, B., Stanojević, I., Ninković, M., Vojvodić, D., Pantelić, A., Zebić, G., Prokić, V., Dejanović, B., Stojanović, I., Pavlica, M., Đukić, D., Saso, L., Đurđević, D., Pavlović, M., Topić, A., Vujanović, D., Stevanović, I.,& Đukić, M.. (2015). Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 86, 25-33.
https://doi.org/10.1016/j.fct.2015.09.004

Đurić A, Begić A, Gobeljić B, Stanojević I, Ninković M, Vojvodić D, Pantelić A, Zebić G, Prokić V, Dejanović B, Stojanović I, Pavlica M, Đukić D, Saso L, Đurđević D, Pavlović M, Topić A, Vujanović D, Stevanović I, Đukić M. Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology. 2015;86:25-33.
doi:10.1016/j.fct.2015.09.004 .

Đurić, Ana, Begić, Aida, Gobeljić, Borko, Stanojević, Ivan, Ninković, Milica, Vojvodić, Danilo, Pantelić, Ana, Zebić, Goran, Prokić, Vera, Dejanović, Bratislav, Stojanović, Ivana, Pavlica, Marina, Đukić, Dusan, Saso, Luciano, Đurđević, Dragan, Pavlović, Miloš, Topić, Aleksandra, Vujanović, Dragana, Stevanović, Ivana, Đukić, Mirjana, "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium" in Food and Chemical Toxicology, 86 (2015):25-33,
https://doi.org/10.1016/j.fct.2015.09.004 . .

TY  - JOUR
AU  - Nikolić, Tatjana V.
AU  - Purac, Jelena
AU  - Orcić, Snežana
AU  - Kojić, Danijela
AU  - Vujanović, Dragana
AU  - Stanimirović, Zoran
AU  - Grzetić, Ivan
AU  - Ilijević, Konstantin
AU  - Sikoparija, Branko
AU  - Blagojević, Duško P.
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1305
AB  - Understanding the cellular stress response in honey bees will significantly contribute to their conservation. The aim of this study was to analyze the response of the antioxidative enzymes superoxide dismutase and catalase in honey bees related to the presence of toxic metals in different habitats. Three locations were selected: (i) Tunovo on the mountain Golija, as control area, without industry and large human impact, (ii) Belgrade as urban area, and (iii) Zajaca, as mining and industrial zone. Our results showed that the concentrations of lead (Pb) in whole body of bees vary according to habitat, but there was very significant increase of Pb in bees from investigated industrial area. Bees from urban and industrial area had increased expression of both Sod1 and Cat genes, suggesting adaptation to increased oxidative stress. However, in spite increased gene expression, the enzyme activity of catalase was lower in bees from industrial area suggesting inhibitory effect of Pb on catalase.
PB  - Wiley-Blackwell, Hoboken
T2  - Archives of Insect Biochemistry and Physiology
T1  - Environmental effects on superoxide dismutase and catalase activity and expression in honey bee
VL  - 90
IS  - 4
SP  - 181
EP  - 194
DO  - 10.1002/arch.21253
ER  - 

@article{
author = "Nikolić, Tatjana V. and Purac, Jelena and Orcić, Snežana and Kojić, Danijela and Vujanović, Dragana and Stanimirović, Zoran and Grzetić, Ivan and Ilijević, Konstantin and Sikoparija, Branko and Blagojević, Duško P.",
year = "2015",
abstract = "Understanding the cellular stress response in honey bees will significantly contribute to their conservation. The aim of this study was to analyze the response of the antioxidative enzymes superoxide dismutase and catalase in honey bees related to the presence of toxic metals in different habitats. Three locations were selected: (i) Tunovo on the mountain Golija, as control area, without industry and large human impact, (ii) Belgrade as urban area, and (iii) Zajaca, as mining and industrial zone. Our results showed that the concentrations of lead (Pb) in whole body of bees vary according to habitat, but there was very significant increase of Pb in bees from investigated industrial area. Bees from urban and industrial area had increased expression of both Sod1 and Cat genes, suggesting adaptation to increased oxidative stress. However, in spite increased gene expression, the enzyme activity of catalase was lower in bees from industrial area suggesting inhibitory effect of Pb on catalase.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Archives of Insect Biochemistry and Physiology",
title = "Environmental effects on superoxide dismutase and catalase activity and expression in honey bee",
volume = "90",
number = "4",
pages = "181-194",
doi = "10.1002/arch.21253"
}

Nikolić, T. V., Purac, J., Orcić, S., Kojić, D., Vujanović, D., Stanimirović, Z., Grzetić, I., Ilijević, K., Sikoparija, B.,& Blagojević, D. P.. (2015). Environmental effects on superoxide dismutase and catalase activity and expression in honey bee. in Archives of Insect Biochemistry and Physiology
Wiley-Blackwell, Hoboken., 90(4), 181-194.
https://doi.org/10.1002/arch.21253

Nikolić TV, Purac J, Orcić S, Kojić D, Vujanović D, Stanimirović Z, Grzetić I, Ilijević K, Sikoparija B, Blagojević DP. Environmental effects on superoxide dismutase and catalase activity and expression in honey bee. in Archives of Insect Biochemistry and Physiology. 2015;90(4):181-194.
doi:10.1002/arch.21253 .

Nikolić, Tatjana V., Purac, Jelena, Orcić, Snežana, Kojić, Danijela, Vujanović, Dragana, Stanimirović, Zoran, Grzetić, Ivan, Ilijević, Konstantin, Sikoparija, Branko, Blagojević, Duško P., "Environmental effects on superoxide dismutase and catalase activity and expression in honey bee" in Archives of Insect Biochemistry and Physiology, 90, no. 4 (2015):181-194,
https://doi.org/10.1002/arch.21253 . .