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Characterization of mecC gene-carrying coagulase-negative Staphylococcus spp. isolated from various animals
dc.creator | Loncarić, Igor | |
dc.creator | Kuebber-Heiss, Anna | |
dc.creator | Posautz, Annika | |
dc.creator | Ruppitsch, Werner | |
dc.creator | Lepuschitz, Sarah | |
dc.creator | Schauer, Bernhard | |
dc.creator | Fessler, Andrea T. | |
dc.creator | Krametter-Froetscher, Reinhild | |
dc.creator | Harrison, Ewan M. | |
dc.creator | Holmes, Mark A. | |
dc.creator | Kuenzel, Frank | |
dc.creator | Szostak, Michael | |
dc.creator | Hauschild, Tomasz | |
dc.creator | Desvars-Larrive, Amelie | |
dc.creator | Mišić, Dušan | |
dc.creator | Rosengarten, Renate | |
dc.creator | Walzer, Chris | |
dc.creator | Slickers, Peter | |
dc.creator | Monecke, Stefan | |
dc.creator | Ehricht, Ralf | |
dc.creator | Schwarz, Stefan | |
dc.creator | Spergser, Joachim | |
dc.date.accessioned | 2020-06-18T22:18:56Z | |
dc.date.available | 2020-02-05 | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0378-1135 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/1845 | |
dc.description.abstract | The presence of the methicillin resistance gene mecC in coagulase-negative Staphylococcus spp. (CoNS) is scarce. The aim of this study was to characterize mecC-positive CoNS isolated from various wild and domestic animals. The presence of the mecC gene was screened in 4299 samples from wild animals and domestic animals. Fifteen coagulase-negative staphylococci, that displayed a cefoxitin-resistant phenotype, were tested mecC-positive by PCR. Antimicrobial susceptibility testing was performed for all isolates. The 15 isolates were genotyped by sequencing of the entire class E mec gene complex (blaZ-mecC-mecRI-mecI), the ccrA and ccrB recombinase genes and other determinants within the type XI SCCmec element. DNA microarray analysis was performed and five selected isolates were additionally whole genome sequenced and analyzed. S. stepanovicii (n = 3), S. caprae (n = 1), S. warneri (n = 1), S. xylosus (n = 1) and S. sciuri (n = 9) were detected. All but the S. sciuri isolates were found to be susceptible to all non-beta lactams. The entire class E mec gene complex was detected in all isolates but ccrA and ccrB genes were not identified in S. stepanovicii and S. xylosus. The genes erm(B) and fexA (n = 4, each) were the most predominant non-beta lactam resistance genes detected in the S. sciuri isolates. Even though the presence of the mecC gene among CoNS is a rare observation, this study further expands our knowledge by showing that the mecC gene, including its allotypes, are present in more staphylococcal species from different animal species than has been previously described. | en |
dc.publisher | Elsevier, Amsterdam | |
dc.relation | Research Institute of Wildlife Ecology from University of Veterinary Medicine Vienna, Austria | |
dc.relation | Austrian Buiatric association | |
dc.relation | Federal Ministry of Education and Research (BMBF) as part of the Research Network Zoonotic Infectious DiseasesFederal Ministry of Education & Research (BMBF) [01KI1727D] | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Veterinary Microbiology | |
dc.subject | mecA | en |
dc.subject | mecC | en |
dc.subject | Coagulase-negative Staphylococcus spp. | en |
dc.subject | Animals | en |
dc.subject | Antimicrobial resistance | en |
dc.title | Characterization of mecC gene-carrying coagulase-negative Staphylococcus spp. isolated from various animals | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Лонцарић, Игор; Сзостак, Мицхаел; Хаусцхилд, Томасз; Десварс-Ларриве, Aмелие; Спергсер, Јоацхим; Куеббер-Хеисс, Aнна; Посаутз, Aнника; Руппитсцх, Wернер; Лепусцхитз, Сарах; Сцхауер, Бернхард; Фесслер, Aндреа Т.; Краметтер-Фроетсцхер, Реинхилд; Харрисон, Еwан М.; Холмес, Марк A.; Куензел, Франк; Мишић, Душан; Росенгартен, Ренате; Wалзер, Цхрис; Слицкерс, Петер; Монецке, Стефан; Ехрицхт, Ралф; Сцхwарз, Стефан; | |
dc.citation.volume | 230 | |
dc.citation.spage | 138 | |
dc.citation.epage | 144 | |
dc.citation.other | 230: 138-144 | |
dc.citation.rank | aM21 | |
dc.description.other | This is the peer-reviewed version of the article: Loncarić, I.; Kuebber-Heiss, A.; Posautz, A.; Ruppitsch, W.; Lepuschitz, S.; Schauer, B.; Fessler, A. T.; Krametter-Froetscher, R.; Harrison, E. M.; Holmes, M. A.; Kuenzel, F.; Szostak, M.; Hauschild, T.; Desvars-Larrive, A.; Mišić, D.; Rosengarten, R.; Walzer, C.; Slickers, P.; Monecke, S.; Ehricht, R.; Schwarz, S.; Spergser, J. Characterization of MecC Gene-Carrying Coagulase-Negative Staphylococcus Spp. Isolated from Various Animals. Veterinary Microbiology 2019, 230, 138–144. [https://doi.org/10.1016/j.vetmic.2019.02.014] | |
dc.identifier.wos | 000461534600020 | |
dc.identifier.doi | 10.1016/j.vetmic.2019.02.014 | |
dc.identifier.pmid | 30827379 | |
dc.identifier.scopus | 2-s2.0-85061198671 | |
dc.identifier.fulltext | https://vet-erinar.vet.bg.ac.rs/bitstream/id/4854/Characterization_of_mecC_acc_2019.pdf | |
dc.type.version | acceptedVersion |