The effect of carvacrol on inflammatory pain and motor coordination in rats
Uticaj karvakrola na inflamatorni bol i koordinaciju kretanja kod pacova
2016
Аутори
Milovanović, MirjanaMilosavljević, Miloš
Marjanović, Đorđe
Trailović, Saša
Vučinić, Marijana
Nedeljković-Trailović, Jelena
Marković, Maja
Đurđević, Dragan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Carvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperalgesia was induced by formalin (1.5%), which was administered SC in the upper lip of rat. Hyperalgesia and effects of carvacrol and indomethacin were measured by using the orofacial formalin test. The influence on motor coordination in animals treated with carvacrol was investigated by using the rota-rod test. Carvacrol administered PO in pre-treatment (45 min. prior to formalin) at a single dose of 50, 75 and 100 mg /kg BW, in the male, 50 and 100 mg /kg BW, in female rats caused a dose-dependent antinociceptive effect. This effect of carvacrol was significantly higher (P lt 0.01, P lt 0.001) in male rats. Compared with indomethacin administered during pre-treatment (2 mg/kg, PO), carvacrol ...(100 mg/kg) exhibits significantly higher (P lt 0.05 and P lt 0.001) antinociceptive effect on formalininduced hyperalgesia in male rats. In the rota-rod test carvacrol did not disturb the motor coordination in male rats, nor the dose of carvacrol with clear antinociceptive properties exhibited depressive effect on the CNS of treated rats. Keeping in mind that the monoterpene carvacrol is of plant origin, with potentially less side effects and without residues, it is realistic to expect the possibility of its therapeutic use in the treatment of inflammatory pain in animals.
Karvakrol je monoterpenski fenol i sastavni je deo esencijalnih ulja biljaka iz familije Lamiaceae. Cilj ovog istraživanja bio je da se ispita analgetičko dejstvo karvakrola, moguće razlike u farmakološkom odgovoru između polova, i uticaj karvakrola na koordinaciju kretanja kod pacova. Hiperalgezija je izazvana formalinom (1,5%) koji je aplikovan s.c. u gornju usnu pacova. Hiperalgezija i efekti karvakrola i indometacina mereni su orofacijalnim formalinskim testom. Uticaj na motornu koordinaciju kod životinja tretiranih karvakrolom ispitali smo rota-rod testom. Karvakrol primenjen p.o. u pretretmanu (45 min. pre aplikacije formalina) u dozi od 50, 75 i 100 mg/kg t.m. kod mužjaka i dozi od 50 i 100 mg/kg t.m. kod ženki pacova, prouzrokuje dozno zavisan antinociceptivni efekat. Ovaj efekat karvakrola je značajno veći (P lt 0,01, P lt 0,001) kod pacova muškog pola. U poređenju sa indometacinom aplikovanim u pretretmanu (2 mg/kg, p.o.), karvakrol (100 mg/kg) ispoljava značajno veći (P lt 0...,05 i P lt 0,001) antinociceptivni efekat na formalinom izazvanu hiperalgeziju kod mužjaka pacova. U rota-rod testu karvakrol nije narušio motornu koordinaciju kod mužjka pacova, niti doza karvakrol sa jasnim antinociceptivnim svojstvima deluje depresivno na CNS tretiranih pacova. Imajući u vidu da je karvakrol monoterpen biljnog porekla sa malo potencijalnih neželjenih dejstava i bez rezidua, realno je očekivati mogućnost njegove primenu u terapiji inflamatornog bola kod životinja.
Кључне речи:
carvacrol / indomethacin / nociception / motor coordination / ratИзвор:
Acta Veterinaria-Beograd, 2016, 66, 4, 478-488Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Финансирање / пројекти:
- Развој биљних лекова и биоцида на бази карвакрола, тимола и цинамалдехида за примену у ветеринарској медицини, сточарству и производњи хране без штетних резидуа (RS-MESTD-Technological Development (TD or TR)-31087)
DOI: 10.1515/acve-2016-0041
ISSN: 0567-8315
WoS: 000392931700005
Scopus: 2-s2.0-85013498625
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Milovanović, Mirjana AU - Milosavljević, Miloš AU - Marjanović, Đorđe AU - Trailović, Saša AU - Vučinić, Marijana AU - Nedeljković-Trailović, Jelena AU - Marković, Maja AU - Đurđević, Dragan PY - 2016 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1354 AB - Carvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperalgesia was induced by formalin (1.5%), which was administered SC in the upper lip of rat. Hyperalgesia and effects of carvacrol and indomethacin were measured by using the orofacial formalin test. The influence on motor coordination in animals treated with carvacrol was investigated by using the rota-rod test. Carvacrol administered PO in pre-treatment (45 min. prior to formalin) at a single dose of 50, 75 and 100 mg /kg BW, in the male, 50 and 100 mg /kg BW, in female rats caused a dose-dependent antinociceptive effect. This effect of carvacrol was significantly higher (P lt 0.01, P lt 0.001) in male rats. Compared with indomethacin administered during pre-treatment (2 mg/kg, PO), carvacrol (100 mg/kg) exhibits significantly higher (P lt 0.05 and P lt 0.001) antinociceptive effect on formalininduced hyperalgesia in male rats. In the rota-rod test carvacrol did not disturb the motor coordination in male rats, nor the dose of carvacrol with clear antinociceptive properties exhibited depressive effect on the CNS of treated rats. Keeping in mind that the monoterpene carvacrol is of plant origin, with potentially less side effects and without residues, it is realistic to expect the possibility of its therapeutic use in the treatment of inflammatory pain in animals. AB - Karvakrol je monoterpenski fenol i sastavni je deo esencijalnih ulja biljaka iz familije Lamiaceae. Cilj ovog istraživanja bio je da se ispita analgetičko dejstvo karvakrola, moguće razlike u farmakološkom odgovoru između polova, i uticaj karvakrola na koordinaciju kretanja kod pacova. Hiperalgezija je izazvana formalinom (1,5%) koji je aplikovan s.c. u gornju usnu pacova. Hiperalgezija i efekti karvakrola i indometacina mereni su orofacijalnim formalinskim testom. Uticaj na motornu koordinaciju kod životinja tretiranih karvakrolom ispitali smo rota-rod testom. Karvakrol primenjen p.o. u pretretmanu (45 min. pre aplikacije formalina) u dozi od 50, 75 i 100 mg/kg t.m. kod mužjaka i dozi od 50 i 100 mg/kg t.m. kod ženki pacova, prouzrokuje dozno zavisan antinociceptivni efekat. Ovaj efekat karvakrola je značajno veći (P lt 0,01, P lt 0,001) kod pacova muškog pola. U poređenju sa indometacinom aplikovanim u pretretmanu (2 mg/kg, p.o.), karvakrol (100 mg/kg) ispoljava značajno veći (P lt 0,05 i P lt 0,001) antinociceptivni efekat na formalinom izazvanu hiperalgeziju kod mužjaka pacova. U rota-rod testu karvakrol nije narušio motornu koordinaciju kod mužjka pacova, niti doza karvakrol sa jasnim antinociceptivnim svojstvima deluje depresivno na CNS tretiranih pacova. Imajući u vidu da je karvakrol monoterpen biljnog porekla sa malo potencijalnih neželjenih dejstava i bez rezidua, realno je očekivati mogućnost njegove primenu u terapiji inflamatornog bola kod životinja. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - The effect of carvacrol on inflammatory pain and motor coordination in rats T1 - Uticaj karvakrola na inflamatorni bol i koordinaciju kretanja kod pacova VL - 66 IS - 4 SP - 478 EP - 488 DO - 10.1515/acve-2016-0041 ER -
@article{ author = "Milovanović, Mirjana and Milosavljević, Miloš and Marjanović, Đorđe and Trailović, Saša and Vučinić, Marijana and Nedeljković-Trailović, Jelena and Marković, Maja and Đurđević, Dragan", year = "2016", abstract = "Carvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperalgesia was induced by formalin (1.5%), which was administered SC in the upper lip of rat. Hyperalgesia and effects of carvacrol and indomethacin were measured by using the orofacial formalin test. The influence on motor coordination in animals treated with carvacrol was investigated by using the rota-rod test. Carvacrol administered PO in pre-treatment (45 min. prior to formalin) at a single dose of 50, 75 and 100 mg /kg BW, in the male, 50 and 100 mg /kg BW, in female rats caused a dose-dependent antinociceptive effect. This effect of carvacrol was significantly higher (P lt 0.01, P lt 0.001) in male rats. Compared with indomethacin administered during pre-treatment (2 mg/kg, PO), carvacrol (100 mg/kg) exhibits significantly higher (P lt 0.05 and P lt 0.001) antinociceptive effect on formalininduced hyperalgesia in male rats. In the rota-rod test carvacrol did not disturb the motor coordination in male rats, nor the dose of carvacrol with clear antinociceptive properties exhibited depressive effect on the CNS of treated rats. Keeping in mind that the monoterpene carvacrol is of plant origin, with potentially less side effects and without residues, it is realistic to expect the possibility of its therapeutic use in the treatment of inflammatory pain in animals., Karvakrol je monoterpenski fenol i sastavni je deo esencijalnih ulja biljaka iz familije Lamiaceae. Cilj ovog istraživanja bio je da se ispita analgetičko dejstvo karvakrola, moguće razlike u farmakološkom odgovoru između polova, i uticaj karvakrola na koordinaciju kretanja kod pacova. Hiperalgezija je izazvana formalinom (1,5%) koji je aplikovan s.c. u gornju usnu pacova. Hiperalgezija i efekti karvakrola i indometacina mereni su orofacijalnim formalinskim testom. Uticaj na motornu koordinaciju kod životinja tretiranih karvakrolom ispitali smo rota-rod testom. Karvakrol primenjen p.o. u pretretmanu (45 min. pre aplikacije formalina) u dozi od 50, 75 i 100 mg/kg t.m. kod mužjaka i dozi od 50 i 100 mg/kg t.m. kod ženki pacova, prouzrokuje dozno zavisan antinociceptivni efekat. Ovaj efekat karvakrola je značajno veći (P lt 0,01, P lt 0,001) kod pacova muškog pola. U poređenju sa indometacinom aplikovanim u pretretmanu (2 mg/kg, p.o.), karvakrol (100 mg/kg) ispoljava značajno veći (P lt 0,05 i P lt 0,001) antinociceptivni efekat na formalinom izazvanu hiperalgeziju kod mužjaka pacova. U rota-rod testu karvakrol nije narušio motornu koordinaciju kod mužjka pacova, niti doza karvakrol sa jasnim antinociceptivnim svojstvima deluje depresivno na CNS tretiranih pacova. Imajući u vidu da je karvakrol monoterpen biljnog porekla sa malo potencijalnih neželjenih dejstava i bez rezidua, realno je očekivati mogućnost njegove primenu u terapiji inflamatornog bola kod životinja.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "The effect of carvacrol on inflammatory pain and motor coordination in rats, Uticaj karvakrola na inflamatorni bol i koordinaciju kretanja kod pacova", volume = "66", number = "4", pages = "478-488", doi = "10.1515/acve-2016-0041" }
Milovanović, M., Milosavljević, M., Marjanović, Đ., Trailović, S., Vučinić, M., Nedeljković-Trailović, J., Marković, M.,& Đurđević, D.. (2016). The effect of carvacrol on inflammatory pain and motor coordination in rats. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(4), 478-488. https://doi.org/10.1515/acve-2016-0041
Milovanović M, Milosavljević M, Marjanović Đ, Trailović S, Vučinić M, Nedeljković-Trailović J, Marković M, Đurđević D. The effect of carvacrol on inflammatory pain and motor coordination in rats. in Acta Veterinaria-Beograd. 2016;66(4):478-488. doi:10.1515/acve-2016-0041 .
Milovanović, Mirjana, Milosavljević, Miloš, Marjanović, Đorđe, Trailović, Saša, Vučinić, Marijana, Nedeljković-Trailović, Jelena, Marković, Maja, Đurđević, Dragan, "The effect of carvacrol on inflammatory pain and motor coordination in rats" in Acta Veterinaria-Beograd, 66, no. 4 (2016):478-488, https://doi.org/10.1515/acve-2016-0041 . .