Supercritical carbon dioxide hops extracts with antimicrobial properties
2015
Autori
Roj, EdwardTadić, Vanja M.
Mišić, Dušan
Žižović, Irena
Arsić, Ivana
Dobrzynska-Inger, Agnieszka
Kostrzewa, Dorota
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Extracts obtained from hops (Humulus lupulus L., Cannabaceae) by supercritical fluid extraction (SFE), SFE followed by isomerization, as well as by conventional technique, were investigated for their chemical composition and antibacterial activity against selected foodborne pathogens and microorganisms capable to cause the food spoilage. The antibacterial activity of the extracts was compared with the antibacterial activity of xanthohumol, compound known for its broad pharmacological properties, isolated from the raw material remained after the SFE. Xanthohumol (XH, 96%) proved to posses the most prominent activity against all the tested strains, with the MIC values ranged between 2.5 and 20 mu g mL(-1). Supercritical hops extract and potassium isomerized supercritical hops extract showed strong antibacterial activity against the tested strains as well. Escherichia coli was not affected by the extracts, meaning that their oral admission would not cause the same problem as antibiotic ap...plication in intestinal flora. The chemical composition of the investigated hops extracts was analysed by GC-MS. Contents of a-acids, beta-acids, iso-alpha-acids and xanthohumol in the samples were determined by HPLC.
Ključne reči:
supercritical hops extract / isomerized hops extract / supercritical CO2 extraction / xanthohumol / antibacterial activityIzvor:
Open Chemistry, 2015, 13, 1, 1157-1171Izdavač:
- De Gruyter Open Ltd, Warsaw
Finansiranje / projekti:
- grant "Development of the new generation and ecological and safe in use cosmetics and products of the household chemistry based on the plant supercritical extracts" [PBS1/A5/18/2012]
- Funkcionalni fiziološki aktivni biljni materijali sa dodatom vrednošću za primenu u farmaceutskoj i prehrambenoj industriji (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45017)
DOI: 10.1515/chem-2015-0131
ISSN: 2391-5420
WoS: 000378431600022
Scopus: 2-s2.0-84982698715
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Roj, Edward AU - Tadić, Vanja M. AU - Mišić, Dušan AU - Žižović, Irena AU - Arsić, Ivana AU - Dobrzynska-Inger, Agnieszka AU - Kostrzewa, Dorota PY - 2015 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1230 AB - Extracts obtained from hops (Humulus lupulus L., Cannabaceae) by supercritical fluid extraction (SFE), SFE followed by isomerization, as well as by conventional technique, were investigated for their chemical composition and antibacterial activity against selected foodborne pathogens and microorganisms capable to cause the food spoilage. The antibacterial activity of the extracts was compared with the antibacterial activity of xanthohumol, compound known for its broad pharmacological properties, isolated from the raw material remained after the SFE. Xanthohumol (XH, 96%) proved to posses the most prominent activity against all the tested strains, with the MIC values ranged between 2.5 and 20 mu g mL(-1). Supercritical hops extract and potassium isomerized supercritical hops extract showed strong antibacterial activity against the tested strains as well. Escherichia coli was not affected by the extracts, meaning that their oral admission would not cause the same problem as antibiotic application in intestinal flora. The chemical composition of the investigated hops extracts was analysed by GC-MS. Contents of a-acids, beta-acids, iso-alpha-acids and xanthohumol in the samples were determined by HPLC. PB - De Gruyter Open Ltd, Warsaw T2 - Open Chemistry T1 - Supercritical carbon dioxide hops extracts with antimicrobial properties VL - 13 IS - 1 SP - 1157 EP - 1171 DO - 10.1515/chem-2015-0131 ER -
@article{ author = "Roj, Edward and Tadić, Vanja M. and Mišić, Dušan and Žižović, Irena and Arsić, Ivana and Dobrzynska-Inger, Agnieszka and Kostrzewa, Dorota", year = "2015", abstract = "Extracts obtained from hops (Humulus lupulus L., Cannabaceae) by supercritical fluid extraction (SFE), SFE followed by isomerization, as well as by conventional technique, were investigated for their chemical composition and antibacterial activity against selected foodborne pathogens and microorganisms capable to cause the food spoilage. The antibacterial activity of the extracts was compared with the antibacterial activity of xanthohumol, compound known for its broad pharmacological properties, isolated from the raw material remained after the SFE. Xanthohumol (XH, 96%) proved to posses the most prominent activity against all the tested strains, with the MIC values ranged between 2.5 and 20 mu g mL(-1). Supercritical hops extract and potassium isomerized supercritical hops extract showed strong antibacterial activity against the tested strains as well. Escherichia coli was not affected by the extracts, meaning that their oral admission would not cause the same problem as antibiotic application in intestinal flora. The chemical composition of the investigated hops extracts was analysed by GC-MS. Contents of a-acids, beta-acids, iso-alpha-acids and xanthohumol in the samples were determined by HPLC.", publisher = "De Gruyter Open Ltd, Warsaw", journal = "Open Chemistry", title = "Supercritical carbon dioxide hops extracts with antimicrobial properties", volume = "13", number = "1", pages = "1157-1171", doi = "10.1515/chem-2015-0131" }
Roj, E., Tadić, V. M., Mišić, D., Žižović, I., Arsić, I., Dobrzynska-Inger, A.,& Kostrzewa, D.. (2015). Supercritical carbon dioxide hops extracts with antimicrobial properties. in Open Chemistry De Gruyter Open Ltd, Warsaw., 13(1), 1157-1171. https://doi.org/10.1515/chem-2015-0131
Roj E, Tadić VM, Mišić D, Žižović I, Arsić I, Dobrzynska-Inger A, Kostrzewa D. Supercritical carbon dioxide hops extracts with antimicrobial properties. in Open Chemistry. 2015;13(1):1157-1171. doi:10.1515/chem-2015-0131 .
Roj, Edward, Tadić, Vanja M., Mišić, Dušan, Žižović, Irena, Arsić, Ivana, Dobrzynska-Inger, Agnieszka, Kostrzewa, Dorota, "Supercritical carbon dioxide hops extracts with antimicrobial properties" in Open Chemistry, 13, no. 1 (2015):1157-1171, https://doi.org/10.1515/chem-2015-0131 . .