Genotoxicity and potential chemosterilant effects of Rosol
Апстракт
Rosol is an anticoagulant rodenticide which, according to the specification of its producer (VZ-Zemun), contains 0.5 g of warfarin-sodium in 100 mililiters of solution. Its cytogenetical effects on bone marrow mitotic cells and testicular meiotic cells of Mus musculus L. (1758) of the BALB/c strain were investigated in an in vivo experiment. Animals were intragastrically treated with Rosol at doses of 0,25 mg, 0,50 mg and 0,75 mg of warfarin-sodium/kg b. w. The applied doses of warfarin-sodium were chosen according to the results of Kastori (1993), who found 0,562 mg anticoagulant rodenticides could be detected in 1 kg of soil polluted by various pesticides. The investigated doses of Rosol induced numerical (polyploidy and aneuploidy) and structural chromosomal changes (lesions, gaps, acentrics, Robertsonian fusions) of both cell types. The results obtained in the experiment point to genotoxic and mutagenic effects of Rosol or of its active component, warfarin-sodium. These effects are... significant for rodent pest control as they might cause fertility failure of the treated rodents. The occurrence of numerical and structural chromosomal changes in testicular meiotic cells could lead to the production of genetically unbalanced gametes. If the unbalanced products mature and are capable of fertilization, unbalanced zygotes will be formed and may die in utero or give rise to congenitally abnormal offspring. It appears that the anticoagulant rodenticide Rosol causes antifertile effects and also acts as a chemosterilant.
Кључне речи:
Rosol / warfarin-sodium / mice / chromosomal changes / genotoxicity / chemosterilantИзвор:
Acta Veterinaria-Beograd, 1997, 47, 4, 237-245Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Stanimirović, Zoran AU - Vučinić, Marijana AU - Soldatović, Bogosav AU - Marković, B PY - 1997 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/80 AB - Rosol is an anticoagulant rodenticide which, according to the specification of its producer (VZ-Zemun), contains 0.5 g of warfarin-sodium in 100 mililiters of solution. Its cytogenetical effects on bone marrow mitotic cells and testicular meiotic cells of Mus musculus L. (1758) of the BALB/c strain were investigated in an in vivo experiment. Animals were intragastrically treated with Rosol at doses of 0,25 mg, 0,50 mg and 0,75 mg of warfarin-sodium/kg b. w. The applied doses of warfarin-sodium were chosen according to the results of Kastori (1993), who found 0,562 mg anticoagulant rodenticides could be detected in 1 kg of soil polluted by various pesticides. The investigated doses of Rosol induced numerical (polyploidy and aneuploidy) and structural chromosomal changes (lesions, gaps, acentrics, Robertsonian fusions) of both cell types. The results obtained in the experiment point to genotoxic and mutagenic effects of Rosol or of its active component, warfarin-sodium. These effects are significant for rodent pest control as they might cause fertility failure of the treated rodents. The occurrence of numerical and structural chromosomal changes in testicular meiotic cells could lead to the production of genetically unbalanced gametes. If the unbalanced products mature and are capable of fertilization, unbalanced zygotes will be formed and may die in utero or give rise to congenitally abnormal offspring. It appears that the anticoagulant rodenticide Rosol causes antifertile effects and also acts as a chemosterilant. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Genotoxicity and potential chemosterilant effects of Rosol VL - 47 IS - 4 SP - 237 EP - 245 UR - https://hdl.handle.net/21.15107/rcub_veterinar_80 ER -
@article{ author = "Stanimirović, Zoran and Vučinić, Marijana and Soldatović, Bogosav and Marković, B", year = "1997", abstract = "Rosol is an anticoagulant rodenticide which, according to the specification of its producer (VZ-Zemun), contains 0.5 g of warfarin-sodium in 100 mililiters of solution. Its cytogenetical effects on bone marrow mitotic cells and testicular meiotic cells of Mus musculus L. (1758) of the BALB/c strain were investigated in an in vivo experiment. Animals were intragastrically treated with Rosol at doses of 0,25 mg, 0,50 mg and 0,75 mg of warfarin-sodium/kg b. w. The applied doses of warfarin-sodium were chosen according to the results of Kastori (1993), who found 0,562 mg anticoagulant rodenticides could be detected in 1 kg of soil polluted by various pesticides. The investigated doses of Rosol induced numerical (polyploidy and aneuploidy) and structural chromosomal changes (lesions, gaps, acentrics, Robertsonian fusions) of both cell types. The results obtained in the experiment point to genotoxic and mutagenic effects of Rosol or of its active component, warfarin-sodium. These effects are significant for rodent pest control as they might cause fertility failure of the treated rodents. The occurrence of numerical and structural chromosomal changes in testicular meiotic cells could lead to the production of genetically unbalanced gametes. If the unbalanced products mature and are capable of fertilization, unbalanced zygotes will be formed and may die in utero or give rise to congenitally abnormal offspring. It appears that the anticoagulant rodenticide Rosol causes antifertile effects and also acts as a chemosterilant.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Genotoxicity and potential chemosterilant effects of Rosol", volume = "47", number = "4", pages = "237-245", url = "https://hdl.handle.net/21.15107/rcub_veterinar_80" }
Stanimirović, Z., Vučinić, M., Soldatović, B.,& Marković, B.. (1997). Genotoxicity and potential chemosterilant effects of Rosol. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 47(4), 237-245. https://hdl.handle.net/21.15107/rcub_veterinar_80
Stanimirović Z, Vučinić M, Soldatović B, Marković B. Genotoxicity and potential chemosterilant effects of Rosol. in Acta Veterinaria-Beograd. 1997;47(4):237-245. https://hdl.handle.net/21.15107/rcub_veterinar_80 .
Stanimirović, Zoran, Vučinić, Marijana, Soldatović, Bogosav, Marković, B, "Genotoxicity and potential chemosterilant effects of Rosol" in Acta Veterinaria-Beograd, 47, no. 4 (1997):237-245, https://hdl.handle.net/21.15107/rcub_veterinar_80 .