Thyroid gland function in the belgrade laboratory (b/b) rat
Apstrakt
The Belgrade laboratory (b/b) rat has a unique hereditary defect in iron metabolism, that induces profound anemia and hypoxia. Serum thyroid hormone levels in anemic b/b rats and non-anemic controls (+/+) were investigated using radio-immunoassay (RIA). Hematologic parameters and erythropoietin (Epo) concentrations were also determined in the anemic b/b and control rats. Our results confirmed the existence of severe anemia and extremely high Epo concentrations in the anemic b/b rats. The results for serum thyroid hormone concentrations imply the existence of thyroid gland hypofunction in the b/b rats. These preliminary results points to the b/b rat anemic syndrome as a unique model, which is not only interesting for the hematologist, but also for the endocrinologist.
Ključne reči:
thyroid hormones / anemia / hypoxia / Belgrade laboratory (b/b) ratIzvor:
Acta Veterinaria-Beograd, 1997, 47, 5-6, 277-282Izdavač:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Gvozdić, Dragan AU - Bozić, T AU - Ivanović, Z AU - Stevanović, J AU - Jelkmann, W PY - 1997 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/78 AB - The Belgrade laboratory (b/b) rat has a unique hereditary defect in iron metabolism, that induces profound anemia and hypoxia. Serum thyroid hormone levels in anemic b/b rats and non-anemic controls (+/+) were investigated using radio-immunoassay (RIA). Hematologic parameters and erythropoietin (Epo) concentrations were also determined in the anemic b/b and control rats. Our results confirmed the existence of severe anemia and extremely high Epo concentrations in the anemic b/b rats. The results for serum thyroid hormone concentrations imply the existence of thyroid gland hypofunction in the b/b rats. These preliminary results points to the b/b rat anemic syndrome as a unique model, which is not only interesting for the hematologist, but also for the endocrinologist. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Thyroid gland function in the belgrade laboratory (b/b) rat VL - 47 IS - 5-6 SP - 277 EP - 282 UR - https://hdl.handle.net/21.15107/rcub_veterinar_78 ER -
@article{ author = "Gvozdić, Dragan and Bozić, T and Ivanović, Z and Stevanović, J and Jelkmann, W", year = "1997", abstract = "The Belgrade laboratory (b/b) rat has a unique hereditary defect in iron metabolism, that induces profound anemia and hypoxia. Serum thyroid hormone levels in anemic b/b rats and non-anemic controls (+/+) were investigated using radio-immunoassay (RIA). Hematologic parameters and erythropoietin (Epo) concentrations were also determined in the anemic b/b and control rats. Our results confirmed the existence of severe anemia and extremely high Epo concentrations in the anemic b/b rats. The results for serum thyroid hormone concentrations imply the existence of thyroid gland hypofunction in the b/b rats. These preliminary results points to the b/b rat anemic syndrome as a unique model, which is not only interesting for the hematologist, but also for the endocrinologist.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Thyroid gland function in the belgrade laboratory (b/b) rat", volume = "47", number = "5-6", pages = "277-282", url = "https://hdl.handle.net/21.15107/rcub_veterinar_78" }
Gvozdić, D., Bozić, T., Ivanović, Z., Stevanović, J.,& Jelkmann, W.. (1997). Thyroid gland function in the belgrade laboratory (b/b) rat. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 47(5-6), 277-282. https://hdl.handle.net/21.15107/rcub_veterinar_78
Gvozdić D, Bozić T, Ivanović Z, Stevanović J, Jelkmann W. Thyroid gland function in the belgrade laboratory (b/b) rat. in Acta Veterinaria-Beograd. 1997;47(5-6):277-282. https://hdl.handle.net/21.15107/rcub_veterinar_78 .
Gvozdić, Dragan, Bozić, T, Ivanović, Z, Stevanović, J, Jelkmann, W, "Thyroid gland function in the belgrade laboratory (b/b) rat" in Acta Veterinaria-Beograd, 47, no. 5-6 (1997):277-282, https://hdl.handle.net/21.15107/rcub_veterinar_78 .