TY  - JOUR
AU  - Stojanović, M.
AU  - Todorović, D.
AU  - Šćepanović, Ljiljana
AU  - Mitrović, D.
AU  - Borozan, Sunčica
AU  - Dragutinović, Vesna
AU  - Labudović-Borović, Milica
AU  - Krstić, D.
AU  - Colović, M.
AU  - Đurić, D.
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1585
AB  - The aim of this study was to assess the effects of l-cysteine (Cys) (7 mg/kg) and N-acetyl-l-cysteine (NAC) (50 mg/kg) in the rat liver caused by subchronic i.p. application of methionine (Met) (0.8 mmol/kg) during 21 days. Malondialdehyde (MDA) concentration, glutathione content (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and acetylcholinesterase (AchE) activities were determined in the liver tissue and activities of liver enzymes (AST, ALT, ALP, and GGT) and concentrations of total proteins and albumin were determinated in plasma/serum. Catalase, superoxide dismutase, and acetylcholinesterase activities were increased by Cys and NAC. Met caused periportal mononuclear infiltration and rare focal necrosis of hepatocytes. In Cys- and NAC-supplemented groups, intracellular edema and microvesicular fatty changes without necrosis were noticed. We observed decrease of AST, ALT, and ALP activity in the methionine-treated group. Our results indicate that Cys and NAC application can increase activity of antioxidative enzymes and prevent intensive histological changes in liver in condition of subchronic methionine exposure.
PB  - Springer, Dordrecht
T2  - Molecular and Cellular Biochemistry
T1  - Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue
VL  - 448
IS  - 1-2
SP  - 43
EP  - 50
DO  - 10.1007/s11010-018-3311-2
ER  - 

@article{
author = "Stojanović, M. and Todorović, D. and Šćepanović, Ljiljana and Mitrović, D. and Borozan, Sunčica and Dragutinović, Vesna and Labudović-Borović, Milica and Krstić, D. and Colović, M. and Đurić, D.",
year = "2018",
abstract = "The aim of this study was to assess the effects of l-cysteine (Cys) (7 mg/kg) and N-acetyl-l-cysteine (NAC) (50 mg/kg) in the rat liver caused by subchronic i.p. application of methionine (Met) (0.8 mmol/kg) during 21 days. Malondialdehyde (MDA) concentration, glutathione content (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and acetylcholinesterase (AchE) activities were determined in the liver tissue and activities of liver enzymes (AST, ALT, ALP, and GGT) and concentrations of total proteins and albumin were determinated in plasma/serum. Catalase, superoxide dismutase, and acetylcholinesterase activities were increased by Cys and NAC. Met caused periportal mononuclear infiltration and rare focal necrosis of hepatocytes. In Cys- and NAC-supplemented groups, intracellular edema and microvesicular fatty changes without necrosis were noticed. We observed decrease of AST, ALT, and ALP activity in the methionine-treated group. Our results indicate that Cys and NAC application can increase activity of antioxidative enzymes and prevent intensive histological changes in liver in condition of subchronic methionine exposure.",
publisher = "Springer, Dordrecht",
journal = "Molecular and Cellular Biochemistry",
title = "Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue",
volume = "448",
number = "1-2",
pages = "43-50",
doi = "10.1007/s11010-018-3311-2"
}

Stojanović, M., Todorović, D., Šćepanović, L., Mitrović, D., Borozan, S., Dragutinović, V., Labudović-Borović, M., Krstić, D., Colović, M.,& Đurić, D.. (2018). Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue. in Molecular and Cellular Biochemistry
Springer, Dordrecht., 448(1-2), 43-50.
https://doi.org/10.1007/s11010-018-3311-2

Stojanović M, Todorović D, Šćepanović L, Mitrović D, Borozan S, Dragutinović V, Labudović-Borović M, Krstić D, Colović M, Đurić D. Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue. in Molecular and Cellular Biochemistry. 2018;448(1-2):43-50.
doi:10.1007/s11010-018-3311-2 .

Stojanović, M., Todorović, D., Šćepanović, Ljiljana, Mitrović, D., Borozan, Sunčica, Dragutinović, Vesna, Labudović-Borović, Milica, Krstić, D., Colović, M., Đurić, D., "Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue" in Molecular and Cellular Biochemistry, 448, no. 1-2 (2018):43-50,
https://doi.org/10.1007/s11010-018-3311-2 . .

TY  - JOUR
AU  - Šćepanović, V.
AU  - Tasić, G.
AU  - Repac, N.
AU  - Nikolić, I.
AU  - Janicijević, A.
AU  - Todorović, D.
AU  - Stojanović, M.
AU  - Scepanović, R.
AU  - Mitrović, D.
AU  - Šćepanović, T.
AU  - Borozan, Sunčica
AU  - Šćepanović, Ljiljana
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1608
AB  - Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurysm development and rupture. The aim of this study was to examine the role of overall oxidative stress as a risk factor for rupture of PICA aneurysms. This study included 29 patients with PICA aneurysms: 18 ruptured and 11 unruptured. We determined catalase, malondialdehyde, myeloperoxidase and carbonyl groups in homogenates of excised aneurysm tissue after surgery and plasma levels of C reactive protein and fibrinogen. The patients age and sex, size of aneurysms, multiplicity, history of previous subarachnoidal hemorrhage (SAH) and risk factors for oxidative stress such as hypertension and smoking were compared between unruptured and ruptured aneurysms. Maximal diameter and SAH history were independent predictors for aneurysm rupture. Activity of catalase was decreased while activity of myeloperoxidase, levels of malondialdehyde, carbonyl groups in aneurismal tissue and plasma levels of C reactive protein and fibrinogen were increased in patients with ruptured aneurysms. Plasma levels of C reactive protein and fibrinogen showed positive correlation with myeloperoxidase, malondialdehyde, carbonyl groups and PHASES score and negative correlation with catalase. These findings suggest that oxidative stress may contribute importantly to rupture of PICA aneurysms and plasma levels of C reactive protein and fibrinogen correlate with oxidative stress markers in tissue.
PB  - Springer, Dordrecht
T2  - Molecular Biology Reports
T1  - The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms
VL  - 45
IS  - 6
SP  - 2157
EP  - 2165
DO  - 10.1007/s11033-018-4374-6
ER  - 

@article{
author = "Šćepanović, V. and Tasić, G. and Repac, N. and Nikolić, I. and Janicijević, A. and Todorović, D. and Stojanović, M. and Scepanović, R. and Mitrović, D. and Šćepanović, T. and Borozan, Sunčica and Šćepanović, Ljiljana",
year = "2018",
abstract = "Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurysm development and rupture. The aim of this study was to examine the role of overall oxidative stress as a risk factor for rupture of PICA aneurysms. This study included 29 patients with PICA aneurysms: 18 ruptured and 11 unruptured. We determined catalase, malondialdehyde, myeloperoxidase and carbonyl groups in homogenates of excised aneurysm tissue after surgery and plasma levels of C reactive protein and fibrinogen. The patients age and sex, size of aneurysms, multiplicity, history of previous subarachnoidal hemorrhage (SAH) and risk factors for oxidative stress such as hypertension and smoking were compared between unruptured and ruptured aneurysms. Maximal diameter and SAH history were independent predictors for aneurysm rupture. Activity of catalase was decreased while activity of myeloperoxidase, levels of malondialdehyde, carbonyl groups in aneurismal tissue and plasma levels of C reactive protein and fibrinogen were increased in patients with ruptured aneurysms. Plasma levels of C reactive protein and fibrinogen showed positive correlation with myeloperoxidase, malondialdehyde, carbonyl groups and PHASES score and negative correlation with catalase. These findings suggest that oxidative stress may contribute importantly to rupture of PICA aneurysms and plasma levels of C reactive protein and fibrinogen correlate with oxidative stress markers in tissue.",
publisher = "Springer, Dordrecht",
journal = "Molecular Biology Reports",
title = "The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms",
volume = "45",
number = "6",
pages = "2157-2165",
doi = "10.1007/s11033-018-4374-6"
}

Šćepanović, V., Tasić, G., Repac, N., Nikolić, I., Janicijević, A., Todorović, D., Stojanović, M., Scepanović, R., Mitrović, D., Šćepanović, T., Borozan, S.,& Šćepanović, L.. (2018). The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms. in Molecular Biology Reports
Springer, Dordrecht., 45(6), 2157-2165.
https://doi.org/10.1007/s11033-018-4374-6

Šćepanović V, Tasić G, Repac N, Nikolić I, Janicijević A, Todorović D, Stojanović M, Scepanović R, Mitrović D, Šćepanović T, Borozan S, Šćepanović L. The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms. in Molecular Biology Reports. 2018;45(6):2157-2165.
doi:10.1007/s11033-018-4374-6 .

Šćepanović, V., Tasić, G., Repac, N., Nikolić, I., Janicijević, A., Todorović, D., Stojanović, M., Scepanović, R., Mitrović, D., Šćepanović, T., Borozan, Sunčica, Šćepanović, Ljiljana, "The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms" in Molecular Biology Reports, 45, no. 6 (2018):2157-2165,
https://doi.org/10.1007/s11033-018-4374-6 . .

TY  - JOUR
AU  - Stojanović, Marija
AU  - Šćepanović, Ljiljana
AU  - Todorović, Dusan
AU  - Mitrović, Dušan
AU  - Šćepanović, Vuk
AU  - Scepanović, Radomir
AU  - Ilić, Slobodan
AU  - Šćepanović, Teja
AU  - Labudović-Borović, Milica
AU  - Milicević, Zivana
AU  - Dragutinović, Vesna
AU  - Borozan, Sunčica
AU  - Lalić, Ivana
AU  - Despotović, Sanja
AU  - Đurić, Dragan
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1662
AB  - Changes in the methionine metabolism can cause a state called hyperhomocysteinemia, inducing oxidative stress in the gut. The production of free radicals is important in the colon damage caused by methionine. This study aimed at evaluating the effect of the use of l-cysteine and N-acetyl-l-cysteine on the colon morphometry of young rats treated with methionine. A total number of 32 male rats were distributed in a randomized experimental design in 4 groups: control group treated with saline; methionine group; cysteine + methionine group, and N-acetyl-l-cysteine + methionine group. After 21 days of treatment, rats were sacrificed and the colon samples were taken for histological and biochemical analysis. Methionine load increased depth of crypts, the lamina muscularis mucosae thickness, the mucosal height, and the number of cells in lamina propria (p < 0.01). Combination of methionine with l-cysteine (C group) and with N-acetyl-l-cysteine (N group) reversed methionine effects. Methionine treatment increased the GPx activity and MDA concentration, while l-cysteine and N-acetyl-l-cysteine increased the catalase activity compared to methionine group. It was concluded that the use of l-cysteine and N-acetyl-l-cysteine was beneficial to decrease intestinal mucosal height and oxidative damage when methionine was used in combination with them.
PB  - Springer, Dordrecht
T2  - Molecular and Cellular Biochemistry
T1  - Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-l-cysteine
VL  - 440
IS  - 1-2
SP  - 53
EP  - 64
DO  - 10.1007/s11010-017-3155-1
ER  - 

@article{
author = "Stojanović, Marija and Šćepanović, Ljiljana and Todorović, Dusan and Mitrović, Dušan and Šćepanović, Vuk and Scepanović, Radomir and Ilić, Slobodan and Šćepanović, Teja and Labudović-Borović, Milica and Milicević, Zivana and Dragutinović, Vesna and Borozan, Sunčica and Lalić, Ivana and Despotović, Sanja and Đurić, Dragan",
year = "2018",
abstract = "Changes in the methionine metabolism can cause a state called hyperhomocysteinemia, inducing oxidative stress in the gut. The production of free radicals is important in the colon damage caused by methionine. This study aimed at evaluating the effect of the use of l-cysteine and N-acetyl-l-cysteine on the colon morphometry of young rats treated with methionine. A total number of 32 male rats were distributed in a randomized experimental design in 4 groups: control group treated with saline; methionine group; cysteine + methionine group, and N-acetyl-l-cysteine + methionine group. After 21 days of treatment, rats were sacrificed and the colon samples were taken for histological and biochemical analysis. Methionine load increased depth of crypts, the lamina muscularis mucosae thickness, the mucosal height, and the number of cells in lamina propria (p < 0.01). Combination of methionine with l-cysteine (C group) and with N-acetyl-l-cysteine (N group) reversed methionine effects. Methionine treatment increased the GPx activity and MDA concentration, while l-cysteine and N-acetyl-l-cysteine increased the catalase activity compared to methionine group. It was concluded that the use of l-cysteine and N-acetyl-l-cysteine was beneficial to decrease intestinal mucosal height and oxidative damage when methionine was used in combination with them.",
publisher = "Springer, Dordrecht",
journal = "Molecular and Cellular Biochemistry",
title = "Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-l-cysteine",
volume = "440",
number = "1-2",
pages = "53-64",
doi = "10.1007/s11010-017-3155-1"
}

Stojanović, M., Šćepanović, L., Todorović, D., Mitrović, D., Šćepanović, V., Scepanović, R., Ilić, S., Šćepanović, T., Labudović-Borović, M., Milicević, Z., Dragutinović, V., Borozan, S., Lalić, I., Despotović, S.,& Đurić, D.. (2018). Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-l-cysteine. in Molecular and Cellular Biochemistry
Springer, Dordrecht., 440(1-2), 53-64.
https://doi.org/10.1007/s11010-017-3155-1

Stojanović M, Šćepanović L, Todorović D, Mitrović D, Šćepanović V, Scepanović R, Ilić S, Šćepanović T, Labudović-Borović M, Milicević Z, Dragutinović V, Borozan S, Lalić I, Despotović S, Đurić D. Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-l-cysteine. in Molecular and Cellular Biochemistry. 2018;440(1-2):53-64.
doi:10.1007/s11010-017-3155-1 .

Stojanović, Marija, Šćepanović, Ljiljana, Todorović, Dusan, Mitrović, Dušan, Šćepanović, Vuk, Scepanović, Radomir, Ilić, Slobodan, Šćepanović, Teja, Labudović-Borović, Milica, Milicević, Zivana, Dragutinović, Vesna, Borozan, Sunčica, Lalić, Ivana, Despotović, Sanja, Đurić, Dragan, "Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-l-cysteine" in Molecular and Cellular Biochemistry, 440, no. 1-2 (2018):53-64,
https://doi.org/10.1007/s11010-017-3155-1 . .

TY  - JOUR
AU  - Arsić, Aleksandra
AU  - Vucić, Vesna
AU  - Glibetić, Marija
AU  - Popović, Tamara
AU  - Debeljak-Martačić, Jasmina
AU  - Cubrilo, Dejan
AU  - Ahmetović, Zlatko
AU  - Perić, Dusan
AU  - Borozan, Sunčica
AU  - Đurić, Dragan
AU  - Barudzić, Nevena
AU  - Jakovljević, Vladimir
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1427
AB  - BACKGROUND: The aim of the present study was to analyze changes in redox balance throughout parameters of oxidative stress and activities of antioxidant enzymes in elite female water polo (N.=15) and football players (N.=19) aged between 20 and 23. Fourteen age-matched sedentary women were also included in the study. METHODS: Blood sampling was performed to measure levels of lipid peroxidation (MDA), total antioxidant status (TAS), superoxide anion radical (O2), hydrogen peroxide (H2O2), reduced glutathione (GSH), oxidized glutathione (GSSG), nitrites, superoxide dismutase activity (SOD), catalase activity (CAT) and glutathione-peroxidase activity (GPx). RESULTS: Levels of MDA, TAS, GSSG and H2O2 were significantly higher in athletes than in the control women. Football players had higher levels of O2- than the other two groups. Activity of SOD was higher in water polo players when compared with the football and control groups, CAT was increased in all athletes, while GPx did not differ among groups. CONCLUSIONS: Therefore, prolonged intensive training markedly increases oxidative stress in women, which depends on the type of sport. Lower concentration of O2- and increased activity of SOD in water polo players compared to football players suggest that mechanisms of adaptation of antioxidative defense are related to the type of exercise.
PB  - Edizioni Minerva Medica, Turin
T2  - Journal of Sports Medicine and Physical Fitness
T1  - Redox balance in elite female athletes: Differences based on sport types
VL  - 56
IS  - 1-2
SP  - 1
EP  - 8
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_1427
ER  - 

@article{
author = "Arsić, Aleksandra and Vucić, Vesna and Glibetić, Marija and Popović, Tamara and Debeljak-Martačić, Jasmina and Cubrilo, Dejan and Ahmetović, Zlatko and Perić, Dusan and Borozan, Sunčica and Đurić, Dragan and Barudzić, Nevena and Jakovljević, Vladimir",
year = "2016",
abstract = "BACKGROUND: The aim of the present study was to analyze changes in redox balance throughout parameters of oxidative stress and activities of antioxidant enzymes in elite female water polo (N.=15) and football players (N.=19) aged between 20 and 23. Fourteen age-matched sedentary women were also included in the study. METHODS: Blood sampling was performed to measure levels of lipid peroxidation (MDA), total antioxidant status (TAS), superoxide anion radical (O2), hydrogen peroxide (H2O2), reduced glutathione (GSH), oxidized glutathione (GSSG), nitrites, superoxide dismutase activity (SOD), catalase activity (CAT) and glutathione-peroxidase activity (GPx). RESULTS: Levels of MDA, TAS, GSSG and H2O2 were significantly higher in athletes than in the control women. Football players had higher levels of O2- than the other two groups. Activity of SOD was higher in water polo players when compared with the football and control groups, CAT was increased in all athletes, while GPx did not differ among groups. CONCLUSIONS: Therefore, prolonged intensive training markedly increases oxidative stress in women, which depends on the type of sport. Lower concentration of O2- and increased activity of SOD in water polo players compared to football players suggest that mechanisms of adaptation of antioxidative defense are related to the type of exercise.",
publisher = "Edizioni Minerva Medica, Turin",
journal = "Journal of Sports Medicine and Physical Fitness",
title = "Redox balance in elite female athletes: Differences based on sport types",
volume = "56",
number = "1-2",
pages = "1-8",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_1427"
}

Arsić, A., Vucić, V., Glibetić, M., Popović, T., Debeljak-Martačić, J., Cubrilo, D., Ahmetović, Z., Perić, D., Borozan, S., Đurić, D., Barudzić, N.,& Jakovljević, V.. (2016). Redox balance in elite female athletes: Differences based on sport types. in Journal of Sports Medicine and Physical Fitness
Edizioni Minerva Medica, Turin., 56(1-2), 1-8.
https://hdl.handle.net/21.15107/rcub_veterinar_1427

Arsić A, Vucić V, Glibetić M, Popović T, Debeljak-Martačić J, Cubrilo D, Ahmetović Z, Perić D, Borozan S, Đurić D, Barudzić N, Jakovljević V. Redox balance in elite female athletes: Differences based on sport types. in Journal of Sports Medicine and Physical Fitness. 2016;56(1-2):1-8.
https://hdl.handle.net/21.15107/rcub_veterinar_1427 .

Arsić, Aleksandra, Vucić, Vesna, Glibetić, Marija, Popović, Tamara, Debeljak-Martačić, Jasmina, Cubrilo, Dejan, Ahmetović, Zlatko, Perić, Dusan, Borozan, Sunčica, Đurić, Dragan, Barudzić, Nevena, Jakovljević, Vladimir, "Redox balance in elite female athletes: Differences based on sport types" in Journal of Sports Medicine and Physical Fitness, 56, no. 1-2 (2016):1-8,
https://hdl.handle.net/21.15107/rcub_veterinar_1427 .

TY  - JOUR
AU  - Kojić, Z.
AU  - Gopcević, K.
AU  - Marinković, Darko
AU  - Tasić, G.
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/766
AB  - Angiotensin converting enzyme inhibitors are widely used in therapy of cardiovascular diseases. However, the consensus on effects of these inhibitors in control of myocardial oxygen consumption during the process of experimental hypercholesterolemia and under the condition of endothelial dysfunction has not been reached. Here we examined effects of captopril, an angiotensin converting enzyme inhibitor, on serum lipid levels and oxygen consumption rate in mitochondria isolated from heart of rabbits treated by hypercholesterolemic diet. During the twelve-week period, the Chinchilla male rabbits were daily treated by saline (controls); 1 % cholesterol diet; 5 mg/kg/day captopril or 1 % cholesterol + 5 mg/kg/day captopril. Total- and high-density lipoprotein cholesterol and triglyceride in serum were measured spectrophotometricly. The left ventricle mitochondrial fraction was isolated and myocardial oxygen consumption was measured by Biological Oxygen Monitor. Mitochondria isolated from hearts of rabbits exposed to hypercholesterolemic diet showed significantly reduced respiration rates (state 3 and state 4) with altering adenosine diphosphate/oxygen ratio, whereas the respiratory control ratio was not affected when compared to controls. Mitochondria from cholesterol/captopril-treated animals showed significantly reduced respiration rates without altering adenosine diphosphate/oxygen ratio index or respiratory control ratio. Although captopril did not exert the favorable effect on serum lipid levels in cholesterol-treated animals, it restored the mitochondrial oxygen consumption. Further studies should be performed to define the underlying physiological and/or pathophysiological mechanisms and clinical implications.
PB  - Acad Sciences Czech Republic, Inst Physiology, Prague 4
T2  - Physiological Research
T1  - Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits
VL  - 60
SP  - S177
EP  - S184
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_766
ER  - 

@article{
author = "Kojić, Z. and Gopcević, K. and Marinković, Darko and Tasić, G.",
year = "2011",
abstract = "Angiotensin converting enzyme inhibitors are widely used in therapy of cardiovascular diseases. However, the consensus on effects of these inhibitors in control of myocardial oxygen consumption during the process of experimental hypercholesterolemia and under the condition of endothelial dysfunction has not been reached. Here we examined effects of captopril, an angiotensin converting enzyme inhibitor, on serum lipid levels and oxygen consumption rate in mitochondria isolated from heart of rabbits treated by hypercholesterolemic diet. During the twelve-week period, the Chinchilla male rabbits were daily treated by saline (controls); 1 % cholesterol diet; 5 mg/kg/day captopril or 1 % cholesterol + 5 mg/kg/day captopril. Total- and high-density lipoprotein cholesterol and triglyceride in serum were measured spectrophotometricly. The left ventricle mitochondrial fraction was isolated and myocardial oxygen consumption was measured by Biological Oxygen Monitor. Mitochondria isolated from hearts of rabbits exposed to hypercholesterolemic diet showed significantly reduced respiration rates (state 3 and state 4) with altering adenosine diphosphate/oxygen ratio, whereas the respiratory control ratio was not affected when compared to controls. Mitochondria from cholesterol/captopril-treated animals showed significantly reduced respiration rates without altering adenosine diphosphate/oxygen ratio index or respiratory control ratio. Although captopril did not exert the favorable effect on serum lipid levels in cholesterol-treated animals, it restored the mitochondrial oxygen consumption. Further studies should be performed to define the underlying physiological and/or pathophysiological mechanisms and clinical implications.",
publisher = "Acad Sciences Czech Republic, Inst Physiology, Prague 4",
journal = "Physiological Research",
title = "Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits",
volume = "60",
pages = "S177-S184",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_766"
}

Kojić, Z., Gopcević, K., Marinković, D.,& Tasić, G.. (2011). Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. in Physiological Research
Acad Sciences Czech Republic, Inst Physiology, Prague 4., 60, S177-S184.
https://hdl.handle.net/21.15107/rcub_veterinar_766

Kojić Z, Gopcević K, Marinković D, Tasić G. Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. in Physiological Research. 2011;60:S177-S184.
https://hdl.handle.net/21.15107/rcub_veterinar_766 .

Kojić, Z., Gopcević, K., Marinković, Darko, Tasić, G., "Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits" in Physiological Research, 60 (2011):S177-S184,
https://hdl.handle.net/21.15107/rcub_veterinar_766 .