Effects of cymiazole hydrochloride on sister-chromatid exchanges, mitotic and proliferation indices in cultured human lymphocytes
Delovanje cimiazol hidrohlorida na razmenu sestrinskih hromatida, mitotski i proliferativni indeks u kulturama humanih limfocita
Abstract
Cymiazole hydrochloride is the active component of the acaricides and Apichem which are used as varroacide in beekeeping. Since residues of cymiazole hydrochloride were detected in all bee products being used for human nutrition and as alternative medications in human and veterinary medicine the aim of this study was to evaluate the capability of this substance to produce genotoxic effects in peripheral human blood lymphocytes and its possible influence on mitotic activity and cell cycle kinetics. The genotoxic effects were studied by in vitro SCE-test. The results that were obtained for all doses applied in cultures (0.01 mg/ml, 0.1 mg/ml and 1 mg/ml) showed the very significant increases in frequencies of SCEs (p lt 0.001) in comparison to negative controls; i.e. the cymiazole hydrochloricde exhibited genotoxic properties. All experimental concentrations of cymiazole hydrochloride caused statistically highly significant (p lt 0.001) increased mitotic index values (Ml) and proliferati...on index (PI), too. Thus, the obtained data indicate significant cytomodulatoring effects and genotoxic properties.
Cimiazol hidrohlorid je aktivna komponenta akaricida Apitol-a i Apihem-a koji se koriste kao varoacidi u pčelarstvu. Imajući u vidu da su rezidue cimiazol hidrohlorida ustanovljene u svim pčelinjim proizvodima koji su u upotrebi u ljudskoj ishrani, kao i u humanoj i veterinarskoj medicini - kao alternativni medikamenti, cilj ovog proučavanja je bio da se proceni sposobnost ove supstancije da izazove genotoksične efekte u kulturama limfocita periferne krvi čoveka i njen mogući uticaj na mitotsku aktivnost i kinetiku ćelijskog ciklusa. Genotoksični efekti su proučavani primenom SCE-testa in vitro. Rezultati su pokazali statistički vrlo značajno povećanje SCE-a (p lt 0,001) u poređenju sa negativnom kontrolom; tj. cimiazol hidrohlorid je ispoljio genotoksična svojstva. Sve eksperimentalne koncentracije cimiazol hidrohlorida su statistički značajno (p lt 0,001) povisile vrednosti mitotskog indeksa (Ml) i indeksa proliferacije (Pl), takođe. Tako, dobijeni rezultati ukazuju na značajne citom...odulirajuće efekte i genotoksična svojstva.
Keywords:
cymiazole hydrochloride / acaricides / beekeeping / genotoxicity / SCE-test / mitotic index / proliferation index / cimiazol hidrohlorid / akaricidi / pčelarstvo / genotoksičnost / SCE-test / mitotski indeks / indeks proliferacijeSource:
Veterinarski Glasnik, 2003, 57, 7-8, 385-392Publisher:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
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Fakultet veterinarske medicineTY - JOUR AU - Stanimirović, Zoran AU - Fišter, Svetlana L. AU - Ćirković, Dragan PY - 2003 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/251 AB - Cymiazole hydrochloride is the active component of the acaricides and Apichem which are used as varroacide in beekeeping. Since residues of cymiazole hydrochloride were detected in all bee products being used for human nutrition and as alternative medications in human and veterinary medicine the aim of this study was to evaluate the capability of this substance to produce genotoxic effects in peripheral human blood lymphocytes and its possible influence on mitotic activity and cell cycle kinetics. The genotoxic effects were studied by in vitro SCE-test. The results that were obtained for all doses applied in cultures (0.01 mg/ml, 0.1 mg/ml and 1 mg/ml) showed the very significant increases in frequencies of SCEs (p lt 0.001) in comparison to negative controls; i.e. the cymiazole hydrochloricde exhibited genotoxic properties. All experimental concentrations of cymiazole hydrochloride caused statistically highly significant (p lt 0.001) increased mitotic index values (Ml) and proliferation index (PI), too. Thus, the obtained data indicate significant cytomodulatoring effects and genotoxic properties. AB - Cimiazol hidrohlorid je aktivna komponenta akaricida Apitol-a i Apihem-a koji se koriste kao varoacidi u pčelarstvu. Imajući u vidu da su rezidue cimiazol hidrohlorida ustanovljene u svim pčelinjim proizvodima koji su u upotrebi u ljudskoj ishrani, kao i u humanoj i veterinarskoj medicini - kao alternativni medikamenti, cilj ovog proučavanja je bio da se proceni sposobnost ove supstancije da izazove genotoksične efekte u kulturama limfocita periferne krvi čoveka i njen mogući uticaj na mitotsku aktivnost i kinetiku ćelijskog ciklusa. Genotoksični efekti su proučavani primenom SCE-testa in vitro. Rezultati su pokazali statistički vrlo značajno povećanje SCE-a (p lt 0,001) u poređenju sa negativnom kontrolom; tj. cimiazol hidrohlorid je ispoljio genotoksična svojstva. Sve eksperimentalne koncentracije cimiazol hidrohlorida su statistički značajno (p lt 0,001) povisile vrednosti mitotskog indeksa (Ml) i indeksa proliferacije (Pl), takođe. Tako, dobijeni rezultati ukazuju na značajne citomodulirajuće efekte i genotoksična svojstva. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Veterinarski Glasnik T1 - Effects of cymiazole hydrochloride on sister-chromatid exchanges, mitotic and proliferation indices in cultured human lymphocytes T1 - Delovanje cimiazol hidrohlorida na razmenu sestrinskih hromatida, mitotski i proliferativni indeks u kulturama humanih limfocita VL - 57 IS - 7-8 SP - 385 EP - 392 UR - https://hdl.handle.net/21.15107/rcub_veterinar_251 ER -
@article{ author = "Stanimirović, Zoran and Fišter, Svetlana L. and Ćirković, Dragan", year = "2003", abstract = "Cymiazole hydrochloride is the active component of the acaricides and Apichem which are used as varroacide in beekeeping. Since residues of cymiazole hydrochloride were detected in all bee products being used for human nutrition and as alternative medications in human and veterinary medicine the aim of this study was to evaluate the capability of this substance to produce genotoxic effects in peripheral human blood lymphocytes and its possible influence on mitotic activity and cell cycle kinetics. The genotoxic effects were studied by in vitro SCE-test. The results that were obtained for all doses applied in cultures (0.01 mg/ml, 0.1 mg/ml and 1 mg/ml) showed the very significant increases in frequencies of SCEs (p lt 0.001) in comparison to negative controls; i.e. the cymiazole hydrochloricde exhibited genotoxic properties. All experimental concentrations of cymiazole hydrochloride caused statistically highly significant (p lt 0.001) increased mitotic index values (Ml) and proliferation index (PI), too. Thus, the obtained data indicate significant cytomodulatoring effects and genotoxic properties., Cimiazol hidrohlorid je aktivna komponenta akaricida Apitol-a i Apihem-a koji se koriste kao varoacidi u pčelarstvu. Imajući u vidu da su rezidue cimiazol hidrohlorida ustanovljene u svim pčelinjim proizvodima koji su u upotrebi u ljudskoj ishrani, kao i u humanoj i veterinarskoj medicini - kao alternativni medikamenti, cilj ovog proučavanja je bio da se proceni sposobnost ove supstancije da izazove genotoksične efekte u kulturama limfocita periferne krvi čoveka i njen mogući uticaj na mitotsku aktivnost i kinetiku ćelijskog ciklusa. Genotoksični efekti su proučavani primenom SCE-testa in vitro. Rezultati su pokazali statistički vrlo značajno povećanje SCE-a (p lt 0,001) u poređenju sa negativnom kontrolom; tj. cimiazol hidrohlorid je ispoljio genotoksična svojstva. Sve eksperimentalne koncentracije cimiazol hidrohlorida su statistički značajno (p lt 0,001) povisile vrednosti mitotskog indeksa (Ml) i indeksa proliferacije (Pl), takođe. Tako, dobijeni rezultati ukazuju na značajne citomodulirajuće efekte i genotoksična svojstva.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Veterinarski Glasnik", title = "Effects of cymiazole hydrochloride on sister-chromatid exchanges, mitotic and proliferation indices in cultured human lymphocytes, Delovanje cimiazol hidrohlorida na razmenu sestrinskih hromatida, mitotski i proliferativni indeks u kulturama humanih limfocita", volume = "57", number = "7-8", pages = "385-392", url = "https://hdl.handle.net/21.15107/rcub_veterinar_251" }
Stanimirović, Z., Fišter, S. L.,& Ćirković, D.. (2003). Effects of cymiazole hydrochloride on sister-chromatid exchanges, mitotic and proliferation indices in cultured human lymphocytes. in Veterinarski Glasnik Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 57(7-8), 385-392. https://hdl.handle.net/21.15107/rcub_veterinar_251
Stanimirović Z, Fišter SL, Ćirković D. Effects of cymiazole hydrochloride on sister-chromatid exchanges, mitotic and proliferation indices in cultured human lymphocytes. in Veterinarski Glasnik. 2003;57(7-8):385-392. https://hdl.handle.net/21.15107/rcub_veterinar_251 .
Stanimirović, Zoran, Fišter, Svetlana L., Ćirković, Dragan, "Effects of cymiazole hydrochloride on sister-chromatid exchanges, mitotic and proliferation indices in cultured human lymphocytes" in Veterinarski Glasnik, 57, no. 7-8 (2003):385-392, https://hdl.handle.net/21.15107/rcub_veterinar_251 .