TY  - JOUR
AU  - Francuski, Jelena
AU  - Radovanović, Anita
AU  - Andrić, Nenad
AU  - Krstić, Vanja
AU  - Bogdanović, Dragan
AU  - Hadzić, V.
AU  - Todorović, V.
AU  - Lazarević Macanović, Mirjana
AU  - Petit, S. Sourice
AU  - Beck-Cormier, Sarah
AU  - Guicheux, J.
AU  - Gauthier, O.
AU  - Kovačević-Filipović, Milica
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1093
AB  - The aims of this study were to define age-related histological changes in the articular cartilage of the stifle joint in non-chondrodystrophic dogs and to determine whether physical activity has a positive impact on preservation of cartilage structure during ageing. Twenty-eight German shepherd dogs were included in the study. These dogs had no evidence of joint inflammation as defined by clinical assessment, radiology and synovial fluid analysis (specifically absence of synovial fluid serum amyloid A). The dogs were grouped as young working (n = 4), young non-working (n = 5), aged working (n = 13) and aged non-working (n = 6) animals. Gross changes in the stifle joints were recorded and biopsy samples of femoral and tibial articular cartilage were evaluated for thickness; chondrocyte number, density, surface area and morphology; isogenous group morphology; tidemark integrity; subchondral bone structure; presence of proteoglycans/glycosaminoglycans; and expression of type I, II and X collagens. The major age-related changes, not related to type of physical activity, included elevated chondrocyte density and thinning of tibial cartilage and increased chondrocyte surface area in the superficial and intermediate zone of the femoral cartilage. There was also expression of type X collagen in the femoral and tibial calcified and non-calcified cartilage; however, type X collagen was not detected in the superficial zone of old working dogs. Therefore, ageing, with or without physical activity, leads to slight cartilage degeneration, while physical activity modulates the synthesis of type X collagen in the superficial cartilage zone, partially preserving the structure of hyaline cartilage.
PB  - Elsevier Sci Ltd, Oxford
T2  - Journal of Comparative Pathology
T1  - Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs
VL  - 151
IS  - 4
SP  - 363
EP  - 374
DO  - 10.1016/j.jcpa.2014.09.002
ER  - 

@article{
author = "Francuski, Jelena and Radovanović, Anita and Andrić, Nenad and Krstić, Vanja and Bogdanović, Dragan and Hadzić, V. and Todorović, V. and Lazarević Macanović, Mirjana and Petit, S. Sourice and Beck-Cormier, Sarah and Guicheux, J. and Gauthier, O. and Kovačević-Filipović, Milica",
year = "2014",
abstract = "The aims of this study were to define age-related histological changes in the articular cartilage of the stifle joint in non-chondrodystrophic dogs and to determine whether physical activity has a positive impact on preservation of cartilage structure during ageing. Twenty-eight German shepherd dogs were included in the study. These dogs had no evidence of joint inflammation as defined by clinical assessment, radiology and synovial fluid analysis (specifically absence of synovial fluid serum amyloid A). The dogs were grouped as young working (n = 4), young non-working (n = 5), aged working (n = 13) and aged non-working (n = 6) animals. Gross changes in the stifle joints were recorded and biopsy samples of femoral and tibial articular cartilage were evaluated for thickness; chondrocyte number, density, surface area and morphology; isogenous group morphology; tidemark integrity; subchondral bone structure; presence of proteoglycans/glycosaminoglycans; and expression of type I, II and X collagens. The major age-related changes, not related to type of physical activity, included elevated chondrocyte density and thinning of tibial cartilage and increased chondrocyte surface area in the superficial and intermediate zone of the femoral cartilage. There was also expression of type X collagen in the femoral and tibial calcified and non-calcified cartilage; however, type X collagen was not detected in the superficial zone of old working dogs. Therefore, ageing, with or without physical activity, leads to slight cartilage degeneration, while physical activity modulates the synthesis of type X collagen in the superficial cartilage zone, partially preserving the structure of hyaline cartilage.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Journal of Comparative Pathology",
title = "Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs",
volume = "151",
number = "4",
pages = "363-374",
doi = "10.1016/j.jcpa.2014.09.002"
}

Francuski, J., Radovanović, A., Andrić, N., Krstić, V., Bogdanović, D., Hadzić, V., Todorović, V., Lazarević Macanović, M., Petit, S. S., Beck-Cormier, S., Guicheux, J., Gauthier, O.,& Kovačević-Filipović, M.. (2014). Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs. in Journal of Comparative Pathology
Elsevier Sci Ltd, Oxford., 151(4), 363-374.
https://doi.org/10.1016/j.jcpa.2014.09.002

Francuski J, Radovanović A, Andrić N, Krstić V, Bogdanović D, Hadzić V, Todorović V, Lazarević Macanović M, Petit SS, Beck-Cormier S, Guicheux J, Gauthier O, Kovačević-Filipović M. Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs. in Journal of Comparative Pathology. 2014;151(4):363-374.
doi:10.1016/j.jcpa.2014.09.002 .

Francuski, Jelena, Radovanović, Anita, Andrić, Nenad, Krstić, Vanja, Bogdanović, Dragan, Hadzić, V., Todorović, V., Lazarević Macanović, Mirjana, Petit, S. Sourice, Beck-Cormier, Sarah, Guicheux, J., Gauthier, O., Kovačević-Filipović, Milica, "Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs" in Journal of Comparative Pathology, 151, no. 4 (2014):363-374,
https://doi.org/10.1016/j.jcpa.2014.09.002 . .