TY  - JOUR
AU  - Novakovic, Miroslav
AU  - Todorovic, Nina
AU  - Jadranin, Milka
AU  - Đorđevic, Iris
AU  - Milosavljevic, Slobodan
AU  - Mandic, Boris
AU  - Tesevic, Vele
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2946
AB  - A new auronolignan, named cotinignan B, was isolated from Cotinus coggygria Scop. Structure elucidation was performed on the basis of 1H, 13C NMR, COSY, NOESY, HSQC, and HMBC experiments, supported with HR-ESI-MS, IR and UV. Additional J-HMBC NMR experiment was essential to resolve the configuration of the trisubstituted double bond. This compound represents the secondly discovered natural compound belonging to the rare auronolignan type.
PB  - Springer
T2  - Chemistry of Natural Compounds
T1  - A New Auronolignan from the Cotinus coggygria Heartwood
VL  - 59
IS  - 3
SP  - 428
EP  - 430
DO  - 10.1007/s10600-023-04016-5
ER  - 

@article{
author = "Novakovic, Miroslav and Todorovic, Nina and Jadranin, Milka and Đorđevic, Iris and Milosavljevic, Slobodan and Mandic, Boris and Tesevic, Vele",
year = "2023",
abstract = "A new auronolignan, named cotinignan B, was isolated from Cotinus coggygria Scop. Structure elucidation was performed on the basis of 1H, 13C NMR, COSY, NOESY, HSQC, and HMBC experiments, supported with HR-ESI-MS, IR and UV. Additional J-HMBC NMR experiment was essential to resolve the configuration of the trisubstituted double bond. This compound represents the secondly discovered natural compound belonging to the rare auronolignan type.",
publisher = "Springer",
journal = "Chemistry of Natural Compounds",
title = "A New Auronolignan from the Cotinus coggygria Heartwood",
volume = "59",
number = "3",
pages = "428-430",
doi = "10.1007/s10600-023-04016-5"
}

Novakovic, M., Todorovic, N., Jadranin, M., Đorđevic, I., Milosavljevic, S., Mandic, B.,& Tesevic, V.. (2023). A New Auronolignan from the Cotinus coggygria Heartwood. in Chemistry of Natural Compounds
Springer., 59(3), 428-430.
https://doi.org/10.1007/s10600-023-04016-5

Novakovic M, Todorovic N, Jadranin M, Đorđevic I, Milosavljevic S, Mandic B, Tesevic V. A New Auronolignan from the Cotinus coggygria Heartwood. in Chemistry of Natural Compounds. 2023;59(3):428-430.
doi:10.1007/s10600-023-04016-5 .

Novakovic, Miroslav, Todorovic, Nina, Jadranin, Milka, Đorđevic, Iris, Milosavljevic, Slobodan, Mandic, Boris, Tesevic, Vele, "A New Auronolignan from the Cotinus coggygria Heartwood" in Chemistry of Natural Compounds, 59, no. 3 (2023):428-430,
https://doi.org/10.1007/s10600-023-04016-5 . .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Krstić, Gordana
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2995
AB  - Our previous phytochemical studies revealed that the
plant species of the genus Amphoricarpos from
Montenegro are characterized with an appreciable content
(>0.3–2.3% per dry weight of aerial plant material) of γsesquiterpene lactones with guaianolide skeleton, socalled amphoricarpolides that are mostly deposited on the
leaf surface (>1.0–3.4% per dry weight of leaves)
(Djordjević et al., 2021; Jadranin et al., 2013). These
compounds showed in vitro protective effect on
chromosome aberrations in peripheral human
lymphocytes (Cvetković et al., 2021) and in vitro
cytotoxic (Djordjević et al., 2021), antifungal (Jadranin et
al., 2013) and antibacterial (Gavrilović et al., 2016)
activities. The amphoricarpolides are significant as
chemotaxonomic markers as they gave insights about the
taxonomic status of the genus (Djordjević et al., 2021).
This study revealed results from reinvestigation of
sesquiterpene lactones composition in the crude and leaf
surface extracts of Amphoricarpos plants by rapid
resolution liquid chromatography (RRLC) coupled with
quadrupole time-of-flight mass spectrometry (QToF MS)
and the tentative identification of undescribed
sesquiterpene lactones is presented.
PB  - Skopje : Macedonian Pharmaceutical Association
T2  - Macedonian Pharmaceutical Bulletin
T1  - New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
VL  - 68
SP  - 71
EP  - 72
DO  - 10.33320/maced.pharm.bull.2022.68.04.030
ER  - 

@article{
author = "Jadranin, Milka and Cvetković, Mirjana and Đorđević, Iris and Krstić, Gordana and Tešević, Vele and Milosavljević, Slobodan",
year = "2022",
abstract = "Our previous phytochemical studies revealed that the
plant species of the genus Amphoricarpos from
Montenegro are characterized with an appreciable content
(>0.3–2.3% per dry weight of aerial plant material) of γsesquiterpene lactones with guaianolide skeleton, socalled amphoricarpolides that are mostly deposited on the
leaf surface (>1.0–3.4% per dry weight of leaves)
(Djordjević et al., 2021; Jadranin et al., 2013). These
compounds showed in vitro protective effect on
chromosome aberrations in peripheral human
lymphocytes (Cvetković et al., 2021) and in vitro
cytotoxic (Djordjević et al., 2021), antifungal (Jadranin et
al., 2013) and antibacterial (Gavrilović et al., 2016)
activities. The amphoricarpolides are significant as
chemotaxonomic markers as they gave insights about the
taxonomic status of the genus (Djordjević et al., 2021).
This study revealed results from reinvestigation of
sesquiterpene lactones composition in the crude and leaf
surface extracts of Amphoricarpos plants by rapid
resolution liquid chromatography (RRLC) coupled with
quadrupole time-of-flight mass spectrometry (QToF MS)
and the tentative identification of undescribed
sesquiterpene lactones is presented.",
publisher = "Skopje : Macedonian Pharmaceutical Association",
journal = "Macedonian Pharmaceutical Bulletin",
title = "New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry",
volume = "68",
pages = "71-72",
doi = "10.33320/maced.pharm.bull.2022.68.04.030"
}

Jadranin, M., Cvetković, M., Đorđević, I., Krstić, G., Tešević, V.,& Milosavljević, S.. (2022). New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin
Skopje : Macedonian Pharmaceutical Association., 68, 71-72.
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030

Jadranin M, Cvetković M, Đorđević I, Krstić G, Tešević V, Milosavljević S. New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin. 2022;68:71-72.
doi:10.33320/maced.pharm.bull.2022.68.04.030 .

Jadranin, Milka, Cvetković, Mirjana, Đorđević, Iris, Krstić, Gordana, Tešević, Vele, Milosavljević, Slobodan, "New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry" in Macedonian Pharmaceutical Bulletin, 68 (2022):71-72,
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030 . .

TY  - JOUR
AU  - Đorđević, Iris
AU  - Cvetković, Mirjana
AU  - Jadranin, Milka
AU  - Bojović, Srđan
AU  - Anđelković, Boban
AU  - Sofrenić, Ivana
AU  - Simić, Katarina
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2538
AB  - Phytochemistry deals with the study of secondary metabolites produced by plants that synthesize these compounds for many reasons, including their own protection against attack of herbivores and plant diseases. Secondary metabolites are believed to represent plant adaptation to various environmental factors and that they enabled the survival of the species. Secondary metabolites of plants can have curative or toxic effects in humans and animals. Herbal medicine has a long tradition in folk medicine and until the early 20th century, when synthetic organic chemistry began to develop, plants were the main source of medicines. The two basic goals of our phytochemical research are: Isolation and identification of new (biologically active) compounds - potential drugs, and chemotaxonomy (chemosystematics). In the following text through one selected example, the genus Amphoricarpos Vis., our phytochemical research is shown on both aspects.
PB  - Belgrade :: Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Phytochemical study of the genus Amphoricarpos
VL  - 86
IS  - 12
SP  - 1177
SP  - 1193
DO  - 10.2298/JSC210726083D
ER  - 

@article{
author = "Đorđević, Iris and Cvetković, Mirjana and Jadranin, Milka and Bojović, Srđan and Anđelković, Boban and Sofrenić, Ivana and Simić, Katarina",
year = "2021",
abstract = "Phytochemistry deals with the study of secondary metabolites produced by plants that synthesize these compounds for many reasons, including their own protection against attack of herbivores and plant diseases. Secondary metabolites are believed to represent plant adaptation to various environmental factors and that they enabled the survival of the species. Secondary metabolites of plants can have curative or toxic effects in humans and animals. Herbal medicine has a long tradition in folk medicine and until the early 20th century, when synthetic organic chemistry began to develop, plants were the main source of medicines. The two basic goals of our phytochemical research are: Isolation and identification of new (biologically active) compounds - potential drugs, and chemotaxonomy (chemosystematics). In the following text through one selected example, the genus Amphoricarpos Vis., our phytochemical research is shown on both aspects.",
publisher = "Belgrade :: Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Phytochemical study of the genus Amphoricarpos",
volume = "86",
number = "12",
pages = "1177-1193",
doi = "10.2298/JSC210726083D"
}

Đorđević, I., Cvetković, M., Jadranin, M., Bojović, S., Anđelković, B., Sofrenić, I.,& Simić, K.. (2021). Phytochemical study of the genus Amphoricarpos. in Journal of the Serbian Chemical Society
Belgrade :: Serbian Chemical Society., 86(12), 1177.
https://doi.org/10.2298/JSC210726083D

Đorđević I, Cvetković M, Jadranin M, Bojović S, Anđelković B, Sofrenić I, Simić K. Phytochemical study of the genus Amphoricarpos. in Journal of the Serbian Chemical Society. 2021;86(12):1177.
doi:10.2298/JSC210726083D .

Đorđević, Iris, Cvetković, Mirjana, Jadranin, Milka, Bojović, Srđan, Anđelković, Boban, Sofrenić, Ivana, Simić, Katarina, "Phytochemical study of the genus Amphoricarpos" in Journal of the Serbian Chemical Society, 86, no. 12 (2021):1177,
https://doi.org/10.2298/JSC210726083D . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Mandić, Boris
AU  - Milosavljević, Slobodan M.
AU  - Vujisić, Ljubodrag
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1799
AB  - Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13-16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9 beta-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA
DO  - 10.1080/14786419.2019.1687470
ER  - 

@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Stanković, Miroslava and Mandić, Boris and Milosavljević, Slobodan M. and Vujisić, Ljubodrag",
year = "2020",
abstract = "Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13-16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9 beta-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA",
doi = "10.1080/14786419.2019.1687470"
}

Cvetković, M., Đorđević, I., Jadranin, M., Stanković, M., Mandić, B., Milosavljević, S. M.,& Vujisić, L.. (2020). Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA. in Natural Product Research
Taylor & Francis Ltd, Abingdon..
https://doi.org/10.1080/14786419.2019.1687470

Cvetković M, Đorđević I, Jadranin M, Stanković M, Mandić B, Milosavljević SM, Vujisić L. Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA. in Natural Product Research. 2020;.
doi:10.1080/14786419.2019.1687470 .

Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Stanković, Miroslava, Mandić, Boris, Milosavljević, Slobodan M., Vujisić, Ljubodrag, "Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA" in Natural Product Research (2020),
https://doi.org/10.1080/14786419.2019.1687470 . .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Đorđević, Iris
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Anđelković, Boban
AU  - Mandić, Boris
AU  - Jadranin, Milka
AU  - Vucković, Ivan
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Tešević, Vele
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1734
AB  - New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and new auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of Cotinus coggygria Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-trans-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3,5,5,7-tetrahydroxyflavanone, 3,4,7-trihydroxyflavone, 3-O-methyl-2,3-trans-fustin, 3-O-galloyl-2,3-trans-fustin, beta-resorcylic acid and 3-O-beta-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3 and 4 hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from C. coggygria. Cotinignan A (15) represents new subclass of secondary metabolites - auronolignans. [GRAPHICS]
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop
VL  - 33
IS  - 19
SP  - 2837
EP  - 2844
DO  - 10.1080/14786419.2018.1508141
ER  - 

@article{
author = "Novaković, Miroslav and Đorđević, Iris and Todorović, Nina and Trifunović, Snežana and Anđelković, Boban and Mandić, Boris and Jadranin, Milka and Vucković, Ivan and Vajs, Vlatka and Milosavljević, Slobodan M. and Tešević, Vele",
year = "2019",
abstract = "New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and new auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of Cotinus coggygria Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-trans-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3,5,5,7-tetrahydroxyflavanone, 3,4,7-trihydroxyflavone, 3-O-methyl-2,3-trans-fustin, 3-O-galloyl-2,3-trans-fustin, beta-resorcylic acid and 3-O-beta-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3 and 4 hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from C. coggygria. Cotinignan A (15) represents new subclass of secondary metabolites - auronolignans. [GRAPHICS]",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop",
volume = "33",
number = "19",
pages = "2837-2844",
doi = "10.1080/14786419.2018.1508141"
}

Novaković, M., Đorđević, I., Todorović, N., Trifunović, S., Anđelković, B., Mandić, B., Jadranin, M., Vucković, I., Vajs, V., Milosavljević, S. M.,& Tešević, V.. (2019). New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(19), 2837-2844.
https://doi.org/10.1080/14786419.2018.1508141

Novaković M, Đorđević I, Todorović N, Trifunović S, Anđelković B, Mandić B, Jadranin M, Vucković I, Vajs V, Milosavljević SM, Tešević V. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop. in Natural Product Research. 2019;33(19):2837-2844.
doi:10.1080/14786419.2018.1508141 .

Novaković, Miroslav, Đorđević, Iris, Todorović, Nina, Trifunović, Snežana, Anđelković, Boban, Mandić, Boris, Jadranin, Milka, Vucković, Ivan, Vajs, Vlatka, Milosavljević, Slobodan M., Tešević, Vele, "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop" in Natural Product Research, 33, no. 19 (2019):2837-2844,
https://doi.org/10.1080/14786419.2018.1508141 . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Anđelković, Boban
AU  - Stevanović, Vladimir
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1673
AB  - The genus Amphoricarpos Vis. is endemic of westpart of Balkan peninsula. In order to get more insight into the ambiguous taxonomy of the genus, the metabolomic study of the Amphoricarpos samples, has been undertaken. The(1)H NMR spectroscopy combined with multivariate data analysis has been applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples based on the metabolites present in the extracts. The main difference between A. autariatus and A. neumayeri has been found to be the presence of characteristic sesquiterpene lactones of guaianolide type named amphoricarpolides. While the main sesquiterpene lactone in A. neumayeri was oxidized in position 2, those present in both subspecies of A. autariatus samples were oxidized in position 9. The use of sesquiterpene lactones as taxonomic characters for differentiating species of the Asteraceae family was reviewed elsewhere. For the differentiation of two subspecies, A. autariatus ssp. autariatus, and A. autariatus ssp. bertisceus, chlorogenic and malic acid have been found to be decisive, but these compounds do not have chemotaxonomic significance. Our results were in accordance with above mentioned classification of Blecic and Mayer but they differentiate from those of the recent genomic study of the genus indicating a single, genetically, morphologically and ecologically variable species, without intraspecific taxa.
PB  - Elsevier Science Bv, Amsterdam
T2  - Phytochemistry Letters
T1  - NMR-based metabolomics study of Amphoricarpos species from Montenegro
VL  - 25
SP  - 1
EP  - 5
DO  - 10.1016/j.phytol.2018.03.013
ER  - 

@article{
author = "Cvetković, Mirjana and Anđelković, Boban and Stevanović, Vladimir and Jadranin, Milka and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2018",
abstract = "The genus Amphoricarpos Vis. is endemic of westpart of Balkan peninsula. In order to get more insight into the ambiguous taxonomy of the genus, the metabolomic study of the Amphoricarpos samples, has been undertaken. The(1)H NMR spectroscopy combined with multivariate data analysis has been applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples based on the metabolites present in the extracts. The main difference between A. autariatus and A. neumayeri has been found to be the presence of characteristic sesquiterpene lactones of guaianolide type named amphoricarpolides. While the main sesquiterpene lactone in A. neumayeri was oxidized in position 2, those present in both subspecies of A. autariatus samples were oxidized in position 9. The use of sesquiterpene lactones as taxonomic characters for differentiating species of the Asteraceae family was reviewed elsewhere. For the differentiation of two subspecies, A. autariatus ssp. autariatus, and A. autariatus ssp. bertisceus, chlorogenic and malic acid have been found to be decisive, but these compounds do not have chemotaxonomic significance. Our results were in accordance with above mentioned classification of Blecic and Mayer but they differentiate from those of the recent genomic study of the genus indicating a single, genetically, morphologically and ecologically variable species, without intraspecific taxa.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Phytochemistry Letters",
title = "NMR-based metabolomics study of Amphoricarpos species from Montenegro",
volume = "25",
pages = "1-5",
doi = "10.1016/j.phytol.2018.03.013"
}

Cvetković, M., Anđelković, B., Stevanović, V., Jadranin, M., Đorđević, I., Tešević, V., Milosavljević, S. M.,& Gođevac, D.. (2018). NMR-based metabolomics study of Amphoricarpos species from Montenegro. in Phytochemistry Letters
Elsevier Science Bv, Amsterdam., 25, 1-5.
https://doi.org/10.1016/j.phytol.2018.03.013

Cvetković M, Anđelković B, Stevanović V, Jadranin M, Đorđević I, Tešević V, Milosavljević SM, Gođevac D. NMR-based metabolomics study of Amphoricarpos species from Montenegro. in Phytochemistry Letters. 2018;25:1-5.
doi:10.1016/j.phytol.2018.03.013 .

Cvetković, Mirjana, Anđelković, Boban, Stevanović, Vladimir, Jadranin, Milka, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Gođevac, Dejan, "NMR-based metabolomics study of Amphoricarpos species from Montenegro" in Phytochemistry Letters, 25 (2018):1-5,
https://doi.org/10.1016/j.phytol.2018.03.013 . .

TY  - CHAP
AU  - Šavikin, K.
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Menković, Nebojša
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1213
AB  - The results are presented of phytochemical investigations, during the last decade, of some wild-growing species of the family Gentianaceae from Serbia and Montenegro. Some of the species investigated, members of the genera Gentiana, Gentianella, and Swertia, are endemic, and the emphasis in this report is on those exhibiting biological activities that could be regarded as a potential source of drugs. This review discusses more than fifty compounds, such as xanthones, secoiridoids, and C-glucoflavonoids.
PB  - Springer Berlin Heidelberg
T2  - The Gentianaceae - Volume 2: Biotechnology and Applications
T1  - Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula
SP  - 319
EP  - 347
DO  - 10.1007/978-3-642-54102-5_14
ER  - 

@inbook{
author = "Šavikin, K. and Aljančić, Ivana and Vajs, Vlatka and Milosavljević, Slobodan M. and Jadranin, Milka and Đorđević, Iris and Menković, Nebojša",
year = "2015",
abstract = "The results are presented of phytochemical investigations, during the last decade, of some wild-growing species of the family Gentianaceae from Serbia and Montenegro. Some of the species investigated, members of the genera Gentiana, Gentianella, and Swertia, are endemic, and the emphasis in this report is on those exhibiting biological activities that could be regarded as a potential source of drugs. This review discusses more than fifty compounds, such as xanthones, secoiridoids, and C-glucoflavonoids.",
publisher = "Springer Berlin Heidelberg",
journal = "The Gentianaceae - Volume 2: Biotechnology and Applications",
booktitle = "Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula",
pages = "319-347",
doi = "10.1007/978-3-642-54102-5_14"
}

Šavikin, K., Aljančić, I., Vajs, V., Milosavljević, S. M., Jadranin, M., Đorđević, I.,& Menković, N.. (2015). Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula. in The Gentianaceae - Volume 2: Biotechnology and Applications
Springer Berlin Heidelberg., 319-347.
https://doi.org/10.1007/978-3-642-54102-5_14

Šavikin K, Aljančić I, Vajs V, Milosavljević SM, Jadranin M, Đorđević I, Menković N. Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula. in The Gentianaceae - Volume 2: Biotechnology and Applications. 2015;:319-347.
doi:10.1007/978-3-642-54102-5_14 .

Šavikin, K., Aljančić, Ivana, Vajs, Vlatka, Milosavljević, Slobodan M., Jadranin, Milka, Đorđević, Iris, Menković, Nebojša, "Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula" in The Gentianaceae - Volume 2: Biotechnology and Applications (2015):319-347,
https://doi.org/10.1007/978-3-642-54102-5_14 . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Menković, Nebojša
AU  - Matevski, Vlado
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1082
AB  - The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Secondary metabolites of three endemic Centaurea L. species
VL  - 79
IS  - 11
SP  - 1355
EP  - 1362
DO  - 10.2298/JSC140318048T
ER  - 

@article{
author = "Tešević, Vele and Aljančić, Ivana and Milosavljević, Slobodan M. and Vajs, Vlatka and Đorđević, Iris and Jadranin, Milka and Menković, Nebojša and Matevski, Vlado",
year = "2014",
abstract = "The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Secondary metabolites of three endemic Centaurea L. species",
volume = "79",
number = "11",
pages = "1355-1362",
doi = "10.2298/JSC140318048T"
}

Tešević, V., Aljančić, I., Milosavljević, S. M., Vajs, V., Đorđević, I., Jadranin, M., Menković, N.,& Matevski, V.. (2014). Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 79(11), 1355-1362.
https://doi.org/10.2298/JSC140318048T

Tešević V, Aljančić I, Milosavljević SM, Vajs V, Đorđević I, Jadranin M, Menković N, Matevski V. Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society. 2014;79(11):1355-1362.
doi:10.2298/JSC140318048T .

Tešević, Vele, Aljančić, Ivana, Milosavljević, Slobodan M., Vajs, Vlatka, Đorđević, Iris, Jadranin, Milka, Menković, Nebojša, Matevski, Vlado, "Secondary metabolites of three endemic Centaurea L. species" in Journal of the Serbian Chemical Society, 79, no. 11 (2014):1355-1362,
https://doi.org/10.2298/JSC140318048T . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Vucković, Ivan
AU  - Menković, Nebojša
AU  - Milosavljević, Slobodan M.
AU  - Tešević, Vele
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1086
AB  - Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry & Biodiversity
T1  - Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro
VL  - 11
IS  - 9
SP  - 1428
EP  - 1437
DO  - 10.1002/cbdv.201400101
ER  - 

@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Vajs, Vlatka and Vucković, Ivan and Menković, Nebojša and Milosavljević, Slobodan M. and Tešević, Vele",
year = "2014",
abstract = "Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro",
volume = "11",
number = "9",
pages = "1428-1437",
doi = "10.1002/cbdv.201400101"
}

Cvetković, M., Đorđević, I., Jadranin, M., Vajs, V., Vucković, I., Menković, N., Milosavljević, S. M.,& Tešević, V.. (2014). Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry & Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(9), 1428-1437.
https://doi.org/10.1002/cbdv.201400101

Cvetković M, Đorđević I, Jadranin M, Vajs V, Vucković I, Menković N, Milosavljević SM, Tešević V. Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry & Biodiversity. 2014;11(9):1428-1437.
doi:10.1002/cbdv.201400101 .

Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Vajs, Vlatka, Vucković, Ivan, Menković, Nebojša, Milosavljević, Slobodan M., Tešević, Vele, "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro" in Chemistry & Biodiversity, 11, no. 9 (2014):1428-1437,
https://doi.org/10.1002/cbdv.201400101 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vucković, Ivan
AU  - Jadranin, Milka
AU  - Pesić, Milica
AU  - Đorđević, Iris
AU  - Podolski-Renić, Ana
AU  - Stojković, Sonja
AU  - Menković, Nebojša
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1102
AB  - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
VL  - 98
SP  - 190
EP  - 196
DO  - 10.1016/j.phytochem.2013.11.025
ER  - 

@article{
author = "Aljančić, Ivana and Vucković, Ivan and Jadranin, Milka and Pesić, Milica and Đorđević, Iris and Podolski-Renić, Ana and Stojković, Sonja and Menković, Nebojša and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines",
volume = "98",
pages = "190-196",
doi = "10.1016/j.phytochem.2013.11.025"
}

Aljančić, I., Vucković, I., Jadranin, M., Pesić, M., Đorđević, I., Podolski-Renić, A., Stojković, S., Menković, N., Vajs, V.,& Milosavljević, S. M.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 98, 190-196.
https://doi.org/10.1016/j.phytochem.2013.11.025

Aljančić I, Vucković I, Jadranin M, Pesić M, Đorđević I, Podolski-Renić A, Stojković S, Menković N, Vajs V, Milosavljević SM. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196.
doi:10.1016/j.phytochem.2013.11.025 .

Aljančić, Ivana, Vucković, Ivan, Jadranin, Milka, Pesić, Milica, Đorđević, Iris, Podolski-Renić, Ana, Stojković, Sonja, Menković, Nebojša, Vajs, Vlatka, Milosavljević, Slobodan M., "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196,
https://doi.org/10.1016/j.phytochem.2013.11.025 . .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Menković, Nebojša
AU  - Soković, Marina
AU  - Glamoclija, Jasmina
AU  - Milosavljević, Slobodan M.
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1010
AB  - The composition of leaf cuticular neutral lipids of Amphoricarpos autariatus ssp. autariatus collected at canyon of river Tara (North Montenegro) was investigated by GC/MS (nonpolar fraction), LC-ESI TOF MS and H-1 NMR spectroscopy (more polar fraction). The nonpolar fraction (ca. 15% of the whole surface extract) contained C-27 (-) (33) n-alkanes, those with odd-number of carbons predominating. The LC-ESI MS and H-1 NMR of the more polar fraction revealed 13 sesquiterpene lactones, constituting ca. 97.5% of the lactone mixture, identified as the known guaianolides, so-called amphoricarpolides, found previously in the aerial parts of the genus. The lactone fraction exhibited considerable in vitro effect against eight fungi, i.e. Aspergillus ochraceus, A. niger, A. versicolor, Penicillium funiculosum, P. ochrochloron, Trichoderma viride, Fusarium verticillioides and Fulvia fulvum.
PB  - Acg Publications, Gebze-Kocaeli
T2  - Records of Natural Products
T1  - Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents
VL  - 7
IS  - 3
SP  - 234
EP  - 238
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1360
ER  - 

@article{
author = "Jadranin, Milka and Đorđević, Iris and Tešević, Vele and Vajs, Vlatka and Menković, Nebojša and Soković, Marina and Glamoclija, Jasmina and Milosavljević, Slobodan M.",
year = "2013",
abstract = "The composition of leaf cuticular neutral lipids of Amphoricarpos autariatus ssp. autariatus collected at canyon of river Tara (North Montenegro) was investigated by GC/MS (nonpolar fraction), LC-ESI TOF MS and H-1 NMR spectroscopy (more polar fraction). The nonpolar fraction (ca. 15% of the whole surface extract) contained C-27 (-) (33) n-alkanes, those with odd-number of carbons predominating. The LC-ESI MS and H-1 NMR of the more polar fraction revealed 13 sesquiterpene lactones, constituting ca. 97.5% of the lactone mixture, identified as the known guaianolides, so-called amphoricarpolides, found previously in the aerial parts of the genus. The lactone fraction exhibited considerable in vitro effect against eight fungi, i.e. Aspergillus ochraceus, A. niger, A. versicolor, Penicillium funiculosum, P. ochrochloron, Trichoderma viride, Fusarium verticillioides and Fulvia fulvum.",
publisher = "Acg Publications, Gebze-Kocaeli",
journal = "Records of Natural Products",
title = "Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents",
volume = "7",
number = "3",
pages = "234-238",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1360"
}

Jadranin, M., Đorđević, I., Tešević, V., Vajs, V., Menković, N., Soković, M., Glamoclija, J.,& Milosavljević, S. M.. (2013). Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents. in Records of Natural Products
Acg Publications, Gebze-Kocaeli., 7(3), 234-238.
https://hdl.handle.net/21.15107/rcub_cherry_1360

Jadranin M, Đorđević I, Tešević V, Vajs V, Menković N, Soković M, Glamoclija J, Milosavljević SM. Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents. in Records of Natural Products. 2013;7(3):234-238.
https://hdl.handle.net/21.15107/rcub_cherry_1360 .

Jadranin, Milka, Đorđević, Iris, Tešević, Vele, Vajs, Vlatka, Menković, Nebojša, Soković, Marina, Glamoclija, Jasmina, Milosavljević, Slobodan M., "Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents" in Records of Natural Products, 7, no. 3 (2013):234-238,
https://hdl.handle.net/21.15107/rcub_cherry_1360 .

TY  - JOUR
AU  - Nikolić, Biljana
AU  - Tešević, Vele
AU  - Đorđević, Iris
AU  - Todosijević, Marina
AU  - Jadranin, Milka
AU  - Bojović, Srđan
AU  - Marin, Petar D.
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1011
AB  - This is the first report of population variability of the contents of n-alkanes and nonacosan-10-ol in the needle epicuticular waxes of Serbian spruce (Picea omorika). The hexane extracts of needle samples originated from three natural populations in Serbia (Vranjak, Zmajevaki potok, and Mileevka Canyon) were investigated by GC and GC/MS analyses. The amount of nonacosan-10-ol varied individually from 50.05 to 74.42% (65.74% in average), but the differences between the three investigated populations were not statistically confirmed. The results exhibited variability of the composition of n-alkanes in the epicuticular waxes with their size ranging from C18 to C35. The most abundant n-alkanes were C29, C31, and C27 (35.22, 13.77, and 12.28% in average, resp.). The carbon preference index of all the n-alkanes (CPItotal) of the P. omorika populations (average of populations IIII) ranged from 3.3 to 11.5 (mean of 5.9), while the average chain length (ACL) ranged from 26.6 to 29.2. The principal component and cluster analyses of the contents of nine n-alkanes showed the greatest difference for the population growing in the Mileevka Canyon. The obtained results were compared with previous literature data given for other Picea species, and this comparison was briefly discussed.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry & Biodiversity
T1  - Variability of n-Alkanes and Nonacosan-10-ol in Natural Populations of Picea omorika
VL  - 10
IS  - 3
SP  - 473
EP  - 483
DO  - 10.1002/cbdv.201200271
ER  - 

@article{
author = "Nikolić, Biljana and Tešević, Vele and Đorđević, Iris and Todosijević, Marina and Jadranin, Milka and Bojović, Srđan and Marin, Petar D.",
year = "2013",
abstract = "This is the first report of population variability of the contents of n-alkanes and nonacosan-10-ol in the needle epicuticular waxes of Serbian spruce (Picea omorika). The hexane extracts of needle samples originated from three natural populations in Serbia (Vranjak, Zmajevaki potok, and Mileevka Canyon) were investigated by GC and GC/MS analyses. The amount of nonacosan-10-ol varied individually from 50.05 to 74.42% (65.74% in average), but the differences between the three investigated populations were not statistically confirmed. The results exhibited variability of the composition of n-alkanes in the epicuticular waxes with their size ranging from C18 to C35. The most abundant n-alkanes were C29, C31, and C27 (35.22, 13.77, and 12.28% in average, resp.). The carbon preference index of all the n-alkanes (CPItotal) of the P. omorika populations (average of populations IIII) ranged from 3.3 to 11.5 (mean of 5.9), while the average chain length (ACL) ranged from 26.6 to 29.2. The principal component and cluster analyses of the contents of nine n-alkanes showed the greatest difference for the population growing in the Mileevka Canyon. The obtained results were compared with previous literature data given for other Picea species, and this comparison was briefly discussed.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Variability of n-Alkanes and Nonacosan-10-ol in Natural Populations of Picea omorika",
volume = "10",
number = "3",
pages = "473-483",
doi = "10.1002/cbdv.201200271"
}

Nikolić, B., Tešević, V., Đorđević, I., Todosijević, M., Jadranin, M., Bojović, S.,& Marin, P. D.. (2013). Variability of n-Alkanes and Nonacosan-10-ol in Natural Populations of Picea omorika. in Chemistry & Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 10(3), 473-483.
https://doi.org/10.1002/cbdv.201200271

Nikolić B, Tešević V, Đorđević I, Todosijević M, Jadranin M, Bojović S, Marin PD. Variability of n-Alkanes and Nonacosan-10-ol in Natural Populations of Picea omorika. in Chemistry & Biodiversity. 2013;10(3):473-483.
doi:10.1002/cbdv.201200271 .

Nikolić, Biljana, Tešević, Vele, Đorđević, Iris, Todosijević, Marina, Jadranin, Milka, Bojović, Srđan, Marin, Petar D., "Variability of n-Alkanes and Nonacosan-10-ol in Natural Populations of Picea omorika" in Chemistry & Biodiversity, 10, no. 3 (2013):473-483,
https://doi.org/10.1002/cbdv.201200271 . .

TY  - JOUR
AU  - Pavlović, Voja
AU  - Stojanović, Igor
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Smelcerović, Andrija
AU  - Stojanović, Gordana
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1041
AB  - Four lichen acids, physodalic acid (F1), physodic acid (F2), 3-hydroxyphysodic acid (F3), and isophysodic acid (F4), were isolated from Hypogymnia physodes methanol extract using preparative reversed-phase high performance liquid chromatography and their structures were determined by UV, MS, H-1 NMR and C-13 NMR. This is the first report on the isolation of F4 from H. physodes. Isolated rat thymocytes were cultivated with increasing F1-F4 concentrations (0.1, 1, 10 mu g/well) and proliferative activity, viability, ROS (reactive oxygen species) production and MMP (mitochondrial membrane potential) disturbances were evaluated. Obtained results show significantly decreased thymocytes proliferation was observed when cells were treated with F1 (1 mu g, p < 0.05; 10 mu g; p < 0.001), F2 (10 mu g, p < 0.05) and F3 compound (10 mu g, p < 0.05). Significantly increased cytotoxicity was detected when cells were incubated with F1 (1 mu g, p < 0.05; 10 mu g, p < 0.01), F2 (10 mu g, p < 0.05) and F3 compound (10 mu g, p < 0.001). Increased H2DCF-DA fluorescence intensity, when cells were treated with F1 (1 mu g, p < 0.001; 1 mu g, p < 0.01; 10 mu g, p < 0.001) and F2 (1 mu g, p < 0.05; 10 mu g, p < 0.01) compound, indicating the increase of intracellular ROS production. Simultaneously, increased ROS levels were followed with significantly decreased MMP when thymocytes were cultivated with F1 (0.1 mu g, p < 0.001; 1 mu g, p < 0.001; 10 mu g, p < 0.001) and F2 compound (10 mu g, p < 0.001). Thymocytes exposure to increased (0.1, 1, 10 mu g) concentrations of F3 and F4 compounds did not result with significant alterations in MMP and intracellular ROS production. We have shown that higher F1 and F2 concentrations induce thymocytes toxicity mainly through induction of oxidative stress, while cytotoxicity effect of F3 is followed with altered antioxidant/oxidant balance. The rigid 11H-dibenzo[b,e][1,4]dioxepin-11-one ring in the depsidone structure may play a important role for the examined biological activities.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Effect of four lichen acids isolated from Hypogymnia physodes on viability of rat thymocytes
VL  - 51
SP  - 160
EP  - 164
DO  - 10.1016/j.fct.2012.04.043
ER  - 

@article{
author = "Pavlović, Voja and Stojanović, Igor and Jadranin, Milka and Vajs, Vlatka and Đorđević, Iris and Smelcerović, Andrija and Stojanović, Gordana",
year = "2013",
abstract = "Four lichen acids, physodalic acid (F1), physodic acid (F2), 3-hydroxyphysodic acid (F3), and isophysodic acid (F4), were isolated from Hypogymnia physodes methanol extract using preparative reversed-phase high performance liquid chromatography and their structures were determined by UV, MS, H-1 NMR and C-13 NMR. This is the first report on the isolation of F4 from H. physodes. Isolated rat thymocytes were cultivated with increasing F1-F4 concentrations (0.1, 1, 10 mu g/well) and proliferative activity, viability, ROS (reactive oxygen species) production and MMP (mitochondrial membrane potential) disturbances were evaluated. Obtained results show significantly decreased thymocytes proliferation was observed when cells were treated with F1 (1 mu g, p < 0.05; 10 mu g; p < 0.001), F2 (10 mu g, p < 0.05) and F3 compound (10 mu g, p < 0.05). Significantly increased cytotoxicity was detected when cells were incubated with F1 (1 mu g, p < 0.05; 10 mu g, p < 0.01), F2 (10 mu g, p < 0.05) and F3 compound (10 mu g, p < 0.001). Increased H2DCF-DA fluorescence intensity, when cells were treated with F1 (1 mu g, p < 0.001; 1 mu g, p < 0.01; 10 mu g, p < 0.001) and F2 (1 mu g, p < 0.05; 10 mu g, p < 0.01) compound, indicating the increase of intracellular ROS production. Simultaneously, increased ROS levels were followed with significantly decreased MMP when thymocytes were cultivated with F1 (0.1 mu g, p < 0.001; 1 mu g, p < 0.001; 10 mu g, p < 0.001) and F2 compound (10 mu g, p < 0.001). Thymocytes exposure to increased (0.1, 1, 10 mu g) concentrations of F3 and F4 compounds did not result with significant alterations in MMP and intracellular ROS production. We have shown that higher F1 and F2 concentrations induce thymocytes toxicity mainly through induction of oxidative stress, while cytotoxicity effect of F3 is followed with altered antioxidant/oxidant balance. The rigid 11H-dibenzo[b,e][1,4]dioxepin-11-one ring in the depsidone structure may play a important role for the examined biological activities.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Effect of four lichen acids isolated from Hypogymnia physodes on viability of rat thymocytes",
volume = "51",
pages = "160-164",
doi = "10.1016/j.fct.2012.04.043"
}

Pavlović, V., Stojanović, I., Jadranin, M., Vajs, V., Đorđević, I., Smelcerović, A.,& Stojanović, G.. (2013). Effect of four lichen acids isolated from Hypogymnia physodes on viability of rat thymocytes. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 51, 160-164.
https://doi.org/10.1016/j.fct.2012.04.043

Pavlović V, Stojanović I, Jadranin M, Vajs V, Đorđević I, Smelcerović A, Stojanović G. Effect of four lichen acids isolated from Hypogymnia physodes on viability of rat thymocytes. in Food and Chemical Toxicology. 2013;51:160-164.
doi:10.1016/j.fct.2012.04.043 .

Pavlović, Voja, Stojanović, Igor, Jadranin, Milka, Vajs, Vlatka, Đorđević, Iris, Smelcerović, Andrija, Stojanović, Gordana, "Effect of four lichen acids isolated from Hypogymnia physodes on viability of rat thymocytes" in Food and Chemical Toxicology, 51 (2013):160-164,
https://doi.org/10.1016/j.fct.2012.04.043 . .

TY  - JOUR
AU  - Nikolić, Biljana
AU  - Tešević, Vele
AU  - Đorđević, Iris
AU  - Todosijević, Marina
AU  - Jadranin, Milka
AU  - Bojović, Srđan
AU  - Marin, Petar D.
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/853
AB  - This is the first report on population variability of nonacosan-10-ol and n-alkanes in needle epicuticular waxes of Macedonian pine (Pinus peuce Griseb.) Hexane extracts of needle samples, originating from two natural populations in Montenegro (Zeletin and Sjekirica) and from one population in Serbia (Mokra Gora) were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The amount of nonacosan-10-ol varied individually from 41.3 to 72.31% (average 55.9%), with the Sjekirica population being statistically divergent (64.4% on average). The results showed n-alkanes in epicuticular waxes ranging from C18 to C33. The most abundant alkanes were C29, C25, C27, and C23 (15.5, 11.1, 10.6, and 10.5% on average, resp.). The carbon preference index of Pinus peuce ranged from 1.0 to 4.3 (1.9 on average). Average chain length ranged from 18.4 to 27.7 (average 25.7). A high level of inidividual quantitative variation in all of these hydrocarbon parameters was also detected. These results were compared with published data on other species from the Pinus genus.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry & Biodiversity
T1  - Population Variability of Nonacosan-10-ol and n-Alkanes in Needle Cuticular Waxes of Macedonian Pine (Pinus peuce Griseb.)
VL  - 9
IS  - 6
SP  - 1155
EP  - 1165
DO  - 10.1002/cbdv.201100316
ER  - 

@article{
author = "Nikolić, Biljana and Tešević, Vele and Đorđević, Iris and Todosijević, Marina and Jadranin, Milka and Bojović, Srđan and Marin, Petar D.",
year = "2012",
abstract = "This is the first report on population variability of nonacosan-10-ol and n-alkanes in needle epicuticular waxes of Macedonian pine (Pinus peuce Griseb.) Hexane extracts of needle samples, originating from two natural populations in Montenegro (Zeletin and Sjekirica) and from one population in Serbia (Mokra Gora) were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The amount of nonacosan-10-ol varied individually from 41.3 to 72.31% (average 55.9%), with the Sjekirica population being statistically divergent (64.4% on average). The results showed n-alkanes in epicuticular waxes ranging from C18 to C33. The most abundant alkanes were C29, C25, C27, and C23 (15.5, 11.1, 10.6, and 10.5% on average, resp.). The carbon preference index of Pinus peuce ranged from 1.0 to 4.3 (1.9 on average). Average chain length ranged from 18.4 to 27.7 (average 25.7). A high level of inidividual quantitative variation in all of these hydrocarbon parameters was also detected. These results were compared with published data on other species from the Pinus genus.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Population Variability of Nonacosan-10-ol and n-Alkanes in Needle Cuticular Waxes of Macedonian Pine (Pinus peuce Griseb.)",
volume = "9",
number = "6",
pages = "1155-1165",
doi = "10.1002/cbdv.201100316"
}

Nikolić, B., Tešević, V., Đorđević, I., Todosijević, M., Jadranin, M., Bojović, S.,& Marin, P. D.. (2012). Population Variability of Nonacosan-10-ol and n-Alkanes in Needle Cuticular Waxes of Macedonian Pine (Pinus peuce Griseb.). in Chemistry & Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 9(6), 1155-1165.
https://doi.org/10.1002/cbdv.201100316

Nikolić B, Tešević V, Đorđević I, Todosijević M, Jadranin M, Bojović S, Marin PD. Population Variability of Nonacosan-10-ol and n-Alkanes in Needle Cuticular Waxes of Macedonian Pine (Pinus peuce Griseb.). in Chemistry & Biodiversity. 2012;9(6):1155-1165.
doi:10.1002/cbdv.201100316 .

Nikolić, Biljana, Tešević, Vele, Đorđević, Iris, Todosijević, Marina, Jadranin, Milka, Bojović, Srđan, Marin, Petar D., "Population Variability of Nonacosan-10-ol and n-Alkanes in Needle Cuticular Waxes of Macedonian Pine (Pinus peuce Griseb.)" in Chemistry & Biodiversity, 9, no. 6 (2012):1155-1165,
https://doi.org/10.1002/cbdv.201100316 . .

TY  - JOUR
AU  - Nikolić, Biljana
AU  - Tešević, Vele
AU  - Đorđević, Iris
AU  - Todosijević, Marina
AU  - Jadranin, Milka
AU  - Bojović, Srđan
AU  - Marin, Petar D.
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/891
AB  - This is the first report of individual variability and population diversity of the contents of nonacosan-10-ol and n-alkanes in the needle cuticular waxes of Bosnian pines originated from Montenegro, regarded as Pinus heldreichii var. leucodermis, and from Serbia, regarded as P. heldreichii var. pancici. The amount of nonacosan-10-ol varied individually from 27.4 to 73.2% (55.5% in average), but differences between the four investigated populations were not statistically confirmed. The size of the n-alkanes ranged from C18 to C33. The most abundant n-alkanes were C23, C27, and C25 (12.2, 11.2, and 10.8% in average, resp.). The carbon preference index (CPI) of the n-alkanes ranged from 0.8 to 3.1 (1.6 in average), while the average chain length (ACL) ranged from 20.9 to 26.5 (24.4 in average). Long-chain and mid-chain n-alkanes prevailed (49.6 and 37.9% in average, resp.). It was also found that the populations of P. heldreichii var. leucodermis had predominantly a narrower range of n-alkanes (C18?C31) than the trees of the variety pancici (C18?C33). Differences between the varieties were also significant for most of the other characteristics of the n-alkane pattern (e.g., most abundant n-alkanes, CPI, ACL, and relative proportion of short-, mid-, and long-chain n-alkanes). The principle component and cluster analyses of eleven n-alkanes confirmed the significant diversity of these two varieties.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry & Biodiversity
T1  - Chemodiversity of Nonacosan-10-ol and n-Alkanes in the Needle Wax of Pinus heldreichii
VL  - 9
IS  - 1
SP  - 80
EP  - 90
DO  - 10.1002/cbdv.201100179
ER  - 

@article{
author = "Nikolić, Biljana and Tešević, Vele and Đorđević, Iris and Todosijević, Marina and Jadranin, Milka and Bojović, Srđan and Marin, Petar D.",
year = "2012",
abstract = "This is the first report of individual variability and population diversity of the contents of nonacosan-10-ol and n-alkanes in the needle cuticular waxes of Bosnian pines originated from Montenegro, regarded as Pinus heldreichii var. leucodermis, and from Serbia, regarded as P. heldreichii var. pancici. The amount of nonacosan-10-ol varied individually from 27.4 to 73.2% (55.5% in average), but differences between the four investigated populations were not statistically confirmed. The size of the n-alkanes ranged from C18 to C33. The most abundant n-alkanes were C23, C27, and C25 (12.2, 11.2, and 10.8% in average, resp.). The carbon preference index (CPI) of the n-alkanes ranged from 0.8 to 3.1 (1.6 in average), while the average chain length (ACL) ranged from 20.9 to 26.5 (24.4 in average). Long-chain and mid-chain n-alkanes prevailed (49.6 and 37.9% in average, resp.). It was also found that the populations of P. heldreichii var. leucodermis had predominantly a narrower range of n-alkanes (C18?C31) than the trees of the variety pancici (C18?C33). Differences between the varieties were also significant for most of the other characteristics of the n-alkane pattern (e.g., most abundant n-alkanes, CPI, ACL, and relative proportion of short-, mid-, and long-chain n-alkanes). The principle component and cluster analyses of eleven n-alkanes confirmed the significant diversity of these two varieties.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Chemodiversity of Nonacosan-10-ol and n-Alkanes in the Needle Wax of Pinus heldreichii",
volume = "9",
number = "1",
pages = "80-90",
doi = "10.1002/cbdv.201100179"
}

Nikolić, B., Tešević, V., Đorđević, I., Todosijević, M., Jadranin, M., Bojović, S.,& Marin, P. D.. (2012). Chemodiversity of Nonacosan-10-ol and n-Alkanes in the Needle Wax of Pinus heldreichii. in Chemistry & Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 9(1), 80-90.
https://doi.org/10.1002/cbdv.201100179

Nikolić B, Tešević V, Đorđević I, Todosijević M, Jadranin M, Bojović S, Marin PD. Chemodiversity of Nonacosan-10-ol and n-Alkanes in the Needle Wax of Pinus heldreichii. in Chemistry & Biodiversity. 2012;9(1):80-90.
doi:10.1002/cbdv.201100179 .

Nikolić, Biljana, Tešević, Vele, Đorđević, Iris, Todosijević, Marina, Jadranin, Milka, Bojović, Srđan, Marin, Petar D., "Chemodiversity of Nonacosan-10-ol and n-Alkanes in the Needle Wax of Pinus heldreichii" in Chemistry & Biodiversity, 9, no. 1 (2012):80-90,
https://doi.org/10.1002/cbdv.201100179 . .

TY  - CONF
AU  - Mihajlović, L.
AU  - Cirkovic-Velicković, T.
AU  - Jadranin, Milka
AU  - Burazer, Lidija
AU  - Milčić-Matić, Natalija
PY  - 2010
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/729
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy: European Journal of Allergy and Clinical Immunology
T1  - The role of phenolic components of short ragweed pollen in igE binding and immune response to allergens
VL  - 65
SP  - 331
EP  - 331
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1469
ER  - 

@conference{
author = "Mihajlović, L. and Cirkovic-Velicković, T. and Jadranin, Milka and Burazer, Lidija and Milčić-Matić, Natalija",
year = "2010",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
title = "The role of phenolic components of short ragweed pollen in igE binding and immune response to allergens",
volume = "65",
pages = "331-331",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1469"
}

Mihajlović, L., Cirkovic-Velicković, T., Jadranin, M., Burazer, L.,& Milčić-Matić, N.. (2010). The role of phenolic components of short ragweed pollen in igE binding and immune response to allergens. in Allergy: European Journal of Allergy and Clinical Immunology
Wiley-Blackwell, Hoboken., 65, 331-331.
https://hdl.handle.net/21.15107/rcub_cherry_1469

Mihajlović L, Cirkovic-Velicković T, Jadranin M, Burazer L, Milčić-Matić N. The role of phenolic components of short ragweed pollen in igE binding and immune response to allergens. in Allergy: European Journal of Allergy and Clinical Immunology. 2010;65:331-331.
https://hdl.handle.net/21.15107/rcub_cherry_1469 .

Mihajlović, L., Cirkovic-Velicković, T., Jadranin, Milka, Burazer, Lidija, Milčić-Matić, Natalija, "The role of phenolic components of short ragweed pollen in igE binding and immune response to allergens" in Allergy: European Journal of Allergy and Clinical Immunology, 65 (2010):331-331,
https://hdl.handle.net/21.15107/rcub_cherry_1469 .

TY  - JOUR
AU  - Nikolić, Biljana
AU  - Tešević, Vele
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Todosijević, Marina
AU  - Bojović, Srđan
AU  - Marin, Petar D.
PY  - 2010
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/738
AB  - This is the first report of n-alkanes in needle epicuticular waxes of the variety Bosnian pine, Pinus heldreichii var. pančići. n-Hexane extracts of needle samples, originating from seven isolated localities in Serbia, were analysed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The results evidenced n-alkanes ranging from C18 to C33 in epicuticular waxes. The most abundant alkanes were C27, C23, C25 and C29 (12.53 %, 12.46 %, 12.00 % and 10.38 % on average, respectively). The carbon preference index (CPItotal) of Pinus heldreichii var. pančići ranged from 1.1 to 2.1 (1.6 on average), while the average chain length (ACLtotal) ranged from 25.0 to 25.8 (25.3 on average). A high level of individual quantitative variation in all of these hydrocarbon parameters was also found. The obtained results were compared with the bibliographic references for Pinus heldreichii var. leucodermis and other species of the Pinus genus.
AB  - Ovo je prvo saopštenje o n-alkanima u voskovima iglica varijeteta munike, Pinus heldreichii var. pančići. n-Heksanski ekstrakti uzoraka iglica koji potiču sa sedam izolovanih lokaliteta u Srbiji analizirani su gasnom hromatografijom (GC) i gasnom hromatografijom-masenom spektrometrijom (GC-MS). Rezultati su pokazali da se n-alkani nalaze u opsegu od C18 do C33. Među njima su najobilniji C27, C23, C25 i C29 (12,53, 12,46, 12,00 i 10,38 % u proseku, redom). Ugljenični preferencijalni indeks (CPItotal) Pinus heldreichii var. pančići je bio u opsegu od 1,1 do 2,1 (prosečno 1,6), a dužina niza ugljenikovih atoma (ACLtotal) u opsegu od 25,0 do 25,8 (prosečno 25,3). Takođe je utvrđen visok nivo individualne kvantitativne varijabilnosti u svim analiziranim parametrima ovih ugljovodonika. Dobijeni rezultati su upoređeni sa literaturnim podacima koji se odnose na Pinus heldreichii var. leucodermis i druge vrste roda Pinus.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - n-alkanes in the needle waxes of Pinus heldreichii var. pančići
T1  - n-alkani u voskovima iglica Pinus heldreichii var. pančići
VL  - 75
IS  - 10
SP  - 1337
EP  - 1346
DO  - 10.2298/JSC100322089N
ER  - 

@article{
author = "Nikolić, Biljana and Tešević, Vele and Đorđević, Iris and Jadranin, Milka and Todosijević, Marina and Bojović, Srđan and Marin, Petar D.",
year = "2010",
abstract = "This is the first report of n-alkanes in needle epicuticular waxes of the variety Bosnian pine, Pinus heldreichii var. pančići. n-Hexane extracts of needle samples, originating from seven isolated localities in Serbia, were analysed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The results evidenced n-alkanes ranging from C18 to C33 in epicuticular waxes. The most abundant alkanes were C27, C23, C25 and C29 (12.53 %, 12.46 %, 12.00 % and 10.38 % on average, respectively). The carbon preference index (CPItotal) of Pinus heldreichii var. pančići ranged from 1.1 to 2.1 (1.6 on average), while the average chain length (ACLtotal) ranged from 25.0 to 25.8 (25.3 on average). A high level of individual quantitative variation in all of these hydrocarbon parameters was also found. The obtained results were compared with the bibliographic references for Pinus heldreichii var. leucodermis and other species of the Pinus genus., Ovo je prvo saopštenje o n-alkanima u voskovima iglica varijeteta munike, Pinus heldreichii var. pančići. n-Heksanski ekstrakti uzoraka iglica koji potiču sa sedam izolovanih lokaliteta u Srbiji analizirani su gasnom hromatografijom (GC) i gasnom hromatografijom-masenom spektrometrijom (GC-MS). Rezultati su pokazali da se n-alkani nalaze u opsegu od C18 do C33. Među njima su najobilniji C27, C23, C25 i C29 (12,53, 12,46, 12,00 i 10,38 % u proseku, redom). Ugljenični preferencijalni indeks (CPItotal) Pinus heldreichii var. pančići je bio u opsegu od 1,1 do 2,1 (prosečno 1,6), a dužina niza ugljenikovih atoma (ACLtotal) u opsegu od 25,0 do 25,8 (prosečno 25,3). Takođe je utvrđen visok nivo individualne kvantitativne varijabilnosti u svim analiziranim parametrima ovih ugljovodonika. Dobijeni rezultati su upoređeni sa literaturnim podacima koji se odnose na Pinus heldreichii var. leucodermis i druge vrste roda Pinus.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "n-alkanes in the needle waxes of Pinus heldreichii var. pančići, n-alkani u voskovima iglica Pinus heldreichii var. pančići",
volume = "75",
number = "10",
pages = "1337-1346",
doi = "10.2298/JSC100322089N"
}

Nikolić, B., Tešević, V., Đorđević, I., Jadranin, M., Todosijević, M., Bojović, S.,& Marin, P. D.. (2010). n-alkanes in the needle waxes of Pinus heldreichii var. pančići. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 75(10), 1337-1346.
https://doi.org/10.2298/JSC100322089N

Nikolić B, Tešević V, Đorđević I, Jadranin M, Todosijević M, Bojović S, Marin PD. n-alkanes in the needle waxes of Pinus heldreichii var. pančići. in Journal of the Serbian Chemical Society. 2010;75(10):1337-1346.
doi:10.2298/JSC100322089N .

Nikolić, Biljana, Tešević, Vele, Đorđević, Iris, Jadranin, Milka, Todosijević, Marina, Bojović, Srđan, Marin, Petar D., "n-alkanes in the needle waxes of Pinus heldreichii var. pančići" in Journal of the Serbian Chemical Society, 75, no. 10 (2010):1337-1346,
https://doi.org/10.2298/JSC100322089N . .

TY  - JOUR
AU  - Nikolić, Biljana
AU  - Tešević, Vele
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Bojović, Srđan
AU  - Marin, Petar D.
PY  - 2009
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/603
PB  - Springer, New York
T2  - Chemistry of Natural Compounds
T1  - n-Alkanes in needle waxes of Picea omorika var. vukomanii
VL  - 45
IS  - 5
SP  - 697
EP  - 699
DO  - 10.1007/s10600-009-9430-y
ER  - 

@article{
author = "Nikolić, Biljana and Tešević, Vele and Đorđević, Iris and Jadranin, Milka and Bojović, Srđan and Marin, Petar D.",
year = "2009",
publisher = "Springer, New York",
journal = "Chemistry of Natural Compounds",
title = "n-Alkanes in needle waxes of Picea omorika var. vukomanii",
volume = "45",
number = "5",
pages = "697-699",
doi = "10.1007/s10600-009-9430-y"
}

Nikolić, B., Tešević, V., Đorđević, I., Jadranin, M., Bojović, S.,& Marin, P. D.. (2009). n-Alkanes in needle waxes of Picea omorika var. vukomanii. in Chemistry of Natural Compounds
Springer, New York., 45(5), 697-699.
https://doi.org/10.1007/s10600-009-9430-y

Nikolić B, Tešević V, Đorđević I, Jadranin M, Bojović S, Marin PD. n-Alkanes in needle waxes of Picea omorika var. vukomanii. in Chemistry of Natural Compounds. 2009;45(5):697-699.
doi:10.1007/s10600-009-9430-y .

Nikolić, Biljana, Tešević, Vele, Đorđević, Iris, Jadranin, Milka, Bojović, Srđan, Marin, Petar D., "n-Alkanes in needle waxes of Picea omorika var. vukomanii" in Chemistry of Natural Compounds, 45, no. 5 (2009):697-699,
https://doi.org/10.1007/s10600-009-9430-y . .

TY  - JOUR
AU  - Atrrog, Abubaker A. B.
AU  - Natić, Maja
AU  - Tosti, Tomislav
AU  - Milojković-Opsenica, Dušanka
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan M.
AU  - Lazić, Milan
AU  - Radulović, Siniša
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/619
AB  - In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R-M(0) and C-0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright
PB  - Wiley, Hoboken
T2  - Biomedical Chromatography
T1  - Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro
VL  - 23
IS  - 3
SP  - 250
EP  - 256
DO  - 10.1002/bmc.1091
ER  - 

@article{
author = "Atrrog, Abubaker A. B. and Natić, Maja and Tosti, Tomislav and Milojković-Opsenica, Dušanka and Đorđević, Iris and Tešević, Vele and Jadranin, Milka and Milosavljević, Slobodan M. and Lazić, Milan and Radulović, Siniša and Tešić, Živoslav",
year = "2009",
abstract = "In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R-M(0) and C-0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright",
publisher = "Wiley, Hoboken",
journal = "Biomedical Chromatography",
title = "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro",
volume = "23",
number = "3",
pages = "250-256",
doi = "10.1002/bmc.1091"
}

Atrrog, A. A. B., Natić, M., Tosti, T., Milojković-Opsenica, D., Đorđević, I., Tešević, V., Jadranin, M., Milosavljević, S. M., Lazić, M., Radulović, S.,& Tešić, Ž.. (2009). Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography
Wiley, Hoboken., 23(3), 250-256.
https://doi.org/10.1002/bmc.1091

Atrrog AAB, Natić M, Tosti T, Milojković-Opsenica D, Đorđević I, Tešević V, Jadranin M, Milosavljević SM, Lazić M, Radulović S, Tešić Ž. Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography. 2009;23(3):250-256.
doi:10.1002/bmc.1091 .

Atrrog, Abubaker A. B., Natić, Maja, Tosti, Tomislav, Milojković-Opsenica, Dušanka, Đorđević, Iris, Tešević, Vele, Jadranin, Milka, Milosavljević, Slobodan M., Lazić, Milan, Radulović, Siniša, Tešić, Živoslav, "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro" in Biomedical Chromatography, 23, no. 3 (2009):250-256,
https://doi.org/10.1002/bmc.1091 . .

TY  - JOUR
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Menković, Nebojša
AU  - Vajs, Vlatka
AU  - Jadranin, Milka
AU  - Jovanović, A.
AU  - Đoković, Dejan
PY  - 2008
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/536
PB  - Springer, New York
T2  - Chemistry of Natural Compounds
T1  - Composition of the essential oil of Ptilostemon gnaphaloides
VL  - 44
IS  - 5
SP  - 668
EP  - 669
DO  - 10.1007/s10600-008-9158-0
ER  - 

@article{
author = "Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Menković, Nebojša and Vajs, Vlatka and Jadranin, Milka and Jovanović, A. and Đoković, Dejan",
year = "2008",
publisher = "Springer, New York",
journal = "Chemistry of Natural Compounds",
title = "Composition of the essential oil of Ptilostemon gnaphaloides",
volume = "44",
number = "5",
pages = "668-669",
doi = "10.1007/s10600-008-9158-0"
}

Đorđević, I., Tešević, V., Milosavljević, S. M., Menković, N., Vajs, V., Jadranin, M., Jovanović, A.,& Đoković, D.. (2008). Composition of the essential oil of Ptilostemon gnaphaloides. in Chemistry of Natural Compounds
Springer, New York., 44(5), 668-669.
https://doi.org/10.1007/s10600-008-9158-0

Đorđević I, Tešević V, Milosavljević SM, Menković N, Vajs V, Jadranin M, Jovanović A, Đoković D. Composition of the essential oil of Ptilostemon gnaphaloides. in Chemistry of Natural Compounds. 2008;44(5):668-669.
doi:10.1007/s10600-008-9158-0 .

Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Menković, Nebojša, Vajs, Vlatka, Jadranin, Milka, Jovanović, A., Đoković, Dejan, "Composition of the essential oil of Ptilostemon gnaphaloides" in Chemistry of Natural Compounds, 44, no. 5 (2008):668-669,
https://doi.org/10.1007/s10600-008-9158-0 . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Vajs, Vlatka
AU  - Janaćković, Peđa
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Vučković, Ivan
PY  - 2007
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/499
AB  - 1H-NMR spectroscopy was applied for the quantitative analysis of cnicin, a bioactive germacranolide type sesquiterpene lactone, in the aerial parts of seven wild-growing Centaurea species collected in Serbia and Montenegro. The analysis was performed by comparison of the integral of the one-proton signal of cnicin (H-13, δ 5.75) with that of the two-proton singlet ( δ 6.98) of 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT), used as the internal standard. Cnicin, within the concentration range 1.06-6.12 mg/g, calculated per weight of the fresh plant material was detected in six species, the exception being C. salonitana. This method allows the rapid and simple quantification of cnicin without any pre-purification step.
AB  - 1H-NMR spektrometrija je primenjena za kvantitativnu analizu knicina, bioaktivnog seskviterpenskog laktona germakranolidnog tipa, u nadzemnom delu sedam samoniklih biljnih vrsta roda Centaurea sakupljenih u Srbiji i Crnoj Gori. Analiza je izvršena poređenjem integrala signala jednog protona knicina (H-13, δ 5.75) sa singletom koji potiče od dva protona ( δ 6.98) internog standarda, 2,6-bis(1,1-dimetiletil)-4-metilfenola (BHT). Knicin je detektovan u svim vrstama, osim u C. salonitana, u koncentracijama u opsegu od 1,06 do 6,12 mg/g, računato na masu svežeg biljnog materijala. Ovaj metod omogućava brzu i jednostavnu kvantifikaciju knicina bez prethodnog prečišćavanja.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy
T1  - Kvantitativna analiza seskviterpenskog laktona knicina u sedam samoniklih biljnih vrsta roda Centaurea, koje rastu u Srbiji i Crnoj Gori, korišćenjem 1H-NMR
VL  - 72
IS  - 12
SP  - 1275
EP  - 1280
DO  - 10.2298/JSC0712275T
ER  - 

@article{
author = "Tešević, Vele and Milosavljević, Slobodan M. and Vajs, Vlatka and Janaćković, Peđa and Đorđević, Iris and Jadranin, Milka and Vučković, Ivan",
year = "2007",
abstract = "1H-NMR spectroscopy was applied for the quantitative analysis of cnicin, a bioactive germacranolide type sesquiterpene lactone, in the aerial parts of seven wild-growing Centaurea species collected in Serbia and Montenegro. The analysis was performed by comparison of the integral of the one-proton signal of cnicin (H-13, δ 5.75) with that of the two-proton singlet ( δ 6.98) of 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT), used as the internal standard. Cnicin, within the concentration range 1.06-6.12 mg/g, calculated per weight of the fresh plant material was detected in six species, the exception being C. salonitana. This method allows the rapid and simple quantification of cnicin without any pre-purification step., 1H-NMR spektrometrija je primenjena za kvantitativnu analizu knicina, bioaktivnog seskviterpenskog laktona germakranolidnog tipa, u nadzemnom delu sedam samoniklih biljnih vrsta roda Centaurea sakupljenih u Srbiji i Crnoj Gori. Analiza je izvršena poređenjem integrala signala jednog protona knicina (H-13, δ 5.75) sa singletom koji potiče od dva protona ( δ 6.98) internog standarda, 2,6-bis(1,1-dimetiletil)-4-metilfenola (BHT). Knicin je detektovan u svim vrstama, osim u C. salonitana, u koncentracijama u opsegu od 1,06 do 6,12 mg/g, računato na masu svežeg biljnog materijala. Ovaj metod omogućava brzu i jednostavnu kvantifikaciju knicina bez prethodnog prečišćavanja.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy, Kvantitativna analiza seskviterpenskog laktona knicina u sedam samoniklih biljnih vrsta roda Centaurea, koje rastu u Srbiji i Crnoj Gori, korišćenjem 1H-NMR",
volume = "72",
number = "12",
pages = "1275-1280",
doi = "10.2298/JSC0712275T"
}

Tešević, V., Milosavljević, S. M., Vajs, V., Janaćković, P., Đorđević, I., Jadranin, M.,& Vučković, I.. (2007). Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 72(12), 1275-1280.
https://doi.org/10.2298/JSC0712275T

Tešević V, Milosavljević SM, Vajs V, Janaćković P, Đorđević I, Jadranin M, Vučković I. Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy. in Journal of the Serbian Chemical Society. 2007;72(12):1275-1280.
doi:10.2298/JSC0712275T .

Tešević, Vele, Milosavljević, Slobodan M., Vajs, Vlatka, Janaćković, Peđa, Đorđević, Iris, Jadranin, Milka, Vučković, Ivan, "Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1275-1280,
https://doi.org/10.2298/JSC0712275T . .

TY  - JOUR
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Menković, Nebojša
AU  - Tešević, Vele
AU  - Macura, Slobodan
AU  - Milosavljević, Slobodan M.
PY  - 2006
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/436
AB  - The aerial parts of Amphoricarpos neumayeri ssp. murbeckii afforded eleven guaianolides with the same relative (1 alpha H,4 beta H,5 alpha H, 7 alpha H) configuration of the basic skeleton. All of them contained a CH2OX (X = H, acetyl or isovaleroyl) group in 4 alpha-position, typical for amphoricarpolides. Four compounds (1-4) were isolated before from the same species, originating from different localities. Guaianolides 5-11 are new compounds. Compounds 7 and 8 were epoxidized at the 10 alpha(14)-position. Instead of the Delta(11(13))-double bond, observed in all previously isolated guaianolides from the same species, the four lactones contained 11 alpha,13-diol (8-10) or 11 alpha-OH, 13-chloro (11) moieties respectively.
PB  - Walter De Gruyter Gmbh, Berlin
T2  - Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences
T1  - Further guaianolides from Amphoricarpos neumayeri ssp murbeckii from Montenegro
VL  - 61
IS  - 11
SP  - 1437
EP  - 1442
DO  - 10.1515/znb-2006-1119
ER  - 

@article{
author = "Đorđević, Iris and Jadranin, Milka and Vajs, Vlatka and Menković, Nebojša and Tešević, Vele and Macura, Slobodan and Milosavljević, Slobodan M.",
year = "2006",
abstract = "The aerial parts of Amphoricarpos neumayeri ssp. murbeckii afforded eleven guaianolides with the same relative (1 alpha H,4 beta H,5 alpha H, 7 alpha H) configuration of the basic skeleton. All of them contained a CH2OX (X = H, acetyl or isovaleroyl) group in 4 alpha-position, typical for amphoricarpolides. Four compounds (1-4) were isolated before from the same species, originating from different localities. Guaianolides 5-11 are new compounds. Compounds 7 and 8 were epoxidized at the 10 alpha(14)-position. Instead of the Delta(11(13))-double bond, observed in all previously isolated guaianolides from the same species, the four lactones contained 11 alpha,13-diol (8-10) or 11 alpha-OH, 13-chloro (11) moieties respectively.",
publisher = "Walter De Gruyter Gmbh, Berlin",
journal = "Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences",
title = "Further guaianolides from Amphoricarpos neumayeri ssp murbeckii from Montenegro",
volume = "61",
number = "11",
pages = "1437-1442",
doi = "10.1515/znb-2006-1119"
}

Đorđević, I., Jadranin, M., Vajs, V., Menković, N., Tešević, V., Macura, S.,& Milosavljević, S. M.. (2006). Further guaianolides from Amphoricarpos neumayeri ssp murbeckii from Montenegro. in Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences
Walter De Gruyter Gmbh, Berlin., 61(11), 1437-1442.
https://doi.org/10.1515/znb-2006-1119

Đorđević I, Jadranin M, Vajs V, Menković N, Tešević V, Macura S, Milosavljević SM. Further guaianolides from Amphoricarpos neumayeri ssp murbeckii from Montenegro. in Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences. 2006;61(11):1437-1442.
doi:10.1515/znb-2006-1119 .

Đorđević, Iris, Jadranin, Milka, Vajs, Vlatka, Menković, Nebojša, Tešević, Vele, Macura, Slobodan, Milosavljević, Slobodan M., "Further guaianolides from Amphoricarpos neumayeri ssp murbeckii from Montenegro" in Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences, 61, no. 11 (2006):1437-1442,
https://doi.org/10.1515/znb-2006-1119 . .