Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs
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2012
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Studies of clinical uses of brain natriuretic peptide (BNP) represent one of the most important advances in cardiology since the introduction of echocardiography as a clinical diagnostic procedure. Defining the clinical potential of BNP in canine cardiology has not been completed yet. The aim of this study is to measure BNP concentrations in healthy German Shepherd dogs of different ages as a baseline in resting and when conventional protocol of the dobutamine stress test (DST) is applied to dogs. Concentrations of BNP were measured in blood serum by the radioimmunoassay method. The values of BNP concentrations were compared to cardiac parameters obtained by standard cardiac diagnostic procedures (radiology, electrocardiography and echocardiography). No significant differences in serum BNP concentrations existed in dogs of different ages. A statistically significant increase in BNP concentrations was registered after DST. These changes in BNP concentrations were related to ST/T electro...cardiographic changes, and correlated to changes in the left ventricular internal diameter in systole (LVESD). These data suggest that BNP is not increased in aged dogs with normal cardiac systolic function and renal function, and that myocardial ischemia leads to a significant increase in BNP concentrations even in dogs with normal left ventricular function.
Ključne reči:
BNP / German Shepherd dogs / DST / IschemiaIzvor:
Research in Veterinary Science, 2012, 93, 3, 1446-1453Izdavač:
- Elsevier Sci Ltd, Oxford
DOI: 10.1016/j.rvsc.2012.04.002
ISSN: 0034-5288
PubMed: 22537461
WoS: 000311185900061
Scopus: 2-s2.0-84866862167
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Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Kosić-Spasojević, Ljubica AU - Trailović, Dragiša AU - Matunović, Radomir PY - 2012 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/932 AB - Studies of clinical uses of brain natriuretic peptide (BNP) represent one of the most important advances in cardiology since the introduction of echocardiography as a clinical diagnostic procedure. Defining the clinical potential of BNP in canine cardiology has not been completed yet. The aim of this study is to measure BNP concentrations in healthy German Shepherd dogs of different ages as a baseline in resting and when conventional protocol of the dobutamine stress test (DST) is applied to dogs. Concentrations of BNP were measured in blood serum by the radioimmunoassay method. The values of BNP concentrations were compared to cardiac parameters obtained by standard cardiac diagnostic procedures (radiology, electrocardiography and echocardiography). No significant differences in serum BNP concentrations existed in dogs of different ages. A statistically significant increase in BNP concentrations was registered after DST. These changes in BNP concentrations were related to ST/T electrocardiographic changes, and correlated to changes in the left ventricular internal diameter in systole (LVESD). These data suggest that BNP is not increased in aged dogs with normal cardiac systolic function and renal function, and that myocardial ischemia leads to a significant increase in BNP concentrations even in dogs with normal left ventricular function. PB - Elsevier Sci Ltd, Oxford T2 - Research in Veterinary Science T1 - Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs VL - 93 IS - 3 SP - 1446 EP - 1453 DO - 10.1016/j.rvsc.2012.04.002 ER -
@article{ author = "Kosić-Spasojević, Ljubica and Trailović, Dragiša and Matunović, Radomir", year = "2012", abstract = "Studies of clinical uses of brain natriuretic peptide (BNP) represent one of the most important advances in cardiology since the introduction of echocardiography as a clinical diagnostic procedure. Defining the clinical potential of BNP in canine cardiology has not been completed yet. The aim of this study is to measure BNP concentrations in healthy German Shepherd dogs of different ages as a baseline in resting and when conventional protocol of the dobutamine stress test (DST) is applied to dogs. Concentrations of BNP were measured in blood serum by the radioimmunoassay method. The values of BNP concentrations were compared to cardiac parameters obtained by standard cardiac diagnostic procedures (radiology, electrocardiography and echocardiography). No significant differences in serum BNP concentrations existed in dogs of different ages. A statistically significant increase in BNP concentrations was registered after DST. These changes in BNP concentrations were related to ST/T electrocardiographic changes, and correlated to changes in the left ventricular internal diameter in systole (LVESD). These data suggest that BNP is not increased in aged dogs with normal cardiac systolic function and renal function, and that myocardial ischemia leads to a significant increase in BNP concentrations even in dogs with normal left ventricular function.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Research in Veterinary Science", title = "Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs", volume = "93", number = "3", pages = "1446-1453", doi = "10.1016/j.rvsc.2012.04.002" }
Kosić-Spasojević, L., Trailović, D.,& Matunović, R.. (2012). Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs. in Research in Veterinary Science Elsevier Sci Ltd, Oxford., 93(3), 1446-1453. https://doi.org/10.1016/j.rvsc.2012.04.002
Kosić-Spasojević L, Trailović D, Matunović R. Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs. in Research in Veterinary Science. 2012;93(3):1446-1453. doi:10.1016/j.rvsc.2012.04.002 .
Kosić-Spasojević, Ljubica, Trailović, Dragiša, Matunović, Radomir, "Resting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogs" in Research in Veterinary Science, 93, no. 3 (2012):1446-1453, https://doi.org/10.1016/j.rvsc.2012.04.002 . .