DNA-binding and DNA-protecting activities of small natural organic molecules and food extracts
Abstract
The review summarizes literature data on the DNA-binding, DNA-protecting and DNA-damaging activities of a range of natural human endogenous and exogenous compounds. Small natural organic molecules bind DNA in a site-specific mode, by arranging tight touch with the structure of the major and minor grooves, as well as individual bases in the local duplex DNA. Polyphenols are the best-studied exogenous compounds from this point of view. Many of them demonstrate hormetic effects, producing both beneficial and damaging effects. An attempt to establish the dependence of DNA damage or DNA protection on the concentration of the compound turned out to be successful for some polyphenols, daidzein, genistein and resveratrol, which were DNA protecting in low concentrations and DNA damaging in high concentrations. There was no evident dependence on concentration for quercetin and kaempferol. Probably, the DNA-protecting effect is associated with the affinity to DNA. Caffeine and theophylline are DN...A binders; at the same time, they favor DNA repair. Although most alkaloids damage DNA, berberine can protect DNA against damage. Among the endogenous compounds, hormones belonging to the amine class, thyroid and steroid hormones appear to bind DNA and produce some DNA damage. Thus, natural compounds continue to reveal beneficial or adverse effects on genome integrity and provide a promising source of therapeutic activities.
Source:
Chemico-Biological Interactions, 2020, 323, 109030-Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
- hCOMET COST actionEuropean Cooperation in Science and Technology (COST) [15132]
DOI: 10.1016/j.cbi.2020.109030
ISSN: 0009-2797
PubMed: 32205154
WoS: 000526113900006
Scopus: 2-s2.0-85082523612
Collections
Institution/Community
Fakultet veterinarske medicineTY - JOUR AU - Sjakste, Nikolajs AU - Đelić, Ninoslav AU - Dzintare, Maija AU - Živković, Lada PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1817 AB - The review summarizes literature data on the DNA-binding, DNA-protecting and DNA-damaging activities of a range of natural human endogenous and exogenous compounds. Small natural organic molecules bind DNA in a site-specific mode, by arranging tight touch with the structure of the major and minor grooves, as well as individual bases in the local duplex DNA. Polyphenols are the best-studied exogenous compounds from this point of view. Many of them demonstrate hormetic effects, producing both beneficial and damaging effects. An attempt to establish the dependence of DNA damage or DNA protection on the concentration of the compound turned out to be successful for some polyphenols, daidzein, genistein and resveratrol, which were DNA protecting in low concentrations and DNA damaging in high concentrations. There was no evident dependence on concentration for quercetin and kaempferol. Probably, the DNA-protecting effect is associated with the affinity to DNA. Caffeine and theophylline are DNA binders; at the same time, they favor DNA repair. Although most alkaloids damage DNA, berberine can protect DNA against damage. Among the endogenous compounds, hormones belonging to the amine class, thyroid and steroid hormones appear to bind DNA and produce some DNA damage. Thus, natural compounds continue to reveal beneficial or adverse effects on genome integrity and provide a promising source of therapeutic activities. PB - Elsevier Ireland Ltd, Clare T2 - Chemico-Biological Interactions T1 - DNA-binding and DNA-protecting activities of small natural organic molecules and food extracts VL - 323 SP - 109030 DO - 10.1016/j.cbi.2020.109030 ER -
@article{ author = "Sjakste, Nikolajs and Đelić, Ninoslav and Dzintare, Maija and Živković, Lada", year = "2020", abstract = "The review summarizes literature data on the DNA-binding, DNA-protecting and DNA-damaging activities of a range of natural human endogenous and exogenous compounds. Small natural organic molecules bind DNA in a site-specific mode, by arranging tight touch with the structure of the major and minor grooves, as well as individual bases in the local duplex DNA. Polyphenols are the best-studied exogenous compounds from this point of view. Many of them demonstrate hormetic effects, producing both beneficial and damaging effects. An attempt to establish the dependence of DNA damage or DNA protection on the concentration of the compound turned out to be successful for some polyphenols, daidzein, genistein and resveratrol, which were DNA protecting in low concentrations and DNA damaging in high concentrations. There was no evident dependence on concentration for quercetin and kaempferol. Probably, the DNA-protecting effect is associated with the affinity to DNA. Caffeine and theophylline are DNA binders; at the same time, they favor DNA repair. Although most alkaloids damage DNA, berberine can protect DNA against damage. Among the endogenous compounds, hormones belonging to the amine class, thyroid and steroid hormones appear to bind DNA and produce some DNA damage. Thus, natural compounds continue to reveal beneficial or adverse effects on genome integrity and provide a promising source of therapeutic activities.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Chemico-Biological Interactions", title = "DNA-binding and DNA-protecting activities of small natural organic molecules and food extracts", volume = "323", pages = "109030", doi = "10.1016/j.cbi.2020.109030" }
Sjakste, N., Đelić, N., Dzintare, M.,& Živković, L.. (2020). DNA-binding and DNA-protecting activities of small natural organic molecules and food extracts. in Chemico-Biological Interactions Elsevier Ireland Ltd, Clare., 323, 109030. https://doi.org/10.1016/j.cbi.2020.109030
Sjakste N, Đelić N, Dzintare M, Živković L. DNA-binding and DNA-protecting activities of small natural organic molecules and food extracts. in Chemico-Biological Interactions. 2020;323:109030. doi:10.1016/j.cbi.2020.109030 .
Sjakste, Nikolajs, Đelić, Ninoslav, Dzintare, Maija, Živković, Lada, "DNA-binding and DNA-protecting activities of small natural organic molecules and food extracts" in Chemico-Biological Interactions, 323 (2020):109030, https://doi.org/10.1016/j.cbi.2020.109030 . .