Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs
Само за регистроване кориснике
2014
Аутори
Francuski, JelenaRadovanović, Anita
Andrić, Nenad
Krstić, Vanja
Bogdanović, Dragan
Hadzić, V.
Todorović, V.
Lazarević Macanović, Mirjana
Petit, S. Sourice
Beck-Cormier, Sarah
Guicheux, J.
Gauthier, O.
Kovačević-Filipović, Milica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aims of this study were to define age-related histological changes in the articular cartilage of the stifle joint in non-chondrodystrophic dogs and to determine whether physical activity has a positive impact on preservation of cartilage structure during ageing. Twenty-eight German shepherd dogs were included in the study. These dogs had no evidence of joint inflammation as defined by clinical assessment, radiology and synovial fluid analysis (specifically absence of synovial fluid serum amyloid A). The dogs were grouped as young working (n = 4), young non-working (n = 5), aged working (n = 13) and aged non-working (n = 6) animals. Gross changes in the stifle joints were recorded and biopsy samples of femoral and tibial articular cartilage were evaluated for thickness; chondrocyte number, density, surface area and morphology; isogenous group morphology; tidemark integrity; subchondral bone structure; presence of proteoglycans/glycosaminoglycans; and expression of type I, II and X c...ollagens. The major age-related changes, not related to type of physical activity, included elevated chondrocyte density and thinning of tibial cartilage and increased chondrocyte surface area in the superficial and intermediate zone of the femoral cartilage. There was also expression of type X collagen in the femoral and tibial calcified and non-calcified cartilage; however, type X collagen was not detected in the superficial zone of old working dogs. Therefore, ageing, with or without physical activity, leads to slight cartilage degeneration, while physical activity modulates the synthesis of type X collagen in the superficial cartilage zone, partially preserving the structure of hyaline cartilage.
Кључне речи:
ageing / cartilage / degeneration / dogИзвор:
Journal of Comparative Pathology, 2014, 151, 4, 363-374Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Антиоксидативна заштита и потенцијали за диференцијацију и регенерацију мезенхималних матичних ћелија из различитих ткива током процеса старења (RS-MESTD-Basic Research (BR or ON)-175061)
- Serbian French technological co-operation (Pavle Savic-Hubert Curien)
- COST Action MP1005 From Nano [ECOST-STSM-MP 1005-010412-013435]
- Applications to Stem Cell Regenerative Orthopedic and Dental Medicine (NAMABIO)
- ANR TecSAN 'Chondrograft'French National Research Agency (ANR)
- Fondation Arthritis Courtin 'the Road Network'
DOI: 10.1016/j.jcpa.2014.09.002
ISSN: 0021-9975
PubMed: 25443147
WoS: 000347662200010
Scopus: 2-s2.0-84923268185
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Francuski, Jelena AU - Radovanović, Anita AU - Andrić, Nenad AU - Krstić, Vanja AU - Bogdanović, Dragan AU - Hadzić, V. AU - Todorović, V. AU - Lazarević Macanović, Mirjana AU - Petit, S. Sourice AU - Beck-Cormier, Sarah AU - Guicheux, J. AU - Gauthier, O. AU - Kovačević-Filipović, Milica PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1093 AB - The aims of this study were to define age-related histological changes in the articular cartilage of the stifle joint in non-chondrodystrophic dogs and to determine whether physical activity has a positive impact on preservation of cartilage structure during ageing. Twenty-eight German shepherd dogs were included in the study. These dogs had no evidence of joint inflammation as defined by clinical assessment, radiology and synovial fluid analysis (specifically absence of synovial fluid serum amyloid A). The dogs were grouped as young working (n = 4), young non-working (n = 5), aged working (n = 13) and aged non-working (n = 6) animals. Gross changes in the stifle joints were recorded and biopsy samples of femoral and tibial articular cartilage were evaluated for thickness; chondrocyte number, density, surface area and morphology; isogenous group morphology; tidemark integrity; subchondral bone structure; presence of proteoglycans/glycosaminoglycans; and expression of type I, II and X collagens. The major age-related changes, not related to type of physical activity, included elevated chondrocyte density and thinning of tibial cartilage and increased chondrocyte surface area in the superficial and intermediate zone of the femoral cartilage. There was also expression of type X collagen in the femoral and tibial calcified and non-calcified cartilage; however, type X collagen was not detected in the superficial zone of old working dogs. Therefore, ageing, with or without physical activity, leads to slight cartilage degeneration, while physical activity modulates the synthesis of type X collagen in the superficial cartilage zone, partially preserving the structure of hyaline cartilage. PB - Elsevier Sci Ltd, Oxford T2 - Journal of Comparative Pathology T1 - Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs VL - 151 IS - 4 SP - 363 EP - 374 DO - 10.1016/j.jcpa.2014.09.002 ER -
@article{ author = "Francuski, Jelena and Radovanović, Anita and Andrić, Nenad and Krstić, Vanja and Bogdanović, Dragan and Hadzić, V. and Todorović, V. and Lazarević Macanović, Mirjana and Petit, S. Sourice and Beck-Cormier, Sarah and Guicheux, J. and Gauthier, O. and Kovačević-Filipović, Milica", year = "2014", abstract = "The aims of this study were to define age-related histological changes in the articular cartilage of the stifle joint in non-chondrodystrophic dogs and to determine whether physical activity has a positive impact on preservation of cartilage structure during ageing. Twenty-eight German shepherd dogs were included in the study. These dogs had no evidence of joint inflammation as defined by clinical assessment, radiology and synovial fluid analysis (specifically absence of synovial fluid serum amyloid A). The dogs were grouped as young working (n = 4), young non-working (n = 5), aged working (n = 13) and aged non-working (n = 6) animals. Gross changes in the stifle joints were recorded and biopsy samples of femoral and tibial articular cartilage were evaluated for thickness; chondrocyte number, density, surface area and morphology; isogenous group morphology; tidemark integrity; subchondral bone structure; presence of proteoglycans/glycosaminoglycans; and expression of type I, II and X collagens. The major age-related changes, not related to type of physical activity, included elevated chondrocyte density and thinning of tibial cartilage and increased chondrocyte surface area in the superficial and intermediate zone of the femoral cartilage. There was also expression of type X collagen in the femoral and tibial calcified and non-calcified cartilage; however, type X collagen was not detected in the superficial zone of old working dogs. Therefore, ageing, with or without physical activity, leads to slight cartilage degeneration, while physical activity modulates the synthesis of type X collagen in the superficial cartilage zone, partially preserving the structure of hyaline cartilage.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Journal of Comparative Pathology", title = "Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs", volume = "151", number = "4", pages = "363-374", doi = "10.1016/j.jcpa.2014.09.002" }
Francuski, J., Radovanović, A., Andrić, N., Krstić, V., Bogdanović, D., Hadzić, V., Todorović, V., Lazarević Macanović, M., Petit, S. S., Beck-Cormier, S., Guicheux, J., Gauthier, O.,& Kovačević-Filipović, M.. (2014). Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs. in Journal of Comparative Pathology Elsevier Sci Ltd, Oxford., 151(4), 363-374. https://doi.org/10.1016/j.jcpa.2014.09.002
Francuski J, Radovanović A, Andrić N, Krstić V, Bogdanović D, Hadzić V, Todorović V, Lazarević Macanović M, Petit SS, Beck-Cormier S, Guicheux J, Gauthier O, Kovačević-Filipović M. Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs. in Journal of Comparative Pathology. 2014;151(4):363-374. doi:10.1016/j.jcpa.2014.09.002 .
Francuski, Jelena, Radovanović, Anita, Andrić, Nenad, Krstić, Vanja, Bogdanović, Dragan, Hadzić, V., Todorović, V., Lazarević Macanović, Mirjana, Petit, S. Sourice, Beck-Cormier, Sarah, Guicheux, J., Gauthier, O., Kovačević-Filipović, Milica, "Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs" in Journal of Comparative Pathology, 151, no. 4 (2014):363-374, https://doi.org/10.1016/j.jcpa.2014.09.002 . .