TY  - JOUR
AU  - Radaković, Milena
AU  - Đelić, Ninoslav
AU  - Stevanović, Jevrosima
AU  - Soković, Marina
AU  - Radović, Dejan
AU  - van Griensven, Leo J. L. D.
AU  - Stanimirović, Zoran
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1184
AB  - The aim of this investigation was to evaluate the possible protective activity of Agaricus brasiliensis (=A. blazei sensu Murrill) ethanol extract against thymol-induced DNA damage in human lymphocytes. Before we studied the possible interaction of thymol and A. brasiliensis extract, each component was tested in the comet assay. Thymol significantly increased DNA damage in human lymphocytes at higher concentrations (20, 50, 100, 150, and 200 mu g/mL), whereas no genotoxic effect of A. brasiliensis ethanol extract was observed. In simultaneous treatment with thymol (200 mu g/mL) and A. brasiliensis ethanol extract (50, 100, 150, and 200 mu g/mL), the latter failed to reduce a thymol-induced DNA damaging effect regardless of the applied concentrations. To confirm that thymol induces DNA damage via reactive oxygen species, we performed cotreatment with quercetin. Cotreatment with quercetin (100 and 500 mu g/mL) significantly reduced DNA damage caused by thymol (200 mu g/mL), indicating that thymol exhibits genotoxicity mainly through induction of reactive oxygen species.
PB  - Begell House Inc, Danbury
T2  - International Journal of Medicinal Mushrooms
T1  - Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay
VL  - 17
IS  - 4
SP  - 321
EP  - 330
DO  - 10.1615/IntJMedMushrooms.v17.i4.10
ER  - 

@article{
author = "Radaković, Milena and Đelić, Ninoslav and Stevanović, Jevrosima and Soković, Marina and Radović, Dejan and van Griensven, Leo J. L. D. and Stanimirović, Zoran",
year = "2015",
abstract = "The aim of this investigation was to evaluate the possible protective activity of Agaricus brasiliensis (=A. blazei sensu Murrill) ethanol extract against thymol-induced DNA damage in human lymphocytes. Before we studied the possible interaction of thymol and A. brasiliensis extract, each component was tested in the comet assay. Thymol significantly increased DNA damage in human lymphocytes at higher concentrations (20, 50, 100, 150, and 200 mu g/mL), whereas no genotoxic effect of A. brasiliensis ethanol extract was observed. In simultaneous treatment with thymol (200 mu g/mL) and A. brasiliensis ethanol extract (50, 100, 150, and 200 mu g/mL), the latter failed to reduce a thymol-induced DNA damaging effect regardless of the applied concentrations. To confirm that thymol induces DNA damage via reactive oxygen species, we performed cotreatment with quercetin. Cotreatment with quercetin (100 and 500 mu g/mL) significantly reduced DNA damage caused by thymol (200 mu g/mL), indicating that thymol exhibits genotoxicity mainly through induction of reactive oxygen species.",
publisher = "Begell House Inc, Danbury",
journal = "International Journal of Medicinal Mushrooms",
title = "Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay",
volume = "17",
number = "4",
pages = "321-330",
doi = "10.1615/IntJMedMushrooms.v17.i4.10"
}

Radaković, M., Đelić, N., Stevanović, J., Soković, M., Radović, D., van Griensven, L. J. L. D.,& Stanimirović, Z.. (2015). Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay. in International Journal of Medicinal Mushrooms
Begell House Inc, Danbury., 17(4), 321-330.
https://doi.org/10.1615/IntJMedMushrooms.v17.i4.10

Radaković M, Đelić N, Stevanović J, Soković M, Radović D, van Griensven LJLD, Stanimirović Z. Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay. in International Journal of Medicinal Mushrooms. 2015;17(4):321-330.
doi:10.1615/IntJMedMushrooms.v17.i4.10 .

Radaković, Milena, Đelić, Ninoslav, Stevanović, Jevrosima, Soković, Marina, Radović, Dejan, van Griensven, Leo J. L. D., Stanimirović, Zoran, "Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay" in International Journal of Medicinal Mushrooms, 17, no. 4 (2015):321-330,
https://doi.org/10.1615/IntJMedMushrooms.v17.i4.10 . .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Menković, Nebojša
AU  - Soković, Marina
AU  - Glamoclija, Jasmina
AU  - Milosavljević, Slobodan M.
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1010
AB  - The composition of leaf cuticular neutral lipids of Amphoricarpos autariatus ssp. autariatus collected at canyon of river Tara (North Montenegro) was investigated by GC/MS (nonpolar fraction), LC-ESI TOF MS and H-1 NMR spectroscopy (more polar fraction). The nonpolar fraction (ca. 15% of the whole surface extract) contained C-27 (-) (33) n-alkanes, those with odd-number of carbons predominating. The LC-ESI MS and H-1 NMR of the more polar fraction revealed 13 sesquiterpene lactones, constituting ca. 97.5% of the lactone mixture, identified as the known guaianolides, so-called amphoricarpolides, found previously in the aerial parts of the genus. The lactone fraction exhibited considerable in vitro effect against eight fungi, i.e. Aspergillus ochraceus, A. niger, A. versicolor, Penicillium funiculosum, P. ochrochloron, Trichoderma viride, Fusarium verticillioides and Fulvia fulvum.
PB  - Acg Publications, Gebze-Kocaeli
T2  - Records of Natural Products
T1  - Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents
VL  - 7
IS  - 3
SP  - 234
EP  - 238
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1360
ER  - 

@article{
author = "Jadranin, Milka and Đorđević, Iris and Tešević, Vele and Vajs, Vlatka and Menković, Nebojša and Soković, Marina and Glamoclija, Jasmina and Milosavljević, Slobodan M.",
year = "2013",
abstract = "The composition of leaf cuticular neutral lipids of Amphoricarpos autariatus ssp. autariatus collected at canyon of river Tara (North Montenegro) was investigated by GC/MS (nonpolar fraction), LC-ESI TOF MS and H-1 NMR spectroscopy (more polar fraction). The nonpolar fraction (ca. 15% of the whole surface extract) contained C-27 (-) (33) n-alkanes, those with odd-number of carbons predominating. The LC-ESI MS and H-1 NMR of the more polar fraction revealed 13 sesquiterpene lactones, constituting ca. 97.5% of the lactone mixture, identified as the known guaianolides, so-called amphoricarpolides, found previously in the aerial parts of the genus. The lactone fraction exhibited considerable in vitro effect against eight fungi, i.e. Aspergillus ochraceus, A. niger, A. versicolor, Penicillium funiculosum, P. ochrochloron, Trichoderma viride, Fusarium verticillioides and Fulvia fulvum.",
publisher = "Acg Publications, Gebze-Kocaeli",
journal = "Records of Natural Products",
title = "Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents",
volume = "7",
number = "3",
pages = "234-238",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1360"
}

Jadranin, M., Đorđević, I., Tešević, V., Vajs, V., Menković, N., Soković, M., Glamoclija, J.,& Milosavljević, S. M.. (2013). Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents. in Records of Natural Products
Acg Publications, Gebze-Kocaeli., 7(3), 234-238.
https://hdl.handle.net/21.15107/rcub_cherry_1360

Jadranin M, Đorđević I, Tešević V, Vajs V, Menković N, Soković M, Glamoclija J, Milosavljević SM. Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents. in Records of Natural Products. 2013;7(3):234-238.
https://hdl.handle.net/21.15107/rcub_cherry_1360 .

Jadranin, Milka, Đorđević, Iris, Tešević, Vele, Vajs, Vlatka, Menković, Nebojša, Soković, Marina, Glamoclija, Jasmina, Milosavljević, Slobodan M., "Sesquiterpene Lactones of Amphoricarpos autariatus ssp autariatus from Montenegro - Antifungal Leaf - Surface Constituents" in Records of Natural Products, 7, no. 3 (2013):234-238,
https://hdl.handle.net/21.15107/rcub_cherry_1360 .