TY  - JOUR
AU  - Novakovic, Miroslav
AU  - Ilic-Tomic, Tatjana
AU  - Djordjevic, Iris
AU  - Andjelkovic, Boban
AU  - Tesevic, Vele
AU  - Milosavljevic, Slobodan
AU  - Asakawa, Yoshinori
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3135
AB  - Bisbibenzyls are specialized metabolites found exclusively in liverworts, until recently; they represent chemical
markers of liverworts. Their occurrence in vascular plants was noticed in 2007, when they were found in Primula
veris subsp. macrocalyx from Russia. This report prompted us to chemically analyze the two most common
Serbian Primula species, P. veris subsp. columnae and P. acaulis, in order to determine the presence of bisbibenzyls
in them. Our study revealed nine structurally distinct bisbibenzyls (1–9), identified based on 1D and 2D NMR, IR,
UV and HRESIMS data. Among them were five previously undescribed compounds (2–6). The remaining compounds found and previously described in the literature were: the bisbibenzyls riccardin C (1), isoperrottetin A
(7), isoplagiochin E (8) and 11-O-demethylmarchantin I (9), as well as 4-hydroxyphenylmethylketone (10) and
4-hydroxy-3-methoxyphenylmethylketone (11). Riccardin C was the most dominant bisbibenzyl in both species
studied. Previously, it was the first bisbibenzyl found in vascular plants (P. veris subsp. macrocalyx). An
assessment of the cytotoxic activity of the isolated compounds against A549 lung cancer and healthy MRC5 cell
lines was also the subject of our study. Compounds 6 and 9 exhibited significant cytotoxic activity expressed by
IC50 values of 12 μM, but the selectivity was not satisfactory.
PB  - Elsevier
T2  - Phytochemistry
T1  - Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L
VL  - 212
SP  - 113719
DO  - 10.1016/j.phytochem.2023.113719
ER  - 

@article{
author = "Novakovic, Miroslav and Ilic-Tomic, Tatjana and Djordjevic, Iris and Andjelkovic, Boban and Tesevic, Vele and Milosavljevic, Slobodan and Asakawa, Yoshinori",
year = "2023",
abstract = "Bisbibenzyls are specialized metabolites found exclusively in liverworts, until recently; they represent chemical
markers of liverworts. Their occurrence in vascular plants was noticed in 2007, when they were found in Primula
veris subsp. macrocalyx from Russia. This report prompted us to chemically analyze the two most common
Serbian Primula species, P. veris subsp. columnae and P. acaulis, in order to determine the presence of bisbibenzyls
in them. Our study revealed nine structurally distinct bisbibenzyls (1–9), identified based on 1D and 2D NMR, IR,
UV and HRESIMS data. Among them were five previously undescribed compounds (2–6). The remaining compounds found and previously described in the literature were: the bisbibenzyls riccardin C (1), isoperrottetin A
(7), isoplagiochin E (8) and 11-O-demethylmarchantin I (9), as well as 4-hydroxyphenylmethylketone (10) and
4-hydroxy-3-methoxyphenylmethylketone (11). Riccardin C was the most dominant bisbibenzyl in both species
studied. Previously, it was the first bisbibenzyl found in vascular plants (P. veris subsp. macrocalyx). An
assessment of the cytotoxic activity of the isolated compounds against A549 lung cancer and healthy MRC5 cell
lines was also the subject of our study. Compounds 6 and 9 exhibited significant cytotoxic activity expressed by
IC50 values of 12 μM, but the selectivity was not satisfactory.",
publisher = "Elsevier",
journal = "Phytochemistry",
title = "Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L",
volume = "212",
pages = "113719",
doi = "10.1016/j.phytochem.2023.113719"
}

Novakovic, M., Ilic-Tomic, T., Djordjevic, I., Andjelkovic, B., Tesevic, V., Milosavljevic, S.,& Asakawa, Y.. (2023). Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L. in Phytochemistry
Elsevier., 212, 113719.
https://doi.org/10.1016/j.phytochem.2023.113719

Novakovic M, Ilic-Tomic T, Djordjevic I, Andjelkovic B, Tesevic V, Milosavljevic S, Asakawa Y. Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L. in Phytochemistry. 2023;212:113719.
doi:10.1016/j.phytochem.2023.113719 .

Novakovic, Miroslav, Ilic-Tomic, Tatjana, Djordjevic, Iris, Andjelkovic, Boban, Tesevic, Vele, Milosavljevic, Slobodan, Asakawa, Yoshinori, "Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L" in Phytochemistry, 212 (2023):113719,
https://doi.org/10.1016/j.phytochem.2023.113719 . .

TY  - JOUR
AU  - Stanimirović, Zoran
AU  - Glavinić, Uroš
AU  - Jovanović, Nemanja M.
AU  - Ristanić, Marko
AU  - Milojković-Opsenica, Dušanka
AU  - Mutić, Jelena
AU  - Stevanović, Jevrosima
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2474
AB  - In a cage experiment, lithium chloride (LiCl) and lithium citrate hydrate (Li-cit) were tested for varroacidal efficacy and impact on bees. Treatment with Li-cit (4, 7.5, 10, and 25 mM) resulted in 100% varroacidal efficacy and 100% bee survival. Due to better results in the cage experiment, Li-cit was further tested in field experiments on full-sized free-flying colonies treated three times in 6-day intervals. All the concentrations of Li-cit in the field experiment (5, 10, 15, 20, and 25 mM) expressed high varroacidal efficacy: 93.2–95.5%, significantly (p < 0.01) greater than in the negative and positive (amitraz-treated) controls. Lithium residues in honey from brood chambers were much higher nine months after the last treatment (169.3–1756.0 μg/kg) than seven days post-treatment (19.2–27.8 μg/kg). In honey from honey chambers (eligible for human consumption), the average lithium residues were 26.9 μg/kg and 33.7 μg/kg seven days after the last treatment. In wax combs taken from the brood chamber nine months post-treatment, lithium residues ranged from 410 μg/kg to 2314 µg/kg, without significant differences from the negative control. Lithium residues in wax matrices seven days after the last treatment were in a narrow range of 234.3–300 µg/kg, in wax combs and cappings being significantly lower than in commercial wax foundations. For the first time, Li-cit proved to be effective against Varroa destructor under field conditions.
PB  - International Bee Research Association
PB  - Taylor and Francis
T2  - Journal of Apicultural Research
T1  - Preliminary trials on effects of lithium salts on Varroa destructor, honey and wax matrices
VL  - 61
IS  - 3
SP  - 375
EP  - 391
DO  - 10.1080/00218839.2021.1988277
ER  - 

@article{
author = "Stanimirović, Zoran and Glavinić, Uroš and Jovanović, Nemanja M. and Ristanić, Marko and Milojković-Opsenica, Dušanka and Mutić, Jelena and Stevanović, Jevrosima",
year = "2022",
abstract = "In a cage experiment, lithium chloride (LiCl) and lithium citrate hydrate (Li-cit) were tested for varroacidal efficacy and impact on bees. Treatment with Li-cit (4, 7.5, 10, and 25 mM) resulted in 100% varroacidal efficacy and 100% bee survival. Due to better results in the cage experiment, Li-cit was further tested in field experiments on full-sized free-flying colonies treated three times in 6-day intervals. All the concentrations of Li-cit in the field experiment (5, 10, 15, 20, and 25 mM) expressed high varroacidal efficacy: 93.2–95.5%, significantly (p < 0.01) greater than in the negative and positive (amitraz-treated) controls. Lithium residues in honey from brood chambers were much higher nine months after the last treatment (169.3–1756.0 μg/kg) than seven days post-treatment (19.2–27.8 μg/kg). In honey from honey chambers (eligible for human consumption), the average lithium residues were 26.9 μg/kg and 33.7 μg/kg seven days after the last treatment. In wax combs taken from the brood chamber nine months post-treatment, lithium residues ranged from 410 μg/kg to 2314 µg/kg, without significant differences from the negative control. Lithium residues in wax matrices seven days after the last treatment were in a narrow range of 234.3–300 µg/kg, in wax combs and cappings being significantly lower than in commercial wax foundations. For the first time, Li-cit proved to be effective against Varroa destructor under field conditions.",
publisher = "International Bee Research Association, Taylor and Francis",
journal = "Journal of Apicultural Research",
title = "Preliminary trials on effects of lithium salts on Varroa destructor, honey and wax matrices",
volume = "61",
number = "3",
pages = "375-391",
doi = "10.1080/00218839.2021.1988277"
}

Stanimirović, Z., Glavinić, U., Jovanović, N. M., Ristanić, M., Milojković-Opsenica, D., Mutić, J.,& Stevanović, J.. (2022). Preliminary trials on effects of lithium salts on Varroa destructor, honey and wax matrices. in Journal of Apicultural Research
International Bee Research Association., 61(3), 375-391.
https://doi.org/10.1080/00218839.2021.1988277

Stanimirović Z, Glavinić U, Jovanović NM, Ristanić M, Milojković-Opsenica D, Mutić J, Stevanović J. Preliminary trials on effects of lithium salts on Varroa destructor, honey and wax matrices. in Journal of Apicultural Research. 2022;61(3):375-391.
doi:10.1080/00218839.2021.1988277 .

Stanimirović, Zoran, Glavinić, Uroš, Jovanović, Nemanja M., Ristanić, Marko, Milojković-Opsenica, Dušanka, Mutić, Jelena, Stevanović, Jevrosima, "Preliminary trials on effects of lithium salts on Varroa destructor, honey and wax matrices" in Journal of Apicultural Research, 61, no. 3 (2022):375-391,
https://doi.org/10.1080/00218839.2021.1988277 . .

TY  - JOUR
AU  - Stanimirović, Zoran
AU  - Glavinić, Uroš
AU  - Jovanović, Nemanja M.
AU  - Ristanić, Marko
AU  - Milojković-Opsenica, Dušanka
AU  - Mutić, Jelena
AU  - Stevanović, Jevrosima
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2475
AB  - In a cage experiment, lithium chloride (LiCl) and lithium citrate hydrate (Li-cit) were tested for varroacidal efficacy and impact on bees. Treatment with Li-cit (4, 7.5, 10, and 25 mM) resulted in 100% varroacidal efficacy and 100% bee survival. Due to better results in the cage experiment, Li-cit was further tested in field experiments on full-sized free-flying colonies treated three times in 6-day intervals. All the concentrations of Li-cit in the field experiment (5, 10, 15, 20, and 25 mM) expressed high varroacidal efficacy: 93.2–95.5%, significantly (p < 0.01) greater than in the negative and positive (amitraz-treated) controls. Lithium residues in honey from brood chambers were much higher nine months after the last treatment (169.3–1756.0 μg/kg) than seven days post-treatment (19.2–27.8 μg/kg). In honey from honey chambers (eligible for human consumption), the average lithium residues were 26.9 μg/kg and 33.7 μg/kg seven days after the last treatment. In wax combs taken from the brood chamber nine months post-treatment, lithium residues ranged from 410 μg/kg to 2314 µg/kg, without significant differences from the negative control. Lithium residues in wax matrices seven days after the last treatment were in a narrow range of 234.3–300 µg/kg, in wax combs and cappings being significantly lower than in commercial wax foundations. For the first time, Li-cit proved to be effective against Varroa destructor under field conditions.
PB  - International Bee Research Association
PB  - Taylor and Francis
T2  - Journal of Apicultural Research
T1  - Supplementary information for the article: Stanimirovic, Z.; Glavinic, U.; Jovanovic, N. M.; Ristanic, M.; Milojković-Opsenica, D.; Mutic, J.; Stevanovic, J. Preliminary Trials on Effects of Lithium Salts on Varroa Destructor, Honey and Wax Matrices. Journal of Apicultural Research 2022, 61 (3), 375–391. https://doi.org/10.1080/00218839.2021.1988277.
VL  - 61
IS  - 3
SP  - 375
EP  - 391
DO  - 10.1080/00218839.2021.1988277
ER  - 

@article{
author = "Stanimirović, Zoran and Glavinić, Uroš and Jovanović, Nemanja M. and Ristanić, Marko and Milojković-Opsenica, Dušanka and Mutić, Jelena and Stevanović, Jevrosima",
year = "2022",
abstract = "In a cage experiment, lithium chloride (LiCl) and lithium citrate hydrate (Li-cit) were tested for varroacidal efficacy and impact on bees. Treatment with Li-cit (4, 7.5, 10, and 25 mM) resulted in 100% varroacidal efficacy and 100% bee survival. Due to better results in the cage experiment, Li-cit was further tested in field experiments on full-sized free-flying colonies treated three times in 6-day intervals. All the concentrations of Li-cit in the field experiment (5, 10, 15, 20, and 25 mM) expressed high varroacidal efficacy: 93.2–95.5%, significantly (p < 0.01) greater than in the negative and positive (amitraz-treated) controls. Lithium residues in honey from brood chambers were much higher nine months after the last treatment (169.3–1756.0 μg/kg) than seven days post-treatment (19.2–27.8 μg/kg). In honey from honey chambers (eligible for human consumption), the average lithium residues were 26.9 μg/kg and 33.7 μg/kg seven days after the last treatment. In wax combs taken from the brood chamber nine months post-treatment, lithium residues ranged from 410 μg/kg to 2314 µg/kg, without significant differences from the negative control. Lithium residues in wax matrices seven days after the last treatment were in a narrow range of 234.3–300 µg/kg, in wax combs and cappings being significantly lower than in commercial wax foundations. For the first time, Li-cit proved to be effective against Varroa destructor under field conditions.",
publisher = "International Bee Research Association, Taylor and Francis",
journal = "Journal of Apicultural Research",
title = "Supplementary information for the article: Stanimirovic, Z.; Glavinic, U.; Jovanovic, N. M.; Ristanic, M.; Milojković-Opsenica, D.; Mutic, J.; Stevanovic, J. Preliminary Trials on Effects of Lithium Salts on Varroa Destructor, Honey and Wax Matrices. Journal of Apicultural Research 2022, 61 (3), 375–391. https://doi.org/10.1080/00218839.2021.1988277.",
volume = "61",
number = "3",
pages = "375-391",
doi = "10.1080/00218839.2021.1988277"
}

Stanimirović, Z., Glavinić, U., Jovanović, N. M., Ristanić, M., Milojković-Opsenica, D., Mutić, J.,& Stevanović, J.. (2022). Supplementary information for the article: Stanimirovic, Z.; Glavinic, U.; Jovanovic, N. M.; Ristanic, M.; Milojković-Opsenica, D.; Mutic, J.; Stevanovic, J. Preliminary Trials on Effects of Lithium Salts on Varroa Destructor, Honey and Wax Matrices. Journal of Apicultural Research 2022, 61 (3), 375–391. https://doi.org/10.1080/00218839.2021.1988277.. in Journal of Apicultural Research
International Bee Research Association., 61(3), 375-391.
https://doi.org/10.1080/00218839.2021.1988277

Stanimirović Z, Glavinić U, Jovanović NM, Ristanić M, Milojković-Opsenica D, Mutić J, Stevanović J. Supplementary information for the article: Stanimirovic, Z.; Glavinic, U.; Jovanovic, N. M.; Ristanic, M.; Milojković-Opsenica, D.; Mutic, J.; Stevanovic, J. Preliminary Trials on Effects of Lithium Salts on Varroa Destructor, Honey and Wax Matrices. Journal of Apicultural Research 2022, 61 (3), 375–391. https://doi.org/10.1080/00218839.2021.1988277.. in Journal of Apicultural Research. 2022;61(3):375-391.
doi:10.1080/00218839.2021.1988277 .

Stanimirović, Zoran, Glavinić, Uroš, Jovanović, Nemanja M., Ristanić, Marko, Milojković-Opsenica, Dušanka, Mutić, Jelena, Stevanović, Jevrosima, "Supplementary information for the article: Stanimirovic, Z.; Glavinic, U.; Jovanovic, N. M.; Ristanic, M.; Milojković-Opsenica, D.; Mutic, J.; Stevanovic, J. Preliminary Trials on Effects of Lithium Salts on Varroa Destructor, Honey and Wax Matrices. Journal of Apicultural Research 2022, 61 (3), 375–391. https://doi.org/10.1080/00218839.2021.1988277." in Journal of Apicultural Research, 61, no. 3 (2022):375-391,
https://doi.org/10.1080/00218839.2021.1988277 . .

TY  - JOUR
AU  - Nikolić, Biljana M.
AU  - Milanović, Slobodan D.
AU  - Milenković, Ivan Lj.
AU  - Todosijević, Marina
AU  - Đorđević, Iris
AU  - Brkić, Milana Z.
AU  - Mitić, Zorica S.
AU  - Marin, Petar D.
AU  - Tešević, Vele
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4885
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2481
AB  - We examined essential oils (EOs) of Chamaecyparis lawsoniana and Thuja plicata (Cupressaceae), their antifeedant activity on Lymanthria dispar larvae and their antimicrobial activity. Studies of EOs showed that these two conifer species differed both in content of terpene classes and the major compounds. Total monoterpenes strongly dominated in T. plicata (96.4%), while C. lawsoniana was rich in both mono- and sesquiterpenes (40.8% and 30.3%, respectively) as well as in diterpenes (19.1%). The most dominant compounds of C. lawsoniana EO were: limonene (16.7%), oplopanonyl acetate (14.5%), beyerene (10.1%), and 13-epi-dolabradiene (6.7%). The dominant compound of T. plicata EOs was α-thujone (76.9%), followed by relatively small amounts of β- thujone (5.3%), sabinene (4.5%) and terpinene-4-ol (3.2%). The difference in EO compositions of the conifers was reflected on Lymantria dispar larvae performance. Larvae fed on the leaf discs treated by C. lawsoniana EO had a slight phagostimulatory effect at lower concentration shown by higher relative rate of food consumption and relative growth rate than the larvae in the control group. Contrastingly, leaf discs treated with EO of T. plicata EO had an antifeedant effect and lower relative consumption rate (RCR) and relative growth rate RGR than the larvae in the control group. Both tested EOs influenced substantially the colony growth of the subjected Phytophthora plurivora and P. quercina. Namely, 100% inhibitory effect was recorded at concentration of 0.1% in the case of C. lawsoniana EO, whereas of T. plicata colonies did not grow at 0.5% concentration. The implications of these findings and possibility of using the tested EOs in further experiments in vitro and in vivo are discussed.
PB  - Elsevier
T2  - Industrial Crops and Products
T2  - Industrial Crops and ProductsIndustrial Crops and Products
T1  - Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens
VL  - 178
SP  - 114550
DO  - 10.1016/j.indcrop.2022.114550
ER  - 

@article{
author = "Nikolić, Biljana M. and Milanović, Slobodan D. and Milenković, Ivan Lj. and Todosijević, Marina and Đorđević, Iris and Brkić, Milana Z. and Mitić, Zorica S. and Marin, Petar D. and Tešević, Vele",
year = "2022",
abstract = "We examined essential oils (EOs) of Chamaecyparis lawsoniana and Thuja plicata (Cupressaceae), their antifeedant activity on Lymanthria dispar larvae and their antimicrobial activity. Studies of EOs showed that these two conifer species differed both in content of terpene classes and the major compounds. Total monoterpenes strongly dominated in T. plicata (96.4%), while C. lawsoniana was rich in both mono- and sesquiterpenes (40.8% and 30.3%, respectively) as well as in diterpenes (19.1%). The most dominant compounds of C. lawsoniana EO were: limonene (16.7%), oplopanonyl acetate (14.5%), beyerene (10.1%), and 13-epi-dolabradiene (6.7%). The dominant compound of T. plicata EOs was α-thujone (76.9%), followed by relatively small amounts of β- thujone (5.3%), sabinene (4.5%) and terpinene-4-ol (3.2%). The difference in EO compositions of the conifers was reflected on Lymantria dispar larvae performance. Larvae fed on the leaf discs treated by C. lawsoniana EO had a slight phagostimulatory effect at lower concentration shown by higher relative rate of food consumption and relative growth rate than the larvae in the control group. Contrastingly, leaf discs treated with EO of T. plicata EO had an antifeedant effect and lower relative consumption rate (RCR) and relative growth rate RGR than the larvae in the control group. Both tested EOs influenced substantially the colony growth of the subjected Phytophthora plurivora and P. quercina. Namely, 100% inhibitory effect was recorded at concentration of 0.1% in the case of C. lawsoniana EO, whereas of T. plicata colonies did not grow at 0.5% concentration. The implications of these findings and possibility of using the tested EOs in further experiments in vitro and in vivo are discussed.",
publisher = "Elsevier",
journal = "Industrial Crops and Products, Industrial Crops and ProductsIndustrial Crops and Products",
title = "Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens",
volume = "178",
pages = "114550",
doi = "10.1016/j.indcrop.2022.114550"
}

Nikolić, B. M., Milanović, S. D., Milenković, I. Lj., Todosijević, M., Đorđević, I., Brkić, M. Z., Mitić, Z. S., Marin, P. D.,& Tešević, V.. (2022). Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens. in Industrial Crops and Products
Elsevier., 178, 114550.
https://doi.org/10.1016/j.indcrop.2022.114550

Nikolić BM, Milanović SD, Milenković IL, Todosijević M, Đorđević I, Brkić MZ, Mitić ZS, Marin PD, Tešević V. Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens. in Industrial Crops and Products. 2022;178:114550.
doi:10.1016/j.indcrop.2022.114550 .

Nikolić, Biljana M., Milanović, Slobodan D., Milenković, Ivan Lj., Todosijević, Marina, Đorđević, Iris, Brkić, Milana Z., Mitić, Zorica S., Marin, Petar D., Tešević, Vele, "Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens" in Industrial Crops and Products, 178 (2022):114550,
https://doi.org/10.1016/j.indcrop.2022.114550 . .

TY  - JOUR
AU  - Ljujić, Jovana
AU  - Sofrenić, Ivana
AU  - Đorđević, Iris
AU  - Macura, Predrag
AU  - Tešević, Vele
AU  - Vujisić, Ljubodrag
AU  - Anđelković, Boban
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2994
AB  - During 2021 and 2022, the pandemic of corona viruses
(COVID-19) caused the enormous increase in use of
antioxidants and supplements. The latest recommendations
from the World Health Organization were to use natural
sources of antioxidants which can help in boosting
immunity (WHO, 2019). Dietary antioxidants from fruits
and vegetables play an important role in mitigating the
damaging effects of reactive oxygen species (ROS) on
cellular macromolecules (lipids, proteins, and DNA) (Rao
et al., 2010). The raspberries have high antioxidant
phytochemical contents which can be preserved by freezedried process. The yield of bioactive compounds from
plant sources depends on solvent properties, nature of the
plant material and extraction temperature and time (Xue et
al., 2020). In the green chemistry approaches, natural deep
eutectic solvents (NADES) were typically used as a
substitute for organic solvents in order to preserve the
environment (Espino et al., 2016).
PB  - Skopje : Macedonian Pharmaceutical Association
T2  - Macedonian pharmaceutical bulletin
T1  - Antioxidant potential and polyphenol content of five new cultivars of raspberries
VL  - 68
SP  - 47
EP  - 48
DO  - 10.33320/maced.pharm.bull.2022.68.04.018
ER  - 

@article{
author = "Ljujić, Jovana and Sofrenić, Ivana and Đorđević, Iris and Macura, Predrag and Tešević, Vele and Vujisić, Ljubodrag and Anđelković, Boban",
year = "2022",
abstract = "During 2021 and 2022, the pandemic of corona viruses
(COVID-19) caused the enormous increase in use of
antioxidants and supplements. The latest recommendations
from the World Health Organization were to use natural
sources of antioxidants which can help in boosting
immunity (WHO, 2019). Dietary antioxidants from fruits
and vegetables play an important role in mitigating the
damaging effects of reactive oxygen species (ROS) on
cellular macromolecules (lipids, proteins, and DNA) (Rao
et al., 2010). The raspberries have high antioxidant
phytochemical contents which can be preserved by freezedried process. The yield of bioactive compounds from
plant sources depends on solvent properties, nature of the
plant material and extraction temperature and time (Xue et
al., 2020). In the green chemistry approaches, natural deep
eutectic solvents (NADES) were typically used as a
substitute for organic solvents in order to preserve the
environment (Espino et al., 2016).",
publisher = "Skopje : Macedonian Pharmaceutical Association",
journal = "Macedonian pharmaceutical bulletin",
title = "Antioxidant potential and polyphenol content of five new cultivars of raspberries",
volume = "68",
pages = "47-48",
doi = "10.33320/maced.pharm.bull.2022.68.04.018"
}

Ljujić, J., Sofrenić, I., Đorđević, I., Macura, P., Tešević, V., Vujisić, L.,& Anđelković, B.. (2022). Antioxidant potential and polyphenol content of five new cultivars of raspberries. in Macedonian pharmaceutical bulletin
Skopje : Macedonian Pharmaceutical Association., 68, 47-48.
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.018

Ljujić J, Sofrenić I, Đorđević I, Macura P, Tešević V, Vujisić L, Anđelković B. Antioxidant potential and polyphenol content of five new cultivars of raspberries. in Macedonian pharmaceutical bulletin. 2022;68:47-48.
doi:10.33320/maced.pharm.bull.2022.68.04.018 .

Ljujić, Jovana, Sofrenić, Ivana, Đorđević, Iris, Macura, Predrag, Tešević, Vele, Vujisić, Ljubodrag, Anđelković, Boban, "Antioxidant potential and polyphenol content of five new cultivars of raspberries" in Macedonian pharmaceutical bulletin, 68 (2022):47-48,
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.018 . .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Krstić, Gordana
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2995
AB  - Our previous phytochemical studies revealed that the
plant species of the genus Amphoricarpos from
Montenegro are characterized with an appreciable content
(>0.3–2.3% per dry weight of aerial plant material) of γsesquiterpene lactones with guaianolide skeleton, socalled amphoricarpolides that are mostly deposited on the
leaf surface (>1.0–3.4% per dry weight of leaves)
(Djordjević et al., 2021; Jadranin et al., 2013). These
compounds showed in vitro protective effect on
chromosome aberrations in peripheral human
lymphocytes (Cvetković et al., 2021) and in vitro
cytotoxic (Djordjević et al., 2021), antifungal (Jadranin et
al., 2013) and antibacterial (Gavrilović et al., 2016)
activities. The amphoricarpolides are significant as
chemotaxonomic markers as they gave insights about the
taxonomic status of the genus (Djordjević et al., 2021).
This study revealed results from reinvestigation of
sesquiterpene lactones composition in the crude and leaf
surface extracts of Amphoricarpos plants by rapid
resolution liquid chromatography (RRLC) coupled with
quadrupole time-of-flight mass spectrometry (QToF MS)
and the tentative identification of undescribed
sesquiterpene lactones is presented.
PB  - Skopje : Macedonian Pharmaceutical Association
T2  - Macedonian Pharmaceutical Bulletin
T1  - New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
VL  - 68
SP  - 71
EP  - 72
DO  - 10.33320/maced.pharm.bull.2022.68.04.030
ER  - 

@article{
author = "Jadranin, Milka and Cvetković, Mirjana and Đorđević, Iris and Krstić, Gordana and Tešević, Vele and Milosavljević, Slobodan",
year = "2022",
abstract = "Our previous phytochemical studies revealed that the
plant species of the genus Amphoricarpos from
Montenegro are characterized with an appreciable content
(>0.3–2.3% per dry weight of aerial plant material) of γsesquiterpene lactones with guaianolide skeleton, socalled amphoricarpolides that are mostly deposited on the
leaf surface (>1.0–3.4% per dry weight of leaves)
(Djordjević et al., 2021; Jadranin et al., 2013). These
compounds showed in vitro protective effect on
chromosome aberrations in peripheral human
lymphocytes (Cvetković et al., 2021) and in vitro
cytotoxic (Djordjević et al., 2021), antifungal (Jadranin et
al., 2013) and antibacterial (Gavrilović et al., 2016)
activities. The amphoricarpolides are significant as
chemotaxonomic markers as they gave insights about the
taxonomic status of the genus (Djordjević et al., 2021).
This study revealed results from reinvestigation of
sesquiterpene lactones composition in the crude and leaf
surface extracts of Amphoricarpos plants by rapid
resolution liquid chromatography (RRLC) coupled with
quadrupole time-of-flight mass spectrometry (QToF MS)
and the tentative identification of undescribed
sesquiterpene lactones is presented.",
publisher = "Skopje : Macedonian Pharmaceutical Association",
journal = "Macedonian Pharmaceutical Bulletin",
title = "New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry",
volume = "68",
pages = "71-72",
doi = "10.33320/maced.pharm.bull.2022.68.04.030"
}

Jadranin, M., Cvetković, M., Đorđević, I., Krstić, G., Tešević, V.,& Milosavljević, S.. (2022). New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin
Skopje : Macedonian Pharmaceutical Association., 68, 71-72.
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030

Jadranin M, Cvetković M, Đorđević I, Krstić G, Tešević V, Milosavljević S. New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin. 2022;68:71-72.
doi:10.33320/maced.pharm.bull.2022.68.04.030 .

Jadranin, Milka, Cvetković, Mirjana, Đorđević, Iris, Krstić, Gordana, Tešević, Vele, Milosavljević, Slobodan, "New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry" in Macedonian Pharmaceutical Bulletin, 68 (2022):71-72,
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030 . .

TY  - JOUR
AU  - Milosavljević, Slobodan
AU  - Đorđević, Iris
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Stanković, Miroslava
AU  - Todorović, Nina
AU  - Novaković, Miroslav
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2386
AB  - In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.
PB  - SAGE Publications
T2  - Natural Product Communications
T1  - Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA
VL  - 16
IS  - 12
DO  - 10.1177/1934578X211067289
ER  - 

@article{
author = "Milosavljević, Slobodan and Đorđević, Iris and Mandić, Boris and Tešević, Vele and Stanković, Miroslava and Todorović, Nina and Novaković, Miroslav",
year = "2021",
abstract = "In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.",
publisher = "SAGE Publications",
journal = "Natural Product Communications",
title = "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA",
volume = "16",
number = "12",
doi = "10.1177/1934578X211067289"
}

Milosavljević, S., Đorđević, I., Mandić, B., Tešević, V., Stanković, M., Todorović, N.,& Novaković, M.. (2021). Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications
SAGE Publications., 16(12).
https://doi.org/10.1177/1934578X211067289

Milosavljević S, Đorđević I, Mandić B, Tešević V, Stanković M, Todorović N, Novaković M. Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications. 2021;16(12).
doi:10.1177/1934578X211067289 .

Milosavljević, Slobodan, Đorđević, Iris, Mandić, Boris, Tešević, Vele, Stanković, Miroslava, Todorović, Nina, Novaković, Miroslav, "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA" in Natural Product Communications, 16, no. 12 (2021),
https://doi.org/10.1177/1934578X211067289 . .

TY  - JOUR
AU  - Đorđević, Iris
AU  - Cvetković, Mirjana
AU  - Jadranin, Milka
AU  - Bojović, Srđan
AU  - Anđelković, Boban
AU  - Sofrenić, Ivana
AU  - Simić, Katarina
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2538
AB  - Phytochemistry deals with the study of secondary metabolites produced by plants that synthesize these compounds for many reasons, including their own protection against attack of herbivores and plant diseases. Secondary metabolites are believed to represent plant adaptation to various environmental factors and that they enabled the survival of the species. Secondary metabolites of plants can have curative or toxic effects in humans and animals. Herbal medicine has a long tradition in folk medicine and until the early 20th century, when synthetic organic chemistry began to develop, plants were the main source of medicines. The two basic goals of our phytochemical research are: Isolation and identification of new (biologically active) compounds - potential drugs, and chemotaxonomy (chemosystematics). In the following text through one selected example, the genus Amphoricarpos Vis., our phytochemical research is shown on both aspects.
PB  - Belgrade :: Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Phytochemical study of the genus Amphoricarpos
VL  - 86
IS  - 12
SP  - 1177
SP  - 1193
DO  - 10.2298/JSC210726083D
ER  - 

@article{
author = "Đorđević, Iris and Cvetković, Mirjana and Jadranin, Milka and Bojović, Srđan and Anđelković, Boban and Sofrenić, Ivana and Simić, Katarina",
year = "2021",
abstract = "Phytochemistry deals with the study of secondary metabolites produced by plants that synthesize these compounds for many reasons, including their own protection against attack of herbivores and plant diseases. Secondary metabolites are believed to represent plant adaptation to various environmental factors and that they enabled the survival of the species. Secondary metabolites of plants can have curative or toxic effects in humans and animals. Herbal medicine has a long tradition in folk medicine and until the early 20th century, when synthetic organic chemistry began to develop, plants were the main source of medicines. The two basic goals of our phytochemical research are: Isolation and identification of new (biologically active) compounds - potential drugs, and chemotaxonomy (chemosystematics). In the following text through one selected example, the genus Amphoricarpos Vis., our phytochemical research is shown on both aspects.",
publisher = "Belgrade :: Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Phytochemical study of the genus Amphoricarpos",
volume = "86",
number = "12",
pages = "1177-1193",
doi = "10.2298/JSC210726083D"
}

Đorđević, I., Cvetković, M., Jadranin, M., Bojović, S., Anđelković, B., Sofrenić, I.,& Simić, K.. (2021). Phytochemical study of the genus Amphoricarpos. in Journal of the Serbian Chemical Society
Belgrade :: Serbian Chemical Society., 86(12), 1177.
https://doi.org/10.2298/JSC210726083D

Đorđević I, Cvetković M, Jadranin M, Bojović S, Anđelković B, Sofrenić I, Simić K. Phytochemical study of the genus Amphoricarpos. in Journal of the Serbian Chemical Society. 2021;86(12):1177.
doi:10.2298/JSC210726083D .

Đorđević, Iris, Cvetković, Mirjana, Jadranin, Milka, Bojović, Srđan, Anđelković, Boban, Sofrenić, Ivana, Simić, Katarina, "Phytochemical study of the genus Amphoricarpos" in Journal of the Serbian Chemical Society, 86, no. 12 (2021):1177,
https://doi.org/10.2298/JSC210726083D . .

TY  - JOUR
AU  - Nikolić, Biljana M.
AU  - Đorđević, Iris
AU  - Todosijević, Marina
AU  - Mitić, Zorica
AU  - Stefanović, Milena A.
AU  - Stankovic, Jovana M.
AU  - Bojović, Srdjan
AU  - Tešević, Vele
AU  - Marin, Petar D.
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2245
AB  - The content of nonacosan-10-ol and n-alkanes in needle waxes of twelve Pinus taxa (Pinus halepensis, P. heldreichii, P. mugo, P. nigra ssp. nigra, P. nigra ssp. dalmatica, P. peuce, P. pinaster, P. pinea, P. ponderosa, P. strobus, P. sylvestris, and P. wallichiana) were examined. In eight Pinus taxa (except of P. halepensis, P. pinaster, P. heldreichii and P. peuce) nonacosan-10-ol contents were examined for the first time. In all examined pines C29, C27 or C25 were the main n-alkane compounds. C range was mainly 18-33. In six Pinus taxa (P. mugo, P. nigra ssp. dalmatica, P. sylvestris, P. pinea, P. strobus and P. wallichiana) CPI and ACL values were examined for the first time. In the plane of Axis 1 (PCA), P. strobus, P. mugo, and P. wallichiana were strongly separated from P. heldreichii and P. pinea. In the plane of Axis 2, P. peuce, P. strobus, and P. wallichiana as well as P. heldreichii and P. pinea diverged from other examined species. In DA P. heldreichii, P. strobus, P. peuce, and P. wallichiana diversed. CA divided sections Pinus and Pinaster from section Strobi.
PB  - Taylor and Francis
T2  - Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
T1  - Diversity of nonacosan-10-ol and n-alkanes among 12 Pinus taxa
SP  - 1
EP  - 8
DO  - 10.1080/11263504.2020.1857867
ER  - 

@article{
author = "Nikolić, Biljana M. and Đorđević, Iris and Todosijević, Marina and Mitić, Zorica and Stefanović, Milena A. and Stankovic, Jovana M. and Bojović, Srdjan and Tešević, Vele and Marin, Petar D.",
year = "2020",
abstract = "The content of nonacosan-10-ol and n-alkanes in needle waxes of twelve Pinus taxa (Pinus halepensis, P. heldreichii, P. mugo, P. nigra ssp. nigra, P. nigra ssp. dalmatica, P. peuce, P. pinaster, P. pinea, P. ponderosa, P. strobus, P. sylvestris, and P. wallichiana) were examined. In eight Pinus taxa (except of P. halepensis, P. pinaster, P. heldreichii and P. peuce) nonacosan-10-ol contents were examined for the first time. In all examined pines C29, C27 or C25 were the main n-alkane compounds. C range was mainly 18-33. In six Pinus taxa (P. mugo, P. nigra ssp. dalmatica, P. sylvestris, P. pinea, P. strobus and P. wallichiana) CPI and ACL values were examined for the first time. In the plane of Axis 1 (PCA), P. strobus, P. mugo, and P. wallichiana were strongly separated from P. heldreichii and P. pinea. In the plane of Axis 2, P. peuce, P. strobus, and P. wallichiana as well as P. heldreichii and P. pinea diverged from other examined species. In DA P. heldreichii, P. strobus, P. peuce, and P. wallichiana diversed. CA divided sections Pinus and Pinaster from section Strobi.",
publisher = "Taylor and Francis",
journal = "Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology",
title = "Diversity of nonacosan-10-ol and n-alkanes among 12 Pinus taxa",
pages = "1-8",
doi = "10.1080/11263504.2020.1857867"
}

Nikolić, B. M., Đorđević, I., Todosijević, M., Mitić, Z., Stefanović, M. A., Stankovic, J. M., Bojović, S., Tešević, V.,& Marin, P. D.. (2020). Diversity of nonacosan-10-ol and n-alkanes among 12 Pinus taxa. in Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
Taylor and Francis., 1-8.
https://doi.org/10.1080/11263504.2020.1857867

Nikolić BM, Đorđević I, Todosijević M, Mitić Z, Stefanović MA, Stankovic JM, Bojović S, Tešević V, Marin PD. Diversity of nonacosan-10-ol and n-alkanes among 12 Pinus taxa. in Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology. 2020;:1-8.
doi:10.1080/11263504.2020.1857867 .

Nikolić, Biljana M., Đorđević, Iris, Todosijević, Marina, Mitić, Zorica, Stefanović, Milena A., Stankovic, Jovana M., Bojović, Srdjan, Tešević, Vele, Marin, Petar D., "Diversity of nonacosan-10-ol and n-alkanes among 12 Pinus taxa" in Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology (2020):1-8,
https://doi.org/10.1080/11263504.2020.1857867 . .