TY  - JOUR
AU  - Janković, Dušan
AU  - Norrman, Johanna
AU  - Aronsson, Mia
AU  - Vojvodić, Danilo
AU  - Mirilović, Milorad
AU  - Vejnović, Branislav
AU  - Stanišić, Ljubodrag
AU  - Nedić, Svetlana
AU  - Maletić, Milan
AU  - Đurić, Miloje
AU  - Magaš, Vladimir
AU  - Vakanjac, Slobodanka
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2517
AB  - The work was aimed to research into the vital signs, haematological and biochemical parameters, acute-phase protein concentrations (CRP, albumin), progesterone (PG) and anti-Müllerian hormone (AMH) concentrations in bitches with pyometra and their comparison with those in healthy bitches. In addition, the goal of this work was to assess if some of the tested parameters may be used as a biomarker in the diagnostics of pyometra and the monitoring of the postoperative recovery. Forty 3-6-year-old bitches of various breeds were included in the research and allotted to two groups: the control (C, n = 20) and the diseased – bitches diagnosed with pyometra (P, n = 20). Blood samples for the analyses were taken immediately before surgery (0 h), and 12 h, 24 h, 48 h and 72 h after, excepting for AMH and PG concentrations, which were determined only at 0 h. Clinical examination detected significantly higher respiration rates in bitches with pyometra in comparison to healthy ones at all time points, higher heart rates before and 12 h after surgery, and higher body temperature before and 12 h, 48 h and 72 h post operation (p <.01). Significantly higher concentrations of CRP (p <.01) and lower concentrations of albumin were detected in bitches with pyometra in comparison to their healthy counterparts at all time points. Progesterone and AMH concentration analysis immediately before surgery detected significantly higher levels of the hormone in bitches with pyometra than in the control (p <.01). The inflammatory reaction of the endometrium resulted in a significant AMH concentration increase, whilst increased CRP concentrations and lower albumin concentrations throughout the research may be used as biomarkers of proinflammatory activities, that is of the acute-phase response.
PB  - John Wiley & Sons, Ltd
T2  - Reproduction in Domestic Animals
T1  - Analysis of the concentrations of some haematological parameters, C-reactive protein and anti-Müllerian hormone in bitches affected by pyometra
VL  - 57
IS  - 10
SP  - 1156
EP  - 1164
DO  - 10.1111/rda.14186
ER  - 

@article{
author = "Janković, Dušan and Norrman, Johanna and Aronsson, Mia and Vojvodić, Danilo and Mirilović, Milorad and Vejnović, Branislav and Stanišić, Ljubodrag and Nedić, Svetlana and Maletić, Milan and Đurić, Miloje and Magaš, Vladimir and Vakanjac, Slobodanka",
year = "2022",
abstract = "The work was aimed to research into the vital signs, haematological and biochemical parameters, acute-phase protein concentrations (CRP, albumin), progesterone (PG) and anti-Müllerian hormone (AMH) concentrations in bitches with pyometra and their comparison with those in healthy bitches. In addition, the goal of this work was to assess if some of the tested parameters may be used as a biomarker in the diagnostics of pyometra and the monitoring of the postoperative recovery. Forty 3-6-year-old bitches of various breeds were included in the research and allotted to two groups: the control (C, n = 20) and the diseased – bitches diagnosed with pyometra (P, n = 20). Blood samples for the analyses were taken immediately before surgery (0 h), and 12 h, 24 h, 48 h and 72 h after, excepting for AMH and PG concentrations, which were determined only at 0 h. Clinical examination detected significantly higher respiration rates in bitches with pyometra in comparison to healthy ones at all time points, higher heart rates before and 12 h after surgery, and higher body temperature before and 12 h, 48 h and 72 h post operation (p <.01). Significantly higher concentrations of CRP (p <.01) and lower concentrations of albumin were detected in bitches with pyometra in comparison to their healthy counterparts at all time points. Progesterone and AMH concentration analysis immediately before surgery detected significantly higher levels of the hormone in bitches with pyometra than in the control (p <.01). The inflammatory reaction of the endometrium resulted in a significant AMH concentration increase, whilst increased CRP concentrations and lower albumin concentrations throughout the research may be used as biomarkers of proinflammatory activities, that is of the acute-phase response.",
publisher = "John Wiley & Sons, Ltd",
journal = "Reproduction in Domestic Animals",
title = "Analysis of the concentrations of some haematological parameters, C-reactive protein and anti-Müllerian hormone in bitches affected by pyometra",
volume = "57",
number = "10",
pages = "1156-1164",
doi = "10.1111/rda.14186"
}

Janković, D., Norrman, J., Aronsson, M., Vojvodić, D., Mirilović, M., Vejnović, B., Stanišić, L., Nedić, S., Maletić, M., Đurić, M., Magaš, V.,& Vakanjac, S.. (2022). Analysis of the concentrations of some haematological parameters, C-reactive protein and anti-Müllerian hormone in bitches affected by pyometra. in Reproduction in Domestic Animals
John Wiley & Sons, Ltd., 57(10), 1156-1164.
https://doi.org/10.1111/rda.14186

Janković D, Norrman J, Aronsson M, Vojvodić D, Mirilović M, Vejnović B, Stanišić L, Nedić S, Maletić M, Đurić M, Magaš V, Vakanjac S. Analysis of the concentrations of some haematological parameters, C-reactive protein and anti-Müllerian hormone in bitches affected by pyometra. in Reproduction in Domestic Animals. 2022;57(10):1156-1164.
doi:10.1111/rda.14186 .

Janković, Dušan, Norrman, Johanna, Aronsson, Mia, Vojvodić, Danilo, Mirilović, Milorad, Vejnović, Branislav, Stanišić, Ljubodrag, Nedić, Svetlana, Maletić, Milan, Đurić, Miloje, Magaš, Vladimir, Vakanjac, Slobodanka, "Analysis of the concentrations of some haematological parameters, C-reactive protein and anti-Müllerian hormone in bitches affected by pyometra" in Reproduction in Domestic Animals, 57, no. 10 (2022):1156-1164,
https://doi.org/10.1111/rda.14186 . .

TY  - JOUR
AU  - Vuković, Jelena
AU  - Karličić, Vukojica
AU  - Ristić, Saša
AU  - Stanojević, Ivan
AU  - Nikolić, Nevena
AU  - Štefik, Debra
AU  - Jović, Milena
AU  - Abazović, Džihan
AU  - Šupić, Gordana
AU  - Vojvodić, Danilo
AU  - Pavlović, Miloš
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2125
AB  - Background/Aim. Myeloid-derived suppressor cells (MDSCs) suppress immune responses via a series of inhibitory mechanisms, which ultimately could lead to tumor growth. B7-H4 expression is significantly associated with poor outcome and promotion of tumor cell proliferation, invasion and migration in patients with various cancers. Data concerning B7-H4 expression in lung cancers (LC), either on tumor or immunological cells, are still sporadic. The aim was to estimate and correlate the number of CD14+B7-H4+MDSCs in blood and lung tumor microcirculation with clinical stage, histology type of tumor, tumor node metastasis (TNM) stadium, nodal status and disease outspread. Methods. The study included 44 lung cancer patients (III and IV clinical stage) and 30 healthy controls. CD14+B7-H4+ MDSC number was estimated by flow cytometry in blood and tumor microcirculation samples of each patient. Results. CD14+B7-H4+ MDSCs number was significantly higher in patients’ samples compared to controls. CD14+B7-H4+ MDSC number was significantly increased in tumor compared to blood sample of the same patient. Clinical stage III patients had the increased number of the CD14+B7-H4+ MDSC compared to stage IV, in both types of samples. According to histology, small cell lung cancer (SCLC) patients had the highest average CD14+B7-H4+ MDSCs number, significantly increased compared to patients with squamous and large cell LC histology type. Tumor size was directly associated with the number of the CD14+B7-H4+ MDSC, both in blood and tumor samples. Furthermore, nodal involvement was associated with the gradual increase of the CD14+B7-H4+ MDSC number, being the highest in the N3 group, again both in blood and tumor samples. Finally, we detected higher CD14+B7-H4+ MDSCs number in the samples of patients without metastases. Conclusion. CD14+B7-H4+ MDSCs n umber in L C patients is significantly associated with tumor histology type, lymph node involvement, disease extent degree and tumor size. Concerning their large number in LC tumor microenvironment together with immunosuppressive capacities, CD14+B7-H4+ MDSCs could represent important tumor promoting factor in LC pathophysiology.
PB  - Univerzitet odbrane - Vojnomedicinska akademija, Medicinski fakultet
T2  - Vojnosanitetski pregled
T1  - Significance of myeloid-derived suppressor cells (MDSCs) like CD14+B7-H4 cells frequency in blood and tumor microcirculation of lung cancer patients
VL  - 78
IS  - 6
SP  - 599
EP  - 606
DO  - 10.2298/VSP190430106V
ER  - 

@article{
author = "Vuković, Jelena and Karličić, Vukojica and Ristić, Saša and Stanojević, Ivan and Nikolić, Nevena and Štefik, Debra and Jović, Milena and Abazović, Džihan and Šupić, Gordana and Vojvodić, Danilo and Pavlović, Miloš",
year = "2021",
abstract = "Background/Aim. Myeloid-derived suppressor cells (MDSCs) suppress immune responses via a series of inhibitory mechanisms, which ultimately could lead to tumor growth. B7-H4 expression is significantly associated with poor outcome and promotion of tumor cell proliferation, invasion and migration in patients with various cancers. Data concerning B7-H4 expression in lung cancers (LC), either on tumor or immunological cells, are still sporadic. The aim was to estimate and correlate the number of CD14+B7-H4+MDSCs in blood and lung tumor microcirculation with clinical stage, histology type of tumor, tumor node metastasis (TNM) stadium, nodal status and disease outspread. Methods. The study included 44 lung cancer patients (III and IV clinical stage) and 30 healthy controls. CD14+B7-H4+ MDSC number was estimated by flow cytometry in blood and tumor microcirculation samples of each patient. Results. CD14+B7-H4+ MDSCs number was significantly higher in patients’ samples compared to controls. CD14+B7-H4+ MDSC number was significantly increased in tumor compared to blood sample of the same patient. Clinical stage III patients had the increased number of the CD14+B7-H4+ MDSC compared to stage IV, in both types of samples. According to histology, small cell lung cancer (SCLC) patients had the highest average CD14+B7-H4+ MDSCs number, significantly increased compared to patients with squamous and large cell LC histology type. Tumor size was directly associated with the number of the CD14+B7-H4+ MDSC, both in blood and tumor samples. Furthermore, nodal involvement was associated with the gradual increase of the CD14+B7-H4+ MDSC number, being the highest in the N3 group, again both in blood and tumor samples. Finally, we detected higher CD14+B7-H4+ MDSCs number in the samples of patients without metastases. Conclusion. CD14+B7-H4+ MDSCs n umber in L C patients is significantly associated with tumor histology type, lymph node involvement, disease extent degree and tumor size. Concerning their large number in LC tumor microenvironment together with immunosuppressive capacities, CD14+B7-H4+ MDSCs could represent important tumor promoting factor in LC pathophysiology.",
publisher = "Univerzitet odbrane - Vojnomedicinska akademija, Medicinski fakultet",
journal = "Vojnosanitetski pregled",
title = "Significance of myeloid-derived suppressor cells (MDSCs) like CD14+B7-H4 cells frequency in blood and tumor microcirculation of lung cancer patients",
volume = "78",
number = "6",
pages = "599-606",
doi = "10.2298/VSP190430106V"
}

Vuković, J., Karličić, V., Ristić, S., Stanojević, I., Nikolić, N., Štefik, D., Jović, M., Abazović, D., Šupić, G., Vojvodić, D.,& Pavlović, M.. (2021). Significance of myeloid-derived suppressor cells (MDSCs) like CD14+B7-H4 cells frequency in blood and tumor microcirculation of lung cancer patients. in Vojnosanitetski pregled
Univerzitet odbrane - Vojnomedicinska akademija, Medicinski fakultet., 78(6), 599-606.
https://doi.org/10.2298/VSP190430106V

Vuković J, Karličić V, Ristić S, Stanojević I, Nikolić N, Štefik D, Jović M, Abazović D, Šupić G, Vojvodić D, Pavlović M. Significance of myeloid-derived suppressor cells (MDSCs) like CD14+B7-H4 cells frequency in blood and tumor microcirculation of lung cancer patients. in Vojnosanitetski pregled. 2021;78(6):599-606.
doi:10.2298/VSP190430106V .

Vuković, Jelena, Karličić, Vukojica, Ristić, Saša, Stanojević, Ivan, Nikolić, Nevena, Štefik, Debra, Jović, Milena, Abazović, Džihan, Šupić, Gordana, Vojvodić, Danilo, Pavlović, Miloš, "Significance of myeloid-derived suppressor cells (MDSCs) like CD14+B7-H4 cells frequency in blood and tumor microcirculation of lung cancer patients" in Vojnosanitetski pregled, 78, no. 6 (2021):599-606,
https://doi.org/10.2298/VSP190430106V . .

TY  - JOUR
AU  - Pavlović, Miloš
AU  - Đukić, Mirjana
AU  - Vojvodić, Danilo
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Đurić, Ana
AU  - Stanojević, Boban
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2219
AB  - Background/Aim. Exposure of living organisms to γ-radiation results in the overproduction of free radicals. The aim of the study was to test if the subacute administration of micronized zeolite (MZC) accomplishes radioprotective role based on the evaluation of the status of oxidative stress (OS) in the brain and 8-hydroxyguanosine (8-OH-dG) in the plasma of the rats exposed to the single γ-ray irradiation of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a four-week normal or 5% MZC supplemented diet and afterward exposed to the single γ-ray irradiation of 2 and 10 Gy. Groups of rats were: a) on a normal diet (the control group, and 2Gy and 10Gy groups); b) on 5% MZC supplemented diet (the control group – MZC, MZC + 2Gy, and MZC + 10Gy groups). We measured malondialdehyde (MDA), glutathione (GSH) total, and activity of total super-oxide dismutase (tSOD) and manganese superoxide dismutase (MnSOD) in vulnerable brain regions (cerebellum, hippocampus, and cerebral cortex) and 8-OH-dG in plasma. Results. Lower MDA was found in the MZC+2Gy and MZC+10Gy groups compared to the 2Gy and 10Gy groups. Activity od total SOD was higher in the MZC+10Gy group than in the 10Gy one. GSH was the highest in the 10Gy group. Compared to the control group, 8-OH-dG was extremely higher in groups radiated with 10 Gy regardless of a diet, but slightly lower in the MZC+2Gy and 2Gy groups. Conclusion. Subacute MZC pretreatment accomplished partial radioprotective effect in irradiated rats compared to non-irradiated rats, based on suppressed SOD activity at 2 Gy, and reduced brain MDA when exposed to 2 Gy and 10 Gy.
AB  - Background/Aim. Exposure of living organisms to γradiation results in the overproduction of free radicals. The aim of the study was to test if the subacute administration of micronized zeolite (MZC) accomplishes radioprotective role based on the evaluation of the status of oxidative stress (OS) in the brain and 8-hydroxyguanosine (8-OH-dG) in the plasma of the rats exposed to the single γ-ray irradiation of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a four-week normal or 5% MZC supplemented diet and afterward exposed to the single γ-ray irradiation of 2 and 10 Gy. Groups of rats were: a) on a normal diet (the control group, and 2Gy and 10Gy groups); b) on 5% MZC supplemented diet (the control group – MZC, MZC + 2Gy, and MZC + 10Gy groups). We measured malondialdehyde (MDA), glutathione (GSH) total, and activity of total superoxide dismutase (tSOD) and manganese superoxide dismutase (MnSOD) in vulnerable brain regions (cerebellum, hippocampus, and cerebral cortex) and 8-OH-dG in plasma. Results. Lower MDA was found in the MZC+2Gy and MZC+10Gy groups compared to the 2Gy and 10Gy groups. Activity od total SOD was higher in the MZC+10Gy group than in the 10Gy one. GSH was the highest in the 10Gy group. Compared to the control group, 8-OH-dG was extremely higher in groups radiated with 10 Gy regardless of a diet, but slightly lower in the MZC+2Gy and 2Gy groups. Conclusion. Subacute MZC pretreatment accomplished partial radioprotective effect in irradiated rats compared to non-irradiated rats, based on suppressed SOD activity at 2 Gy, and reduced brain MDA when exposed to 2 Gy and 10 Gy.
PB  - Military Medical Academy
T2  - Vojnosanitetski pregled
T1  - Moderate radioprotective role of zeolite in rats
T1  - Umerena radioprotektivna uloga zeolita kod pacova
VL  - 78
IS  - 7
SP  - 760
EP  - 768
DO  - 10.2298/VSP190702136P
ER  - 

@article{
author = "Pavlović, Miloš and Đukić, Mirjana and Vojvodić, Danilo and Ninković, Milica and Stevanović, Ivana and Đurić, Ana and Stanojević, Boban",
year = "2021",
abstract = "Background/Aim. Exposure of living organisms to γ-radiation results in the overproduction of free radicals. The aim of the study was to test if the subacute administration of micronized zeolite (MZC) accomplishes radioprotective role based on the evaluation of the status of oxidative stress (OS) in the brain and 8-hydroxyguanosine (8-OH-dG) in the plasma of the rats exposed to the single γ-ray irradiation of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a four-week normal or 5% MZC supplemented diet and afterward exposed to the single γ-ray irradiation of 2 and 10 Gy. Groups of rats were: a) on a normal diet (the control group, and 2Gy and 10Gy groups); b) on 5% MZC supplemented diet (the control group – MZC, MZC + 2Gy, and MZC + 10Gy groups). We measured malondialdehyde (MDA), glutathione (GSH) total, and activity of total super-oxide dismutase (tSOD) and manganese superoxide dismutase (MnSOD) in vulnerable brain regions (cerebellum, hippocampus, and cerebral cortex) and 8-OH-dG in plasma. Results. Lower MDA was found in the MZC+2Gy and MZC+10Gy groups compared to the 2Gy and 10Gy groups. Activity od total SOD was higher in the MZC+10Gy group than in the 10Gy one. GSH was the highest in the 10Gy group. Compared to the control group, 8-OH-dG was extremely higher in groups radiated with 10 Gy regardless of a diet, but slightly lower in the MZC+2Gy and 2Gy groups. Conclusion. Subacute MZC pretreatment accomplished partial radioprotective effect in irradiated rats compared to non-irradiated rats, based on suppressed SOD activity at 2 Gy, and reduced brain MDA when exposed to 2 Gy and 10 Gy., Background/Aim. Exposure of living organisms to γradiation results in the overproduction of free radicals. The aim of the study was to test if the subacute administration of micronized zeolite (MZC) accomplishes radioprotective role based on the evaluation of the status of oxidative stress (OS) in the brain and 8-hydroxyguanosine (8-OH-dG) in the plasma of the rats exposed to the single γ-ray irradiation of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a four-week normal or 5% MZC supplemented diet and afterward exposed to the single γ-ray irradiation of 2 and 10 Gy. Groups of rats were: a) on a normal diet (the control group, and 2Gy and 10Gy groups); b) on 5% MZC supplemented diet (the control group – MZC, MZC + 2Gy, and MZC + 10Gy groups). We measured malondialdehyde (MDA), glutathione (GSH) total, and activity of total superoxide dismutase (tSOD) and manganese superoxide dismutase (MnSOD) in vulnerable brain regions (cerebellum, hippocampus, and cerebral cortex) and 8-OH-dG in plasma. Results. Lower MDA was found in the MZC+2Gy and MZC+10Gy groups compared to the 2Gy and 10Gy groups. Activity od total SOD was higher in the MZC+10Gy group than in the 10Gy one. GSH was the highest in the 10Gy group. Compared to the control group, 8-OH-dG was extremely higher in groups radiated with 10 Gy regardless of a diet, but slightly lower in the MZC+2Gy and 2Gy groups. Conclusion. Subacute MZC pretreatment accomplished partial radioprotective effect in irradiated rats compared to non-irradiated rats, based on suppressed SOD activity at 2 Gy, and reduced brain MDA when exposed to 2 Gy and 10 Gy.",
publisher = "Military Medical Academy",
journal = "Vojnosanitetski pregled",
title = "Moderate radioprotective role of zeolite in rats, Umerena radioprotektivna uloga zeolita kod pacova",
volume = "78",
number = "7",
pages = "760-768",
doi = "10.2298/VSP190702136P"
}

Pavlović, M., Đukić, M., Vojvodić, D., Ninković, M., Stevanović, I., Đurić, A.,& Stanojević, B.. (2021). Moderate radioprotective role of zeolite in rats. in Vojnosanitetski pregled
Military Medical Academy., 78(7), 760-768.
https://doi.org/10.2298/VSP190702136P

Pavlović M, Đukić M, Vojvodić D, Ninković M, Stevanović I, Đurić A, Stanojević B. Moderate radioprotective role of zeolite in rats. in Vojnosanitetski pregled. 2021;78(7):760-768.
doi:10.2298/VSP190702136P .

Pavlović, Miloš, Đukić, Mirjana, Vojvodić, Danilo, Ninković, Milica, Stevanović, Ivana, Đurić, Ana, Stanojević, Boban, "Moderate radioprotective role of zeolite in rats" in Vojnosanitetski pregled, 78, no. 7 (2021):760-768,
https://doi.org/10.2298/VSP190702136P . .

TY  - JOUR
AU  - Begić, Aida
AU  - Đurić, Ana
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Jelić, Katarina
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Dejanović, Bratislav
AU  - Stanojević, Ivan
AU  - Vojvodić, Danilo
AU  - Milosavljević, Petar
AU  - Đukić, Mirjana
AU  - Saso, Luciano
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1496
AB  - Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium
VL  - 32
IS  - 1
SP  - 478
EP  - 489
DO  - 10.1080/14756366.2016.1261132
ER  - 

@article{
author = "Begić, Aida and Đurić, Ana and Ninković, Milica and Stevanović, Ivana and Đurđević, Dragan and Pavlović, Miloš and Jelić, Katarina and Pantelić, Ana and Zebić, Goran and Dejanović, Bratislav and Stanojević, Ivan and Vojvodić, Danilo and Milosavljević, Petar and Đukić, Mirjana and Saso, Luciano",
year = "2017",
abstract = "Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium",
volume = "32",
number = "1",
pages = "478-489",
doi = "10.1080/14756366.2016.1261132"
}

Begić, A., Đurić, A., Ninković, M., Stevanović, I., Đurđević, D., Pavlović, M., Jelić, K., Pantelić, A., Zebić, G., Dejanović, B., Stanojević, I., Vojvodić, D., Milosavljević, P., Đukić, M.,& Saso, L.. (2017). Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 32(1), 478-489.
https://doi.org/10.1080/14756366.2016.1261132

Begić A, Đurić A, Ninković M, Stevanović I, Đurđević D, Pavlović M, Jelić K, Pantelić A, Zebić G, Dejanović B, Stanojević I, Vojvodić D, Milosavljević P, Đukić M, Saso L. Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):478-489.
doi:10.1080/14756366.2016.1261132 .

Begić, Aida, Đurić, Ana, Ninković, Milica, Stevanović, Ivana, Đurđević, Dragan, Pavlović, Miloš, Jelić, Katarina, Pantelić, Ana, Zebić, Goran, Dejanović, Bratislav, Stanojević, Ivan, Vojvodić, Danilo, Milosavljević, Petar, Đukić, Mirjana, Saso, Luciano, "Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):478-489,
https://doi.org/10.1080/14756366.2016.1261132 . .

TY  - JOUR
AU  - Đurić, Ana
AU  - Begić, Aida
AU  - Gobeljić, Borko
AU  - Stanojević, Ivan
AU  - Ninković, Milica
AU  - Vojvodić, Danilo
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Prokić, Vera
AU  - Dejanović, Bratislav
AU  - Stojanović, Ivana
AU  - Pavlica, Marina
AU  - Đukić, Dusan
AU  - Saso, Luciano
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Topić, Aleksandra
AU  - Vujanović, Dragana
AU  - Stevanović, Ivana
AU  - Đukić, Mirjana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1302
AB  - The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
VL  - 86
SP  - 25
EP  - 33
DO  - 10.1016/j.fct.2015.09.004
ER  - 

@article{
author = "Đurić, Ana and Begić, Aida and Gobeljić, Borko and Stanojević, Ivan and Ninković, Milica and Vojvodić, Danilo and Pantelić, Ana and Zebić, Goran and Prokić, Vera and Dejanović, Bratislav and Stojanović, Ivana and Pavlica, Marina and Đukić, Dusan and Saso, Luciano and Đurđević, Dragan and Pavlović, Miloš and Topić, Aleksandra and Vujanović, Dragana and Stevanović, Ivana and Đukić, Mirjana",
year = "2015",
abstract = "The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium",
volume = "86",
pages = "25-33",
doi = "10.1016/j.fct.2015.09.004"
}

Đurić, A., Begić, A., Gobeljić, B., Stanojević, I., Ninković, M., Vojvodić, D., Pantelić, A., Zebić, G., Prokić, V., Dejanović, B., Stojanović, I., Pavlica, M., Đukić, D., Saso, L., Đurđević, D., Pavlović, M., Topić, A., Vujanović, D., Stevanović, I.,& Đukić, M.. (2015). Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 86, 25-33.
https://doi.org/10.1016/j.fct.2015.09.004

Đurić A, Begić A, Gobeljić B, Stanojević I, Ninković M, Vojvodić D, Pantelić A, Zebić G, Prokić V, Dejanović B, Stojanović I, Pavlica M, Đukić D, Saso L, Đurđević D, Pavlović M, Topić A, Vujanović D, Stevanović I, Đukić M. Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology. 2015;86:25-33.
doi:10.1016/j.fct.2015.09.004 .

Đurić, Ana, Begić, Aida, Gobeljić, Borko, Stanojević, Ivan, Ninković, Milica, Vojvodić, Danilo, Pantelić, Ana, Zebić, Goran, Prokić, Vera, Dejanović, Bratislav, Stojanović, Ivana, Pavlica, Marina, Đukić, Dusan, Saso, Luciano, Đurđević, Dragan, Pavlović, Miloš, Topić, Aleksandra, Vujanović, Dragana, Stevanović, Ivana, Đukić, Mirjana, "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium" in Food and Chemical Toxicology, 86 (2015):25-33,
https://doi.org/10.1016/j.fct.2015.09.004 . .

TY  - JOUR
AU  - Vojvodić, Danilo
AU  - Miljanović, Olivera
AU  - Đurđević, D.
AU  - Gatarić, S.
AU  - Stanojević, I.
AU  - Obradović, Dragana
AU  - Šurbatović, Maja
AU  - Francuski, Jelena
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1043
AB  - Anesthetic agents could alter the course and outcome of physical trauma, as well as experimentally or naturally occuring severe infections, by regulating several immune response mechanisms. The aim of our study was to investigate the influence of several commercially used anesthetic agents (ketamine, propofole, pentylentetrazole - PTZ) on cytokine concentrations, animal survival and pathohistological changes in the model of rat sepsis. In adult, male Wistar rats after different anesthetic traeatment and induction of sepsis by cecal ligation and punction we estimated serum levels of IL1α, TNFα, GM-CSF and MCP-1 at 12h intervals. After 48h of sepsis induction, the largest number of animals survived in the group treated with PTZ (47%), while the lowest survival rate was in the propofole treatment group (24%). Contrary to survival rate, the most abundant pathohistological changes were seen on preparations from PTZ and than in ketamine/PTZ treated groups, without any significant changes in the CNS of propofole treated animals. In the propofole treated group there was a prominent increament of GM-CSF values at 12h and 24h, followed by a significant decreament at 36h. These changes were negatively correlated to the survival rate in this group. This group had the lowest levels of MCP1 at all evaluated time intervals. After high initial levels, IL1α and TNFα levels fell to undetectable concentrations and at 24h increased to a high level. In PTZ as well as ketamine groups, at 12 h interval, GM-CSF levels were lower than in the propofole treated group. Contrary, MCP-1 levels were higher in these groups comparing to propofole group. After a high initial peak, IL1α levels decreased to low but detectable levels, followed by an intensive rise in ketamine treated, but with further decrement in pentazole treated groups. TNFα levels were low through all evaluated intervals in both these groups. Our results indicate that induction of anaesthesia of animals with sepsis with variuos anesthetic agents is connected to different pathohistological CNS changes, distinct serum cytokine profiles and diverse survival rates.
AB  - Anestetici mogu izmeniti tok i ishod uticaja fizičke traume kao i eksperimentalno ili prirodno nastalih teških infekcija, regulacijom nekoliko mehanizama imunskog odgovora. Cilj naše studije je bio da ispitamo uticaj nekoliko komercijalno korišćenih anestetika (ketamina, propofola i pentzlentetrazola) na koncentraciju citokina, preživljavanje životinja i patohistološke promene u modelu sepse indukovane u pacova. U odraslih pacova, muškog pola, po primeni različitih anestetika i indukcije sepse podvezivanjem i punkcijom cekuma, utvrđivali smo nivoe IL1α, TNFα, IL4, IFNy, GM-CSF i MCp-1 u intervalima od 12 sati. Nakon 48 sati od indukcije sepse, najveći broj životinja preživeo je u grupi tretiranoj pentylenetetrazolom (50%), potom u ketamin/pentylenetetrazol tretiranoj grupi, dok je najmanja stopa preživljavanja bila u grupi tretiranoj propofolom (22%). Nasuprot stopi preživljavanja, najizraženije patohistološke promene su utvrđene na preparatima grupa tratiranih pentazolom i ketamin/pentylenetetrazol, bez značajnih promena u CNS u grupi životinja tretiranih propofolom. U uzorcima grupe tretirane propofolom detektovali smo intezivan porast vrednosti GM-CSF 12h i 24h, praćen značajnim padom posle 36h. Ove promene su negativno korelirale sa stopom preživljavanja u ovoj grupi. Ova grupa je imala i najniže vrednosti MCP-1 u svim praćenim vremenskim intervalima. Posle visokih inicijalnih nivoa, vrednosti IL1a i TNFα pale su na nedetektabilne a u terminu od 24h porasle su na visok nivo. U grupama tretiranim pentazolom i ketaminom, 12. sata, vrednosti GM-CSF bile su niže od grupe tretirane propofolom. Nasuprot tome, vrednosti MCP-1 su bile veće u ovim grupama u odnosu na propofolom tretiranu grupu. Posle visokog inicijalnog skoka, vrednosti IL1α smanjuju se na niske ali detektabilne vrednosti, a zatim sledi intezivan rast u ketaminom tretiranoj grupi i dalji pad vrednosti u pentilenetetrazol tretiranoj grupi. Vrednosti TNFα su u ove dve grupe bile niske u svim ispitivanim intervalima. Vrednosti IL4 i IFNy su bile praktično nedetektabilne u svim ispitivanim grupama. Naši rezultati ukazuju da je indukcija anestezije u životinja sa sepsom različitim anesteticima povezana sa različitim patohistološkim nalazima u CNS, različitim serumskim profilom citokina i različitom stopom preživljavanja.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Effects of different anesthetic agents on GM-CSF, MCP1, IL1α and TNFα levels in rat sepsis model
T1  - Efekti različitih anestetika na nivoe GM-CSF, MCP1, IL1α i TNFα na pacovskom modelu sepse
VL  - 63
IS  - 2-3
SP  - 125
EP  - 136
DO  - 10.2298/AVB1303125V
ER  - 

@article{
author = "Vojvodić, Danilo and Miljanović, Olivera and Đurđević, D. and Gatarić, S. and Stanojević, I. and Obradović, Dragana and Šurbatović, Maja and Francuski, Jelena",
year = "2013",
abstract = "Anesthetic agents could alter the course and outcome of physical trauma, as well as experimentally or naturally occuring severe infections, by regulating several immune response mechanisms. The aim of our study was to investigate the influence of several commercially used anesthetic agents (ketamine, propofole, pentylentetrazole - PTZ) on cytokine concentrations, animal survival and pathohistological changes in the model of rat sepsis. In adult, male Wistar rats after different anesthetic traeatment and induction of sepsis by cecal ligation and punction we estimated serum levels of IL1α, TNFα, GM-CSF and MCP-1 at 12h intervals. After 48h of sepsis induction, the largest number of animals survived in the group treated with PTZ (47%), while the lowest survival rate was in the propofole treatment group (24%). Contrary to survival rate, the most abundant pathohistological changes were seen on preparations from PTZ and than in ketamine/PTZ treated groups, without any significant changes in the CNS of propofole treated animals. In the propofole treated group there was a prominent increament of GM-CSF values at 12h and 24h, followed by a significant decreament at 36h. These changes were negatively correlated to the survival rate in this group. This group had the lowest levels of MCP1 at all evaluated time intervals. After high initial levels, IL1α and TNFα levels fell to undetectable concentrations and at 24h increased to a high level. In PTZ as well as ketamine groups, at 12 h interval, GM-CSF levels were lower than in the propofole treated group. Contrary, MCP-1 levels were higher in these groups comparing to propofole group. After a high initial peak, IL1α levels decreased to low but detectable levels, followed by an intensive rise in ketamine treated, but with further decrement in pentazole treated groups. TNFα levels were low through all evaluated intervals in both these groups. Our results indicate that induction of anaesthesia of animals with sepsis with variuos anesthetic agents is connected to different pathohistological CNS changes, distinct serum cytokine profiles and diverse survival rates., Anestetici mogu izmeniti tok i ishod uticaja fizičke traume kao i eksperimentalno ili prirodno nastalih teških infekcija, regulacijom nekoliko mehanizama imunskog odgovora. Cilj naše studije je bio da ispitamo uticaj nekoliko komercijalno korišćenih anestetika (ketamina, propofola i pentzlentetrazola) na koncentraciju citokina, preživljavanje životinja i patohistološke promene u modelu sepse indukovane u pacova. U odraslih pacova, muškog pola, po primeni različitih anestetika i indukcije sepse podvezivanjem i punkcijom cekuma, utvrđivali smo nivoe IL1α, TNFα, IL4, IFNy, GM-CSF i MCp-1 u intervalima od 12 sati. Nakon 48 sati od indukcije sepse, najveći broj životinja preživeo je u grupi tretiranoj pentylenetetrazolom (50%), potom u ketamin/pentylenetetrazol tretiranoj grupi, dok je najmanja stopa preživljavanja bila u grupi tretiranoj propofolom (22%). Nasuprot stopi preživljavanja, najizraženije patohistološke promene su utvrđene na preparatima grupa tratiranih pentazolom i ketamin/pentylenetetrazol, bez značajnih promena u CNS u grupi životinja tretiranih propofolom. U uzorcima grupe tretirane propofolom detektovali smo intezivan porast vrednosti GM-CSF 12h i 24h, praćen značajnim padom posle 36h. Ove promene su negativno korelirale sa stopom preživljavanja u ovoj grupi. Ova grupa je imala i najniže vrednosti MCP-1 u svim praćenim vremenskim intervalima. Posle visokih inicijalnih nivoa, vrednosti IL1a i TNFα pale su na nedetektabilne a u terminu od 24h porasle su na visok nivo. U grupama tretiranim pentazolom i ketaminom, 12. sata, vrednosti GM-CSF bile su niže od grupe tretirane propofolom. Nasuprot tome, vrednosti MCP-1 su bile veće u ovim grupama u odnosu na propofolom tretiranu grupu. Posle visokog inicijalnog skoka, vrednosti IL1α smanjuju se na niske ali detektabilne vrednosti, a zatim sledi intezivan rast u ketaminom tretiranoj grupi i dalji pad vrednosti u pentilenetetrazol tretiranoj grupi. Vrednosti TNFα su u ove dve grupe bile niske u svim ispitivanim intervalima. Vrednosti IL4 i IFNy su bile praktično nedetektabilne u svim ispitivanim grupama. Naši rezultati ukazuju da je indukcija anestezije u životinja sa sepsom različitim anesteticima povezana sa različitim patohistološkim nalazima u CNS, različitim serumskim profilom citokina i različitom stopom preživljavanja.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Effects of different anesthetic agents on GM-CSF, MCP1, IL1α and TNFα levels in rat sepsis model, Efekti različitih anestetika na nivoe GM-CSF, MCP1, IL1α i TNFα na pacovskom modelu sepse",
volume = "63",
number = "2-3",
pages = "125-136",
doi = "10.2298/AVB1303125V"
}

Vojvodić, D., Miljanović, O., Đurđević, D., Gatarić, S., Stanojević, I., Obradović, D., Šurbatović, M.,& Francuski, J.. (2013). Effects of different anesthetic agents on GM-CSF, MCP1, IL1α and TNFα levels in rat sepsis model. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(2-3), 125-136.
https://doi.org/10.2298/AVB1303125V

Vojvodić D, Miljanović O, Đurđević D, Gatarić S, Stanojević I, Obradović D, Šurbatović M, Francuski J. Effects of different anesthetic agents on GM-CSF, MCP1, IL1α and TNFα levels in rat sepsis model. in Acta Veterinaria-Beograd. 2013;63(2-3):125-136.
doi:10.2298/AVB1303125V .

Vojvodić, Danilo, Miljanović, Olivera, Đurđević, D., Gatarić, S., Stanojević, I., Obradović, Dragana, Šurbatović, Maja, Francuski, Jelena, "Effects of different anesthetic agents on GM-CSF, MCP1, IL1α and TNFα levels in rat sepsis model" in Acta Veterinaria-Beograd, 63, no. 2-3 (2013):125-136,
https://doi.org/10.2298/AVB1303125V . .

TY  - JOUR
AU  - Jovanović, Milan
AU  - Lazarević, Miodrag
AU  - Popović, N.
AU  - Vojvodić, Danilo
PY  - 2009
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/613
AB  - Immunomodulation is a phenomenon that is based on the influence of different endogenous and exogenous substances on the function of molecules and cells pertaining to the immune system. Some components extracted from the bovine thymus have immunomodulating features and can, both in animals and humans, by suppressing the immune response (humoral and/or cellular) bring about immunostimulation and increased organism resistance. In this paper the effects of bovine thymus extract (Thymex - L) on the parameters of humoral immune response (concentration of antibodies to tetanus toxoid - ATTx) and cellular immune response (interleukin 2 - IL-2, interferon γ - IFN-γ and degree of cutaneus basophyl hypersensitivity - CBHR) in rats previously irradiated by X-rays at a dose of 4 or 6 Gy. The studied thymus extract had shown positive effects on IL-2 and IFN-γ serum concentrations in irradiated rats. In the group of rats irradiated with 4 Gy the effects were evident on the 7th day of the trial. Rats irradiated with the higher dose (6 Gy) experienced the positive effects of thymus extract on the 21st day of the experiment. In the skin PHA hypersensitivity test, a positive effect was also recorded, being more pronounced in rats which received the lower irradiation dose. The tested thymus extract had shown a positive effect on the concentration of ATTx as early as the 14th day of the trial.
AB  - Pojedini sastojci ekstrakta goveđeg timusa imaju imunomodulatorna svojstva i mogu, kod ljudi i životinja, sa suprimiranim funkcijama imunskog sistema (humoralnim i/ili celularnim) dovesti do imunostimulacije. U ovom radu su prikazani rezultati ispitivanja efekata preparata Thymex-L dobijenog iz ekstrakta goveđ eg timusa na parametre humoralnog imunskog odgovora pacova kod kojih je prethodno izvršeno jednokratno ozračivanje X zracima u dozi od 4 ili 6 Gy. Određivani su sledeći parametri: koncentracija interleukina 2 (IL-2), interferona γ (IFN-γ), koncentracija antitela posle vakcinacije i revakcinacije tetanusnim toksoidom (ATTx) i stepen kožne preosetljivosti (CBHR) na biljni mitogen (PHA) Ispitivani ekstrakt je ispoljio pozitivan efekat na koncentraciju IL-2 i IFN-γ u serumu ozračenih pacova. Ovaj pozitivan efekat je, kod grupe pacova koja je primila nižu dozu zračenja, vidljiv već nakon 7. dana eksperimenta, dok je kod pacova ozračenih višom dozom zračenja pozitivan efekat registrovan 21. dana eksperimenta. Pri proceni stepena reakcije kožne preosetljivosti na PHA, registrovan je pozitivan efekat primenjenog ekstrakta timusa i on je bio izraženiji kod jedinki kod kojih je bila primenjena niža doza zračenja. Ispitivani ekstrakt goveđeg timusa je ispoljio pozitivan efekat i na koncentraciju ATTx i to već 14. dana eksperimenta.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - The influence of bovine thymic extract on the immune response in irradiated wistar rats
T1  - Efekat ekstrakta goveđeg timusa na imunski odgovor ozračenih wistar pacova
VL  - 59
IS  - 4
SP  - 331
EP  - 347
DO  - 10.2298/AVB0904331J
ER  - 

@article{
author = "Jovanović, Milan and Lazarević, Miodrag and Popović, N. and Vojvodić, Danilo",
year = "2009",
abstract = "Immunomodulation is a phenomenon that is based on the influence of different endogenous and exogenous substances on the function of molecules and cells pertaining to the immune system. Some components extracted from the bovine thymus have immunomodulating features and can, both in animals and humans, by suppressing the immune response (humoral and/or cellular) bring about immunostimulation and increased organism resistance. In this paper the effects of bovine thymus extract (Thymex - L) on the parameters of humoral immune response (concentration of antibodies to tetanus toxoid - ATTx) and cellular immune response (interleukin 2 - IL-2, interferon γ - IFN-γ and degree of cutaneus basophyl hypersensitivity - CBHR) in rats previously irradiated by X-rays at a dose of 4 or 6 Gy. The studied thymus extract had shown positive effects on IL-2 and IFN-γ serum concentrations in irradiated rats. In the group of rats irradiated with 4 Gy the effects were evident on the 7th day of the trial. Rats irradiated with the higher dose (6 Gy) experienced the positive effects of thymus extract on the 21st day of the experiment. In the skin PHA hypersensitivity test, a positive effect was also recorded, being more pronounced in rats which received the lower irradiation dose. The tested thymus extract had shown a positive effect on the concentration of ATTx as early as the 14th day of the trial., Pojedini sastojci ekstrakta goveđeg timusa imaju imunomodulatorna svojstva i mogu, kod ljudi i životinja, sa suprimiranim funkcijama imunskog sistema (humoralnim i/ili celularnim) dovesti do imunostimulacije. U ovom radu su prikazani rezultati ispitivanja efekata preparata Thymex-L dobijenog iz ekstrakta goveđ eg timusa na parametre humoralnog imunskog odgovora pacova kod kojih je prethodno izvršeno jednokratno ozračivanje X zracima u dozi od 4 ili 6 Gy. Određivani su sledeći parametri: koncentracija interleukina 2 (IL-2), interferona γ (IFN-γ), koncentracija antitela posle vakcinacije i revakcinacije tetanusnim toksoidom (ATTx) i stepen kožne preosetljivosti (CBHR) na biljni mitogen (PHA) Ispitivani ekstrakt je ispoljio pozitivan efekat na koncentraciju IL-2 i IFN-γ u serumu ozračenih pacova. Ovaj pozitivan efekat je, kod grupe pacova koja je primila nižu dozu zračenja, vidljiv već nakon 7. dana eksperimenta, dok je kod pacova ozračenih višom dozom zračenja pozitivan efekat registrovan 21. dana eksperimenta. Pri proceni stepena reakcije kožne preosetljivosti na PHA, registrovan je pozitivan efekat primenjenog ekstrakta timusa i on je bio izraženiji kod jedinki kod kojih je bila primenjena niža doza zračenja. Ispitivani ekstrakt goveđeg timusa je ispoljio pozitivan efekat i na koncentraciju ATTx i to već 14. dana eksperimenta.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "The influence of bovine thymic extract on the immune response in irradiated wistar rats, Efekat ekstrakta goveđeg timusa na imunski odgovor ozračenih wistar pacova",
volume = "59",
number = "4",
pages = "331-347",
doi = "10.2298/AVB0904331J"
}

Jovanović, M., Lazarević, M., Popović, N.,& Vojvodić, D.. (2009). The influence of bovine thymic extract on the immune response in irradiated wistar rats. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 59(4), 331-347.
https://doi.org/10.2298/AVB0904331J

Jovanović M, Lazarević M, Popović N, Vojvodić D. The influence of bovine thymic extract on the immune response in irradiated wistar rats. in Acta Veterinaria-Beograd. 2009;59(4):331-347.
doi:10.2298/AVB0904331J .

Jovanović, Milan, Lazarević, Miodrag, Popović, N., Vojvodić, Danilo, "The influence of bovine thymic extract on the immune response in irradiated wistar rats" in Acta Veterinaria-Beograd, 59, no. 4 (2009):331-347,
https://doi.org/10.2298/AVB0904331J . .