@article{
author = "Horyanto, Darwin and Bajagai, Yadav S. and Kayal, Advait and von Hellens, Juhani and Chen, Xiaojing and Van, Thi Thu Hao and Radovanović, Anita and Stanley, Dragana",
year = "2024",
abstract = "The supplementation of antimicrobial growth promoters (AGPs) has been banned in many
countries because of the emergence of antimicrobial-resistant pathogens in poultry products and
the environment. Probiotics have been broadly studied and demonstrated as a promising AGP
substitute. Our study is centred on the effects of a multi-strain Bacillus-based probiotic product
on broiler production performance and gut microbial profile in a dexamethasone-induced leaky
gut challenge. Two hundred and fifty-six broiler chicks were hatched and randomly assigned into
four groups (wheat-soybean meal basal diet (BD) = non-supplemented control (C), BD supplemented
with dexamethasone in week 4 (CD), BD containing a probiotic from day one (P), and BD containing
a probiotic from day one and supplemented with dexamethasone during challenge week 4 (PD)).
The production performance and caecal, gizzard, jejunal lumen and jejunal mucosa swab microbiota
were studied by 16S rRNA gene sequencing. The Bacillus probiotic product significantly improved
production performance and altered caecal gut microbiota (p ≤ 0.05), but no significant impact on
microbiota was observed in other gut sections.",
publisher = "MDPI",
journal = "Microorganisms",
title = "Bacillus amyloliquefaciens probiotics mix supplementation in a broiler leaky gut model",
volume = "12",
number = "2",
pages = "419",
doi = "10.3390/microorganisms12020419"
}